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Ratiometric delivery of doxorubicin and berberine by liposome enables superior therapeutic index than Doxil?

Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 385-396页

作者： Ruoshi Zhang Yingxi Zhang Yue Zhang Xin Wang xuanming gao Yuyan Liu Xuanbo Zhang Zhonggui He Dun Wang Yongjun Wang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China

Although the appearance of Doxil alleviated the cardiotoxicity of DOX, the progression-free survival of patients was not prolonged compared with traditional medication regimens, and side effects such as hand-foot syndrome has occurred. In order to solve this dilemma, we have designed a novel co-delivery strategy to construct a co-loaded liposome of berberine(BER) and doxorubicin(DOX), which was called Lipo Be Do. The optimal synergistic ratio of the two drugs was screened by cell cytotoxicity experiments in vitro, and the optimal attenuation ratio was further determined by in vivo cardiac H&E staining pathological sections. The optimal combination treatment caused a robust increase in apoptotic cells of 4T1, as compared to drug alone treatment. The prepared co-loaded liposome, Lipo Be Do, had high encapsulation efficiency and good stability. The nanoliposome carrier controlled the biological fate of the drugs and maintained a pre-defined optimal ratio in vivo. The Lipo Be Do significantly inhibited tumor growth in 4T1 murine mammary carcinoma model compared with Doxil(P < 0.05), and completely overcame the myocardial rupture toxicity caused by Doxil in mice. Our co-loaded liposome delivery platform technology provided a new direction for the clinical treatment of triple-negative breast cancer and the safe application of DOX.

关键词： Berberine Doxorubicin Nanoliposomes Remote loading Combination therapy Cardiotoxity

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Stimulating Start-up Investment Through Government-Sponsored Venture Capital:Theory and Chinese Evidence

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Journal of Systems Science & Complexity 2024年第5期37卷 2021-2053页

作者： NI xuanming ZHENG Tiantian gao Feng ZHAO Huimin School of Software and Microelectronics Peking UniversityBeijing 100871China School of Economics and Management Tsinghua UniversityBeijing 100084China School of Business Sun Yat-sen UniversityGuangzhou 510275China

Government-sponsored venture capital(GVC)has been used to support financially constrained start-ups as an important policy tool in ***,to motivate the social capital to invest in start-ups,GVC provides subsidies for them to bridge the funding gap in the early-stage venture capital ***,the effect and mechanism of GVC affecting social capital investment have not been clearly *** this paper,the authors not only develop a game model to analyze this issue in theory,but conduct an empirical study by analyzing the 14741 records matched by propensity score matching(PSM)of Chinese venture capital market data from 2011 to *** proposed findings are as the ***,the subsidies offered by GVC will simultaneously increase the returns and risks of investments in start-ups of social capital with more volatile incentive effect of *** incentive effect of GVC is only effective when the returns resulting from the subsidies outweigh the risks they *** the context of the Chinese venture capital market,the incentive effect of GVC is ***,the incentive effect of GVC is more pronounced in high-tech industries,which can be attributed to the signaling effect facilitated by *** this context,the subsidy mainly helps social capital to bear the costs associated with screening potential ***,the incentive effect of GVC is more significant in underdeveloped venture capital markets,which can be explained by the“virtuous cycle”effect,in which GVC plays a pioneering role in establishing a more robust early-stage market trading *** examining these three points,this study contributes to a better understanding of how GVC can effectively guide social capital investment,especially in the Chinese landscape.

关键词： Government-sponsored venture capital fund incentive effect social capital subsidy venture capital

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Mechanical behavior and response mechanism of porous metal structures manufactured by laser powder bed fusion under compressive loading

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 737-749页

作者： xuanming Cai Yang Hou Wei Zhang Zhiqiang Fan Yubo gao Junyuan Wang Heyang Sun Zhujun Zhang Wenshu Yang School of Aerospace Engineering North University of ChinaTaiyuan 030051China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China School of Astronautics Harbin Institute of TechnologyHarbin 150080China School of Mechanical Engineering North University of ChinaTaiyuan 030051China Shijiazhuang Campus Army Engineering University of PLAShijiazhuang 050003China 65589 Unit 91 Detachment Daqing 163411China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150080China

Al Si10Mg porous protective structure often produces different damage forms under compressive loading,and these damage modes affect its protective *** order to well meet the service requirements,there is an urgent need to comprehensively understand the mechanical behavior and response mechanism of AlSi10Mg porous structures under compressive *** this paper,Al Si10Mg porous structures with three kinds of volume fractions are designed and optimized to meet the requirements of high-impact,strong-energy absorption,and lightweight *** mechanical behaviors of AlSi10Mg porous structures,including the stress-strain relationship,structural bearing state,deformation and damage modes,and energy absorption characteristics,were obtained through experimental studies at different loading *** damage pattern of the damage section indicates that AlSi10Mg porous structures have both ductile and brittle mechanical *** simulation studies show that the AlSi10Mg porous structure undergoes shear damage due to relative misalignment along the diagonal cross-section,and the damage location is almost at 45°to the load direction,which is the most direct cause of its structural damage,revealing the damage mechanism of AlSi10Mg porous structures under the compressive *** normalized energy absorption model constructed in the paper well interprets the energy absorption state of Al Si10Mg porous structures and gives the sensitive location of the structures,and the results of this paper provide important references for peers in structural design and optimization.

关键词： AlSi10Mg additive manufacture energy absorption characteristics damage by deformation mechanical behavior

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区镇食品药品监管工作一体化管理体系建设研究

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中国药业 2017年第18期26卷 78-81页

作者：贺盛亮聂选明邓启发高勇李平华夏大华赵梦遐湖北省咸宁市咸安区食品药品监督管理局湖北咸宁437000 湖北省新产业技师学院·咸宁职业教育〈集团〉学校湖北咸宁437100 湖北科技学院护理学院湖北咸宁437100

目的构建区、镇食品药品监管工作一体化管理体系模式。方法论述国家新一轮食品药品监管体制改革后咸安区食品药品监督管理局基本情况及派出乡镇食品药品监管所的建设、人员配备、办公场所、执法装备、经费来源、工作运行机制等情况及一... 详细信息

目的构建区、镇食品药品监管工作一体化管理体系模式。方法论述国家新一轮食品药品监管体制改革后咸安区食品药品监督管理局基本情况及派出乡镇食品药品监管所的建设、人员配备、办公场所、执法装备、经费来源、工作运行机制等情况及一体化管理模式设置、监管成效的回顾和思考。结果经过3年的一体化模式监管,咸安区城镇食品药品安全得到满意控制,各乡镇所对区局指示能够上情下达、政令畅通、迅速行动,食品药品安全监管体系建设取得预期成效。结论咸安区食品药品监管体制改革严格落实国务院机构单设要求,已形成国家、省、市、县局及乡镇食品药品监管所"四位一体"的监管模式,对建立统一权威的食品药品监管体制具有一定的借鉴意义。

关键词：食品药品体制改革一体化监管体系

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Seasonal variation in soil microbial biomass carbon and nitrogen in an artificial sand-binding vegetation area in Shapotou, northern China

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Research in Cold and Arid Regions 2013年第6期5卷 733-738页

作者： YuYan Zhou xuanming Zhang XiaoHong Jia JinQin Ma YanHong gao Gansu Productivity Promotion Center Shapotou Desert Research and Experiment Station Cold and Arid Regions Environment and Engineering InstituteChinese Academy of Sciences Institute of Desertification Studies Chinese Academy of Forestry

In this study, seasonal variation characteristics of surface soil microbial biomass carbon （MBC） and soil microbial biomass nitrogen （MBN） of an artificial vegetation area located in Shapotou for different time periods were studied using the chloroform fumigation method, and the results were compared with those of near-natural vegetation areas and mobile dunes. Results showed that the MBC and MBN levels in the 0-5 cm soil layer were higher in autumn than in summer and spring. As the prolongation of vegetation restoration raised the MBC and MBN levels in summer and autumn, no clear variation was found in spring. However, the MBC and MBN in 5-20 cm had no obvious seasonal variation. During summer and autumn, the variation trend of MBC and MBN in the vertical direction was shown to be 0-5 〉 5-10 〉 10-20 cm in the vegetation area, while for mobile dunes, the MBC and MBN levels increased as the depth increased. The natural vegetation area was shown to possess the highest MBC and MBN levels, and yet mobile dunes have the lowest MBC and MBN levels. MBC and MBN levels in artificial sand-binding vegetation increased with the prolongation of vegetation restoration, indicating that the succession of sand-binding vegetation will result in the ac- cumulation of soil carbon and nitrogen, as well as the restoration of soil fertility.

关键词： re-vegetation area soil microbial biomass carbon soil microbial biomass nitrogen

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The osmolyte-producing endophyte Streptomyces albidoflavus OsiLf-2 induces drought and salt tolerance in rice via a multi-level mechanism

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The Crop Journal 2022年第2期10卷 375-386页

作者： Shuqi Niu Yan gao Huixian Zi Ying Liu xuanming Liu Xianqiu Xiong Qingqing Yao Ziwei Qin Ning Chen Liang Guo Yuanzhu Yang Peng Qin Jianzhong Lin Yonghua Zhu Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation College of BiologyHunan UniversityChangsha 410008HunanChina Yuan Longping High-Tech Agriculture Co. Ltd.Changsha 410001HunanChina

Drought and salinity are major environmental stresses that impair crop growth and productivity worldwide. Improving drought and salt tolerance of crops with microbial mutualists is an effective and environmentally sound strategy to meet the demands of the ever-growing world population. In the present study, we found that the Streptomyces albidoflavus Osi Lf-2, a moderately salt-tolerant endophytic actinomycete, produced abundant osmolytes, including proline, polysaccharides, and ectoine. Inoculation with Osi Lf-2 increased the osmotic-adjustment ability of the rice host by increasing the proline content(by250.3% and 49.4%) and soluble sugar(by 20.9% and 49.4%) in rice under drought and salt conditions, relative to the uninoculated control. Osi Lf-2 increased stress responses in the rice host at the physiological and biochemical levels(photosynthesis efficiency, osmolytes and antioxidant content), and the gene level(osmolytes synthesis, stress-responsive and ion-transport related genes), raising rice yields under both greenhouse and saline–alkaline soil conditions. The use of endophytic actinomycetes offers a promising biotechnological approach to developing stress-tolerant plants.

关键词： Rice Endophytic actinomycete Osmolytes Salt tolerance Drought tolerance

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冲击载荷作用下导弹战斗部装药起爆特性研究

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振动与冲击 2019年第11期38卷 37-41,87页

作者：蔡宣明张伟高玉波范志强中北大学地下目标毁伤技术国防重点学科实验室太原030051 哈尔滨工业大学高速撞击研究中心哈尔滨150080

针对远程导弹在攻击地下目标过程当中时常发生对战斗部PBX炸药装药起爆毁伤效应估计不足情况,进而对导弹战斗部PBX炸药装药在高过载冲击载荷作用下的起爆响应特性进行研究。基于二级轻气炮,对导弹战斗部PBX炸药装药跨声速冲击载荷起爆... 详细信息

针对远程导弹在攻击地下目标过程当中时常发生对战斗部PBX炸药装药起爆毁伤效应估计不足情况,进而对导弹战斗部PBX炸药装药在高过载冲击载荷作用下的起爆响应特性进行研究。基于二级轻气炮,对导弹战斗部PBX炸药装药跨声速冲击载荷起爆特性进行一系列试验研究,结合试验结果、数值模拟、以及相关理论分析,探索能量释放行为与冲击载荷之间的相互关联,并建立相互影响机制模型。结果表明,PBX炸药装药的临界起爆压力为5. 34 GPa,完全起爆压力为12.39 GPa;建立的能量释放量和相对反应率与冲击载荷之间的相互关系与试验数据基本吻合,研究结果可为国防防御技术研究提供一定的参考价值。

关键词：冲击起爆战斗部装药数值模拟

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三轴向冲击载荷作用下RDX基PBX炸药损伤模式与表征

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振动与冲击 2019年第5期38卷 86-91页

作者：蔡宣明张伟高玉波范志强中北大学地下目标毁伤技术国防重点学科实验室太原030051 哈尔滨工业大学高速撞击研究中心哈尔滨150080

导弹战斗部在攻击地下目标高速侵彻过程时常因损伤而发生提前起爆,极大削弱了对攻击目标的毁伤作用,甚至影响整个战略局势,针对这一急迫需要解决的问题,进而对导弹战斗部中的RDX基PBX炸药在高g值加载方式下的损伤特性进行研究。基于一... 详细信息

导弹战斗部在攻击地下目标高速侵彻过程时常因损伤而发生提前起爆,极大削弱了对攻击目标的毁伤作用,甚至影响整个战略局势,针对这一急迫需要解决的问题,进而对导弹战斗部中的RDX基PBX炸药在高g值加载方式下的损伤特性进行研究。基于一级轻气炮对PBX炸药试件在三轴向冲击加载方式下的损伤特性进行了一系列的实验研究,结合数值模拟、Griffith晶体颗粒细观裂纹断裂强度和扫描电子显微镜(SEM),对PBX炸药试件损伤模式进行研究和表征,并探索实验后的试件密度与冲击载荷之间的量化关系。结果表明,晶体颗粒表面与黏结剂之间的剪切强度约为0.6 Mpa,因此,在较小冲击载荷作用下就已发生剪切脱黏现象,随着三轴向冲击载荷压力的增大,逐渐出现晶体颗粒孪晶带,颗粒破碎和融化细观损伤模式;实验后的试件密度与冲击载荷压力之间修正的玻尔兹曼关系与实验结果基本相符;Griffith晶体颗粒细观裂纹断裂强度预测结果与SEM测试分析结果基本吻合,可为该PBX炸药细观损伤机理研究提供重要依据。

关键词：冲击 PBX炸药细观损伤数值模拟

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Taylor冲击载荷作用下PBX炸药细观损伤模式及机理研究

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振动与冲击 2019年第7期38卷 9-14页

作者：蔡宣明张伟徐鹏高玉波范志强中北大学国防重点学科实验室太原030051 哈尔滨工业大学高速撞击研究中心哈尔滨150080

空对地钻地弹在高速侵彻过程中,装药部的提前起爆严重影响到对攻击目标的毁伤作用,针对这个急迫需要解决的问题,对装药部(PBX炸药)在高g值载荷作用下的细观损伤模式及机理进行研究。基于一级轻气炮,应用激光测速系统监测实验试件击靶速... 详细信息

空对地钻地弹在高速侵彻过程中,装药部的提前起爆严重影响到对攻击目标的毁伤作用,针对这个急迫需要解决的问题,对装药部(PBX炸药)在高g值载荷作用下的细观损伤模式及机理进行研究。基于一级轻气炮,应用激光测速系统监测实验试件击靶速度,由压电传感器采集实验试件应力状态,进而通过Taylor冲击加载方式对PBX炸药损伤形式进行实验研究。基于细观损伤理论,结合扫描电子显微镜(SEM)对其损伤模式进行分析,结果表明,在较小冲击载荷作用下,晶体颗粒表面与粘结剂之间的剪切脱粘细观损伤模式最先发生;随着冲击载荷能量的增加,产生了细观损伤裂纹,并不断沿应力薄弱路径急剧传播,且萌生新的损伤裂纹,裂纹传播错综复杂,进而导致颗粒破碎,发生穿晶断裂、粘结剂劈裂等细观损伤模式,从而导致该PBX炸药宏观损伤裂纹的出现。PBX炸药细观损伤理论对该PBX炸药细观损伤模式的预测结果与实验分析结果基本相符,该细观损伤理论为其细观损伤机理研究提供了重要依据。

关键词：冲击载荷 PBX炸药变形破坏细观损伤

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一维应力动态加载下战斗部装药力学响应预报模型

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兵工学报 2019年第4期40卷 762-768页

作者：蔡宣明张伟徐鹏高玉波范志强中北大学理学院山西太原030051 哈尔滨工业大学高速撞击研究中心黑龙江哈尔滨150080

为获得战斗部装药在高过载侵彻下的动力学行为,对战斗部装药(黑索今(RDX)基高聚物粘结炸药(PBX))在高应变率下的动态力学响应特性进行了研究。采用改进的分离式霍普金森压杆(SHPB)实验技术对RDX基PBX炸药动态力学性能展开研究、压电传... 详细信息

为获得战斗部装药在高过载侵彻下的动力学行为,对战斗部装药(黑索今(RDX)基高聚物粘结炸药(PBX))在高应变率下的动态力学响应特性进行了研究。采用改进的分离式霍普金森压杆(SHPB)实验技术对RDX基PBX炸药动态力学性能展开研究、压电传感器监测试件两端应力状态、高速相机拍摄实验中的试件变形过程,确保实验试件变形在动态应力平衡和常应变率加载条件下进行,保证实验数据的有效性。结果表明,该RDX基PBX炸药具有明显的密度效应及应变率效应,当应变超越0. 075时应变率效应显著增强。基于应变能函数,建立该RDX基PBX炸药在一维应力状态下修正的Rivilin本构模型,模型拟合结果与实验结果基本相符,仿真结果得到的应变时间信号及试件变形模式与实验结果基本吻合。

关键词：战斗部装药力学响应应变率效应一维应力动态加载数值模拟

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