检索结果-南通市图书馆

The complex role of PD-L1 in antitumor immunity:a recent update

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第8期18卷 2067-2068页

作者： Xiaoqing Zhang Yue Huang xuanming yang Sheng Yushou Center of Cell Biology and Immunology School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Joint International Research Laboratory of Metabolic&Developmental Sciences Shanghai Jiao Tong UniversityShanghaiChina

PD-1,a member of the immunoglobulin gene superfamily,was found to be involved in programmed cell death and subsequently demonstrated to be critical for the negative regulation of T *** ligands PD-L1(B7-H1)and PD-L2(B7-DC)interact with PD-1 and negatively regulate T cell-mediated immune responses.1 CD80 also interacts with PD-L1 as a counterreceptor.

关键词： immunity death CD80

Distinct contribution of PD-L1 suppression by spatial expression of PD-L1 on tumor and non-tumor cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第4期16卷 392-400页

作者： Xiaoqing Zhang Chen Cheng Jiyan Hou Xinyue Qi Xin Wang Ping Han xuanming yang School of Life Science and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Longyao Biotechnology Co. LtdShanghai 200072China

Programmed cell death receptor 1(PD-1)and its ligand,PD-L1,are important immune checkpoint *** antibodies that block PD-1/PD-L1 have shown promising clinical efficacy in a subset of cancer patients,the detailed cellular and molecular mechanisms behind anti-PD-1 and anti-PD-L1 immunotherapy are not well ***,the way in which PD-L1 contributes to immune suppression on tumor and non-tumor cells remains *** selectively blocking PD-L1 on either tumor or non-tumor cells,we demonstrated that PD-L1 from both sources suppressed the anti-tumor T-cell *** PD-L1 on either tumor cells or non-tumor cells inhibited tumor growth and enhanced immune cell infiltration,as well as the tumor-specific T-cell ***,simultaneously blocking tumor-and non-tumor-derived PD-L1 maximized anti-tumor T-cell responses and demonstrated *** addition,the relative contribution of PD-L1 on tumor and non-tumor cells to immune suppression depended on the PD-L1 expression ***,we found that the F4/80 receptor was involved in the anti-tumor effect of PD-L1 *** together,our data indicate that PD-L1 on both tumor and non-tumor cells is critical for T-cell inhibition,which provides new directions for the optimization of PD-L1-blocking antibodies and the development of clinical biomarker strategies.

关键词： inhibited clinical suppression

Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2014年第6期29卷 393-402页

作者： Zhangsheng yang Jun Du Gang Chen Jie Zhao xuanming yang Lishan Su Genhong Cheng Hong Tang Key Laboratory of Infection and Immunity (CASKLII) Institute of BiophysicsChinese Academy of Sciences Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of BiotechnologyShanxi University Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill School of MedicineNC 27599-7295USA Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095USA

It remains challenging to develop animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus(SARS-CoV) and Middle East respiratory syndrome cornavirus(MERS-Co V) without high level of containment. This inevitably hinders understanding of virushost interaction and development of appropriate countermeasures. Here we report that intranasal inoculation of sublethal doses of murine coronavirus mouse hepatitis virus A-59(MHV-A59), a hepatic and neuronal tropic coronavirus, can induce acute pneumonia and severe lung injuries in C57BL/6 mice. Inflammatory leukocyte infiltrations, hemorrhages and fibrosis of alveolar walls can be observed 2-11 days after MHV-A59 infection. This pathological manifestation is associated with dramatical elevation of tissue IP-10 and IFN-γ and moderate increase of TNF-α and IL-1β, but inability of anti-viral type I interferon response. These results suggest that intranasal infection of MHV-A59 would serve as a surrogate mouse model of acute respiratory distress syndrome by SARS-CoV and MERS-CoV infections.

关键词： coronavirus MHV-A59 pneumonia inflammation cytokine

分泌anti-PD-L1及IFNα的间充质干细胞联合治疗小鼠黑色素瘤

在线全文

学校读者我要写书评

暂无评论

中国免疫学杂志 2022年第1期38卷 12-17页

作者：林浩李民韩萍杨选明(指导) 上海交通大学生命科学技术学院上海200240

目的:为了提高免疫检查点阻断治疗的疗效,探讨以间充质干细胞(MSC)为载体,anti-PD-L1和IFNα对小鼠黑色素瘤的联合治疗效果。方法:构建重组质粒并生产慢病毒,利用慢病毒感染MSC细胞并获得MSC-anti-PD-L1-Fc和MSCIFNα4-Fc两种细胞系。利... 详细信息

目的:为了提高免疫检查点阻断治疗的疗效,探讨以间充质干细胞(MSC)为载体,anti-PD-L1和IFNα对小鼠黑色素瘤的联合治疗效果。方法:构建重组质粒并生产慢病毒,利用慢病毒感染MSC细胞并获得MSC-anti-PD-L1-Fc和MSCIFNα4-Fc两种细胞系。利用CCK-8细胞增殖实验及OT-Ⅰ小鼠T细胞杀伤实验检测两种细胞系在体外的抗肿瘤活性,ELISA、qPCR、流式细胞术等方法检测两种细胞系体内治疗的药效、分布及抗肿瘤活性。结果:体内和体外实验表明MSC-anti-PD-L1-Fc和MSC-IFNα4-Fc两种细胞系均可显著抑制小鼠黑色素瘤的生长,二者联合治疗可有效提高对小鼠黑色素瘤的肿瘤负荷控制,延长小鼠生存期并促进肿瘤微环境由免疫抑制向免疫促进的转化。结论:利用MSC作为载体的联合免疫治疗是可行的思路,可能是肿瘤免疫治疗的一种新策略。

关键词：免疫治疗间充质干细胞 Anti-PD-L1 IFNα 黑色素瘤

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

一种有效的吸收边界条件及其应用

微波学报 2002年第3期18卷 14-17页

作者：钟选明廖成杨丹西南交通大学电磁场与微波技术研究所成都610031

从二维波动方程出发 ,经过相关理论分析 ,充分利用其内含的局域性特点 ,得出了局域边界条件 ;并把它和Mur二阶边界条件相比较 ,发现从理论到数值仿真 ,新边界条件都比Mur二阶边界更有效。而且 ,和Mur二阶边界条件相比 ,它只增加非常少... 详细信息

从二维波动方程出发 ,经过相关理论分析 ,充分利用其内含的局域性特点 ,得出了局域边界条件 ;并把它和Mur二阶边界条件相比较 ,发现从理论到数值仿真 ,新边界条件都比Mur二阶边界更有效。而且 ,和Mur二阶边界条件相比 ,它只增加非常少的计算量和计算机内存。最后 ,应用新边界条件来模拟平面波在多层媒质中的传播。

关键词：吸收边界条件,时域有限差分法,多层媒质

Self-enhancing photothermal conversion of 2D Weyl semimetal WTe_(2)with topological surface states for efficient solar vapor generation

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第8期16卷 10976-10984页

作者： Chun Du Ziyi yang Anzhen Mo xuanming Duan Guowei yang Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou 511443China State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

To improve the performance of solar energy-driven water generation,two-dimensional(2D)photothermal materials requisite to be optimized by some strategies such as alloying,combination of plasmonic and defect ***,the challenges faced in practical utilization are the complex preparation process and insufficient solar spectrum ***,we propose a strategy of self-enhancing photothermal performance induced by topological surface states(TSSs).2D WTe_(2)is fabricated on the mixed cellulose ester(MCE)for photothermal *** to the MCE and pure water,WTe_(2)@MCE has an excellent photothermal evaporation rate of 1.09 kg·m^(−2)·h^(−1)upon 1 sun irradiation,promoting 6.1 and 3.1 times,*** can be attributed to the characteristics of 2D Weyl semimetal WTe_(2)with TSSs bringing about high optical absorption capacity,low thermal diffusivity,specific heat capacity,and high carrier density,which are strongly proved by experiments and *** importantly,the contribution of TSSs to the enhancement of optical absorption for efficient solar water generation is revealed by the comparative experiment between 2D WTe_(2)with TSSs and that without ***,photothermal conversion mechanism is explored in-depth understanding that the photoexcited electrons recombinate with the holes through nonradiative mode for releasing thermal energy by phonons emission via multiple *** work promotes the application of Weyl semimetal material with TSSs in solar water evaporation.

关键词： two-dimensional(2D)WTe_(2) Weyl semimetals topological surface states(TSSs) photothermal conversion

High-frequency interference waves in low strain dynamic testing of X-section concrete piles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2021年第4期20卷 877-885页

作者： Qu Liming Fan Yuming Ding xuanming yang Changwei Zhang Yanling Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 610031China Shanghai Chengtou Highway Group Co. LTD.Shanghai 200335China Key Laboratory of New Technology for Construction of Cities in Mountain Area College of Civil EngineeringChongqing UniversityChongqing 400045China MOE Key Laboratory of High-speed Railway Engineering College of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Stress waves propagate along vertical,radial and circumferential directions when a non-uniformly distributed load is applied at one end of a three-dimensional *** a result,the receiving signals are usually mixed with undesired interference components,often featuring as high-frequency *** studies have revealed that sectional geometry(shape and size)greatly affects the high-frequency *** this study,low strain dynamic testing on full-scale X-section concrete is conducted in order to investigate the influences of high-frequency interference on velocity responses at the pile *** is placed on the frequency and peak value of interference waves at various receiving ***,the effects of the geometrical,and mechanical properties of the pile shaft on high-frequency interference are elaborated on through the three-dimensional finite element *** results show that the measured wave is obscured by interference waves superposed by two types of high-frequency *** modulus and cross-sectional area are contributing factors to the frequency and peak value of the interference *** the other hand,the position with the least interference is determined,to some extent,by the accurate shape of the X-section.

关键词： low strain dynamic testing X-section concrete pile high-frequency interference full-scale model test finite element method

嵌合抗原受体T细胞经不同给药途径对小鼠心肌梗死后心律失常的影响

在线全文

学校读者我要写书评

暂无评论

中国临床医学 2024年第4期31卷 612-618页

作者：张源欣杨蒲媛付芃翰孔祥萌杨选明张庆勇上海交通大学医学院附属第九人民医院心内科上海200011 上海交通大学生命科学技术学院上海200240

目的探究嵌合抗原受体(chimeric antigen receptor,CAR)T细胞对心肌梗死的治疗作用,并观察不同给药途径对CAR-T细胞心脏毒性的影响。方法将成功建立心肌梗死模型的24只SCID Beige免疫缺陷小鼠随机均分为Hank’s平衡盐溶液(HBSS)组、CAR-... 详细信息

目的探究嵌合抗原受体(chimeric antigen receptor,CAR)T细胞对心肌梗死的治疗作用,并观察不同给药途径对CAR-T细胞心脏毒性的影响。方法将成功建立心肌梗死模型的24只SCID Beige免疫缺陷小鼠随机均分为Hank’s平衡盐溶液(HBSS)组、CAR-TIM组、CAR-TIV组及CAR-TIMIV组(均n=6),另设Sham组(n=6)。Sham组、HBSS组、CAR-TIM组和CAR-TIMIV组于造模后第7天,心肌局部注射HBSS或CAR-T细胞;Sham组、HBSS组、CAR-TIV组和CAR-TIMIV组于造模后第7天、第14天,尾静脉注射HBSS或CAR-T细胞。造模28 d后,观察小鼠电生理指标,并对心肌组织进行Masson染色,计算心肌梗死面积。结果与Sham组相比,HBSS组心肌梗死面积显著增加(P<0.05),心律失常发生率未明显升高。与HBSS组相比,不同给药途径的CAR-T细胞治疗组的心肌梗死面积均显著缩小(均P<0.05),心律失常发生率均显著升高(均P<0.05)。CAR-TIV组与CAR-TIM组间心肌梗死的治疗效果和心律失常发生率无显著差异;CAR-TIMIV组较CAR-TIV组,心肌梗死面积显著降低(P<0.05),两组间心律失常发生率无显著差异。结论静脉联合心肌局部注射CAR-T细胞可有效降低心肌梗死面积,但增加心律失常发生率,其机制有待进一步研究。

关键词：嵌合抗原受体T 心肌梗死心律失常心肌注射静脉注射

Torsional vibration of a pipe pile in transversely isotropic saturated soil

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2016年第3期15卷 509-517页

作者： Zheng Changjie Hua Jianmin Ding xuanming College of Civil Engineering Chongqing University Key Laboratory of New Technology for Construction of Cities in Mountain Area (Chongqing University) Ministry of Education

This study considers the torsional vibration of a pipe pile in a transversely isotropic saturated soil layer. Based on Biot＇s poroelastic theory and the constitutive relations of the transversely isotropic medium, the dynamic governing equations of the outer and inner transversely isotropic saturated soil layers are derived. The Laplace transform is used to solve the governing equations of the outer and inner soil layers. The dynamic torsional response of the pipe pile in the frequency domain is derived utilizing 1D elastic theory and the continuous conditions at the interfaces between the pipe pile and the soils. The time domain solution is obtained by Fourier inverse transform. A parametric study is conducted to demonstrate the influence of the anisotropies of the outer and inner soil on the torsional dynamic response of the pipe pile.

关键词： torsional vibration saturated soil pipe pile transversely isotropic medium