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Development of pharmacological immunoregulatory anticancer therapeutics:current mechanistic studies and clinical opportunities

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2477-2526页

作者： Nanhao Yin Xintong Li xuanwei zhang Shaolong Xue Yu Cao Gabriele Niedermann You Lu Jianxin Xue Division of Thoracic Tumor Multimodality Treatment Cancer Center&State Key Laboratory of Biotherapyand The National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityNo.20Section 3South Renmin RoadChengdu 610041 SichuanPR China Department of Emergency Medicine Laboratory of Emergency MedicineWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Institute of Disaster Medicine&Institute of Emergency Medicine Sichuan UniversityNo.17Gaopeng AvenueChengdu 610041 SichuanPR China Department of Radiation Oncology Medical Center—University of FreiburgFaculty of MedicineUniversity of FreiburgGerman Cancer Consortium(DKTK)Partner Site DKTK-FreiburgRobert-Koch-Strasse 379106 FreiburgGermany Laboratory of Clinical Cell Therapy West China HospitalSichuan UniversityNo.2222Xinchuan RoadChengdu 610041 SichuanPR China

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment,but challenges related to resistance and toxicity still *** to the advancement of immuno-oncology,an increasing number of novel immunoregulatory targets and mechanisms are being revealed,with relevant therapies promising to improve clinical immunotherapy in the foreseeable ***,comprehending the larger picture is *** this review,we analyze and summarize the current landscape of preclinical and translational mechanistic research,drug development,and clinical trials that brought about next-generation pharmacological immunoregulatory anti-cancer agents and drug candidates beyond classical immune checkpoint *** with further clarification of cancer immunobiology and advances in antibody engineering,agents targeting additional inhibitory immune checkpoints,including LAG-3,TIM-3,TIGIT,CD47,and B7 family members are becoming an important part of cancer immunotherapy research and discovery,as are structurally and functionally optimized novel anti-PD-(L)1 and anti-CTLA-4 agents and agonists of co-stimulatory molecules of T *** by bispecific T cell engagers,newly emerging bi-specific and multi-specific antibodies targeting immunoregulatory molecules can provide considerable clinical ***-generation agents also include immune epigenetic drugs and cytokine-based *** therapies,cancer vaccines,and oncolytic viruses are not covered in this *** comprehensive review might aid in further development and the fastest possible clinical adoption of effective immuno-oncology modalities for the benefit of patients.

关键词： clinical immuno landscape

UV-Based Advanced Oxidation Processes for Antibiotic Resistance Control: Efficiency, Influencing Factors, and Energy Consumption

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Engineering 2024年第6期37卷 27-39页

作者： Jiarui Han Wanxin Li Yun Yang xuanwei zhang Siyu Bao Xiangru zhang Tong zhang Kenneth Mei Yee Leung Department of Civil and Environment Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China Department of Civil Engineering The University of Hong KongHong Kong 999077China State Key Laboratory of Marine Pollution and Department of Chemistry City University of Hong KongHong Kong 999077China

Antibiotic resistant bacteria(ARB)with antibiotic resistance genes(ARGs)can reduce or eliminate the effectiveness of antibiotics and thus threaten human *** United Nations Environment Programme considers antibiotic resistance the first of six emerging issues of *** oxidation processes(AOPs)that combine ultraviolet(UV)irradiation and chemical oxidation(primarily chlorine,hydrogen peroxide,and persulfate)have attracted increasing interest as advanced water and wastewater treatment *** integrated technologies have been reported to significantly elevate the efficiencies of ARB inactivation and ARG degradation compared with direct UV irradiation or chemical oxidation alone due to the generation of multiple reactive *** this study,the performance and underlying mechanisms of UV/chlorine,UV/hydrogen peroxide,and UV/persulfate processes for controlling ARB and ARGs were reviewed based on recent *** affecting the process-specific efficiency in controlling ARB and ARGs were discussed,including biotic factors,oxidant dose,UV fluence,pH,and water matrix *** addition,the cost-effectiveness of the UV-based AOPs was evaluated using the concept of electrical energy per *** UV/chlorine process exhibited a higher efficiency with lower energy consumption than other UV-based AOPs in the wastewater matrix,indicating its potential for ARB inactivation and ARG degradation in wastewater *** studies are required to address the trade-off between toxic byproduct formation and the energy efficiency of the UV/chlorine process in real wastewater to facilitate its optimization and application in the control of ARB and ARGs.

关键词： Advanced oxidation processes Ultraviolet/chlorine Ultraviolet/hydrogen peroxide Ultraviolet/persulfate Antibiotic resistant bacteria Antibiotic resistance genes

A More Effective Method of Extracting the Characteristic Value of Pulse Wave Signal Based on Wavelet Transform

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Journal of Biomedical Science and Engineering 2016年第10期9卷 9-19页

作者： xuanwei zhang Yazhou Shang Daoxin Guo Tianxia Zhao Qiuping Li Xin’an Wang The Key Laboratory of Integrated Microsystems Peking University Shenzhen Graduate School Shenzhen China

Pulse wave contains human physiological and pathological information. Different people will exhibit different characteristics, and hence determining the characteristic points of the pulse wave of human physiological health makes sense. It is common that we extract the characteristic value of pulse wave signal with the method based on wavelet transform on a small scale, and then determine the locations of the characteristic points by modulus maxima and modulus minima. Before determining characteristic value by detecting modulus maxima and modulus minima, we need to determine every period of the pulse wave. This paper presents a new kind of adaptive threshold determination method which is more effective. It can accurately determine every period of the pulse wave, and then extract characteristic values by modulus maxima and modulus minima in every period of the pulse wave. The method presented in this paper promotes the research utilizing pulse wave on health life.

关键词： Pulse Wave Wavelet Transform Adaptive Threshold Characteristic Values

AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues

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The Journal of Biomedical Research 2014年第5期28卷 388-395页

作者： Jia Guo Xin Chen Ruxing Xi Yuwei Chang xuanwei zhang Xiaozhi zhang Department of Radiotherapy First Affiliated Hospital of Xi'an Jiaotong University

Astrocyte elevated gene-1（AEG-1） is associated with tumor genesis and progression in a variety of human *** study aimed to explore the significance of AEG-l in glioma and investigate whether it correlated with radioresistance of glioma *** staining showed that the intensity of AEG-l,CD133 and PPP6 c protein expression in glioma tissues increased significantly,mainly in the *** expression rate of AEG-l,CD133 and PPP6c were 85.9%（67/78）,60.3%（47/78） and 65.8%（51/78）,***-l expression was correlated with age（r=0.227,P=0.045）,clinical stage（r=0.491,P〈0.001） and clinical grade（r=0.450,P〈0.001）.No correlation was found between AEG-l expression and other clinicopathologic parameters（P〉0.05）.The expression of AEG-1 was positively correlated with the expression of CD133（r=0.240,P = 0.035） and PPP6c（r= 0.250,P = 0.027）.In addition,retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-l and PPP6 c in *** findings indicate that AEG-l is positively correlated with CD133 and AEG-l *** may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.

关键词： glioma AEG-1 immunohistochemistry radioresistance

从常规体系域到非常规体系域——河流相层序地层学研究的一个重要进展

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海相油气地质 2013年第1期18卷 39-46页

作者：章轩玮中国地质大学(北京)地球科学与资源学院

在与海平面变化存在联系的近滨线河流相地层中,源于海岸碎屑沉积体系的层序地层学概念得到了较好的应用,从而在河流相地层中产生了低水位体系域(LST)、与海侵体系域类似的水进体系域(TST)及高水位体系域(HST)等常规体系域下的河流相层... 详细信息

在与海平面变化存在联系的近滨线河流相地层中,源于海岸碎屑沉积体系的层序地层学概念得到了较好的应用,从而在河流相地层中产生了低水位体系域(LST)、与海侵体系域类似的水进体系域(TST)及高水位体系域(HST)等常规体系域下的河流相层序地层划分方案。由于源于海岸沉积体系的早期体系域划分存在着概念体系的不协调,故常规体系域划分在河流相层序中的使用也就存在着概念体系的不协调。非常规体系域(低可容纳空间体系域,LAST;高可容纳空间体系域,HAST)的提出可避免这种概念体系的不协调,并为研究复杂的河流沉积过程和提取地层记录规律提供重要的线索和思路。

关键词：河流相层序地层学体系域研究进展

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痛性糖尿病周围神经病变发生机制的研究进展

中国糖尿病杂志 2024年第2期32卷 149-154页

作者：张轩玮柳兴凤聂开瑜遵义医科大学 563000 遵义医科大学附属医院烧伤整形外科

痛性糖尿病周围神经病变(PDPN)是DM慢性并发症,我国PDPN患者占比较高。目前最新指南列出PDPN治疗的一线镇痛药物,大型随机试验证实联合用药的有效性,但PDPN病理生理机制尚未完全明确,临床治疗仍不理想。本文综述PDPN发生机制的研究进展。

关键词：痛性糖尿病周围神经病变机制脊髓背角

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“南海Ⅰ号”发掘现场船体的稳定性保护

博物院 2019年第4期 31-44页

作者：张玄微广东海上丝绸之路博物馆阳江529536

2013年'南海Ⅰ号'全面发掘工作展开后,船体及船载文物陆续暴露于大气环境之中。'南海Ⅰ号'宋代沉船浸泡于水下长达800余年,船体木材降解、损坏严重,加之船载文物数量巨大,材质种类多样,叠积密集,其发掘及保护的模式尚无先例可循,发掘现... 详细信息

2013年'南海Ⅰ号'全面发掘工作展开后,船体及船载文物陆续暴露于大气环境之中。'南海Ⅰ号'宋代沉船浸泡于水下长达800余年,船体木材降解、损坏严重,加之船载文物数量巨大,材质种类多样,叠积密集,其发掘及保护的模式尚无先例可循,发掘现场船体保护任务十分艰巨。维持船体的稳定性,为今后的全面保护、修复做好基础性工作,是'南海Ⅰ号'当前发掘阶段现场保护的重点。为此,结合'南海Ⅰ号'沉船沉积及保存环境变化、船体木材保存状态进行检测分析,梳理了'南海Ⅰ号'现场稳定保护处理的基本技术路线和实施方法。相关监测分析数据显示,'南海Ⅰ号'船体在现场发掘条件下的保存状态没有进一步劣化的趋势,说明发掘现场稳定性保护处理方案得当,实施措施有效。

关键词：海洋环境饱水木材发掘现场稳定性保护

塔里木盆地塔中地区中奥陶统一间房组分布范围

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东北石油大学学报 2015年第5期 1-13页

作者：章轩玮中国地质大学(北京)地球科学与资源学院

塔里木盆地塔中Ⅲ区奥陶系良里塔格组底部发育一套砂屑—生屑滩相颗粒灰岩沉积,与原Ⅰ区、Ⅱ区含泥质条带藻黏结泥晶灰岩的认识有差异.运用目标层位岩心岩屑牙形石古生物分析方法,结合区域性牙形石带划分、岩性岩相特征、测井特征、暴... 详细信息

塔里木盆地塔中Ⅲ区奥陶系良里塔格组底部发育一套砂屑—生屑滩相颗粒灰岩沉积,与原Ⅰ区、Ⅱ区含泥质条带藻黏结泥晶灰岩的认识有差异.运用目标层位岩心岩屑牙形石古生物分析方法,结合区域性牙形石带划分、岩性岩相特征、测井特征、暴露溶蚀特征等,分析该套地层的层位归属,明确一间房组地层在塔中地区的存在;结合地震标定与层位追踪,确定塔中地区一间房组的实际分布范围与有利油气成藏模式.结果表明:该套颗粒灰岩地层归属中奥陶统一间房组地层,塔中地区一间房组的实际分布范围在塔中Ⅲ区及Ⅱ区台缘相区,一间房组顶面溶蚀储层与良里塔格组底泥晶灰岩组合形成上生下储式油气藏的潜能.该研究对塔中地区一间房组下一步油气勘探具有现实意义.

关键词：塔里木盆地塔中北斜坡一间房组牙形石成像测井

利用微动力缓流循环淋洗原理保护处理脆弱有机质文物的应用实践

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遗产与保护研究 2019年第2期4卷 115-118页

作者：张玄微海上丝绸之路博物馆广东阳江529536

在"南海Ⅰ号"发掘工作中,现场提取到的大量木质类器物/标本单体,材质糟朽脆弱情况严重,通过对"南海Ⅰ号"发掘提取到的竹席残片、木盒、琉璃壶麻质包装物脱水加固定型的处理,文章介绍了利用微动力缓流循环淋洗原理保护处理脆弱有机质文... 详细信息

在"南海Ⅰ号"发掘工作中,现场提取到的大量木质类器物/标本单体,材质糟朽脆弱情况严重,通过对"南海Ⅰ号"发掘提取到的竹席残片、木盒、琉璃壶麻质包装物脱水加固定型的处理,文章介绍了利用微动力缓流循环淋洗原理保护处理脆弱有机质文物的应用技术解决方案,旨在为今后开展这类文物的保护处理提供有益的借鉴。

关键词：南海Ⅰ号有机质文物淋洗脱盐加固定型