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“Half of the Node Records Are Forged?”: The Problemof Node Records Forgery in Ethereum Network

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1713-1729页

作者： Yang Liu Zhiyuan lin Yuxi Zhang lin Jiang xuan Wang School of Computer Science and Technology Harbin Institute of Technology(Shenzhen)Shenzhen518055China Peng Cheng Laboratory Shenzhen518055China Guangd.ng Provincial Key Laboratory of Novel Security Intelligence Technologies Shenzhen518055China

Ethereum, currently the most widely utilized smart contracts platform, anchors the security of myriad smartcontracts upon its own robustness. Its foundational peer-to-peer network facilitates a dependable node connectionmechanism, whereas an efficient data-sharing protocol constitutes as the bedrock of Blockchain network *** this paper, we propose NodeHunter, an Ethereum network detector implemented through the application ofsimulation technology, which is capable of aggregating all node records within the network and the interconnectednessbetween them. Utilizing this connection information, NodeHunter can procure more comprehensive insightsfor network status analysis compared to preced.ng detection methodologies. Throughout a three-month period ofunbroken surveillance of the Ethereum network, we obtained an excess of two million node records along with overone hundred million node acquaintances. Analysis of the gathered data revealed that an alarming 49% or more ofthese node records were maliciously forged.

关键词： Blockchain ethereum peer-to-peer networks node discovery protocol malicious behavior

Unlocking the growth potential:harnessing the power of synbiotics to enhance cultivation of Pleurotus spp.

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 293-306页

作者： Reshma PATIL Aizi Nor Mazila RAMLI Ang Shu xuan ng Zhi XIN Nur Izyan Wan AZELEE Prakash BHUYAR Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Al-Sultan Abdullah(UMPSA)Gambang26300Malaysia BioAromatic Research Centre of Excellence Universiti Malaysia Pahang Al-Sultan Abdullah(UMPSA)Gambang26300Malaysia department of Bioprocess&Polymer Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaJohor81310Malaysia Organic Agriculture Management Maejo University International College(MJU-IC)Maejo UniversityChiang Mai50290Thailand International Industry and Agriculture Innovation Research Center(IIAR) International CollegeMaejo UniversityChiang Mai50290Thailand

The oyster mushroom(Pleurotus spp.)is one of the most widely cultivated mushroom species *** present study investigated the effect of synbiotics on the growth and quality of Pleurotus ostreatus and Pleurotus *** synbiotics formulations were applied by spraying mushroom samples daily and measuring their growth parameters,yield,biological efficiency,proximate composition,mineral content,total phenolic content(TPC),and diphenyl-1-picryl-hydrazyl(dPPH)radical scavenging *** demonstrated that the most significant yield of oyster mushrooms was harvested from synbiotics sprayed with inulin and Lactobacillus casei(56.92 g).Likewise,the highest biological efficiency obtained with a similar synbiotic was 12.65%.Combining inulin and *** was the most effective method of improving the mushrooms'growth performance and nutrient content in both ***,synbiotics that combined inulin and *** resulted in the highest TPC(20.550 mg gallic acid equivalent(GAE)/g dry extract(dE))in white oyster mushrooms(***).In comparison,in grey mushroom(***)the highest TPC was yielded by ***(1.098 mg GAE/g dE)followed by inulin and ***(1.079 mg GAE/g dE).The dPPH results indicated that the oyster mushroom could be an efficient *** results revealed that applying synbiotics improved the mushrooms'quality by increasing their antioxidant capacity with higher amounts of phenolic compounds and offering better health benefits with the increased levels of mineral ***,these studies demonstrated the potential of using synbiotics as a biofertilizer,which is helpful for mushroom cultivation;therefore,it might solve the challenge of inconsistent quality mushroom growers face.

关键词： Antioxidant Biofertilizer Growth performance Mushroom cultivation Pleurotus Synbiotics

Myokines:metabolic regulation in obesity and type 2 diabetes

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Life Metabolism 2024年第3期3卷 21-45页

作者： Zhi-Tian Chen Zhi-xuan Weng Jiandie d.lin Zhuo-Xian Meng department of Pathology and Pathophysiology and department of Cardiology of the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Key Laboratory of disease Proteomics of Zhejiang Province School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Zhejiang University-University of Edinburgh Institute(ZJE) School of MedicineZhejiang UniversityHainingZhejiang 314400China Life Sciences Institute and department of Cell and developmental Biology University of MichiganAnn ArborMI 48109United States department of Geriatrics Affiliated Hangzhou First People’s HospitalHangzhouZhejiang 310006China

Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of endocrine factors which are collectively known as *** myokine levels are associated with metabolic diseases,such as type 2 diabetes(T2d).The significance of interorgan crosstalk,particularly through myokines,has emerged as a fundamental aspect of nutrient and energy ***,a comprehensive understand.ng of myokine biology in the setting of obesity and T2d remains a major chal*** this review,we discuss the regulation and biological functions of key myokines that have been extensively studied during the past two decades,namely interleukin 6(IL-6),irisin,myostatin(MSTN),growth differentiation factor 11(GdF11),fibroblast growth factor 21(FGF21),apelin,brain-derived neurotrophic factor(BdNF),meteorin-like(Metrnl),secreted protein acidic and rich in cysteine(SPARC),β-aminoisobutyric acid(BAIBA),Musclin,and dickkopf 3(dkk3).Related to these,we detail the role of exercise in myokine expression and secretion together with their contributions to metabolic physiology and *** significant advancements in myokine research,many myokines remain challenging to measure accurately and investigate ***,new research techniques and detection methods should be developed and rigorously ***,developing a comprehensive perspective on myokine biology is crucial,as this will likely offer new insights into the pathophysiological mechanisms underlying obesity and T2d and may reveal novel targets for therapeutic interventions.

关键词： myokines skeletal muscle obesity type 2 diabetes metabolism

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dynamic manipulation of multimodal emission in Er^(3+)-activated non-core-shell structure for optical thermometry and information security

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Rare Metals 2024年第4期43卷 1702-1712页

作者： xuan Liu Zi-Xia lin Yin-Biao Shi Xiao-Yan Wang Ming-Ye d.ng Xiao-Fei Yang College of Science Nanjing Forestry UniversityNanjing210037China Testing Center Yangzhou UniversityYangzhou225009China

Regulating luminescent dynamics of lanthanide-based luminescent materials via external stimuli is of great significance in the fields of optical thermometry and high-level ***,it is still a huge challenge to realize multimodal emissions with tunable color outputs from a single activator in simple structures via smart dynamic control of photon transition ***,we present a mechanistic strategy to achieve multimodal luminescence of Er^(3+)activators with color-switchable outputs in a non-core-shell *** the control of excitation dynamics(λ_(ex)=980,808,1532,377 nm),the population among the intermediate en ergy levels of Er^(3+)and the interaction between Er^(3+)and Yb^(3+)could be precisely modulated through energy transfer and migration processes,lead.ng to the generation of colortunable multimodal luminescence upon diverse excitation modes(non-steady-state,single-/dual-wavelength steady,thermal activation).Inspired by its special luminescent performance,the as-obtained material exhibits great potential in noncontact thermometry,multimodal anticounterfeiting,and high-capacity information encryption by performing a series of proof-of-concept *** find.ngs might provide a conceptual model to modulate the luminescent dynamics in a simple-structured system for the generation of color-adjustable multimodal emissions,which is convenient for the development of advanced luminescent materials toward versatile cuttingedge applications.

关键词： Lanthanide ions Multimodal emission Upconversion downshifting Anti-counterfeiting Luminescent thermometry

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Reservoir characteristics and controlling factor of tight sandstone in Shuixigou Group in Taibei depression,Turpan-Hami basin

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Energy Geoscience 2024年第2期5卷 70-80页

作者： Tong lin xuan Chen Fan Yang Hongguang Gou Mingyu Liu Runze Yang PetroChina Research Institute of Petroleum Exploration&development Beijing100083China Research Institute of Exploration&development PetroChina Tuha Oilfield Company HamiXinjiang839009China China University of Geosciences(Beijing) Beijing100083China

The positive structure belts surround.ng the Taibei Sag,Turpan-Hami Basin,have been the main targets for oil and gas exploration for years and are now left with remaining resources scattering in reservoirs adjacent to source rocks in the sag,where the Shuixigou Group with substantial oil and gas potential constitutes the primary focus for near-source ***,characterization of development and key controlling factors of reservoir space becomes a must for future exploration in the *** study investigates the development traits,genesis,and controlling factors of the Xishanyao and Sangonghe formations in the Shengbei and Qiud.ng Sub-sags of the Taibei Sag with techniques such as cast thin-section observation,porosity and permeability tests,high-pressure mercury injection,and saturation fluid NMR analysis of reservoir *** find.ngs reveal that the Shuixigou Group in the Taibei Sag consists of lithic *** in the group are mostly poor in terms of physical properties,with undeveloped primary pores dominated by intergranular dissolved pores as a result of a strong *** analysis of key controlling factors of the Sangonghe Formation reveals significant distinctions in sandstone particle size,sand body thickness,genesis and distribution,provenance location,and source rock type between the Qiud.ng area and Shengbei ***,the coal seams of the Xishanyao Formation exhibit heightened development with shallower burial depth and lower maturity compared to those of the Sangonghe ***,this environment fosters the formation of organic acids,which have a stronger dissolution effect on minerals to develop secondary dissolution pores,and ultimately resulting in better reservoir physical ***,the reservoirs within the Qiud.ng area of the Taibei Sag demonstrate superior characteristics compared to those in the Shengbei ***,the reservoir physical properties of the Xishanyao For

关键词： Intergranular dissolved pore Organic acid dissolution Secondary dissolution pore Tight sandstone Shuixigou group Turpan-Hami basin

Heterostructure VO2@VS2 tailored by one-step hydrothermal synthesis for stable and highly efficient Zn-ion storage

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Materials Futures 2024年第4期3卷 171-180页

作者： Enyan Zhao Kesheng Gao xuan Luo lin Li Jinkui Zhao Hongliang Li College of Materials Science and Engineering Qingdao UniversityQingdao 266071People’s Republic of China Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190People’s Republic of China School of Physical Sciences Great Bay UniversityDongguan 523808People’s Republic of China

The increasing demand for advanced energy storage solutions has driven extensive research into Zn-ion batteries due to their safety,cost-effectiveness,and environmental *** study presents a synthesis and evaluation of VO2@VS2 hollow nanospheres as a novel cathode material for Zn-ion *** VO2@VS2 composite,synthesized via a one-step hydrothermal method,demonstrates a significant improvement in electrochemical *** material exhibits a reversible capacity of 468 mAh g-1 at 0.1 A g-1 and maintains a high capacity of 237 mAh g-1 at 1.0 A g-1 over 1000 cycles with a retention rate of 85%.Electrochemical analyses reveal enhanced charge transfer and Zn-ion storage,attributed to the synergistic effect and built-in electric field of the VO2 and VS2 ***,the composite shows superior electrochemical kinetics,facilitating rapid ion transport and charge ***-situ Raman analysis confirms the reversible Zn-ion storage mechanism,further validating the composite’s structural stability during *** functional theory calculations further support these find.ngs,indicating the composite’s potential for high-rate capability and long-term cycling *** research highlights the promise of VO2@VS2 hollow nanospheres in advancing the performance of aqueous Zn-ion batteries.

关键词： Zn-ion batteries vanadium-based cathode hollow nanospheres heterostructure pseudocapacitive

Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression

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Signal Transduction and Targeted Therapy 2024年第1期9卷 279-294页

作者： Liping Chen Shihao Zhu Tianyuan Liu xuan Zhao Tao Xiang Xiao Hu Chen Wu d.ngxin lin department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China CAMS Oxford Institute Chinese Academy of Medical SciencesBeijing 100006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Epithelial-mesenchymal transition(EMT)and proliferation play important roles in epithelial cancer formation and progression,but what molecules and how they trigger EMT is largely *** we performed spatial transcriptomic and functional analyses on samples of multistage esophageal squamous-cell carcinoma(ESCC)from mice and humans to decipher these critical *** investigating spatiotemporal gene expression patterns and cell–cell interactions,we demonstrated that the aberrant epithelial cell interaction via EFNB1-EPHB4 triggers EMT and cell cycle mediated by downstream SRC/ERK/AKT *** aberrant epithelial cell interaction occurs within the basal layer at early precancerous lesions,which expands to the whole epithelial layer and strengthens along the cancer development and *** analysis revealed that the aberrant EFNB1-EPHB4 interaction is caused by overexpressedΔNP63 due to TP53 mutation,the culprit in human ESCC *** results shed new light on the role of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in EMT and cell proliferation in epithelial cancer formation.

关键词： esophageal TP53 squamous

Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

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Chinese Chemical Letters 2024年第6期35卷 433-438页

作者： Boran Cheng Lei Cao Chen Li Fang-Yi Huo Qian-Fang Meng Ganglin Tong xuan Wu lin-lin Bu Lang Rao Shubin Wang department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key Laboratory Breed.ng Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(Cds)possess exceptional optical properties,making them highly desirable for use in fluorescent ***,the Cds with deep-red(dR)or near-infrared(NIR)emission have rarely been *** this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-Cds)by introducing a precursor simultaneously containing fluorine and *** synergistic effect of nitrogen doping and d-π-A pattern production contributed to the maximum emission of F-Cds at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-Cds-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(LOd)as low as 15.4 nmol/L,indicating the high sensitivity of F-Cds to ClO^(-).In real samples,the F-Cds-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily *** cancer cell imaging,the F-Cds not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization *** work presented here suggests the great potential of replacing commercial dyes with F-Cds for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

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Mechanism of Ta on the microstructure and properties of Fe-Mn damping alloys

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Tungsten 2024年第4期6卷 767-777页

作者： Gui-Xiang Liu Kun Zhang Chao Han Xiao-lin Shao Jun Lu lin Zhang Xiao-Song Jiang Zi-xuan Wu Liu Yang The Second Sub-Institute Nuclear Power Institute of China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiao tong University School of Engineering and Materials Science Queen Mary University of London Institute for Applied Materials (IAM-WK) Karlsruhe Institute of Technology (KIT)

Fe-Mn-Co-xTa alloys（x=0,1,2,3 wt.%） were fabricated using spark plasma sintering to explore the influence of Ta content on the microstructure,mechanical properties,and damping characteristics of Fe-17Mn-3Co damping *** micro structural analysis reveals the dominant presence of γ-austenite,ε-martensite,α'-martensite,and Co3Ta precipitates within the *** increments in Ta content exhibit proportional enhancements in hardness,tensile strength,and fracture elongation of the ***,these improvements in mechanical attributes are closely correlated with the generated second-phase *** the Ta content increases,there is a gradual augmentation in the formation of Co3Ta within the ***,the damping property initially experiences an ascent followed by a subsequent decline with rising Ta *** damping behavior finds its origins in multiple mechanisms,includ.ng grain boundary damping stemming from reduced grain size,interfacial damping induced by the generated Co3Ta,and dislocation *** is noteworthy that the emergence of the secondary phase wields a dual impact on damping *** the one hand,the proliferation of the second phase fosters increased interfaces for energy *** the other hand,these interfaces give rise to compressive stresses,constraining interface movement and thus imped.ng damping property enhancement.

关键词： damping Fe–Mn–Co Mechanical properties Spark plasma sintering Ta