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Therapeutic advances in atrial fibrillation based on animal models

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 135-152页

作者： Qian GONG xuan LE Pengcheng yu Lenan ZHUANG Institute of Genetics and Reproduction College of Animal SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Atrial fibrillation(AF)is the most prevalent sustained cardiac arrhythmia among humans,with its incidence increasing significantly with *** the high frequency of AF in clinical practice,its etiology and management remain *** develop effective treatment strategies,it is imperative to comprehend the underlying mechanisms of AF;therefore,the establishment of animal models of AF is vital to explore its *** spontaneous AF is rare in most animal species,several large animal models,particularly those of pigs,dogs,and horses,have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic *** review aims to provide a comprehensive discussion of various animal models of AF,with an emphasis on the unique features of each model and its utility in AF research and *** data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.

关键词： Atrial fibrillation Animal model Therapeutic

Synthesize dual goals:A study on China's ecological poverty alleviation system

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Journal of Integrative Agriculture 2021年第4期20卷 1042-1059页

作者： LEI Ming yuAN xuan-yu YAO Xin-yan Institute on Poverty Research Peking UniversityBeijing 100871P.R.China Guanghua School of Management Peking UniversityBeijing 100871P.R.China

How to break the vicious cycle of poverty and ecological degradation is widely concerned and *** the poverty alleviation practices in China,ecological poverty alleviation(EPA)is regarded as an important way to synthesize the dual goals of poverty reduction and environmental protection and to achieve the win-win *** Chinese researchers have fruitful research achievements on EPA yet they do not recognize that EPA is not a simple combination of various policies,but a complex system involving multiple policy instruments,governmental agencies,social forces,and ***,few studies abroad illustrate EPA in *** focus more on specific components of EPA such as payment for ecosystem services while overlooking the integral concept of EPA and practices from *** on field research in Guizhou Province,China,this paper proposes a framework of EPA with an effective multi-agent and co-government system,for demonstrating the concept and practice of *** case analysis,we illustrate key elements in this system and their relationships,and how they play a vital role in pursuing win-win outcomes in environmental protection and poverty *** three dimensions of this EPA system have been *** first is to strengthen the interaction among the *** efforts should be made for establishing an efficient communication routine and a stable relationship among their *** second is to reinforce the connection between diverse elements in each policy subsystem,such as the systematization and coordination of the ecological industry development,the systematization of the links before,during,and after the relocation of ecological immigrants,*** third is to promote the interactions between the three subsystems,so that ecological enhancement,ecological compensation,and industrial development,and migration and relocation can promote each other,and ultimately promote the coordination of poverty alleviation and ecological protec

关键词： poverty alleviation ecological poverty alleviation systematic characteristics China interaction

Connectedness of Cone-Efficient Solution Set for Cone-Quasiconvex Multiobjective Programming in Locally Convex Spaces

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Acta Mathematicae Applicatae Sinica 2004年第2期20卷 309-316页

作者： xuan-weiZhou yu-daHu SchoolofMathematicsandInformationScience WenzhouUniversityWenzhou325027China DepartmentofMathematics ShanghaiJiaotongUniversityShanghai200030China

This paper deals with the connectedness of the cone-efficient solution set for vector optimization inlocally convex Hausdorff topological vector *** connectedness of the cone-efficient solution set is provedfor multiobjective programming defined by a continuous cone-quasiconvex mapping on a compact convex set *** generalized saddle theorem plays a key role in the proof.

关键词： Multiobjective programming cone-efficient solution cone-quasiconvex mapping generalized saddle theorem connectedness

Prognostic significance of multiple triglycerides-derived metabolic indices in patients with acute coronary syndrome

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Journal of Geriatric Cardiology 2022年第6期19卷 456-468页

作者： Qiao-yu SHAO Xiao-Teng MA Zhi-Qiang YANG qiu-xuan LI yu-Fei WANG Jing LIANG Hua SHEN Xiao-Li LIU yu-Jie ZHOU Dong-Mei SHI Zhi-Jian WANG Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Triglyceride(TG)and its related metabolic indices,all recognized as surrogates of insulin resistance,have been demonstrated to be relevant to clinical ***,the relative value of these TG-related indices for predicting cardiovascular events among patients with acute coronary syndrome(ACS)has not been *** The TG,the triglyceride-glucose(TyG)index,the atherogenic index of plasma,TG to high-density lipoprotein cholesterol ratio,and the lipoprotein combine index were assessed in 1694 ACS patients undergoing percutaneous coronary *** primary endpoint was major adverse cardiovascular event(MACE),which was the composite of all-cause mortality,stroke,myocardial infarction,or unplanned repeat *** During a median follow-up of 31 months,345 patients(20.4%)had *** risk of the MACE was increased with higher TG and the four TG-derived metabolic indices[TG-adjusted hazard ratio(HR)=1.002,95%CI:1.001-1.003;TyG index-adjusted HR=1.736,95%CI:1.398-2.156;atherogenic index of plasma-adjusted HR=2.513,95%CI:1.562-4.043;TG to high-density lipoprotein cholesterol ratio-adjusted HR=1.148,95%CI:1.048-1.258;and lipoprotein combine index-adjusted HR=1.009,95%CI:1.004-1.014;P<0.001 for all indices].TG and all the four indices significantly improved the predictive ability for MACE in addition to the baseline *** them,TyG index showed the best ability for predicting MACE compared with the other three indices from all the three measurements(P<0.05 for all comparison).CONCLUSIONS TG and TG-derived metabolic indices were all strongly associated with MACE among ACS patients undergoing percutaneous coronary *** all the indices,TyG index showed the best ability to predict the risk of MACE.

关键词： patients coronary indices

Phenomenology of Friedberg-Lee Texture in Left-Right Symmetric Model

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Communications in Theoretical Physics 2008年第8期50卷 451-458页

作者： LUO Min-Jie LIU qiu-yu Department of Modern Physics University of Science and Technology of China Hefei 230026 China The Abdus Salams International Center for Theoretical Physics Trieste Italy

We consider that the Higgs triplet yukawa coupling takes the Friedberg-Lee texture, and the Higgs doublet yukawa coupling simply identifies with the diagonal yutawa coupling of charged lepton in the context of left-right symmetric model. In this scenario, the phenomenology, including effective neutrino masses, mixings, and thermal flavor-dependent leptogenesis and lepton flavor violation decays are studied. We investigate the combined constrain of the parameters in this scenario and test its consistency with present data.

关键词： neutrino mass neutrino mixing flavor-dependent leptogenesis lepton flavor violation Friedberg-Lee texture

Segregation of binary particles in gas-solid fluidized bed

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 113-121页

作者： Yaxiong yu Feng Lu xuan He Fei Wei Chenxi Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China Ordos Laboratory Ordos 017010China Institute for Carbon Neutrality Tsinghua UniversityBeijing 100084China

Particle segregation and mixing behavior play a crucial role in industrial *** study investigates the saturated jetsam fraction,which indicates the maximum capacity of flotsam to entrain jetsam,in an initially separated binary fluidized bed with particle size *** to the value of saturated jetsam fraction,three distinct regimes-segregation,mixing,and an intermediate regime-are ***,intriguing relationships between the saturated jetsam fraction and superficial gas velocity are observed,exhibiting monotonic trends in both the segregation and mixing regimes,while a unique volcano-shaped curve in the intermediate ***,a comprehensive entrainment model based on two-fluid model elucidates the observed phenomena,emphasizing the significance of mixing behavior in fluidized layer on the saturated jetsam *** work offers potential insights for evaluating segregation in industrial applications.

关键词： fluidized bed segregation binary bubbles entrainment

Faber-Krahn Inequality for Robin Problems Involving p-Laplacian

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Acta Mathematicae Applicatae Sinica 2011年第1期27卷 13-28页

作者： qiu-yi Dai yu-xia Fu Department of Mathematics Hunan Normal University Changsha 410081 China Group of Mathematics Dongguan Polytechinic College Dongguan 523808 China

The eigenvalue problem for the p-Laplace operator with Robin boundary conditions is considered in this paper. A Faber-Krahn type inequality is proved. More precisely, it is shown that amongst all the domains of fixed ... 详细信息

关键词： Robin problem p-Laplacian Faber-Krahn type inequality

Social-aware device-to-device communications underlaying cellular networks

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The Journal of China Universities of Posts and Telecommunications 2018年第1期25卷 29-36页

作者： yu Jiang qiu Ling Chen Zheng Key Laboratory of Wireless-Optical Communications University of Science and Technology of China School of Information Science and Technology University of Science and Technology of China

This article put forward a resource allocation scheme aimming at maximizing system throughtput for devide-to- device （D2D） communications underlying cellular network. Firstly, user closeness is defined and calculated through social information including friendship, interest similarity and communication strength to represent the willingness of user to share the spectrum resource with others. Then a social-aware resource allocation problem is formulated to maximize the system throughput while guaranteeing the quality of service （QoS） requirements of both D2D pairs and cellular users （CUs）. Then the complicate problem is decomposed into three subproblems. Firstly the admissible D2D pairs are determined and then the power of both CUs and D2D pairs is efficiently allocated. Finally CUs and D2D pairs are matched to reuse the spectrum resource in consideration of both user closeness and physical conditions. Simulation results certify the effectiveness of the proposed scheme which significantly enhances the system throughput compared with the existing algorithms.

关键词： D2D communication user closeness social-aware resource allocation

The Cauchy Boundary Value Problems on Closed Piecewise Smooth Manifolds in C^n

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Acta Mathematica Sinica,English Series 2004年第6期20卷 989-998页

作者： Liang yu LIN Chun Hui qiu School of Mathematical Sciences Xiamen University Academy of Mathematics and System Science CAS

Suppose that D is a bounded domain with a piecewise C 1 smooth boundary in C n . Let ? ∈ C 1+α (?D). By using the Hadamard principal value of the higher order singular integral and solid angle coefficient method of points on the boundary, we give the Plemelj formula of the higher order singular integral with the Bochner–Martinelli kernel, which has integral density ?. Moreover, by means of the Plemelj formula and methods of complex partial differential equations, we discuss the corresponding Cauchy boundary value problem with the Bochner–Martinelli kernel on a closed piecewise smooth manifold and obtain its unique branch complex harmonic solution.

关键词： Bochner–Martinelli kernel Hadamard principal value Plemelj formula Boundary value problem