检索结果-南通市图书馆

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

引用

Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing Dong-Hui Wang Hai-Feng Zhang Li-Dan liu Cheng-Ce Li Chao Wei Jun-Yu liu Nai-Jian Ge xuan-yong liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Au@Ag@Pt core–shell nanorods regulating Ag release behavior endow titanium antibacterial activity and biocompatibility

引用

Rare Metals 2022年第2期41卷 630-638页

作者： Jia-Jun Qiu Ting-Ting Yang Yi-Fan Li Wen-Hao Qian xuan-yong liu School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences School of Materials Science and Engineering Jiamusi University Smart Materials and Surfaces Laboratory Faculty of Engineering and EnvironmentNorthumbria University Shanghai Xuhui District Dental Center

Although titanium and its alloys are extensively used in orthopedics and dentistry fields,implant failures still happen because of implant-associated ***,Au@Ag@Pt core–shell nanorods with noble metal combination were fabricated and assembled on medical titanium surface and the antibacterial activity and biocompatibility were *** results showed that antibacterial rates of Ti–Au@Ag@Pt against *** and *** were 89.7%and 92.7%,***,Ti–Au@Ag@Pt showed no obvious cell toxicity with MC3 T3-E1 cells grew well on the sample *** was discovered that the Pt shell layer on Ti–Au@Ag@Pt slowed down the Ag ion release rate which endowed medical titanium surface with both antibacterial activity and good biocompatibility.

关键词： Titanium Silver Nanorod Antibacterial Biocompatibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lipase and photodecarboxylase coexpression: A potential strategy for alkane-based biodiesel production from natural triglycerides

引用

Chinese Journal of Chemical Engineering 2024年第3期67卷 238-246页

作者： yong-Yi Zeng Xin-Yi Xu Jin-xuan Xie Wen-Li Chen Lan liu Xin-Jian Yin Bi-Shuang Chen School of Marine Sciences Sun Yat-Sen UniversityZhuhai 519080China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Alkane-based biodiesel is considered the next generation of biodiesel owing to its potential environmental benefits and the fact that it exhibits much higher specific caloric values than traditional ***,the formidable obstacle impeding the commercialization of this cutting-edge fuel alternative lies in the cost associated with its *** this study,an engineered strain Escherichia coli(***)showcasing harmonized coexpression of a lipase(from Thermomyces lanuginosus lipase,TLL)and a fatty acid photodecarboxylase(from Chlorella variabilis,CvFAP)was first constructed to transform triglycerides into *** potential of *** BL21(DE3)/pRSFDuet-1-TLL-CvFAP for alkane synthesis was evaluated with tripalmitin as a model substrate under various process *** a comprehensive examination of the reaction parameters,the scope of the biotransformation was expanded to‘real’substrates(vegetable oils).The results showed that bioderived oils can be transformed into alkanes with high yields(0.80-10.20 mmol·L^(-1))under mild conditions(35℃,pH 8.0,and 36 h)and blue light *** selected processes were performed on an increased lab scale(up to 100 ml)with up to 24.77 mmol·L^(-1) tripalmitin,leading to a yield of 18.89 mmol·L^(-1) *** the employment of a method for efficiently producing alkanes under mild conditions and a simple procedure to isolate alkanes from the reaction system,the utilization of sustainable biomass as a fundamental feedstock emerges as the primary solution to lower the cost of alkane-based ***,this study proposes a readily implementable and highly effective approach for alkane-based biodiesel production.

关键词： Alkane-based biodiesel Renewable biomass Co-overexpression Lipase Photodecarboxylase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

引用

Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-xuan Chen Jin-Yue Dai Li-Yue Zhang Shuai-Peng Wang Jing-Kai liu yong-Gang Wu Xin-Wu Ba Xiao-Qing liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preoperative prediction of perineural invasion of rectal cancer based on a magnetic resonance imaging radiomics model:A dual-center study

引用

World Journal of Gastroenterology 2024年第16期30卷 2233-2248页

作者： Yan liu Bai-Jin-Tao Sun Chuan Zhang Bing Li Xiao-xuan Yu yong Du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina.duyong@***

BACKGROUND Perineural invasion(PNI)has been used as an important pathological indicator and independent prognostic factor for patients with rectal cancer(RC).Preoperative prediction of PNI status is helpful for individualized treatment of ***,several radiomics studies have been used to predict the PNI status in RC,demonstrating a good predictive effect,but the results lacked *** preoperative prediction of PNI status is still challenging and needs further *** To establish and validate an optimal radiomics model for predicting PNI status preoperatively in RC *** This retrospective study enrolled 244 postoperative patients with pathologically confirmed RC from two independent *** patients underwent preoperative high-resolution magnetic resonance imaging(MRI)between May 2019 and August *** radiomics features were extracted and selected from oblique axial T2-weighted imaging(T2WI)and contrast-enhanced T1WI(T1CE)*** radiomics signatures were constructed using logistic regression analysis and the predictive potential of various sequences was compared(T2WI,T1CE and T2WI+T1CE fusion sequences).A clinical-radiomics(CR)model was established by combining the radiomics features and clinical risk *** internal and external validation groups were used to validate the proposed *** area under the receiver operating characteristic curve(AUC),DeLong test,net reclassification improvement(NRI),integrated discrimination improvement(IDI),calibration curve,and decision curve analysis(DCA)were used to evaluate the model *** Among the radiomics models,the T2WI+T1CE fusion sequences model showed the best predictive performance,in the training and internal validation groups,the AUCs of the fusion sequence model were 0.839[95%confidence interval(CI):0.757-0.921]and 0.787(95%CI:0.650-0.923),which were higher than those of the T2WI and T1CE sequence *** CR model constructed by combinin

关键词： Rectal cancer Perineural invasion Magnetic resonance imaging Radiomics Nomogram

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relation Between the Eventual Continuity and the E-property for Markov-Feller Semigroups

引用

Acta Mathematicae Applicatae Sinica 2024年第1期40卷 1-16页

作者： yong liu Zi-yu liu LMAM School of Mathematical SciencePeking UniversityBeijing100871China

We investigate some relations between two kinds of semigroup regularities, namely the e-property and the eventual continuity, both of which contribute to the ergodicity for Markov processes on Polish *** precisely, we prove that for Markov-Feller semigroup in discrete time and stochastically continuous MarkovFeller semigroup in continuous time, if there exists an ergodic measure whose support has a nonempty interior,then the e-property is satisfied on the interior of the support. In particular, it implies that, restricted on the support of each ergodic measure, the e-property and the eventual continuity are equivalent for the discrete-time and the stochastically continuous continuous-time Markov-Feller semigroups.

关键词： Markov-Feller semigroup ergodicity e-property eventual continuity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A benchmark-based method for evaluating hyperparameter optimization techniques of neural networks for surface water quality prediction

引用

Frontiers of Environmental Science & Engineering 2024年第5期18卷 13-27页

作者： xuan Wang Yan Dong Jing Yang Zhipeng liu Jinsuo Lu School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an710055China Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an710055China State Key Laboratory of Green Building in West China Xi’an University of Architecture and TechnologyXi’an710055China

Neural networks(NNs)have been used extensively in surface water prediction tasks due to computing algorithm improvements and data *** essential step in developing an NN is the hyperparameter *** practice,it is common to manually determine hyperparameters in the studies of NNs in water resources *** may result in considerable randomness and require significant computation time;therefore,hyperparameter optimization(HPO)is *** study adopted five representatives of the HPO techniques in the surface water quality prediction tasks,including the grid sampling(GS),random search(RS),genetic algorithm(GA),Bayesian optimization(BO)based on the Gaussian process(GP),and the tree Parzen estimator(TPE).For the evaluation of these techniques,this study proposed a method:first,the optimal hyperparameter value sets achieved by GS were regarded as the benchmark;then,the other HPO techniques were evaluated and compared with the benchmark in convergence,optimization orientation,and consistency of the optimized *** results indicated that the TPE-based BO algorithm was recommended because it yielded stable convergence,reasonable optimization orientation,and the highest consistency rates with the benchmark *** optimization consistency rates via TPE for the hyperparameters hidden layers,hidden dimension,learning rate,and batch size were 86.7%,73.3%,73.3%,and 80.0%,*** the evaluation of HPO techniques directly based on the prediction performance of the optimized NN in a single HPO test,the proposed benchmark-based HPO evaluation approach is feasible and robust.

关键词： Neural networks Hyperparameter optimization Surface water quality prediction Bayes optimization Genetic algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Understanding the Activity Performance of Comets 38P/Stephan-Oterma,64P/Swift-Gehrels and C/2017 M4(ATLAS) through Broadband Photometric Observations

引用

Research in Astronomy and Astrophysics 2024年第8期24卷 149-158页

作者： xuan Zhang Jin-Zhong liu Le-Tian Wang Xinjiang Astronomical Observatory Chinese Academy of Sciences

In this work,we report observations of three comets:38P/Stephan-Oterma,64P/Swift-Gehrels,and C/2017 M4（ATLAS）,conducted with the Nanshan one-meter wide-field telescope in 2018 August and November,and *** extracted morphological features through image enhancement techniques and calculated the dust activity parameter,Afρ,along with dust mass loss rates and coma color indices using broadband photometric *** morphological analysis uncovered a spectrum of dust characteristics among the observed comets,ranging from a significant twisted structure in comet 38P/Stephan-Oterma’s coma to the regular coma envelope surrounding comet 64P/*** Afρvalues varied between 148.8±0.3 cm for 64P/Swift-Gehrels and1118.5±6.2 cm for C/2017 M4 （ATLAS）(measured within a reference aperture radius ofρ=6″),indicating a range from moderate to high activity *** mass loss rates were estimated from 328.1 kg s-1for comet 64P/Swift-Gehrels to 1395.5 kg s-1for comet C/2017 M4 （ATLAS）.The color indices of comets 38P/Stephan-Oterma and C/2017 M4 （ATLAS） closely resemble the average colors of active short-period comets and active longperiod comets,*** contrast,64P/Swift-Gehrels exhibits a significantly bluer hue than typical Jupiter family comets.

关键词： comets: general comets: individual (38P/Stephan-Oterma, 64P/Swift-Gehrels, C/2017 M4 (ATLAS)) techniques: photometric

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A visible-light-assisted Pd/TiO_(2)gas sensor with carbon nanotubes electrodes for trace formaldehyde detection

引用

Rare Metals 2024年第1期43卷 257-266页

作者： Can liu Qiao-Qiao Zou Bin liu yong Zhang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Owing to the ppb-level detection standard toward the toxic and harmful gas,the detection of trace gases has become an important subject in the field of indoor environment ***,the traditional resistive gas sensors hardly meet the requirement due to the weak signal generated by trace gas molecules that are difficult to ***,a visible-light-assisted Pd/TiO_(2)gas sensor is proposed to endow the effective detection of trace formaldehyde(HCHO)gas without heating *** from the enhanced photocatalytic properties of TiO_(2)by Pd decoration,the visible-light-assisted Pd/TiO_(2)gas sensor can detect the HCHO gas as low as80×10^(–9)at room *** successful preparation of nanoscale TiO_(2)sensing layer is facilitated by the ultrathin carbon nanotube interdigital electrode in the gas sensor,which avoids the discontinuity of the sensing layer caused by the excessive thickness of the traditional metal *** addition,the whole preparation process of the Pd/TiO_(2)gas sensor with carbon nanotube electrodes is compatible with mainstream CMOS fabrication technology,which is expected to realize the batch fabrication and micro-integrated application of gas *** is expected that our work can provide a new strategy for the batch preparation of high-performance trace HCHO gas sensors and their future applications in portable electronic devices such as smartphones.

关键词： Visible-light-assisted gas sensor Pd/TiO_(2) Trace HCHO detection Carbon nanotubes electrodes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-assembly and morphological characterization of two-component functional amyloid proteins

引用

Chinese Chemical Letters 2017年第5期28卷 1062-1068页

作者： Qi Qi Tian-Xin Zhao Bo-Lin An xuan-yong liu Chao Zhong School of Physical Science and Technology Shanghai Tech UniversityShanghai 200120China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China

Functional amyloid has been increasingly applied as self-assembling nanostructures to construct multifunctional ***,little has been known how different side domains,varied fusion positions and subunits affect self-assembly and morphologies of amyloid ***,we constructed three groups of two-component amyloid proteins based on CsgA,the major protein components of Escherichia coli biofilms,to bridge these *** showed that all fusion proteins have amyloid features,as indicated by Congo red *** force microscopy（AFM） indeed reveals that these fusion proteins are able to self-assemble into fibrils,with an average diameter of 0.5-2 nm and length of hundreds of nanometers to several *** diameter of fibrils increases with the increase of the molecular weight of fusion domains,while the dynamic assembly of recombinant proteins was delayed as a result of the introduction of fusion ***,fusion of the same functional domains but at intermediate position seems to cause the most interference on fibril assembly compared with those fused at C or Nterminus,as mainly short and irregular fibrils were *** phenomenon appears more pronounced for randomly coiled mussel foot proteins（Mfps） than for rigid chitin-binding domain（CBD）.Finally,increase of the molecular weight of tandem repeats in protein monomer seemed to increase the fibril diameter of the resultant fibrils,but either reduction of the tandem repeats of CsgA to one single belta-sheet loop or increase in the number of tandem repeats of CsgAs from one to four produced shorter and intermittent fibrils compared with CsgA control *** studies therefore provide insights into self-assembly of two-component amyloid proteins and lay the foundation for rational design of multifunctional molecular biomaterials.

关键词： Amyloid Biofilms Atomic force microscopy Self-assembly Nanomaterials Supramolecular structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：