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Effect of salinity on the growth,biological activity and secondary metabolites of some marine fungi

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Acta Oceanologica Sinica 2011年第3期30卷 118-123页

作者： HUANG Jingjing lu Chunhua QIAN Xiaoming HUANG Yaojian ZHENG Zhonghui SHEN Yuemao The Key Laboratory of Ministry of Education of Cell biology and Tumor Engineering School of Life Science Xiamen University Xiamen 361005 China

The study investigated the effects of salinity on growth, antimicrobial activities and secondary metabolites of 47 marine filamentous fungi isolated from the East China Sea near the western shore of the Taiwan Straits. The results indicate that NaCl promoted the growth up to 91.5% of test strains. However, only 14.9% of them showed a significant increase of antimicrobial activity against Candida albicans. When incubated in different concentrations of NaCl, the colony growth, antimicrobial activities and composition of secondary metabolites of the strain Ty01b-8 of Penicillium sp. varied. Treatment with KCl also showed a similar effect. An alkaloid isolated from the fermentation broth of Ty01b-8 was identified as chrysogine, inhibition activity of which against Hela cells was 15.05% at 20μg/ml, and yield was 4.4 and 4.9 times higher in 3 percent and 6 percent NaCl treatments, respectively, compared with the non-salt culture condition. These findings prove that salinity is an important factor influencing growth and secondary metabolites of some marine fungi, which can be used to screen for new metabolites from marine fungi, and to enhance their metabolites production in industrial fermentation.

关键词： marine fungi salinity secondary metabolites antimicrobial activities

Theoretical predict structure and property of the novel CL-20/2,4-DNI cocrystal by systematic search approach

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Defence Technology（防务技术） 2022年第6期18卷 907-917页

作者： Hao-jie Li Jian-chao Liu Li Yang Zhen-zhan Yan Yue-wen lu Ji-min Han Xiao-ting Ren Wei Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang441003HubeiChina

Cocrystallization integrates the merits of high energy and insensitivity between energetic molecules to obtain energetics with satisfying ***,how to obtain supramolecular synthons accurately and rapidly for predicting the structure and property of cocrystal remains a challenging *** this research,an efficient systematic search approach to predict CL-20/2,4-DNI cocrystal has been proposed that 2,4-DNI revolves around CL-20 with a stoichiometric ratio of 1:1 in accordance with the specified rules(hydrogen bond length:2.2-3.0 Å;search radius:6.5 Å;the number of hydrogen bond:1-3).Eight possible supramolecular synthons were obtained by combining quantum chemistry with molecular *** structure prediction indicated that there are four structures in cocrystal,namely P21/c,P212121,Pbca and Pna21,and CL-20/2,4-DNI cocrystal is likely to be P21/c and the corresponding cell parameters are Z=4,a=8.28 Å,b=12.17 Å,c=20.42 Å,α=90°,β=96.94°,γ=90°,and ρ=1.9353 g/cm^(3).To further study the intermolecular interaction of CL-20/2,4-DNI cocrystal,a series of theoretical analyses were employed including intermolecular interaction energy,electrostatic potential(ESP),Density of State(DOS),Hirshfeld surface *** C-H…O hydrogen bonds are demonstrated as the predominant driving forces in the cocrystal *** mechanical properties and detonation properties of CL-20/2,4-DNI cocrystal implies that the cocrystal shows better ductility and excellent detonation performances(9257 m/s,39.27 GPa)and can serve as a promising energetic *** structure predicted was compared with the experimental one to verify the accuracy of systematic search *** is a less than 8.8%error between experiment and predict results,indicating the systematic search approach has extremely high reliability and *** systematic search approach can be a new strategy to search supramolecular synthons and identify structures effectively and does have t

关键词： CL-20 2,4-DNI Cocrystal Intermolecular interaction Systematic search

MgO/Carbon nanocomposites synthesized in molten salts for catalytic isomerization of glucose to fructose in aqueous media

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Green Chemical Engineering 2022年第4期3卷 359-366页

作者： Yuchao Shao Dong-Yang Zhao Wenjing lu Yuyang Long Weicheng Zheng Jun Zhao Zhong-Ting Hu College of Environment Zhejiang University of Technology(ZJUT)Hangzhou310014China HKbU Institute of Research and Continuing Education Shenzhen518057China Institute of bioresource and Agriculture Department of BiologyHong Kong Baptist UniversityHong Kong SARChina School of Environment Tsinghua UniversityBeijing100084China Industrial Catalysts Institute of ZJUT Hangzhou310014China Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling Instrumental Analysis CenterSchool of Environmental Science and EngineeringZhejiang Gongshang UniversityHangzhou310012China Hangzhou Research Institute of China Coal Technology&Engineering Group Hangzhou311201China

Isomerization of glucose into fructose has always been an important step in the biorefining *** study synthesized a novel Mg-decorated carbonaceous catalyst by molten salt method for the application of glucose *** morphology of carbon microspheres was formed with high specific surface area and pore *** effects of Mg loading,catalyst dosage,reaction temperature,and reaction time were investigated and *** highest fructose yield of 34.58%and fructose selectivity of 81.17%were achieved by the catalyst named Mg(100mg)/Carbon at hydrothermal temperature of 100℃ with reaction time of 1.5-2 h,showing the superiority of the *** results of recycling tests indicated Mg(100mg)/Carbon has good recyclability and can restore its activity after a simple *** the possible mechanism of glucose isomerization by Mg(100mg)/Carbon was *** study provided a new method for overcoming the difficulty of high energy barrier required for glucose isomerization in the biorefining process.

关键词： Glucose isomerization Heterogeneous catalyst Molten salt method Magnesium Hydrothermal

Effect of HMW-GS 6 + 8 and 1.5 + 10 from Synthetic Hexaploid Wheat on Wheat Quality Traits

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Agricultural Sciences in China 2008年第10期7卷 1161-1171页

作者： TANG Yong-lu YANG Wu-yun TIAN Ji-chun LI Jun CHEN Fang College of Life Sciences Sichuan University Chengdu 610064 P.R.China Crop Research Institute Sichuan Academy of Agricultural Sciences Chengdu 610066 P.R.China Agricultural College Shandong Agricultural University Tai＇an 250100 P.R.China

To determine the effect of 6 ＋ 8 and 1.5 ＋ 10 HMW-GS of synthetic hexaploid wheat （SHW） on main quality parameters of wheat, a set of recombinant inbred lines （RILs） derived from the cross between a SHW with N, 6 ＋ 8, 1.5 ＋ 10 HMW-GS and a cultivar Chuanyu 12-1 （CY 12-1） with 1, 7 ＋ 8, 2 ＋ 12 were planted in three environments in 2005 and 2006 and totally 16 quality parameters were tested for each line. Significant differences in all tested quality parameters but flour yield were observed between the two parents. The mean values of the RILs were intermediate to the parents for grain and protein parameters and some farinograph parameters, flour water absorption （FWA）, and farinograph softening （SOF） but beyond parents at dough stability time （DST）, breakdown time （bRT）, quality number （QN）, noodle score （NS）, and loaf volume （LOV）. All of the quality traits, especially in grain hardness （GH）, zeleny sedimentation volume （SED）, and most of farinograph parameters had significant difference between the different HMW-GS components. The effects of different alleles of HMW-GS at same locus （Glu-A1 or Glu-b1 or GIu-D1） on the different quality parameters were also different and affected by the other two loci. For most of parameters tested, 6 ＋ 8 was better than 7 ＋ 8 and there was no difference between 1.5 ＋ 10 and 2 ＋ 12. End-use quality was greatly influenced by components of HMW-GS. The components of 1, 6 ＋ 8, 1.5 ＋ 10 had the highest LOV and bread score （bS） values, whereas the components of 1, 7＋ 8 and 1.5 ＋ 10 had the highest NS values. Noodle score performed a positive linear relationship with falling number （FN） and its relationships to other quality parameters were affected by environments. Loaf volume had a significant negative relationship to SOF and positive associations with most of quality parameters. It could be concluded that HMW-GS 6＋ 8 from SHW had better overall quality characteristics than 7 ＋ 8, whereas the effects of 1.5 ＋ 10 on quality was different i

关键词： synthetic hexaploid wheat recombinant inbred lines 6 + 8 1.5 + 10 HMW-GS HMW-GS component quality traits

基于医疗临床数据的两阶段专业级大语言模型微调

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计算机应用研究 2024年第10期41卷 2906-2910页

作者：孙丽萍童子龙钱乾陆鑫涛凌晨方诚汤其宇蒋晓上海健康医学院医疗器械学院上海201318 复旦大学信息科学与工程学院上海200433 上海理工大学健康科学与工程学院上海200093 海军军医大学附属第三医院上海200438 中国人民解放军第905医院上海200052

通用大语言模型(large language model,LLM)缺乏对专业领域知识理解的深度和广度,对专业领域问题回答的准确度不够,常常产生幻觉,阻碍了大语言模型的商业应用落地。因此,基于专业领域特有数据提高大型语言模型的专业性成为当前大语言模... 详细信息

通用大语言模型(large language model,LLM)缺乏对专业领域知识理解的深度和广度,对专业领域问题回答的准确度不够,常常产生幻觉,阻碍了大语言模型的商业应用落地。因此,基于专业领域特有数据提高大型语言模型的专业性成为当前大语言模型应用落地的关键挑战。针对通用大语言模型在特定领域知识理解与生成内容专业性不够的问题进行了研究。基于P-Tuning v2与Freeze两种参数高效微调方法,提出了一种专业级大语言模型的两阶段微调框架。依赖该框架与肝胆科临床数据对ChatGLM-6b进行微调,得到一个针对肝胆专科的专业级大语言模型,命名为MedGLM.H。根据实验显示,微调后的大语言模型对于肝胆专科问题的准确率从31%提升到了62%;得分率从57%提升到了73%。在进行两阶段微调后,模型在肝胆专科的问答中表现出更高的准确性与专业性,根据三名临床医生进行的对话实验,证明了微调后的模型在更专业的医疗场景中具备应用潜力。

关键词：大语言模型微调肝胆科人工智能

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基于伪随机场的面板坝运行期库岸渗漏成因分析

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水电能源科学 2024年第7期42卷 124-128页

作者：鞠鲁忆沈振中曹福君吴义军李皓璇刘子茜河海大学水利水电学院江苏南京210098 河海大学水文水资源与水利工程科学国家重点实验室江苏南京210098 吉林水利电力职业学院吉林长春130117

四川某混凝土面板堆石坝坝址区地形条件复杂,坝后量水堰处渗水量相比同类工程观测数据偏大,为此,基于饱和—非饱和渗流原理,利用自编程准三维渗流分析程序建立渗流分析模型,在伪随机场探测结果的基础上分别对导流洞封堵区、左岸防渗帷... 详细信息

四川某混凝土面板堆石坝坝址区地形条件复杂,坝后量水堰处渗水量相比同类工程观测数据偏大,为此,基于饱和—非饱和渗流原理,利用自编程准三维渗流分析程序建立渗流分析模型,在伪随机场探测结果的基础上分别对导流洞封堵区、左岸防渗帷幕、止水及右岸渗漏通道进行敏感性分析。结果表明,导流洞封堵区渗水及左岸趾板下死水位以下的上层防渗帷幕失效是造成左岸渗流量增大的重要原因;左岸面板周边缝止水的不同失效性仅对面板附近渗压造成局部影响,表层止水对测点渗压影响更大;右岸存在渗漏通道时,右岸测点拟合效果更好,右岸山体渗流量增大,但量水堰处流量并未同等程度增加。

关键词：混凝土面板堆石坝渗流有限元分析渗漏原因断层防渗帷幕

Genome-wide identification and characterization of basic helix-loop-helix transcription factors in Spodoptera litura upon pathogen infection

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Insect Science 2022年第4期29卷 977-992页

作者： Jie Zhang Mengyao Zhu Qilin Li Ting Tang Liang Wen Jielai Zhong Ruonan Zhang Xiao-Qiang Yu Yuzhen lu Guangdong Provincial Key Laboratory of Insect Developmental biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangzhou Key Laboratory of Insect Development Regulation and Application Research Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina

basic helix-loop-helix(bHLH)transcription factors play an important role in a wide range of metabolic and developmental processes in eukaryotes,and bHLH proteins also participate in immune responses,especially in ***,their roles in insects upon entomopathogen infection are *** this study,54 bHLH genes in 41 families were identified in a polyphagous pest,Spodoptera litura,including a new bHLH gene in group b,which is specifically present in Lepidoptera and was thus named *** conserved amino acids in the bHLH domain,structural architecture,and chromosomal distribution of bHLH genes in *** were *** bHLH genes in Plutella xylostella and Apis mellifera were also updated,and genome-wide comparison and phylogenetic analysis of bHLH members in 5 holometabolous insects were *** expression profiles of *** bHLH(SlbHLH)genes in 3 tissues at different developmental stages and their responses to *** nucleopolyhedrovirus(SpltNPV),Nomuraea rileyi(Nr),and bacillus thuringiensis(bt)infection were *** SlbHLHs in group b were expressed and differentially expressed during pathogen infections,and SlbHLHs tended to be downregulated in the midgut of *** larvae after *** *** study provides an overview of bHLH family members in *** and their responses to different pathogens used for pest *** findings on bHLH members may contribute to uncovering the mechanism of host-pathogen interaction.

关键词： basic helix-loop-helix entomopathogen infection pest biocontrol Spodoptera liura

Effects of ytterbium addition and heat treatment on the mechanical properties and biocorrosion behaviors of Mg-Zn-Zr alloy

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Journal of Magnesium and Alloys 2020年第2期8卷 499-509页

作者： lu Li Tao Wang Yu Wang Cun-cai Zhang Hao Lv Hua Lin Wen-bin Yu Chu-jie Huang School of Materials and Energy Southwest UniversityChongqingChina Department of Clinical Laboratory Chongqing Ninth People's HospitalChongqing 400700PR China

Mechanical properties and biocorrosion behaviors in simulated body fluid(SbF)of newly developed Mg-5.8 Zn-0.5 Zr-x Yb(ZK60-X Yb,x=0,1.0,2.0wt%)magnesium alloys in the solution-treated(T4)and artificially-aged(T6)conditions were *** results of mechanical properties show that with Yb addition,the microhardness and the ultimate tensile strength(UTS)of the tested alloys are significantly increased despite a slight decrease in tensile elongation in both T4 and T6 ***,after the T6 treatment,the microhardness and the UTS of the samples were further improved,which was mainly attributed to the precipitation *** biocorrosion behaviors of the tested alloys were studied using electrochemical examinations and immersion *** results indicate that the biocorrosion resistance of the tested alloys is significantly improved by Yb addition in both T4 and T6 *** the corrosion resistance was slightly deteriorated after T6 treatment,the aged ZK60-2.0 Yb alloy still exhibited a favorable corrosion behavior,which was mainly ascribed to the corrosion barrier effect of a more compact and uniform protective film induced by the dispersed nano-scale *** measurements also confirmed these *** the favorable comprehensive performance in mechanical and biocorrosion behaviors,the T6 treated ZK60-2.0 Yb alloy may be considered as a promising candidate for biomedical applications.

关键词： Mg-Yb-Zn-Zr alloy Mechanical properties biocorrosion behaviors Heat treatment biomedical applications

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胸痹心痛热毒血瘀证血管病变及相关特征分析

广州中医药大学学报 2024年第2期41卷 263-271页

作者：姚美丹李雨黄尉威冼绍祥王卢曦陈洁广州中医药大学广东广州510405 广州中医药大学第一附属医院广东广州510405 华中科技大学协和深圳医院广东深圳518000

【目的】基于冠状动脉(简称冠脉)、颈动脉、心脏病变及其相关指标回顾性研究胸痹心痛患者热毒血瘀证血管及其相关因素的辨证特征。【方法】回顾性收集221例胸痹心痛患者,根据中医辨证分型情况将患者分为热毒血瘀证154例和非热毒血瘀证67... 详细信息

【目的】基于冠状动脉(简称冠脉)、颈动脉、心脏病变及其相关指标回顾性研究胸痹心痛患者热毒血瘀证血管及其相关因素的辨证特征。【方法】回顾性收集221例胸痹心痛患者,根据中医辨证分型情况将患者分为热毒血瘀证154例和非热毒血瘀证67例,进行人口学特征、心血管危险因素相关疾病、理化指标、冠脉Gensini评分、颈动脉超声、心脏超声等指标的采集。比较热毒血瘀证与非热毒血瘀证患者各项指标的差异,并采用Spearman或Pearson分析探讨胸痹心痛热毒血瘀证与冠脉、颈动脉病变及其相关指标的相关性。【结果】(1)人口学特征及相关疾病分析结果提示,与非热毒血瘀证相比,胸痹心痛热毒血瘀证患者以男性发病为主(P=0.001),吸烟史及不稳定型心绞痛(UA)、急性非ST段抬高型心肌梗死(NSTEMI)、急性ST段抬高型心肌梗死(STEMI)等冠心病类型的比例较高,且多合并血脂异常(P0.05)。(2)理化指标分析结果提示,胸痹心痛热毒血瘀证患者的甘油三酯(TG)及肌酸激酶同工酶Mb(CK-Mb)较高,高密度脂蛋白胆固醇(HDL-C)较低,与非热毒血瘀证比较,差异均有统计学意义(PbA1c)、空腹血糖(FbG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、血清尿酸(UA)、同型半胱氨酸(Hcy)、b型钠尿肽(bNP)、体质量指数(bMI)比较,差异均无统计学意义(P>0.05)。(3)冠脉狭窄Gensini评分分析结果提示,热毒血瘀证患者的冠脉狭窄Gensini评分较非热毒血瘀证显著升高(P0.05),但左室舒张功能相关指标e’值较低、E/e’值较高,提示热毒血瘀证患者可能存在舒张功能受损。(6)相关性分析结果提示,胸痹心痛热毒血瘀证与冠心病类型、基于Gensini评分的冠脉狭窄程度及左、右侧颈动脉IMT相关,相关系数分别为0.418、0.320、0.269、0.205(Pb具有一定相关性,相关系数分别为0.216、0.186、0.266、0.193(P<0.01)。【结论】胸痹心痛热毒血瘀证大多处于不稳定阶段,冠脉及颈动脉血管病变均较严重,与血脂异常及左、右侧颈动脉IMT有关,临证时应抓住中医热毒血瘀证的辨证特征,诊病于微,已病防变。

关键词：胸痹心痛冠心病热毒血瘀证颈动脉斑块 Gensini评分相关性