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Development of pharmacological immunoregulatory anticancer therapeutics:current mechanistic studies and clinical opportunities

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2477-2526页

作者： Nanhao Yin Xintong Li xuanwei Zhang Shaolong Xue Yu Cao Gabriele Niedermann You Lu Jianxin Xue Division of Thoracic Tumor Multimodality Treatment Cancer Center&State Key Laboratory of Biotherapyand The National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityNo.20Section 3South Renmin RoadChengdu 610041 SichuanPR China Department of Emergency Medicine Laboratory of Emergency MedicineWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Institute of Disaster Medicine&Institute of Emergency Medicine Sichuan UniversityNo.17Gaopeng AvenueChengdu 610041 SichuanPR China Department of Radiation Oncology Medical Center—University of FreiburgFaculty of MedicineUniversity of FreiburgGerman Cancer Consortium(DKTK)Partner Site DKTK-FreiburgRobert-Koch-Strasse 379106 FreiburgGermany Laboratory of Clinical Cell Therapy West China HospitalSichuan UniversityNo.2222Xinchuan RoadChengdu 610041 SichuanPR China

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment,but challenges related to resistance and toxicity still *** to the advancement of immuno-oncology,an increasing number of novel immunoregulatory targets and mechanisms are being revealed,with relevant therapies promising to improve clinical immunotherapy in the foreseeable ***,comprehending the larger picture is *** this review,we analyze and summarize the current landscape of preclinical and translational mechanistic research,drug development,and clinical trials that brought about next-generation pharmacological immunoregulatory anti-cancer agents and drug candidates beyond classical immune checkpoint *** with further clarification of cancer immunobiology and advances in antibody engineering,agents targeting additional inhibitory immune checkpoints,including LAG-3,TIM-3,TIGIT,CD47,and B7 family members are becoming an important part of cancer immunotherapy research and discovery,as are structurally and functionally optimized novel anti-PD-(L)1 and anti-CTLA-4 agents and agonists of co-stimulatory molecules of T *** by bispecific T cell engagers,newly emerging bi-specific and multi-specific antibodies targeting immunoregulatory molecules can provide considerable clinical ***-generation agents also include immune epigenetic drugs and cytokine-based *** therapies,cancer vaccines,and oncolytic viruses are not covered in this *** comprehensive review might aid in further development and the fastest possible clinical adoption of effective immuno-oncology modalities for the benefit of patients.

关键词： clinical immuno landscape

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Observation of high ionic conductivity of polyelectrolyte microgels in salt-free solutions

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Chinese Chemical Letters 2024年第4期35卷 255-259页

作者： Qiangwei Wang Huijiao Liu Mengjie Wang Haojie Zhang Jianda Xie xuanwei Hu Shiming Zhou Weitai Wu State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsThe Key Laboratory for Chemical Biology of Fujian Provinceand Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of Chemistry and Chemical Engineering Ningxia UniversityYinchuan 750021China

Here, we report an observation that illustrate the potential of polyelectrolyte microgels in salt-free solutions to display a high ionic conductivity. Laser light scattering and ionic conductivity tests on very dilute aqueous dispersions of the microgels indicate that both small size and swollen state of gel particles play vital roles, which should favor the counterions to freely penetrate and leave gel particles, and thus can contribute to the ion-conducting property. Upon discovering this on microgels that are composed of imidazolium-based poly(ionic liquid), we also illustrate the generality of the finding to single lithium-ion polyelectrolyte microgels that are of more technically relevant features for applications, for instance, as injectable liquid “microgel-in-solution” electrolytes of high conductivity(ca. 8.2.× 10^(-2.S/m at 2..0 ℃ for1.0 × 10^(-2.g/m L of microgels in a LiNO_(3)-free 1:1 v/v mixture of 1,2.dioxolane and dimethoxymethane) and high lithium-ion transference number(0.87) for use in the rechargeable lithium-sulfur battery.

关键词： Polyelectrolhyte Stimuli-responsive Single-ion conducting Liquid electrolyte Lithium metal battery

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Analysis and inversion of target polarization characteristics based on pBRDF

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Journal of Systems Engineering and Electronics 2024年第5期35卷 1073-1083页

作者： GU Xiansong FU Qiang WANG Liya LIU xuanwei FAN Xinyu DUAN Jin LI Yingchao School of Optical Engineering Beijing University of TechnologyBeijing 100081China School of Optoelectronic Engineering Changchun University of Science and TechnologyChangchun 130022China

Imaging detection is an important means to obtain target *** traditional imaging detection technology mainly collects the intensity information and spectral information of the target to realize the classification of the *** practical applications,due to the mixed scenario,it is difficult to meet the needs of target *** with intensity detection,the method of polarization detection can effectively enhance the accuracy of ground object target recognition(such as the camouflage target).In this paper,the reflection mechanism of the target surface is studied from the microscopic point of view,and the polarization characteristic model is established to express the relationship between the polarization state of the reflected signal and the target surface *** polarization characteristic test experiment is carried out,and the target surface parameters are retrieved using the experimental *** results show that the degree of polarization(DOP)is closely related to the detection zenith angle and azimuth ***(DOP)of the target is the smallest in the direction of light source incidence and the largest in the direction of specular *** materials have different polarization *** comparing their DOP,target classification can be achieved.

关键词： polarization detection polarization degree zenith angle azimuth angle target classification.

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Effectiveness of machine learning at modeling the relationship between Hi-C data and copy number variation

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Quantitative Biology 2024年第3期12卷 231-244页

作者： Yuyang Wang Yu Sun Zeyu Liu Bijia Chen Hebing Chen Chao Ren xuanwei Lin Pengzhen Hu Peiheng Jia Xiang Xu Kang Xu Ximeng Liu Hao Li Xiaochen Bo Institute of Health Service and Transfusion Medicine BeijingChina College of Computer and Data Science Fuzhou UniversityFuzhouChina Beijing Institute of Radiation Medicine BeijingChina School of Life Sciences Northwestern Polytechnical UniversityXi’anChina School of Mathematics and Computer Science Shanxi Normal UniversityTaiyuanChina School of Software Shandong UniversityQingdaoChina

Copy number variation(CNV)refers to the number of copies of a specific sequence in a genome and is a type of chromatin structural *** development of the Hi-C technique has empowered research on the spatial structure of chromatins by capturing interactions between DNA *** utilized machine-learning methods including the linear transformation model and graph convolutional network(GCN)to detect CNV events from Hi-C data and reveal how CNV is related to three-dimensional interactions between genomic fragments in terms of the one-dimensional read count signal and features of the chromatin *** experimental results demonstrated a specific linear relation between the Hi-C read count and CNV for each chromosome that can be well qualified by the linear transformation *** addition,the GCN-based model could accurately extract features of the spatial structure from Hi-C data and infer the corresponding CNV across different chromosomes in a cancer cell *** performed a series of experiments including dimension reduction,transfer learning,and Hi-C data perturbation to comprehensively evaluate the utility and robustness of the GCN-based *** work can provide a benchmark for using machine learning to infer CNV from Hi-C data and serves as a necessary foundation for deeper understanding of the relationship between Hi-C data and CNV.

关键词： copy number variant deep learning graph convolution network Hi-C

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UV-Based Advanced Oxidation Processes for Antibiotic Resistance Control: Efficiency, Influencing Factors, and Energy Consumption

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Engineering 2024年第6期37卷 27-39页

作者： Jiarui Han Wanxin Li Yun Yang xuanwei Zhang Siyu Bao Xiangru Zhang Tong Zhang Kenneth Mei Yee Leung Department of Civil and Environment Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China Department of Civil Engineering The University of Hong KongHong Kong 999077China State Key Laboratory of Marine Pollution and Department of Chemistry City University of Hong KongHong Kong 999077China

Antibiotic resistant bacteria(ARB)with antibiotic resistance genes(ARGs)can reduce or eliminate the effectiveness of antibiotics and thus threaten human *** United Nations Environment Programme considers antibiotic resistance the first of six emerging issues of *** oxidation processes(AOPs)that combine ultraviolet(UV)irradiation and chemical oxidation(primarily chlorine,hydrogen peroxide,and persulfate)have attracted increasing interest as advanced water and wastewater treatment *** integrated technologies have been reported to significantly elevate the efficiencies of ARB inactivation and ARG degradation compared with direct UV irradiation or chemical oxidation alone due to the generation of multiple reactive *** this study,the performance and underlying mechanisms of UV/chlorine,UV/hydrogen peroxide,and UV/persulfate processes for controlling ARB and ARGs were reviewed based on recent *** affecting the process-specific efficiency in controlling ARB and ARGs were discussed,including biotic factors,oxidant dose,UV fluence,pH,and water matrix *** addition,the cost-effectiveness of the UV-based AOPs was evaluated using the concept of electrical energy per *** UV/chlorine process exhibited a higher efficiency with lower energy consumption than other UV-based AOPs in the wastewater matrix,indicating its potential for ARB inactivation and ARG degradation in wastewater *** studies are required to address the trade-off between toxic byproduct formation and the energy efficiency of the UV/chlorine process in real wastewater to facilitate its optimization and application in the control of ARB and ARGs.

关键词： Advanced oxidation processes Ultraviolet/chlorine Ultraviolet/hydrogen peroxide Ultraviolet/persulfate Antibiotic resistant bacteria Antibiotic resistance genes

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正式性和权势关系在系统功能模型中的理论归位

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中国外语 2024年第2期21卷 23-33页

作者：黄劲怡彭宣维云南师范大学深圳大学

在社交互动中,语言使用的正式程度可以反映人际权势,即等级高低、亲疏远近和庄重性强弱。相关见解散见于功能主义语言学各分支流派中,包括社会语言学、系统功能语言学、批评话语分析等,但先前研究的归纳和整合程度不够,没有将相关范畴... 详细信息

在社交互动中,语言使用的正式程度可以反映人际权势,即等级高低、亲疏远近和庄重性强弱。相关见解散见于功能主义语言学各分支流派中,包括社会语言学、系统功能语言学、批评话语分析等,但先前研究的归纳和整合程度不够,没有将相关范畴系统化和理论化。本文基于“语境-元功能联结假说”,全面考察系统功能语言学内外部的既有认识。研究表明,语境变量、人际权势和措辞的正式性之间存在多对一的体现关系,措辞正式性和人际权势会分别范畴化为“语体”词汇语法系统和“权势”语义系统。本研究为“权势↘语体”模型及其体现关系提供背景支持,明确下一步的研究内容和方向。

关键词：正式性权势系统功能语言学人际功能范畴化

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中外老年教育发展现状比较与启示

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江西开放大学学报 2024年第1期26卷 15-22页

作者：刘暄葳北京开放大学北京100081

随着人口老龄化程度的增加,老年教育越来越受到世界各国的重视。从理论、办学模式、课程三个维度比较中外老年教育,中国应学习国外先进的老年教育理念,完善老年教育理论体系并将其与实践紧密结合;应改变单一行政主导的老年教育办学模式... 详细信息

随着人口老龄化程度的增加,老年教育越来越受到世界各国的重视。从理论、办学模式、课程三个维度比较中外老年教育,中国应学习国外先进的老年教育理念,完善老年教育理论体系并将其与实践紧密结合;应改变单一行政主导的老年教育办学模式,支持社会力量参与举办老年教育,构筑多元开放的老年教育办学体系;应不断丰富老年教育课程内容,促进课程形式多样化。

关键词：老年教育理论办学模式课程

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痛性糖尿病周围神经病变发生机制的研究进展

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中国糖尿病杂志 2024年第2期32卷 149-154页

作者：张轩玮柳兴凤聂开瑜遵义医科大学 563000 遵义医科大学附属医院烧伤整形外科

痛性糖尿病周围神经病变(PDPN)是DM慢性并发症,我国PDPN患者占比较高。目前最新指南列出PDPN治疗的一线镇痛药物,大型随机试验证实联合用药的有效性,但PDPN病理生理机制尚未完全明确,临床治疗仍不理想。本文综述PDPN发生机制的研究进展。

关键词：痛性糖尿病周围神经病变机制脊髓背角

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地方金融机构发展的经济效应研究——基于城乡居民收入差距视角

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财经研究 2024年第04期50卷 19-33页

作者：张珩陈萱玮罗剑朝中国社会科学院金融研究所广州大学经济与统计学院西北农林科技大学经济管理学院

共同富裕是中国在新时代新征程上新的奋斗目标。作为经济发展的血脉,金融对于助力“提低扩中”和缩小城乡居民收入差距,进而实现共同富裕具有重大意义。文章以农信社为切入点,深入讨论了地方金融机构发展对县域城乡居民收入差距的影响,... 详细信息

共同富裕是中国在新时代新征程上新的奋斗目标。作为经济发展的血脉,金融对于助力“提低扩中”和缩小城乡居民收入差距,进而实现共同富裕具有重大意义。文章以农信社为切入点,深入讨论了地方金融机构发展对县域城乡居民收入差距的影响,并检验了Kuznets效应论对地方金融机构是否成立。研究发现,地方金融机构发展不仅会显著缩小县域城乡居民收入差距,还会对经济距离相近县域的城乡居民收入差距产生显著的正向溢出效应。Kuznets效应论对地方金融机构发展并不成立,这与地方金融机构“下沉”服务的积极性较高以及对“非活跃”的农村居民服务门槛较低有关。机制分析表明,地方金融机构发展会通过改变金融支农力度和中间业务创新来影响县域城乡居民收入差距。异质性分析表明,对于法人股持股比例和贷款定价较低的地方金融机构,以及所处县域经济发展速度较快和资金外流程度较低地区的地方金融机构,其发展能够显著缩小县域城乡居民收入差距。文章的研究对于通过建立地方金融机构高质量发展机制、包容性金融服务体系和“有为政府+有效市场”的保障体系来缩小县域城乡居民收入差距、促进实现共同富裕具有重要的政策启示。

关键词：地方金融机构城乡居民收入差距共同富裕

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Repositioning of the complete prolapsed silicone tube with modified suture-probe and silk thread traction method

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Eye Science 2024年第1期1卷 80-87页

作者：李静陈荣新梁轩伟 State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060China

The whole lacrimal passage intubation is widely used in lacrimal ***,one of the most typical complications is the prolapse of the silicone tube from the medial *** case,the bicanalicular silicone tube after whole lacrimal duct intubation has completely prolapsed from the medial canthus before extubation,then cannot be found in the opening of the nasolacrimal duct,and it would be a challenge to reposition or removal.A novel approach to employ a modified suture-probe and silk thread traction technique has been developed,and it is not only safe and effective,but also cost-effective.

关键词： suture-probe silk thread traction complete prolapsed silicone tube reposition

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