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Comparison Between Threshold Method and Artificial Intelligence Approaches for Early Warning of Respiratory Infectious Diseases-Weifang City,Shandong Province,China,2020-2023

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China CDC weekly 2024年第26期6卷 635-641,I0010,I0011页

作者： Ting Zhang Liuyang Yang Ziliang Fan xuancheng hu Jiao Yang Yan Luo Dazhu huo Xuya Yu Ling Xin Xuan Han Jie Shan Zhongjie Li Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC)BeijingChina State Key Laboratory of Respiratory Health and Multimorbidity BeijingChina Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College) Ministry of EducationBeijingChina The Third Affiliated Hospital of Kunming Medical University Yunnan Cancer HospitalKunming CityYunnan ProvinceChina School of Data Science Fudan UniversityShanghaiChina Weifang Center for Disease Control and Prevention Weifang CityShandong ProvinceChina School of Health Policy and Management Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

Introduction:Respiratory infectious diseases,such as influenza and coronavirus disease 2019(COVID-19),present significant global public health *** emergence of artificial intelligence(AI)and big data offers opportunities to improve traditional disease surveillance and early warning ***:The study analyzed data from January 2020 to May 2023,comprising influenza-like illness(ILI)statistics,Baidu index,and clinical data from *** methodologies were evaluated:the adaptive dynamic threshold method(ADTM)for dynamic threshold adjustments,the machine learning supervised method(MLSM),and the machine learning unsupervised method(MLUM)utilizing anomaly *** comparison focused on sensitivity,specificity,timeliness,and warning ***:ADTM issued 37 warnings with a sensitivity of 71%and a specificity of 85%.MLSM generated 35 warnings,with a sensitivity of 82%and a specificity of 87%.MLUM produced 63 warnings with a sensitivity of 100%and specificity of 80%.The initial warnings from ADTM and MLUM preceded those from MLSM by five *** Kappa coefficient indicated moderate agreement between the methods,with values ranging from 0.52 to 0.62(P<0.05).Discussion:The study explores the comparison between traditional methods and two machine learning approaches for early warning *** emphasizes the validation of machine learning’s reliability and underscores the unique advantages of each ***,it stresses the significance of integrating machine learning models with various data sources to enhance public health preparedness and response,alongside acknowledging limitations and the need for broader validation.

关键词： specificity integrating utilizing

应急状态下新冠流行曲线预测的方法学研究——基于北京市百度搜索和传统流感样病例监测

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Engineering 2023年第12期31卷 112-119页

作者： Ting Zhang Liuyang Yang Xuan Han Guohui Fan Jie Qian xuancheng hu Shengjie Lai Zhongjie Li Zhimin Liu Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of management science and information system Faculty of Management and EconomicsKunming University of Science and TechnologyKunming 650504China WorldPop School of Geography and Environmental ScienceUniversity of SouthamptonSouthampton SO171BJUK The Third Affiliated Hospital of Kunming Medical University Kunming 650118China

Surveillance is an essential work on infectious diseases prevention and *** the pandemic occurred,the inadequacy of traditional surveillance was exposed,but it also provided a valuable opportunity to explore new surveillance *** study aimed to estimate the transmission dynamics and epidemic curve of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)Omicron BF.7 in Beijing under the emergent situation using Baidu index and influenza-like illness(ILI)surveillance.A novel hybrid model(multiattention bidirectional gated recurrent unit(MABG)-susceptible-exposed-infected-removed(SEIR))was developed,which leveraged a deep learning algorithm(MABG)to scrutinize the past records of ILI occurrences and the Baidu index of diverse symptoms such as fever,pyrexia,cough,sore throat,anti-fever medicine,and runny *** considering the current Baidu index and the correlation between ILI cases and coronavirus disease 2019(COVID-19)cases,a transmission dynamics model(SEIR)was formulated to estimate the transmission dynamics and epidemic curve of SARS-Co *** the COVID-19 pandemic,when conventional surveillance measures have been suspended temporarily,cases of ILI can serve as a useful indicator for estimating the epidemiological trends of *** the specific case of Beijing,it has been ascertained that cumulative infection attack rate surpass 80.25%(95%confidence interval(95%CI):77.51%-82.99%)since December 17,2022,with the apex of the outbreak projected to transpire on December *** culmination of existing patients is expected to occur three days subsequent to this *** reproduction number(Rt)represents the average number of secondary infections generated from a single infected individual at a specific point in time during an epidemic,remained below 1 since December 17,*** traditional disease surveillance systems should be complemented with information from modern surveillance data such as online data sources with advanced techn

关键词： COVID-19 Epidemic curve Baidu search engine Influenza-like illness Deep learning Transmission dynamics model

基于有限元法和一次二阶矩法的桥梁结构可靠度研究

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特种结构 2021年第4期38卷 55-58页

作者：王虎军贺小卫高宇扈轩诚西安市政设计研究院有限公司

针对一次二阶矩法求解结构可靠度指标时功能函数不能显式表达导致的梯度求解困难问题,采用确定性有限元法与改进的一次二阶矩法相结合的方法,以钢管混凝土拱桥为研究对象,对纵梁跨中截面进行正常使用极限状态下可靠度分析,得到其在几何... 详细信息

针对一次二阶矩法求解结构可靠度指标时功能函数不能显式表达导致的梯度求解困难问题,采用确定性有限元法与改进的一次二阶矩法相结合的方法,以钢管混凝土拱桥为研究对象,对纵梁跨中截面进行正常使用极限状态下可靠度分析,得到其在几何尺寸、材料特性及外荷载等均为随机变量情况下的可靠度指标,并通过灵敏度分析,评价各随机变量对结构可靠度指标的影响程度。

关键词：一次二阶矩法功能函数确定性有限元法可靠度

应急状态下新冠流行曲线预测的方法学研究——基于北京市百度搜索和传统流感样病例监测（英文）

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Engineering 2023年第12期 112-119页

作者： Ting Zhang Liuyang Yang Xuan Han Guohui Fan Jie Qian xuancheng hu Shengjie Lai Zhongjie Li Zhimin Liu Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences & Peking Union Medical College Department of management science and information system Faculty of Management and Economics Kunming University of Science and Technology World Pop School of Geography and Environmental Science University of Southampton The Third Affiliated Hospital of Kunming Medical University

Surveillance is an essential work on infectious diseases prevention and control. When the pandemic occurred, the inadequacy of traditional surveillance was exposed, but it also provided a valuable opportunity to explore new surveillance methods. This study aimed to estimate the transmission dynamics and epidemic curve of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) Omicron BF.7 in Beijing under the emergent situation using Baidu index and influenza-like illness(ILI) surveillance. A novel hybrid model(multiattention bidirectional gated recurrent unit(MABG)–susceptible–exposed–infected–removed(SEIR)) was developed, which leveraged a deep learning algorithm(MABG) to scrutinize the past records of ILI occurrences and the Baidu index of diverse symptoms such as fever, pyrexia,cough, sore throat, anti-fever medicine, and runny nose. By considering the current Baidu index and the correlation between ILI cases and coronavirus disease 2019(COVID-19) cases, a transmission dynamics model(SEIR) was formulated to estimate the transmission dynamics and epidemic curve of SARS-Co V-2. During the COVID-19 pandemic, when conventional surveillance measures have been suspended temporarily, cases of ILI can serve as a useful indicator for estimating the epidemiological trends of *** the specific case of Beijing, it has been ascertained that cumulative infection attack rate surpass 80.25%(95% confidence interval(95% CI): 77.51%–82.99%) since December 17, 2022, with the apex of the outbreak projected to transpire on December 12. The culmination of existing patients is expected to occur three days subsequent to this peak. Effective reproduction number(Rt) represents the average number of secondary infections generated from a single infected individual at a specific point in time during an epidemic, remained below 1 since December 17, 2022. The traditional disease surveillance systems should be complemented with information from modern surveillance data such as onlin

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Extreme high reversible capacity with over 8.0 wt% and excellent hydrogen storage properties of MgH2 combined with LiBH4 and Li3AlH6

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Journal of Energy Chemistry 2020年第11期29卷 296-306页

作者： Wenping Lin Xuezhang Xiao xuancheng Wang Jie-Wei Wong Zhendong Yao Man Chen Jiaguang Zheng Zhencan hu Lixin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province.Hangzhou 310013 ZhejiangChina Guangdong Provincial Key Laboratory of Advance Energy Storage Materials South China University of TechnologyGuangzhou 510640GuangdongChina

Magnesium hydride has attracted great attention because of its high theoretical capacity and outstanding reversibility, nevertheless, its practical applications have been restricted by the disadvantages of the sluggish kinetics and high thermodynamic stability. In this work, an unexpected high reversible hydrogen capacity over 8.0 wt% has been achieved from MgH2 metal hydride composited with small amounts of LiBH4 and Li3AlH6 complex hydrides, which begins to release hydrogen at 276 ℃ and then completely dehydrogenates at 360 ℃. The dehydrogenated MgH2+LiBH4/Li3AlH6 composite can fully reabsorb hydrogen below 300 ℃ with an excellent cycling stability. The composite exhibits a significant reduction of dehydrogenation activation energy from 279.7 kJ/mol(primitive MgH2) to 139.3 kJ/mol(MgH2+LiBH4/Li3AlH6),as well as a remarkable reduction of dehydrogenation enthalpy change from 75.1 k J/mol H2(primitive MgH2) to 62.8 kJ/mol H2(MgH2+LiBH4/Li3AlH6). The additives of LiBH4 and Li3AlH6 not only enhance the cycling hydrogen capacity, but also simultaneously improve the reversible de/rehydrogenation kinetics, as well as the dehydrogenation thermodynamics. This notable improvement on the hydrogen absorption/desorption behaviors of the MgH2+LiBH4/Li3AlH6 composite could be attributed to the dehydrogenated products including Li3Mg7, Mg17Al12 and MgAlB4, which play a key role on reducing the dehydrogenation activation energy and increasing diffusion rate of hydrogen. Meanwhile, the LiBH4 and Li3AlH6 effectively destabilize MgH2 with a remarkable reduction on dehydrogenation enthalpy change in terms of thermodynamics. In particular, the Li3Mg7, Mg17Al12 and MgAlB4 phases can reversibly transform into MgH2, Li3AlH6 and LiBH4 after rehydrogenation, which contribute to maintain a high cycling *** constructing strategy can further promote the development of high reversible capacity Mg-based materials with suitable de/rehydrogenation properties.

关键词： Magnesium hydride Complex hydride Hydrogen storage High reversible capacity Synergistic effect

Carbon composite support improving catalytic effect of NbC nanoparticles on the low-temperature hydrogen storage performance of MgH_(2)

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Journal of Materials Science & Technology 2023年第19期150卷 65-74页

作者： Yuxiao Jia xuancheng Wang Leijie hu Xuezhang Xiao Shuoqing Zhang Jiahuan He Jiacheng Qi Ling Lv Fen Xu Lixian Sun Lixin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou 310013China Guangxi Collaborative Innovation Center of Structure and Property for New Energy and Materials School of Material Science and EngineeringGuilin University of Electronic TechnologyGuilin 541004China

Ultrafine carbon-based transition metal compounds have been widely investigated as efficient catalysts for enhancing the hydrogen storage performance of magnesium *** this work,the carbon ther-mal shock method is applied to synthesize the ultrafine carbon-encapsulated NbC nanoparticles with an average grain size of 17.3 *** MgH_(2)-10 wt%NbC/C composites show excellent low-temperature hy-drogen storage performance with the onset dehydrogenation temperature of 196.1℃,which is 92.2℃ and 98℃ lower than that of MgH_(2)-10 wt%NbC and undoped MgH_(2),***,MgH_(2)-10 wt%NbC/C can absorb 6.71 wt%H_(2) at 100℃ within 30 min around and retain almost 100%reversible hydrogen desorption capacity after 10 *** the catalytic mechanism,the electron transfer process between multi-valence Nb cations of in-situ formed NbH x and Mg,H atoms can greatly improve the cyclic de/rehydrogenation kinetics of MgH_(2)-NbC/***,the enhancement of dehydrogenation kinetics can also be ascribed to MgH_(2) particle refinement by NbC nanoparticles,and destabilization of the Mg-H bond caused by carbon *** investigation not only proves that carbon-encapsulated NbC nanoparti-cles can greatly enhance the hydrogen storage performance of MgH_(2) but provides an idea of preparing carbon-based transition metal carbides as effective catalysts for magnesium-based hydrogen storage ma-terials.

关键词： MgH_(2) Carbon-encapsulated Nanoparticles Catalyst Kinetics

Establishment of a humanized ST6GAL1 mouse model for influenza research

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Animal Models and Experimental Medicine 2024年第3期7卷 337-346页

作者： Lyu Chao Han Feng Gao Qian Lv Limin Lu Ziwei Lu Shuangshuang Li Xiaoyan hu Yuechao Yang Mengjie Zhao Yingze Liu Jun Lu xuancheng Duo Shuguang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Institute of Zoology Chinese Academy of SciencesBeijingChina NHC Key Laboratory of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Zhejiang Provincial Key Laboratory of Medical Genetics Key Laboratory of Laboratory MedicineMinistry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouChina

Background:This study aimed to construct and characterize a humanized influenza mouse model expressing ***:humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encoding gene,and luciferase gene,were microinjected into the fertilized eggs of *** manipulated embryos were transferred into the oviducts of pseudopregnant female *** offspring were identified using *** exhibiting elevated expression of the hST6GAL1 gene were selectively bred for propagation,and in vivo analysis was performed for *** of the humanized gene was tested by performing immunohistochemical(IHC)*** and biochemical analyses using the whole blood and serum of humanized hST6GAL1 mice were ***:Successful integration of the human ST6GAL1 gene into the mouse genome led to the overexpression of human SiaT *** mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hST6GAL1gene expression in positive mice mirrored influenza virus infection *** IHC results revealed that hST6GAL1 was expressed in the lungs of humanized ***,the hematologic and biochemical parameters of the positive mice were within the normal ***:A humanized influenza mouse model expressing the hST6GAL1 gene was successfully established and characterized.

关键词： hST6GAL1 humanized mice influenza animal model

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502胶控制湿度贴显法显现皮革面上手印

刑事技术 2004年第5期29卷 26-27页

作者：胡涌安徽省宣城市公安局刑警支队 242000

目的　研究皮革面上汗潜手印的显现。方法　通过对遗留在皮革面不同时间的指印采用常规熏显、自然贴附、控制湿度贴附三种方法进行处理并比较效果。结果　控制湿度贴附显现法在皮革面上显现的成功率高于效果明显常规熏显法和自然贴附法。

关键词：汗潜手印熏显指印 502胶目的不同时间控制成功率常规处理

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干煤棚网壳结构使用现状与缺陷分析

工业建筑 2005年第5期35卷 88-91页

作者：罗尧治吴玄成沈雁彬胡宁浙江大学空间结构研究中心杭州310027

电厂干煤棚大都采用了大跨度柱面网壳结构,但由于煤场的腐蚀环境影响和堆煤过高,许多已建煤棚不同程度地出现网壳结构杆件的锈蚀和弯曲现象。如果结构中存在大量杆件的锈蚀和弯曲,显然会导致结构安全度降低,甚至破坏。以实际工程为例,... 详细信息

电厂干煤棚大都采用了大跨度柱面网壳结构,但由于煤场的腐蚀环境影响和堆煤过高,许多已建煤棚不同程度地出现网壳结构杆件的锈蚀和弯曲现象。如果结构中存在大量杆件的锈蚀和弯曲,显然会导致结构安全度降低,甚至破坏。以实际工程为例,研究缺陷对结构强度、稳定性的影响。建立杆件锈蚀和弯曲的计算模型,提出并采用随机缺陷模态法研究具有缺陷的结构承载能力。

关键词：干煤棚网壳结构建筑结构腐蚀环境结构承载力等效刚度电厂