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A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats

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Neural Regeneration Research 2022年第11期17卷 2512-2517页

作者： xuan-yu fang Da-Wei Zhao Chao Zhang Hong-Fei Ge Xu-Yang Zhang Feng-Chun Zhao Yi-Bin Jiang Hua Feng Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalArmy Medical UniversityChongqingChina

Brain lesions can cause neural stem cells to activate,proliferate,diffe rentiate,and migrate to the injured ***,after traumatic brain injury,brain tissue defects and microenvironment changes greatly affect the survival and growth of neural stem cells;the resulting reduction in the number of neural stem cells impedes effective repair of the injured *** can promote the survival,proliferation,and differentiation of neural stem cells under adverse conditions such as oxidative stress or hypoxia that can occur after traumatic brain ***,we investigated the therapeutic effects of melatonin combined with neural stem cells on traumatic brain injury in ***,in vitro studies confirmed that melatonin promoted the survival of neural stem cells deprived of oxygen and ***,we established a three-dimensional Matrigel-based transplantation system containing melatonin and neural stem cells and then used it to treat traumatic brain injury in *** found that treatment with the Matrigel system containing melatonin and neural stem cells decreased brain lesion volume,increased the number of surviving neuro ns,and improved recove ry of neurological function compared with treatment with Matrigel alone,neural stem cells alone,Matrigel and neural stem cells combined,and Matrigel and melatonin *** findings suggest that the three-dimensional Matrigelbased transplantation system containing melatonin and neural stem cells is a potential treatment for traumatic brain injury.

关键词： cell therapy magnetic resonance imaging Matrigel melatonin neural stem cells neurological function recovery three-dimensional transplantation traumatic brain injury

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商品林可持续经营问题探析

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浙江林学院学报 2005年第3期22卷 322-325页

作者：宣裕方周伯煌浙江大学法学院浙江杭州310028 浙江林学院浙江临安311300

在分析商品林可持续经营现实意义的基础上,指出了目前制约我国商品林可持续经营的主要因素:投入政策不宽松;现有的限额采伐政策与市场经济条件下商品林经营规律相悖;林业税费繁重,经营者负担过重;商品林经营管理体制与社会生产力发展不... 详细信息

在分析商品林可持续经营现实意义的基础上,指出了目前制约我国商品林可持续经营的主要因素:投入政策不宽松;现有的限额采伐政策与市场经济条件下商品林经营规律相悖;林业税费繁重,经营者负担过重;商品林经营管理体制与社会生产力发展不相适应等。提出了完善商品林可持续经营的主要对策:①加强对商品林发展的金融支持,创造良好的投资环境;②改革商品林的采伐管理制度,促进商品林建设;③改革林业税费制度,减轻商品林经营者的负担;④构建新型商品林经营管理体制。

关键词：商品林可持续经营采伐管理制度税费制度

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林权争议的参与式调解方法

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浙江林学院学报 2007年第4期24卷 473-477页

作者：周伯煌宣裕方余玉豹浙江林学院人文学院浙江临安311300 浙江浙临律师事务所浙江临安311300

林权争议是当前我国森林资源保护工作中的一个突出问题,及时有效地化解林权争议,对于维护权利人的合法权益,保护森林资源,促进林业发展,构建和谐社会,都具有十分重要的意义。传统的林权争议调解方法存在着违背自愿、自治原则,"法、理、... 详细信息

林权争议是当前我国森林资源保护工作中的一个突出问题,及时有效地化解林权争议,对于维护权利人的合法权益,保护森林资源,促进林业发展,构建和谐社会,都具有十分重要的意义。传统的林权争议调解方法存在着违背自愿、自治原则,"法、理、情"不能有机结合,解决程序不够科学、规范等缺陷,因此往往不能从根本上解决问题。文章讨论参与式调查方法在林权争议调解中的应用,提出了林权争议参与式调解方法的设计:参与式工作理念,参与式工作方法,参与式争议解决程序,并同时指出其应用中应注意与乡村综合发展紧密结合,激励机制和外部支撑体系建设等3个问题。

关键词：林业经济学林权争议参与式调解方法森林资源保护

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非公有制林业发展的制度障碍及其对策研究

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林业经济问题 2006年第6期26卷 523-526页

作者：周伯煌宣裕方张慧浙江林学院经济管理学院浙江临安311300 浙江省临安市林业科学研究所浙江临安311300

通过对非公有制林业的内涵和特点的分析,指出了非公有制林业产权保护不力、采伐限额制度的束缚制约、林地使用制度不完善和林业金融保障制度不完善等主要制度障碍,并在此基础上提出了相应对策:①加强产权保护;②改革采伐限额制度;③完... 详细信息

通过对非公有制林业的内涵和特点的分析,指出了非公有制林业产权保护不力、采伐限额制度的束缚制约、林地使用制度不完善和林业金融保障制度不完善等主要制度障碍,并在此基础上提出了相应对策:①加强产权保护;②改革采伐限额制度;③完善林地使用制度;④实施新型林业投资制度。

关键词：非公有制林业制度障碍林地产权

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浙江省非公有制林业发展的法律问题探讨

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浙江林学院学报 2005年第1期22卷 109-113页

作者：周伯煌宣裕方徐金锋浙江大学法学院浙江杭州310028 浙江林学院人事处浙江临安311300 浙江林学院人文学院浙江临安311300

非公有制林业是现代林业发展的必然方向,是实现全社会投资兴办林业的一个较好途径。通过对浙江省非公有制林业发展的现状分析,指出已有非公有制林业法律地位不明确、非公有制林业物权权利人的权利未得到有效保障和山林权属不稳定、山林... 详细信息

非公有制林业是现代林业发展的必然方向,是实现全社会投资兴办林业的一个较好途径。通过对浙江省非公有制林业发展的现状分析,指出已有非公有制林业法律地位不明确、非公有制林业物权权利人的权利未得到有效保障和山林权属不稳定、山林纠纷多发等主要法律问题。提出了浙江省非公有制林业发展的法律对策:①明确非公有制林业的法律地位;②深化改革,健全物权制度;③稳定山权和林权,切实加强山林权属争议调处工作。

关键词：非公有制林业法律地位物权山林权属

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G Protein-Coupled Estrogen Receptor 1 Negatively Regulates the Proliferation of Mouse-Derived Neural Stem/Progenitor Cells via Extracellular Signal-regulated Kinase Pathway

G Protein-Coupled Estrogen Receptor 1 Negatively Regulates t...

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第十四届中国医师协会神经外科医师年会

作者： Jun Zhong Hong-fei Ge Chao Zhang Jing-yu Chen Huan-huan Li xuan-yu fang Liang Tan Xin Liu Zheng-cai Jia Hua Feng Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalThird Military Medical University （Army Medical university）

G protein-coupled estrogen receptor 1（GPER1, also known as GPR30） has been reported to play a wide range of function in the central nervous system（CNS）. However, whether GPER1 is expressed by neural stem/progenitor cells（NSPCs） and its role has not been established. Here, we found the expression of GPER1 in mouse-derived NSPCs via western blot and immunofluorescent staining. Moreover, we revealed that specific activation of GPER1 by the agonist G1 decreased the proliferation of NSPCs in a dose-dependent manner. The neurosphere formation assay and Ki67 staining further demonstrated that activation of GPER1 inhibited the proliferation of NSPCs. Additionally, the inhibitory effect of G1 on the proliferation of NSPCs could be blocked by the specific GPER1 antagonist G15. Intriguingly, ERK pathway was involved in the negative effect of GPER1 on the proliferation of NSPCs, because the phosphorylation level of ERK in NSPCs was remarkably decreased during G1 treatment. However, the antagonist G15 reversed the down-regulated level of p-ERK. Knock-down GPER1 also reversed the inhibitory effect of G1 on NSPCs proliferation. Together, our results provide the first evidence that GPER1 is expressed by NSPCs and its activation negatively modulates the proliferation of NSPCs, highlighting the importance of GPER1 in regulating NSPC behaviors.

关键词： Neural stem/progenitor cells G protein-coupled estrogen receptor 1 Proliferation Extracellular signal-regulated kinase

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优秀传统文化:社会主义核心价值体系的深厚渊源

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创新 2008年第6期2卷 72-74页

作者：商秀秀宣裕方浙江林学院浙江林学院党委

中国传统文化是社会主义核心价值体系的重要渊源,和谐思想、爱国情怀、创新精神和道德观念都继承了优秀传统文化。但它们不仅仅是一种继承,还是结合当今时代特点的一种发展与创新。社会主义和谐理念彰显着中国传统文化中的精华;爱国主... 详细信息

中国传统文化是社会主义核心价值体系的重要渊源,和谐思想、爱国情怀、创新精神和道德观念都继承了优秀传统文化。但它们不仅仅是一种继承,还是结合当今时代特点的一种发展与创新。社会主义和谐理念彰显着中国传统文化中的精华;爱国主义精神赋予新的时代内容;创新精神蕴含了新的理念;社会主义荣辱观弘扬了优秀传统道德。建设社会主义核心价值体系必须要以马克思主义为指导,在厘清中国传统文化中的精华与糟粕的基础上,坚持继承与创新相统一的原则。

关键词：优秀传统文化社会主义核心价值体系渊源

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-fang Feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-fang Wu Yi-Sheng Chen yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： fang, Lei Lin, Xiaoqi Xu, Ruian Liu, Lu Zhang, yu Tian, Feng Li, Jiao Jiao Xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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