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Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage

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Current Medical Science 2023年第5期43卷 988-997页

作者： yu WANG Kai chen Zi-xuan QIAO Xiao-rong BAO Department of Nephrology Jinshan HospitalFudan UniversityShanghai 201508China

Objective Previous research indicates a link between cognitive impairment and chronic kidney disease(CKD),but the underlying factors are not fully *** study aimed to investigate the progression of CKD-induced cognitive impairment and the involvement of cognition-related proteins by developing early-and late-stage CKD models in Sprague-Dawley *** The Morris water maze test and the step-down passive avoidance task were performed to evaluate the cognitive abilities of the rats at 24 weeks after *** examinations were conducted to examine renal and hippocampal ***-time PCR,Western blotting analysis,and immunohistochemical staining were carried out to determine the hippocampal expression of brain-derived neurotrophic factor(BDNF),choline acetyltransferase(ChAT),and synaptophysin(SYP).Results Compared with the control rats,the rats with early-stage CKD exhibited mild renal damage,while those with late-stage CKD showed significantly increased serum creatinine levels as well as apparent renal and brain *** rats with early-stage CKD also demonstrated significantly impaired learning abilities and memory compared with the control rats,with further deterioration observed in the rats with late-stage ***,we observed a significant downregulation of cognition-related proteins in the hippocampus of rats with early-stage CKD,which was further exacerbated with declining renal function as well as worsening brain and renal damage in rats with late-stage *** These results suggest the importance of early screening to identify CKD-induced cognitive dysfunction *** addition,the downregulation of cognition-related proteins may play a role in the progression of cognitive dysfunction.

关键词： chronic kidney disease cognitive impairment Morris water maze test brain-derived neurotrophic factor choline acetyltransferase synaptophysin

Constructing Artificial Nucleobase Compilation to Enable Precise Molecular Medicine

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Chinese Journal of Chemistry 2023年第11期41卷 1385-1398页

作者： Jingqi chen Bo Liu xuan Wang Xueliang Liu Dandan Yang yu Yang Institute of Molecular Medicine (IMM) Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127 China Institute of Functional Nano & Soft Materials Laboratory (FUNSOM) Soochow UniversitySuzhouJiangsu215123 China Evergrande Center for Immunologic Diseases Ann Romney Center for Neurologic DiseasesHarvard Medical School and Brigham and Women's HospitalBostonMA02115 USA

Nucleic acids are the hereditary information storage medium of life. Due to its high programmability and good biocompatibility, the applications of nucleic acids are not limited to their natural function. However, the efficiency of nucleic acids is often hampered by inherent limitations in numerous practical applications, including limited access to complex functional patterns due to only four building blocks, facile degradation by nucleases, rapid renal clearance, poor pharmacokinetic properties, and so on. To end this, the researchers developed unnatural base pairs (UBPs) and numerous artificial analogues of nucleosides and oligonucleotides in recent decades. The developed UBPs and nucleoside base analogues together constitute artificial nucleobase compilation, which promotes the development of biomedical sciences. Here, we describe the development of artificial nucleobase compilation and summarized its applications in precise molecular medicine, including PCR-based diagnostics, aptamer-based diagnostics, nucleobase analogue drugs construction, ASO modification, aptamer-based therapeutics and biomaterials construction. This review provides an overview of current opportunities and challenges of artificial nucleobase-related precise molecular medicine.

关键词： Nucleobases Oligonucleotides Biological activity Aptamer Drug delivery

Evaluation of the Added Value of Probabilistic Nowcasting Ensemble Forecasts on Regional Ensemble Forecasts

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Advances in Atmospheric Sciences 2023年第5期40卷 937-951页

作者： Lu YANG Cong-Lan chenG yu XIA Min chen Ming-xuan chen Han-Bin ZHANG Xiang-yu HUANG Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China

Ensemble forecasting systems have become an important tool for estimating the uncertainties in initial conditions and model formulations and they are receiving increased attention from various *** Regional Ensemble Prediction System(REPS),which has operated at the Beijing Meteorological Service(BMS)since 2017,allows for probabilistic ***,it still suffers from systematic deficiencies during the first couple of forecast *** paper presents an integrated probabilistic nowcasting ensemble prediction system(NEPS)that is constructed by applying a mixed dynamicintegrated *** essentially combines the uncertainty information(i.e.,ensemble variance)provided by the REPS with the nowcasting method provided by the rapid-refresh deterministic nowcasting prediction system(NPS)that has operated at the Beijing Meteorological Service(BMS)since *** NEPS provides hourly updated analyses and probabilistic forecasts in the nowcasting and short range(0-6 h)with a spatial grid spacing of 500 *** covers the three meteorological parameters:temperature,wind,and *** outcome of an evaluation experiment over the deterministic and probabilistic forecasts indicates that the NEPS outperforms the REPS and NPS in terms of surface weather *** of two cases demonstrates the superior reliability of the NEPS and suggests that the NEPS gives more details about the spatial intensity and distribution of the meteorological parameters.

关键词： integration ensemble nowcasting probabilistic prediction evaluation and verification

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying chen Fa Shen Chang cheng yu-Han Wang Wen-Chao cheng De-Zhi yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

An Improved Method for Defining Short-Term Climate Anomalies

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Journal of Meteorological Research 2021年第6期35卷 1012-1022页

作者： xuan chen Tim LI Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and TechnologyUniversity of Hawaii atManoaHonoluluHI 96822USA

A conventional method to define short-term climate anomalies for atmospheric and oceanic variables,recommended by the World Meteorological Organization(WMO),is the departure from a 30-yr climatological mean in the preceding three *** a method,however,introduces spurious errors such as sudden jumps and artificial trends.A new method,named a trend correctional method,is introduced to eliminate the *** demonstrate the capability of this new method,we examine a set of idealized cases first by superposing a"true"interannual or interdecadal signal onto a linear or a nonlinear *** to the conventional method,the trend correctional method is able to retain,to a large extent,the"true"anomaly ***,we examined real-time *** anomaly time series derived based on the trend correctional method show a better agreement with the observed anomaly *** rootmean-square error is greatly improved,comparing to that calculated based on the conventional ***,the results from both the idealized and real cases demonstrate that the new method has a clear advantage to the conventional method in deriving true climate anomalies,in particular under the ongoing global warming circumstance.

关键词： long-term trend climate anomaly definition trend correctional method

基于“云服务”的分布式系统移动应用中心建设

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计算机系统应用 2017年第3期26卷 63-67页

作者：岳轩宇陈远平杜义华李镇阳王镇中国科学院计算机网络信息中心北京100190 中国科学院大学北京100049

介绍了在中科院分布式科研管理系统—ARP系统环境下,基于"云服务"模式移动应用中心的建设方案及具体技术路线,并针对建设过程中的关键问题,如分布式环境下"云"服务功能数据的获取机制、数据访问的安全保障措施以及用户认证机制等方面进... 详细信息

介绍了在中科院分布式科研管理系统—ARP系统环境下,基于"云服务"模式移动应用中心的建设方案及具体技术路线,并针对建设过程中的关键问题,如分布式环境下"云"服务功能数据的获取机制、数据访问的安全保障措施以及用户认证机制等方面进行了重点阐述.

关键词：分布式系统移动应用云服务安全 ARP

Mendelian Randomization Analysis to Analyze the Effect of Emergency Caesarean Section on Different Allergic Diseases and Related Blood Markers

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Biomedical and Environmental Sciences 2023年第11期36卷 1084-1089页

作者： LI yu Jian KAN xuan Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin 300052China

Caesarean section is a well-established surgical procedure that allows for maximum fetal rescue under special circumstances,such as intrauterine distress and intrauterine hypoxia,and minimizes injuries to pregnant women who cannot tolerate vaginal *** caesarean section is a special type of caesarean section that plays an important role in protecting the lives of pregnant mothers and fetuses[1].

关键词： Blood injuries Emergency

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人际距离和策略创造性对人际情绪调节的影响

心理学报 2025年第1期57卷 125-134页

作者：姚雨佳颜之悦林慧慧陈静全宣雨阳浙江工业大学教育学院杭州310023

本研究采用行为学实验和事件相关电位(ERP)技术考察不同人际距离和认知重评创造性对人际情绪调节效果的影响。结果发现,与由陌生人提供的创造性认知重评策略相比,由好友提供的创造性认知重评策略指示语会诱发更大的SPN波。不仅如此,在... 详细信息

本研究采用行为学实验和事件相关电位(ERP)技术考察不同人际距离和认知重评创造性对人际情绪调节效果的影响。结果发现,与由陌生人提供的创造性认知重评策略相比,由好友提供的创造性认知重评策略指示语会诱发更大的SPN波。不仅如此,在使用好友提供的策略调节自身情绪后,个体的愉悦度显著大于使用陌生人提供的策略,但两种条件下个体的LPP波幅没有显著差异。不管提供者是好友还是陌生人,在使用创造性认知重评策略后,个体的愉悦度和唤醒度均显著大于常规性认知重评策略,同时产生更大的LPP波。上述结果表明,相较于人际距离,认知重评策略的创造性在人际情绪调节中发挥更大的作用,而人际距离的作用在更高质量策略的调节效果中凸显。

关键词：人际距离创造性认知重评策略常规性认知重评策略策略创造性人际情绪调节

HC-Store： putting MapReduce＇s foot in two camps

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Frontiers of Computer Science 2014年第6期8卷 859-871页

作者： Huiju WANG Furong LI xuan ZHOU yu CAO Xiongpai QIN Jidong chen Shan WANG DEKE Lab Renmin University of China Ministry of Education Beijing 100872 China School of Information Renmin University of China Beijing 100872 China EMC Labs China Beijing 100084 China School of Computing National University of Singapore Singapore 117417 Singapore

MapReduce is a popular framework for large- scale data analysis. As data access is critical for MapReduce＇s performance, some recent work has applied different storage models, such as column-store or PAX-store, to MapReduce platforms. However, the data access patterns of different queries are very different. No storage model is able to achieve the optimal performance alone. In this paper, we study how MapReduce can benefit from the presence of two different column-store models - pure column-store and PAX-store. We propose a hybrid storage system called hybrid columnstore （HC-store）. Based on the characteristics of the incoming MapReduce tasks, our storage model can determine whether to access the underlying pure column-store or PAX-store. We studied the properties of the different storage models and create a cost model to decide the data access strategy at runtime. We have implemented HC-store on top of Hadoop. Our experimental results show that HC-store is able to outperform PAX-store and column-store, especially when confronted with diverse workload.

关键词： MapReduce Hadoop HC-store cost model column-store PAX-store