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Elucidating Secondary Organic Aerosol Processes through High-Resolution Aerosol Mass Spectrometry in Beijing

Advances in Atmospheric Sciences 2025年第4期42卷 670-681页

作者： Weiqi XU Chun chen Zhijie LI Zhiqiang ZHANG yu ZHANG Zifa WANG Yele SUN Key Laboratory of Atmospheric Environment and Extreme Meteorology Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China China Meteorological Administration Training Centre Beijing 100081China

Exploring secondary organic aerosol(SOA)processes is crucial for understanding climate and air pollution in *** study introduces a new method using positive matrix factorization(PMF)to investigate the SOA process by integrating the OA and associated ions previously misidentified as inorganic aerosol in high-resolution aerosol mass spectrometry *** mass spectra and time series of primary OA(POA)and less oxidized oxygenated OA(OOA)identified by this new method resembled those resolved by traditional ***,more oxidized OOA(MO-OOA)identified by traditional PMF can be further subdivided into multiple OA factors,including nitrogen-enriched OA(ON-OA)and sulfur-enriched OA(OS-OA)in summer,and ON-OA,OS-OA,and OOA in *** findings highlight the significant role of photochemical processes in the formation of OS-OA compared to *** compositions of reconstructed MO-OOA varied under different Ox(=O_(3)+NO_(2))and relative humidity conditions,emphasizing the limitations of using a constant mass *** biomass burning OA(BBOA)and coal combustion OA(CCOA),previously misattributed as POA,contributed 9.2%(0.43μg m^(−3))and 7.0%(0.33μg m^(−3))to SOA,*** BBOA was more prone to forming OS-OA,whereas ON-OA showed higher correlations with aged CCOA,indicating distinct molecular compositions of SOA from different aged POA *** to aged BBOA,aged CCOA was more subject to conversion during aqueous phase *** results suggest that the variations in mass spectra and compositions need to be considered when simulating SOA processes.

关键词： secondary organic aerosol positive matrix factorization aerosol mass spectrometry nitrogen-enriched organic aerosol sulfur-enriched organic aerosol

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城轨交通Check方式调度监督系统的设计与实现

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铁道学报 2002年第1期24卷 5-9页

作者：郑宇轩陈永生郭玉臣邹雷兵同济大学电子与信息工程学院上海200331

针对轨道交通信号系统的特点 ,提出了一种基于 Check方式的城市轨道交通调度监督系统。结合上海明珠线调度监督系统 ,介绍了系统数据库的事务处理和并发控制 ,给出了几种优化系统的措施 ,以及系统的软件结构和系统功能。

关键词：调度监督系统城市 Check方式轨道交通 CAN总线事务处理死锁内存表多线程

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Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

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Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu LIU Zhi-chao ZHAO Zhen-xi HUANG Hui-ping ZHANG Na XIA Jia chen Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

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Dual roles ofα1,4-galactosyltransferase 1 in spermatogenesis of Drosophila melanogaster

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Insect Science 2025年第1期32卷 127-139页

作者： Yanhong Xiao Bo Huang Sibo chen Zhikai Lin Zhiying Zhu yuzhen Lu Xiao-Qiang yu Liang Wen Qihao Hu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina School of Life Sciences Hubei Key Laboratory of Genetic Regulation and Integrative BiologyCentral China Normal UniversityWuhanChina

Spermatogenesis is critical for insect reproduction and the process is regulated by multiple *** have been shown to participate in the development of Drosophila melanogaster;however,their role in spermatogenesis is still *** this study,we found thatα1,4-galactosyltransferase 1(α4GT1)was expressed at a significantly higher level in the testis than in the ovary of ***,the hatching rate was significantly decreased whenα4GT1 RNA interference(RNAi)males were crossed with w1118 females,with only a few mature sperm being present in the seminal vesicle ofα4GT1 RNAi *** staining further revealed that the individualization complex(IC)in the testes fromα4GT1 RNAi flies was scattered and did not move synchronically,compared with the clustered IC observed in the control *** deoxyribonucleotide transferase(TdT)-mediated dUTP nick end labeling(TUNEL)assay showed that apoptosis signals in the sperm bundles ofα4GT1 RNAi flies were significantly ***,the expression of several individualization-related genes,such as Shrub,Obp44a and Hanabi,was significantly decreased,whereas the expression of several apoptosis-related genes,including Dronc and Drice,was significantly increased in the testes ofα4GT1 RNAi ***,these results suggest thatα4GT1 may play dual roles in Drosophila spermatogenesis by regulating the sperm individualization process and maintaining the survival of sperm bundles.

关键词： apoptosis α4GT1 galactosyltransferase individualization spermatogenesis

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Combined BRAF G469A mutation and echinoderm microtubule associated protein like-4-anaplastic lymphoma kinase rearrangement with resistance:A case report and review of literature

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World Journal of Clinical Oncology 2025年第2期16卷 165-172页

作者： xuan Guo Yan Liu yu-Ting Wang Kan Liu Hui Ding Department of Pulmonary and Critical Care Medicine Yixing People’s Hospital of Jiangsu UniversityYixing 214200Jiangsu ProvinceChina

BACKGROUND Through deeper understanding of targetable driver mutations in non-small-cell lung cancer(NSCLC)over the past years,some patients with driver mutations have benefited from the targeted molecular *** the anaplastic lymphoma kinase and BRAF mutations are not frequent subtypes in NSCLC,the availability of several targeted-drugs has been confirmed through a series of clinical *** little is clear about the proper strategy in rare BRAF G469A mutation,not to mention co-exhibition of anaplastic lymphoma kinase and BRAF G469A mutations,which is extremely rare in *** SUMMARY We present a patient to stage IVA lung adenocarcinoma with coexisting echinoderm microtubule associated protein like-4 rearrangement and BRAF G469A *** received several targeted drugs with unintended resistance and suffered from unbearable adverse *** Due to the rarity of co-mutations,the case not only enriches the limited literature on NSCLC harbouring BRAF G469A and echinoderm microtubule associated protein like-4 mutations,but also suggests the efficacy and safety of specific multiple-drug therapy in such patients.

关键词： Non-small-cell lung cancer Driver mutation Rearrangement Resistance Case report

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Changes in retinal capillary density in female with type 2 diabetes and gestational diabetes——an analysis based on OCTA technology

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 435-448页

作者： Jing Zhang Yao yu Xian-Mei Zhou xuan Liao Jin-yu Hu Qian Ling Jie Zou cheng chen Liang-Qi He Hong Wei Xu chen Yi-Xin Wang Yi Shao Rui-Man Li Department of Obstetrics and Gynecology the First Affiliated Hospital of Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Obstetrics and Gynecology Changde HospitalXiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre FOR Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for Metabolic DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology of Affiliated Hospital and Ophthalmology&Optometry of Medical School North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK

AIM:To evaluate alterations in conjunctival vascular density(CVD)and macular capillary density(MCD)in female patients with type 2 diabetes mellitus(T2DM)and gestational diabetes mellitus(GDM)using optical coherence tomography angiography(OCTA).METHODS:A total of 60 female participants were recruited,comprising 20 patients with T2DM,20 patients with GDM,and 20 healthy age-matched controls(HCs).OCTA was used to assess superficial and deep retinal and conjunctival capillary ***,changes in MCD were analyzed using a circular segmentation method(C1-C6),a hemispheric quadrant segmentation method[superior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and the early treatment diabetic retinopathy study(ETDRS)segmentation method(S,I,R,L).RESULTS:OCTA unequivocally demonstrated that the variations in CVD among HCs,T2DM,and GDM groups were statistically significant(P<0.001).In the superficial retinal capillary plexus(sRCP),significant differences were observed in the densities of total microvascular(TMI),microvasculature(MIR),and macrovascular(MAR)between patients with T2DM and HCs(P<0.05).Furthermore,the GDM group exhibited a more substantial reduction in MIR density compared to the T2DM group(P<0.01).In the deep retinal capillary plexus(dRCP),significant differences in the densities of TMI and MIR were identified between the T2DM group and HCs(P<0.05),with a notable difference in TMI density also observed between the GDM and T2DM groups(P<0.01).In the receiver operating characteristic(ROC)curve analysis,the area under the ROC curve(AUC)for TMI in sRCP between the T2DM group and HCs was 0.975,with a 95%confidence interval(CI)of 0.941–*** AUC for MIR was highest in dRCP,with an AUC value of 0.914 and a 95%CI ranging from 0.847 to *** comparing the GDM and T2DM groups,the AUC for I region was maximized in sRCP,achieving a value of 0.978 with a 95%CI of 0.953–***,the AUC for R region was maximized in dRCP,reaching a value

关键词： diabetes optical coherence tomography angiography superficial retinal capillary plexus deep retinal capillary plexus retinal region segmentation method

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Melon2K array:A versatile 2K liquid SNP chip for melon genetics and breeding

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Horticultural Plant Journal 2025年第1期11卷 314-322页

作者： Qing yu Shuai Li Xiaofeng Su Xinxiu chen yuanhua Dong Zhiwang Yao Naiyu Jiang Sen Chai Zhonghua Zhang Kuipeng Xu Engineering Laboratory of Genetic Improvement of Horticultural Crops of Shandong Province College of HorticultureQingdao Agriculture UniversityQingdaoShandong 266109China Key Laboratory of Special Food Proceing(Coconstructionby Ministry and Province) Ministryof Agriculture Rural AairsQingdao Agriculural UniversityQingdaoShandong 266109China Shandong Technology Innovation Center of Special Food QingdaoShandong 266109China Qingdao Special Food Research Institute QingdaoShandong 266109China Genome Analysis Laboratory of the Ministry of Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518124China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesKey Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of AgricultureSino-Dutch Joint Laboratory of Horticultural GenomicsBeijing 100081China

High-throughput genotyping tools can effectively promote molecular breeding in *** this study,genotyping by target sequencing(GBTS)system was utilized to develop a genome-wide liquid SNP chip for facilitating genetics and breeding in melon(Cucumis melo L.),a globally cultivated economically important horticultural *** on over eight million SNPs derived from 823 representative melon accessions,16K,8K,4K,2K,1K,500,250 and 125 informative SNPs were screened and evaluated for their polymorphisms,conservation of flanking sequences,and *** set of 2K SNPs was found to be optimal for representing the maximum diversity with the lowest number of SNPs,and it was selected to develop the liquid chip,named“Melon2K”.Using Melon2K,more than 1500 SNPs were detected across 17 samples of five melon cultivars,and the phylogenetic relationships were clearly *** the same cultivar,genetic differences were also assessed between different *** evaluated the performance of Melon2K in genetic background selection during the breeding process,obtaining the introgression lines of interested trait with more than 97%genetic background of elite variety by only two rounds of *** results suggest that Melon2K provides a cost-effective,efficient and reliable platform for genetic analysis and molecular breeding in melon.

关键词： Melon Cucumis melo L. Melon2K Liquid SNP chip Cultivar identification Background selection

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Methanol steam mediated corrosion engineering towards high-entropy NiFe layered double hydroxide for ultra-stable oxygen evolution

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Chinese Chemical Letters 2025年第1期36卷 338-343页

作者： Jinqiang Gao Haifeng yuan Xinjuan Du Feng Dong yu Zhou Shengnan Na Yanpeng chen Mingyu Hu Mei Hong Shihe Yang Guangdong Provincial Key Laboratory of Nano-Micro Materials Research School of Advanced MaterialsPeking University Shenzhen Graduate School(PKUSZ)Shenzhen 518055China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China Department of Physics Hong Kong Baptist UniversityHong Kong 999077China

Rational design of viable routes to obtain efficient and stable oxygen evolution reaction(OER)electrocatalysts remains challenging,especially under industrial ***,we provide a solvent-steam assisted corrosion engineering strategy to directly fabricate high-entropy NiF e-LDH with spatially resolved structural *** fluoride in methanol steam enables the formation of nanosheets while Fe^(3+)effectively enhances their adhesion to the semi-sacrificial nickel-iron foam(NFF),thereby conjuring up a Ni Fe-LDH@NFF catalyst that exhibits remarkable adaptability to robust electrochemical activation yet with excellent *** measurements reveal the in-situ formation of high-valance metal oxyhydroxide and the enhancement of adsorption-desorption *** the industrial condition(6 mol/L KOH,60℃),the Ni Fe-LDH@NFF exhibits excellent activity of 50 mA/cm^(2) at 1.55 V and high durability of over 120 h at 200 mA/cm^(2).We anticipate that the steam assisted strategy could promote the development of efficient non-precious electrocatalysts for hydrogen energy.

关键词： High-entropy material Corrosion engineering NiFe-LDH Oxygen evolution reaction Stability

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Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： chen Wuxing chen Shuang yu Yan ZHANG Jiangyi XU Haiyang GUO Wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

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Metabolic landscape of human alveolar type II epithelial cells undergoing epithelial-mesenchymal transition induced directly by silica exposure

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Journal of Environmental Sciences 2025年第3期149卷 676-687页

作者： Jin Sun Na Zhao Ruijia Zhang Yizheng Li Tiantian yu Qiying Nong Li Lin Xubin Yang Tiangang Luan Baowei chen Yongshun Huang Southern Marine Science and Engineering Guangdong Laboratory School of Marine SciencesSun Yat-Sen UniversityZhuhai 519082China Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou 510300China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China State Key Lab of Bioresource and Biocontrol School of Life ScienceSun Yat-sen UniversityGuangzhou 510275China Metabolic Innovation Center Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 540080China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Epithelial-mesenchymal transition(EMT)plays an irreplaceable role in the development of ***,molecular mechanisms of EMT induced by silica exposure still remain to be ***,metabolic profiles of human alveolar type II epithelial cells(A549 cells)exposed directly to silica were characterized using non-targeted metabolomic approaches.A total of 84 differential metabolites(DMs)were identified in silica-treated A549 cells undergoing EMT,which were mainly enriched in metabolisms of amino acids(e.g.,glutamate,alanine,aspartate),purine metabolism,glycolysis,*** number of DMs identified in the A549 cells obviously increased with the elevated exposure concentration of ***,glutamine catabolism was significantly promoted in the silica-treated A549 cells,and the levels of related metabolites(e.g.,succinate)and enzymes(e.g.,α-ketoglutarate(α-KG)dehydrogenase)were substantially up-regulated,with a preference toα-KG *** of glutamine into the cell culture could substantially enhance the expression levels of both EMT-related markers and Snail(zinc finger transcription factor).Our results suggest that the EMT of human alveolar epithelial cells directly induced by silica can be essential to the development of silicosis.

关键词： Silica exposure Human alveolar type II epithelial cells(ATII cells) Epithelial-mesenchymal transition (EMT) Metabolomics Glutamine

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