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Genetic variant of cyclooxygenase-2 in gastric cancer:More inflammation and susceptibility

World Journal of Gastroenterology 2021年第28期27卷 4653-4666页

作者： xuan-ke ji Sailaja Vatsalya Madhurapantula Gui He Kun-Yan Wang Chun-Hua Song jian-Ying Zhang Kai-Juan Wang College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001Henan ProvinceChina key Laboratory of Tumor Epidemiology of Henan Province Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina State key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Gastric cancer accounts for the majority cancer-related deaths *** various methods have considerably improved the screening,diagnosis,and treatment of gastric cancer,its incidence is still high in Asia,and the 5-year survival rate of advanced gastric cancer patients is only 10%-20%.Therefore,more effective drugs and better screening strategies are needed for reducing the incidence and mortality of gastric ***-2(COX-2)is considered to be the key inducible enzyme in prostaglandins(PGs)synthesis,which is involved in multiple pathways in the inflammatory *** example,inflammatory cytokines stimulate innate immune responses via Toll-like receptors and nuclear factor-kappa B to induce COX-2/PGE2 *** these processes,the production of an inflammatory microenvironment promotes the occurrence of gastric *** studies have also indicated that non-steroidal antiinflammatory drugs can reduce the risk of malignant tumors of the digestive system by blocking the effect of ***,clinical use of COX-2 inhibitors to prevent or treat gastric cancer may be limited because of potential side effects,especially in the cardiovascular *** these side effects and low treatment efficacy,new therapeutic approaches and early screening strategies are urgently *** studies have shown that genetic variation in COX-2 also play an important role in ***,the genetic variation analysis in these studies is incomplete and isolated,pointing out only a few single nucleotide polymorphisms(SNPs)and the risk of gastric cancer,and no comprehensive study covering the whole gene region has been carried *** addition,copy number variation(CNV)is not *** this review,we summarize the SNPs in the whole COX-2 gene sequence,including exons,introns,and both the 5’and 3’untranslated *** suggest that COX-2 does not increase its expression through the CNV and the SNPs in COX-2 may serve as the p

关键词： Cyclooxygenase-2 Inflammation Genetic variant Gastric cancer Prostaglandin E2

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Helicobacter pylori and gastric cardia cancer:What do we know about their relationship?

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World Journal of Meta-Analysis 2020年第2期8卷 89-97页

作者： jing-jing Yin Fu-jiao Duan Sailaja Vatsalya Madhurapantula Yue-Hua Zhang Gui He Kun-Yan Wang xuan-ke ji Kai-Juan Wang Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001Henan ProvinceChina key Laboratory of Tumor Epidemiology of Henan Province Zhengzhou 450052Henan ProvinceChina

The incidence of gastric cardia cancer is increasing around the *** the discovery of Helicobacter pylori(***),numerous studies have proved that it is a causative factor for many kinds of digestive system *** the literature on gastric cardia cancer and *** is not scarce,there are still many controversies on the relationship between gastric cardia cancer and *** Western research results showed that there was a negative or no correlation between *** infection and gastric cardia cancer,but in several studies in Asian countries,such as China,*** was demonstrated to be a risk factor for gastric cardia ***,we intended to analyze the related studies to find out the relationship between *** and gastric cardia cancer and find out the causes of the above *** also conducted a metaanalysis of the relationship between cagA positive expression of *** and gastric cardia cancer,to find out whether there is an effect between those *** primary purpose of this paper was to explore the relationship between gastric cardia cancer and *** analysis,the study showed the reasons for the controversies mentioned above:(1)Geographical factors could affect the relationship between *** and gastric cardia cancer;(2)The definition of gastric cardia cancer in various studies is *** result of a meta-analysis about the relationship between *** virulence factor cagA and gastric cardia cancer showed that there was no relationship between these two.

关键词： Gastric cardia cancer Helicobacter pylori Cytotoxin-associated gene A Relationship Risk factors Meta-analysis

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New bainite kinetics of high strength low alloy steel in fast cooling process

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Journal of Iron and Steel Research International 2017年第2期24卷 229-233页

作者： xuan-wei Lei ji-hua Huang Shu-hai Chen Xing-ke Zhao School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Based on Kolmgorov-Johnson-Mehl-Avrami analysis, a new bainite kinetics of high strength low alloy steel in fast cooling process was developed by utilizing different experimental methods. Upper bainite transformation morphological evolutions at a cooling rate of 8.3 K/s were directly observed by laser scanning confocal microscopy. This qualitative analysis suggests that bainite packet is more suitable to give a one-dimensional growth model if it is considered as a transformation unit. The nucleation rate of bainite packets in fast cooling process is assumed to give an a priori item. One-dimensional growth model with constant growth rate which is assumed as a function of cooling rate is adopted as well. Thus, the devel- oped new bainite kinetics is simple in expression and contains an adjustable parameter and an empirical pa rameter. Experimental results show upper bainite and lower bainite transformations in fast cooling processes. Their referential phase volume fractions are calculated by the expanded lever rule on the first derivative dilatometer curves. For the similar transformation mechanisms, upper bainite and lower bainite are considered to give the same kinetics. With considering the Nakamura＇s equation, the bainite kinetics is fitted with experimental data. Results show that bainite volume fractions and bainite transformation rates can be expressed precisely bY the newly developed bainite kinetics.

关键词： Bainite kinetics Fast cooling process High strength low alloy steel Upper bainite Lower bainite

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Can sub-GeV dark matter coherently scatter on the electrons in the atom?

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Communications in Theoretical Physics 2023年第1期75卷 74-85页

作者： ji-Heng Guo Yu-xuan Sun Wenyu Wang ke-Yun Wu Faculty of Science Beijing University of TechnologyBeijingChina

A novel detection of sub-GeV dark matter is proposed in the *** electron cloud is boosted by the dark matter and emits an electron when it is dragged back by the heavy nucleus,namely the coherent scattering of the electron cloud of the *** survey in the x-ray diffraction shows that the atomic form factors are much more complex than the naive *** results of the relativistic Hartree-Fock(RHF)method give non-trivial shapes of the *** detailed calculation of the recoil of the electron cloud,the kinetics,the fiducial cross section and the corresponding calculation of detection rate are given *** numerical results show that the limits of the RHF form factors are much more stringent than the recoil of a single electron,almost 4 orders stronger,and also give tight limitations compared to the Migdal effect below about several hundred *** physical picture and the corresponding results are promising and need further exploration.

关键词： dark matter coherent scattering form factor

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Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： ji-Kui Wang Di Zhang jin-Feng Wang Wan-Lin Lu jing-Yuan Wang Shi-Feng Liang Ran Liu jing-Xin jiang Hong-Tao Li xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

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Novel design of a personnel safety system for Hefei Light Source-Ⅱ

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Nuclear Science and Techniques 2019年第6期30卷 114-121页

作者： Zi-Yu Huang ke xuan Chuan Li ji-Gang Wang Gong-Fa Liu National Synchrotron Radiation Laboratory University of Science and Technology of China

The Hefei Light Source-Ⅱ(HLS-Ⅱ) is a vacuum ultraviolet synchrotron light source. The personnel safety system (PSS), which is a personnel access control system, is a crucial part of the HLS-Ⅱ, as it protects the staff and users at HLS-Ⅱfrom radiation damages. The prior version of HLS-Ⅱ PSS was based on an access control system called SiPass. This lacked the personnel management function. Meanwhile, as the prior PSS is a turn-key system, it was not effective for sharing information. To overcome these drawbacks, the novel design of PSS for HLS-Ⅱ is proposed based on the Siemens redundant programmable logic controller under the Experimental Physics and Industrial Control System. The proposed PSS consists of a safety interlock system, access control system, and a radiation monitoring system. The safety interlock system is used to define the interlock logic. The access control system is designed to restrict the access of staff and users at HLS-Ⅱ, and to provide a personnel management function. The radiation monitoring system is used to monitor the radiation dose rate in both the light source and the surrounding areas. This paper details the architecture and the specific design of the novel PSS. The off-line test results demonstrate that the proposed system has achieved the design objectives.

关键词： Personnel safety system Personnel management Redundant programmable logic controller PROFINET Experimental Physics and Industrial Control System

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Effective implementation and improvement of fast labeled multi-Bernoulli filter

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Journal of Systems Engineering and Electronics 2023年第3期34卷 661-673页

作者： CHENG xuan ji Hongbing ZHANG Yongquan School of Electronic Engineering Xidian UniversityXi’an 710071China

Effective implementation of the fast labeled multi-Bernoulli(FLMB)filter is addressed for target tracking with interval ***,a sequential Monte Carlo(SMC)implementation of the FLMB filter,SMC-FLMB filter,is derived based on generalized likelihood function ***,a box particle(BP)implementation of the FLMB filter,BP-FLMB filter,is developed,with a computational complexity reduction of the SMC-FLMB ***,an improved version of the BP-FLMB filter,improved BP-FLMB(IBP-FLMB)filter,is proposed,improving its estimation accuracy and real-time performance under the conditions of low detection probability and high *** results show that the BP-FLMB filter has a great improvement of the real-time performance than the SMC-FLMB filter,with similar tracking *** with the BP-FLMB filter,the IBP-FLMB filter has better estimation performance and real-time performance under the conditions of low detection probability and high clutter.

关键词： multi-target tracking interval measurements fast labeled multi-Bernoulli(FLMB)filter sequential Monte Carlo(SMC)implementation box particle(BP)implementation

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First principles study of Fenton reaction catalyzed by FeOCl:reaction mechanism and location of active site

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Rare Metals 2019年第8期38卷 783-792页

作者： xuan-xuan ji Hai-Feng Wang Pei-Jun Hu key Laboratory for Advanced Materials Research Institute of Industrial Catalysis and Centre for Computational Chemistry School of Chemical and Molecular Engineering East China University of Science and Technology Shanghai 200237 China School of Chemistry and Chemical Engineering The Queen’s University of Belfast Belfast BT9 5AZ UK

Fe-based solid catalysts in promoting Fenton reaction to generate ·OH radical has drawn much attention,and interestingly,FeOCl was reported to have superior activity compared with the traditional Fe2 O3 ***,the mechanism of Fenton reaction on FeOCl and the origin of high activity remain ***,by virtue of DFT+ U calculations,the H2 O2 decomposition and conversion mechanism on FeOCl(100)surface were systematically *** is found that on clean FeOCl(100)surface,the exposed[Fe^3+-Fe^3+]sites can hardly break O-O bond of H2 O2 into OH groups,but instead H2 O2 tends to dehydrogenate by the surface lattice O,resulting in a series of side reactions and final conversion into O2,while the left H atoms gradually saturate the surface lattice O and reduce Fe^3+ into Fe^2+.On fully H-covered FeOCl(100),H2O2 can efficiently dissociate at[Fe^2+-Fe^2+]sites into two OH,but OH binds with Fe^2+ so strongly that it cannot desorb as OH radical as easily as that on Fe^3+.Interestingly,FeOCl(100)tends to be partially protonated in the real acid solution,which,along with H2 O2 dehydrogenation,results in the formation of active unit [Fe^2+-Fe^3+].On[Fe^2+-Fe^3+]unit,H2 O2 can easily break its O-O bond and OH at Fe3+ can desorb as OH radical,while the other OH at Fe^2+ couples with the surface H into H2O and finish the catalytic *** comparison,Fe2 O3(012)cannot provide enough [Fe^2+-Fe^3+] active units due to the relative difficulty in H2 O2 dehydrogenation,which accounts for its inferior catalytic efficiency for Fenton reaction.

关键词： Fenton reaction FeOCl Density functional theory H2O2 Active site

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Characterizing Spatial Patterns of Precipitation Based on Corrected TRMM_3B_(43) Data over the Mid Tianshan Mountains of China

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Journal of Mountain Science 2012年第5期9卷 628-645页

作者： ji xuan CHEN Yunfang Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqiXinjiang830011 Graduate University of the Chinese Academy of Sciences Beijing100049 Center for Development Research Yunnan Normal UniversityKunming65o5oo

The poor distribution of meteorological stations results in a limited understanding of the precipitation pattern in the Tianshan Mountains. The spatial patterns of precipitation over the mid Tianshan Mountains were characterized based on the TRMM 3B43 monthly precipitation data. By comparing satellite estimates with observed data, it shows that TRMM 3B43 data underestimate the precipitation in mountain region. Regression models were developed to improve the TRMM 3B43 data, using geographic location and topographic variables extracted from DEM using GIS technology. The explained variance in observed precipitation was improved from 64% (from TRMM 3B43 products alone) to over 82% and the bias reduced by over 30% when location and topographic variables were added. We recalculated all the TRMM 3B43 monthly precipitation grids for the period 1998 to 2009 using the best regression models, and then studied the variation patterns of precipitation over the mid Tianshan Mountains. The results are well explained by a general understanding of the patterns of precipitation and orographic effects. This indicated that the Tianshan Mountains strongly influences the amount and distribution of precipitation in the region. This is highlighted by the confinement of the precipitation maxima to the windward (northern slope). And complex vertical changes in the provenance and distribution of precipitation, like that a negative increasing rate of precipitation in the vertical direction exists in the north but does not in south. The results have also revealed large gradients and different patterns in seasonal precipitation that are not simply related to elevation, the distribution of precipitation may also be affected by other seasonal factors such as the sources of moist air, wind direction and temperature.

关键词： Spatial pattern Precipitation TianshanMountains TRMM

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Tracking multiple people under occlusion and across cameras using probabilistic models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第7期10卷 985-996页

作者： xuan-he WANG ji-lin LIU Institute of Information and Communication Engineering Zhejiang University Hangzhou 310027 China Zhejiang Provincial key Laboratory of lnformation Network Technology Hangzhou 310027 China

Tracking multiple people under occlusion and across cameras is a challenging question for discussion. Furthermore, the cameras in this study are used to extend the field of view, which are distinguished from the same field of view. Such corre- spondence between multiple cameras is a burgeoning research subject in the area of computer vision. This paper effectively solves the problems of tracking multiple people who pass from one camera to another and segmenting people under occlusion using probabilistic models. The probabilistic models are composed of blob model, motion model and color model, which make the most of the space, motion and color information. First, we present a color model that uses maximum likelihood estimation based on non-parametric kernel density estimation. Second, we introduce a blob model based on mean shift, which segments the body into many regions according to the color of each person in order to spatially localize the color features corresponding to the way people are dressed. Clothes can be any mixture of colors. Third, we bring forward a motion model based on statistical probability which indicates the movement position of the same person between two successive frames in a single camera. Finally, we effectively unify the three models into a general probabilistic model and attain a maximization likelihood probability image, which is used to segment the foreground region under occlusion and to match people across multiple cameras.

关键词： Color model Motion model Blob model People occlusion People tracking kernel density estimation

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