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Mechanical behaviors of mylonitic granite and granitic protomylonite in a deep ductile shear zone

Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2663-2677页

作者： Lanbin Zhang Ru Zhang Li Ren Zhilong Zhang Zetian Zhang Dong Wang Xinzhong Wang Huijun lu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China MOE Key Laboratory of Deep Earth Science and Engineering Sichuan UniversityChengdu610065China China Railway Eryuan Engineering Group Company Ltd.Chengdu610065China School of Architecture and Civil Engineering Xihua UniversityChengdu610065China

For projects near the tectonic belt,mylonite of varying metamorphic degrees may be *** matrix proportion of rock reflects its internal microscopic characteristics,thus it is beneficial for engineering geology to study the effect of the matrix proportion on the mechanical properties and rupture behaviors of *** of mylonitic granite and granitic protomylonite with varying matrix proportions were obtained from a ductile shear zone for a series of uniaxial compression and acoustic emission(AE)*** results showed that with the increase in matrix proportion,the average strength and elastic modulus of the samples increased,and the rock sample with the largest matrix proportion exhibited the maximum peak stress of 244.42 MPa,which was 45.86%greater than the average peak stress of the rock samples with the smallest matrix *** the rock samples with larger matrix proportion,their mechanical parameters exhibited greater dispersion and the large-scale appearance of AE events occurred earlier,showing a relatively gradual failure *** samples had larger accumulated AE parameter values and greater degree of *** contrast,for samples with smaller matrix proportions,the large-scale appearance of AE events occurred close to the peak stress,indicating that the occurrence of damage and fractures was centralized and *** samples had lower accumulated AE parameter values and fewer cracks after ***,for the rock samples with more matrix proportion,the average variance of the b-value was 1.1,which was lower than that of rock samples with the smallest matrix proportion(the average variance of the b-value was 3.7).Furthermore,it can be predicted that under certain stress,the failure depth around a tunnel is generally smaller when the strength of rock samples with larger matrix proportion is greater.

关键词： Mylonite Matrix proportion Mechanical properties Acoustic emission(AE) Rupture behaviors

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Elaidic acid-induced intestinal barrier damage led to gut-liver axis derangement and triggered NLRP3 inflammasome in the liver of SD rats

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Food Science and Human Wellness 2024年第3期13卷 1279-1291页

作者： Hui Liu Xuenan Li lu Li Yucai Li Haiyang Yan Yong Pang Wenliang Li Yuan Yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China School of Public Health Jining Medical UniversityJining 272067China

Previous studies have shown that trans fatty acids(TFA) are associated with several chronic diseases,the gut microbiota is directly influenced by dietary components and linked to chronic *** research investigated the effects of elaidic acid(EA),a typical TFA,on the gut microbiota to understand the underlying mechanisms of TFA-related chronic diseases.16S rDNA gene sequencing on faecal samples from Sprague-Dawley rats were performed to explore the composition change of the gut microbiota by EA gavage for 4 *** results showed that the intake of EA increased the abundance of well-documented harmful bacteria,such as Proteobacteria,Anaerotruncus,Oscillibacter and ***,EA induced translocation of lipopolysaccharides(LPS) and the above pathogenic bacteria,disrupted the intestinal barrier,led to gut-liver axis derangement and TLR4 pathway activation in the ***,EA induced intestinal barrier damage and regulated TLR4-MyD88-NF-κb/MAPK pathways in the liver of SD rats,leading to the activation of NLRP3 inflammasome and inflammatory liver damage.

关键词： Elaidic acid(EA) Gut microbiota Intestinal barrier Gut-liver axis TLR4-MyD88-NF-κb/MAPK pathways NLRP3 inflammasome

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Low-latitude hydroclimate changes related to paleomagnetic variations during the Holocene in coastal southern China

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Frontiers of Earth Science 2024年第2期18卷 324-335页

作者： Tingwei ZHANG Xiaoqiang YANG Jian YIN Qiong CHEN Jianfang HU lu WANG Mengshan JU Qiangqiang WANG School of Earth Science and Engineering/Guangdong Provincial Key Laboratory of Geodynamics and Geohazards/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yat-sen UniversityGuangzhou 510275China Institute of Cultural Heritage Shandong UniversityQingdao 266237China State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China

The variations in precipitation have displayed a complex pattern in different regions since the *** formation processes may have a significant impact on precipitation,especially during the tropical marine processes and summer monsoon which convey abundant water vapor to coastal southern China and inland ***,we use two 7500 year sedimentary records from the Pearl River Delta and the closed Maar Lake,respectively,in coastal southern China to reconstruct the mid-to-late-Holocene humidity variability and explore its possible relationship with cloud cover modulated by the Earth’s magnetic fields(EMF).Our proxy records document an apparent increase in wetness in coastal southern China between 3.0 and 1.8 kyr *** apparent increase in humidity appears to be consistent with the lower virtual axial dipole moments and,in turn,with a lower *** correlation suggests that the EMF might have been superimposed on the weakened monsoon to regulate the mid-to-late-Holocene hydroclimate in coastal southern China through the medium of galactic cosmic rays,aerosols,and cloud ***,further investigations are needed to verify this interaction.

关键词： hydroclimate variations Earth’s magnetic field coastal southern China the Holocene epoch

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Development of pharmacological immunoregulatory anticancer therapeutics:current mechanistic studies and clinical opportunities

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2477-2526页

作者： Nanhao Yin Xintong Li Xuanwei Zhang Shaolong Xue Yu Cao Gabriele Niedermann You lu Jianxin Xue Division of Thoracic Tumor Multimodality Treatment Cancer Center&State Key Laboratory of Biotherapyand The National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityNo.20Section 3South Renmin RoadChengdu 610041 SichuanPR China Department of Emergency Medicine Laboratory of Emergency MedicineWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Institute of Disaster Medicine&Institute of Emergency Medicine Sichuan UniversityNo.17Gaopeng AvenueChengdu 610041 SichuanPR China Department of Radiation Oncology Medical Center—University of FreiburgFaculty of MedicineUniversity of FreiburgGerman Cancer Consortium(DKTK)Partner Site DKTK-FreiburgRobert-Koch-Strasse 379106 FreiburgGermany Laboratory of Clinical Cell Therapy West China HospitalSichuan UniversityNo.2222Xinchuan RoadChengdu 610041 SichuanPR China

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment,but challenges related to resistance and toxicity still *** to the advancement of immuno-oncology,an increasing number of novel immunoregulatory targets and mechanisms are being revealed,with relevant therapies promising to improve clinical immunotherapy in the foreseeable ***,comprehending the larger picture is *** this review,we analyze and summarize the current landscape of preclinical and translational mechanistic research,drug development,and clinical trials that brought about next-generation pharmacological immunoregulatory anti-cancer agents and drug candidates beyond classical immune checkpoint *** with further clarification of cancer immunobiology and advances in antibody engineering,agents targeting additional inhibitory immune checkpoints,including LAG-3,TIM-3,TIGIT,CD47,and b7 family members are becoming an important part of cancer immunotherapy research and discovery,as are structurally and functionally optimized novel anti-PD-(L)1 and anti-CTLA-4 agents and agonists of co-stimulatory molecules of T *** by bispecific T cell engagers,newly emerging bi-specific and multi-specific antibodies targeting immunoregulatory molecules can provide considerable clinical ***-generation agents also include immune epigenetic drugs and cytokine-based *** therapies,cancer vaccines,and oncolytic viruses are not covered in this *** comprehensive review might aid in further development and the fastest possible clinical adoption of effective immuno-oncology modalities for the benefit of patients.

关键词： clinical immuno landscape

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Study on the anti-inflammatory mechanism of moxibustion in rheumatoid arthritis in rats based on phospholipaseA2 signaling inhibition by Annexin 1

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Journal of Traditional Chinese Medicine 2024年第4期44卷 753-761页

作者： GUO Yanding luO Kun ZHANG Linlin lu Wenting SHANG Yanan ZHONG Yumei HU Danhui YANG Xin ZHOU Haiyan Department of Acupuncture-Moxibustion and Tuina the Third Affiliated HospitalChengdu University of Traditional Chinese MedicineChengdu 610075China External Treatment Center First People's Hospital of ChengduChengdu 610095China Department of Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital Chengdu 610075China Department of Health Rehabilitation School Chengdu University of Traditional Chinese MedicineChengdu 610075China

ObJECTIVE:To determine whether moxibustion had an anti-inflammatory effect on rheumatoid arthritis(RA)by regulating Annexin 1 expression and interfering with the phospholipaseA2 signaling ***:Thirty male Sprague-Dawley rats were randomly categorized into five groups(six rats per group):blank control(CON)group,RA model(RA)group,moxibustion(MOX)group,Annexin 1 lentiviral intervention(RNAi-Anxa1)group,and Annexin 1 lentiviral intervention+moxibustion(RNAi-Anxa1+MOX)*** rats in the RNAi-Anxa1 and the RNAi-Anxa1+MOX groups were injected with the lentiviral vector-mediated RNAi-Anxa1 into the rat foot *** experimental RA rat model was established by injecting Freund's complete adjuvant(FCA)into the RA,MOX,RNAi-Anxa1,and RNAi-Anxa1+MOX *** in the MOX and RNAiAnxa1+MOX groups received moxibustion *** modeling,using moxibustion“Shenshu(bL23)”and“Zusanli(ST36)”,each point is 5 times,bilateral alternating,once a day,6 times for a course of treatment,between the courses of rest for a one day.A total of three treatment courses were *** bilateral pad thicknesses were measured using Vernier calipers on experimental days 1,7,14,21,and *** expression of cPLA2αsignaling in the synovium of diseased joints was observed using Western *** pathology of the rat ankle synovium was observed using hematoxylineosin(HE)***(IL)-1β,IL-10,prostaglandin E2(PGE2),and leukotriene b4(LTb4)were detected using enzyme-linked immunosorbent ***:Moxibustion increased the levels of Annexin 1 and decreased the inflammatory response in rats with *** increasing the expression of Annexin 1,the phosphorylated expression of cPLA2αwas inhibited,the serum levels of IL-1β,PGE2,and LTb4 decreased,and the level of IL-10 *** moxibustion treated RA rats after the Annexin 1 lentiviral intervention,the serum levels of IL-1β,PGE2,LTb4,and IL-10 were almost ***:Moxibustion enhanced the negative regulation of

关键词： annexins group IV phospholipases A2 signal transduction moxibustion arthritis,rheumatoid

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基于PSO-IbP神经网络的纯电动汽车电驱总成故障诊断

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现代制造工程 2024年第1期 137-141页

作者：肖伟李泽军管天福贺路陈绪兵武汉工程大学机电工程学院武汉430205 湖北国土资源职业学院汽车与机电学院武汉430090

为了提高纯电动汽车电驱总成的故障诊断准确率,提出了一种基于粒子群优化(Particle Swarm Optimizing,PSO)算法的改进bP(Improved back Propagation,IbP)神经网络(PSO-IbP)故障诊断方法。应用线性整流单元(Rectified Linear Unit,Relu)作为bP神经网络的激活函数,通过粒子群优化算法对bP神经网络权值和阈值进行动态寻优,构建PSO-IbP模型。通过采集纯电动汽车电驱总成故障数据,分别对PSO-IbP神经网络模型、bP神经网络模型和概率神经网络(Probabilistic Neural Network,PNN)模型进行训练与仿真,结果表明,相比于bP神经网络方法及概率神经网络方法,基于PSO-IbP神经网络模型的纯电动汽车电驱总成故障诊断方法具有更高的准确率。

关键词：纯电动汽车粒子群算法 bP神经网络故障诊断

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Coming of age:the formation and function of age-associated b cells

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Cellular & Molecular Immunology 2024年第4期21卷 311-312页

作者： Ke Rui Nan Che Kongyang Ma Hejian Zou Fan Xiao Liwei lu Department of Laboratory Medicine Institute of Medical Immunology of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Rheumatology and Immunology Nanjing First HospitalNanjing Medical UniversityJiangsuChina Centre for Infection and Immunity Studies School of MedicineThe Sun Yat-sen UniversityShenzhen518107GuangdongChina Department of Rheumatology Huashan HospitalFudan UniversityShanghaiChina Department of Pathology and Shenzhen Institute of Research and Innovation HKU Shenzhen HospitalThe University of Hong KongHong KongChina Centre for Oncology and Immunology Hong Kong Science ParkHong KongChina

b cells are generated in the bone marrow during ontogeny and migrate to peripheral lymphoid organs,where they encounter antigens to elicit humoral *** the past decade,many novel b-cell subsets with distinct phenotypes and functions have been identified,and among these subsets,age-associated b cells(AbCs)were first characterized as a b-cell subset that accumulates with age[1].

关键词： organs lymphoid migrate

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Ultra-high-temperature application of MXene: Stabilization of 2D Ti_(3)C_(2)T_(x) for cross-scale strengthening and toughening of 3D TiC

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Journal of Advanced Ceramics 2024年第1期13卷 1-10页

作者： lu Liu Guobing Ying Quanguo Jiang Dong Wen Peng Wang Meng Wu Ziying Ji Yongting Zheng Xiang Wang Department of Materials Science and Engineering College of Mechanics and MaterialsHohai UniversityNanjing 211100China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China

Transition metal carbide/nitride cores within MXenes make them considerably useful for ultra-high-temperature ***,extensive research on Ti_(3)C_(2)T_(x) MXene has revealed its tendency to undergo a phase transition to TiCy at temperatures above 800℃due to high activity of a superficial Ti atomic ***,spark plasma sintering of Ti_(3)C_(2)T_(x) and TiC is performed to prevent the Ti_(3)C_(2)T_(x) phase transition at temperatures up to 1900℃through the fabrication of composites at a pressure of 50 *** a focused ion beam scanning electron microscope to separate layered substances in the composites and examining selected area diffraction spots in a transmission electron microscope enabled identification of non-phase-transitioned ***-principles calculations based on density functional theory indicated the formation of strong chemical bonding interfaces between Ti_(3)C_(2)T_(x) and TiC,which imposed a stability constraint on the Ti atomic layer at the Ti_(3)C_(2)T_(x) *** performance tests,such as three-point bending and fracture toughness analysis,demonstrated that the addition of Ti_(3)C_(2)T_(x) can effectively improve the cross-scale strengthening and toughening of the TiC matrix,providing a new path for designing and developing two-dimensional(2D)carbides cross-scale-enhanced three-dimensional(3D)carbides with the same elements relying on a wide variety of MXenes.

关键词： MXene ultra-high-temperature phase stability interface bonding cross-scale strengthening and toughening structural ceramic composites

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Clinical significance of preoperative nutritional status in elderly gastric cancer patients undergoing radical gastrectomy:A singlecenter retrospective study

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2211-2220页

作者： Xi-Ning Zhao Jing lu Hong-Yong He Sheng-Jin Ge Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Nursing Zhongshan HospitalFudan UniversityShanghai 200032China Department of General Surgery/Emergency Surgery Zhongshan HospitalFudan UniversityShanghai 200032China

bACKGROUND The population of elderly patients with gastric cancer is increasing,which is a major public health issue in *** is one of the greatest risk factors for adverse clinical outcomes in elderly patients with gastric *** To investigate the preoperative nutritional status and its association with delayed discharge of elderly gastric cancer patients following radical *** A total of 783 patients aged 65 years and older harboring gastric adenocarcinoma and following radical gastrectomy were retrospectively analyzed from the prospectively collected database of Zhongshan Hospital of Fudan University between January 2018 and May *** The overall rate of malnutrition was 31.8%.The incidence of postoperative complications was significantly higher in the malnourished group compared to the well-nourished group(Pluding body mass index,prognostic nutritional index(PNI),albumin,prealbumin,and hemoglobin,were all significantly lower than those in the well-nourished *** percentage of patients who received postoperative total nutrient admixture was lower in the malnourished group compared to the wellnourished group(22.1%vs 33.5%,P=0.001).Age≥70 years(HR=1.216,95%CI:1.048-1.411),PNI<44.5(HR=1.792,95%CI:1.058-3.032),operation time≥160 minutes(HR=1.431,95%CI:1.237-1.656),and postoperative complications grade III or higher(HR=2.191,95%CI:1.604-2.991)were all recognized as independent risk factors associated with delayed *** Malnutrition is relatively common in elderly patients undergoing *** PNI is an independent risk factor associated with delay *** strategies are needed to improve the clinical outcome of these patients.

关键词： Gastric cancer Preoperative nutritional status Malnutrition Elderly Radical gastrectomy

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Different timing for abdominal paracentesis catheter placement and drainage in severe acute pancreatitis complicated by intraabdominal fluid accumulation

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 134-142页

作者： Rui Chen Hua-Qiang Chen Rui-Die Li Hui-Min lu Department of General Surgery Chengdu Sixth People’s HospitalChengdu 610058Sichuan ProvinceChina West China Center of Exellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest ChinaDivision of Pancreatic SurgeryDepartment of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina HospitalSichuan University

bACKGROUND Non-surgical methods such as percutaneous drainage are crucial for the treatment of patients with severe acute pancreatitis(SAP).However,there is still an ongoing debate regarding the optimal timing for abdominal paracentesis catheter place-ment and *** To explore the influence of different timing for abdominal paracentesis catheter placement and drainage in SAP complicated by intra-abdominal fluid *** Using a retrospective approach,184 cases of SAP complicated by intra-abdominal fluid accumulation were enrolled and categorized into three groups based on the timing of catheter placement:group A(catheter placement within 2 d of symptom onset,n=89),group b(catheter placement between days 3 and 5 after symptom onset,n=55),and group C(catheter placement between days 6 and 7 after symptom onset,n=40).The differences in progression rate,mortality rate,and the number of cases with organ dysfunction were compared among the three *** The progression rate of group A was significantly lower than those in groups b and groups C(2.25%vs 21.82%and 32.50%,Pb and groups C(41.57%vs 70.91%and 75.00%,Pb,and group C were similar(P>0.05).At postoperative day 3,the levels of C-reactive protein(55.41±19.32 mg/L vs 82.25±20.41 mg/L and 88.65±19.14 mg/L,Pb and group *** length of hospit

关键词： Abdominal paracentesis catheter drainage Timing Severe acute pancreatitis Intra-abdominal fluid Application value

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