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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-xuan Xu Wei wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Synthesis and characterization of three new solid polyoxometalates based on Wells-Dawson-derived sandwich-type polyanions [Co_(4)(H_(2)O)_(2)(P_(2)W_(15)O_(56))_(2)]^(16-)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 268-274页

作者： Jjijie YE xuan XU Chuande wu Department of Chemistry Zhejiang UniversityHangzhou 310058China

Three polyoxometalate-based hybrid coordination materials,[Co_(8)(H_(2)O)_(34)(pz)_(2){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·16H_(2)O(compound 1),[H_(3)O]_(4)[Co_(6)(H_(2)O)_(22)(pz)_(2){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·21H_(2)(compound 2),and[H_(3)O]_(4)[Co_(6)(H_(2)O)_(22){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·29H_(2)O(compound 3)(pz-pyrazine),were built from the linkage of[Co_(4)(H_(2)O)_(2)(P_(2)W_(15)O_(56)_(2)]^(16-)-(abbreviated as{Co_(4)P_(4)W_(30})polyanions and pz and/or cobalt(II)*** compounds 1 and 2 consisted of the same components,their lamellar networks were quite *** inorganic lamellar network in compound 3 was constructed by connecting{Co_(4)P_(4)W_(30)}units with cobalt(I)*** work demonstrates that the coordination modes of{Co_(4)P_(4)W_(30)}are very sensitive to synthesis conditions,while the ring-belt tetrametals are easily substituted by different transition metal cations under mild reaction conditions.

关键词： Cobalt Crystal structure Cyclic voltammetry Hybrid Polyoxometalate

BAM: A Block-Based Bayesian Method for Detecting Genome-Wide Associations with Multiple Diseases

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Tsinghua Science and Technology 2020年第5期25卷 678-689页

作者： Guanying wu xuan Guo Baohua Xu the Dental Center of China-Japan Friendship Hospital Beijing 100029China the Department of Computer Science and Engineering University of North TexasDentonTX 76203USA

Many human diseases involve multiple genes in complex *** Genome-Wide Association Studies (GWASs) have been considered to hold promise for unraveling such ***,statistic tests for high-order epistatic interactions (≥2 Single Nucleotide Polymorphisms (SNPs)) raise enormous computational and analytical *** is well known that the block-wise structure exists in the human genome due to Linkage Disequilibrium (LD) between adjacent *** this paper,we propose a novel Bayesian method,named BAM,for simultaneously partitioning SNPs into LD-blocks and detecting genome-wide multi-locus epistatic interactions that are associated with multiple *** results on the simulated datasets demonstrate that BAM is powerful and *** also applied BAM on two GWAS datasets from WTCCC,i.e.,Rheumatoid Arthritis and Type 1 Diabetes,and accurately recovered the LD-block ***,we believe that BAM is suitable and efficient for the full-scale analysis of multi-disease-related interactions in GWASs.

关键词： disease association study epistasis Linkage Disequilibrium(LD)block Bayesian methods

A Three-row Opposed Gripping Mechanism with Bioinspired Spiny Toes for Wall-climbing Robots

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Journal of Bionic Engineering 2019年第6期16卷 994-1006页

作者： Chao Xie xuan.wu Xiaojie Wang Institute of Advanced Manufacturing Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesChangzhou 213164China Department of Precision Machineiy and Precision Instrumentation University of Science and Technology of ChinaHefei 230026China

This paper presents a study of a three-row opposed gripping mechanism made of bioinspired spiny *** insect Serica orientalis Motschulsky's tarsal system was first described and studied.A compliant single spiny toe model was established assuming that the contact asperities were *** the single toe contact model,a spiny toe array's contact model was then developed using asperity height's distribution *** studying the cngaging and disengaging process of the single toe,the mechanical behavior of the toe and toe array were *** toes as well as the arrays were manufacturcd via rapid prototyping.A customized apparatus using dis-placement-control method has been carried out to measure the pull-in forces and pull-ofT positions of the single toe and toe array undcr various compression *** on the understanding,a three-row opposed gripping mechanism with radial configuration for wall-climbing robots was designed and fabricated according to the mechanical behaviors of the toe and *** an opposed spoke con figuration with 3 rows of 31 toes on each linkage array,the mechanism designed as a foot of climbing robots can vertically resist at least 1 kg of load on rough inverted surface,while the maximum normal load is as high as 31 *** findings may provide a way in developing a high payload wall-climbing robot system for practical applications.

关键词： bioinspired spiny toe contact mechanical model opposed gripping mechanism wall-climbing robot

Experimental Study of Operation Performance for Hydrocarbon Fuel Pump with Low Specific Speed

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Journal of Thermal Science 2017年第5期26卷 440-447页

作者： wu Xianyu YANG Jun JIN xuan College of Aerospace Science and Engineering National Univ. of Defense Technology ChangSha 410073 China

In this paper, a small flow rate hydrocarbon turbine pump was used to pressurize the fuel supply system of scramjet engine. Some experiments were carried out to investigate the characteristics of turbine pump driven by nitrogen or combustion gas under different operating conditions. A experimental database with regard to the curves of the rotational speed, mass flow rate and net head with regard to centrifugal pump were plotted. These curves were represented as functions of the pressure and temperature at turbine inlet/outlet and the throttle diameter at downstream of centrifugal pump. A sensitivity study has been carried out based on design of experiments. The experimental was employed to analyze net head of centrifugal and throttle characteristics. The research results can accumulate foundations for the close loop control system of turbine pump.

关键词： expansion cycle scram jet hydrocarbon fuel turbo-pump operation performance

Identifying candidate genes involved in trichome formation on carrot stems by transcriptome profiling and resequencing

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Journal of Integrative Agriculture 2022年第12期21卷 3589-3599页

作者： wu Zhe YANG xuan ZHAO Yu-xuan JIA Li College of Horticulture Shanxi Agricultural UniversityTaigu 030801P.R.China Key Laboratory of Genetic Improvement and Ecophysiology of Horticultural Crop of Anhui Province Institute of HorticultureAnhui Academy of Agricultural SciencesHefei 230001P.R.China

Trichomes are specialized structures developed from epidermal cells and can protect plants against biotic and abiotic *** cover carrots during the generative ***,the morphology of the carrot trichomes and candidate genes controlling the formation of trichomes are still *** study found that carrot trichomes were nonglandular and unbranched hairs distributed on the stem,leaf,petiole,pedicel,and seed of *** analysis of a trichome mutant with sparse and short trichomes(sst)and a wild type(wt)with long and dense trichomes on carrot stems was conducted.A total of 15396 genes containing nonsynonymous mutations in sst were obtained,including 42 trichomerelated *** also analyzed the transcriptome of the trichomes on secondary branches when these secondary branches were 10 cm long between wt and sst and obtained 6576 differentially expressed genes(DEGs),including 24 trichome-related ***-PCR validation exhibited three significantly up-regulated DEGs,20 significantly downregulated,and one with no *** considered both the resequencing and transcriptome sequencing analyses and found that 12 trichome-related genes that were grouped into five transcription factor families containing nonsynonymous mutations and significantly down-regulated in ***,these genes are potentially promising candidate genes whose nonsynonymous mutations and down-regulation may result in scarce and short trichomes mutation on carrot stems in sst.

关键词： carrot trichome resequencing transcriptome candidate genes

Simulation of Velocity and Temperature Distributions of Displacement Ventilation System with Single or Double Heat Sources

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Journal of Thermal Science 2007年第2期16卷 155-158页

作者： Wenfei wu xuan.wu Yanhui Feng Xinxin Zhang Inner Mongolia University of Science and Technology Baotou 014010 China University of Science and Technology Beijing Beijing 100083 China

In order to obtain a better understanding of flow characteristics of displacement ventilation, the three-dimensional numerical models are developed using the CFD technology. The numerical simulation results are verified by experiments, based on this, the velocity and temperature distribution of three-dimensional displacement ventilation system with single and double heat sources are studied. Velocity and temperature fields under two different cases of heat source are analyzed and compared. The numerical results show that there are three layers in vertical temperature fields of displacement ventilation system with single or double heat sources, and the vertical temperature distribution of single heat source is different from that of double heat sources. When indoor load is large, the comfort requirement of people indoor can＇t be satisfied with displacement ventilation system only, thus an additional refrigeration system is necessary. Furthermore, under the condition of two heat sources, the displacement ventilation parameters can＇t be computed simply according to single heat source inlet parameters, therefore the interaction between heat sources should be considered.

关键词： displacement ventilation velocity distribution vertical temperature distribution CFD

Electromagnetic and Microwave Absorption Properties of Fe Coating on SiC with Metal Organic Chemical Vapor Reaction

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Chinese Physics Letters 2014年第4期31卷 167-169页

作者： LIU Yuan LIU Xiang-xuan WANG xuan-Jun WEN wu No. 603 Faculty Xi'an Institute of High Technology Xi'an 710025

SiC-Fe composites are prepared by metal organic chemical vapor deposition （MOCVD） using silicon carbide （SIC＇） and iron pentacarbonyl （Fe（CO）5） as the precursors. The structure and morphology analyses demonstrate that the Fe nanoparticles have been deposited on the surface of the SiC particles. In terms of reflection loss （RL）, the absorbing frequency band （AFB, the value of RL 〈 -10 dB）, and the matching thickness （tin）, SiC-Fe composites show the best performances： minimum RL of - 31.6 dB with tm= 2.0 mm at 15.1 GHz, AFB of 12.9-17.3 OHz, indicating that Fe-doped SiC by MOCVD can significantly improve the electromagnetic properties of SiC and that SiC-Fe composites could be used as an effective microwave absorption materiM.

关键词： SURFACE coatings METAL organic chemical vapor deposition SILICON carbide -- Electric properties MICROWAVE materials ABSORPTION (Physiology)

New Design Method of LC VCO Improving PVT Tolerance of Phase Noise

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Chinese Journal of Electronics 2015年第3期24卷 550-554页

作者： LI xuan.wu Xiulong CHEN Junning Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China School of Electronic and Information Engineering Anhui University

We present a LC VCO design method of the multiple start-point global optimization. It is used to optimize VCO phase noise variation in different Process,supply voltage and temperature(PVT) conditions at the same time. Based on this method, we can design PVT tolerant LC VCO even without PVT compensation *** design results of different foundry manufacturing process and oscillating frequency is shown to investigate the effect of this phase noise optimization method. The design method also can help to enhance manufacturing yield.

关键词： Process supply voltage and temperature(PVT) Voltage controlled oscillator(VCO) Optimization Phase noise