检索结果-南通市图书馆

Comparison of intravitreal aflibercept and dexamethasone implant in the treatment of macular edema associated with diabetic retinopathy or retinal vein occlusion:a Meta-analysis and systematic review

引用

International Journal of Ophthalmology(English edition) 2022年第9期15卷 1511-1519页

作者： xuan-yu qiu Xiao-Fei Hu Ya-Zhou Qin Ji-Xian Ma qiu-Ping Liu Li Qin Jing-Ming Li Department of Ophthalmology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Vitreoretinal Department Affiliated Eye Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

·AIM:To compare the efficacy and safety of intravitreal aflibercept with dexamethasone implant in the treatment of macular edema(ME)associated with diabetic retinopathy(DR)or retinal vein occlusion(RVO).·METHODS:A comprehensive search of studies comparing dexamethasone and aflibercept in patients with ME was conducted at PubMed,Embase,and Cochrane Central Register of Controlled Trials from the beginning of library to April 16,*** the data including bestcorrected visual acuity(BCVA),central retinal thickness(CRT),number of injections and serious adverse events(SAEs)from the final qualified *** 5.3 software was used for Meta-analysis of the included studies.·RESULTS:Totally 7 studies with 369 eyes were *** causes of ME in the final screening study included RVO and *** with the aflibercept treatment group,the BCVA of the dexamethasone implant treatment group showed no significant difference in the follow-up for 3 mo[mean difference(MD):-0.05,95%confidence interval(CI):-0.11,0.02;P=0.17]and 12 mo(MD:-0.01,95%CI:-0.38,0.37;P=0.98),but it was slightly worse than the aflibercept group at 6 mo(MD:0.12.95%CI:0.03,0.21;P=0.008).In terms of CRT reduction,there was no significant difference between the two groups at 3 mo(MD:-28.14,95%CI:-79.95,23.67;P=0.29),6 mo(MD:27.67,95%CI:-84.89,140.24;P=0.63),and 12 mo(MD:-59.00,95%CI:-127.37,9.37;P=0.09).However,dexamethasone implant had fewer injections,but more adverse events such as elevated intraocular pressure(IOP)and cataract.·CONCLUSION:Intravitreal injection of aflibercept and dexamethasone implant can both effectively increase BCVA and reduce *** with aflibercept,dexamethasone implant is not inferior in improving vision and reducing CRT in the initial treatment period(3 mo)and long-term treatment period(12 mo).Besides,it has fewer injections and more likely to cause elevated IOP and cataract.

关键词： Meta-analysis macular edema dexamethasone aflibercept best-corrected visual acuity central retinal thickness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema

引用

International Journal of Ophthalmology(English edition) 2021年第12期14卷 1888-1894页

作者： Jie Yan Wu-Jun Li Ya-Zhou Qin xuan-yu qiu Li Qin Jing-Ming Li Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Yulin Hospital of Traditional Chinese MedicineYulin 719000Shaanxi ProvinceChina

AIM:To quantitatively detect aqueous levels of angiopoietin-like(ANGPTL)3,ANGPTL4,and ANGPTL6 and investigate their correlation with optical coherence tomography angiography(OCTA)findings in patients with diabetic macular edema(DME).METHODS:This cross-sectional study included 23 patients(27 eyes)with type 2 diabetes and 16 control subjects(20 eyes).All patients underwent OCTA imaging and ultra-wide field fundus *** patients were categorized into two groups according to the presence or absence of diabetic retinopathy(DME group,14 patients,16 eyes);and non-diabetic retinopathy(NDR)group,9 patients,11 eyes,*** levels of ANGPTL3,ANGPTL4,and ANGPTL6 were assessed using suspension array technology,and foveal-centered 3×3 mm2 OCTA scans were automatically graded to determine the central,inner,and full vessel density(CVD,IVD,FVD);central,inner,and full perfusion density(CPD,IPD,FPD),foveal avascular zone(FAZ)area,FAZ perimeter,and FAZ circularity index(FAZ-CI)on superficial capillary ***,central subfield thickness(CST),cube volume(CV),and cube average thickness(CAT)were measured in a model of macular cube 512×***:Aqueous ANGPTL3 levels were not significantly different among the three groups(P>0.05).ANGPTL4 levels were significantly higher in the DME group than the control and NDR groups(P<0.0001 and P<0.001),while ANGPTL6 levels were significantly higher in the DME group than the control group(P<0.05).In the whole cohort,the aqueous ANGPTL3 levels correlated negatively with the IVD,FVD,IPD,and FPD,and positively with the CV and *** aqueous ANGPTL4 levels correlated negatively with the CVD,IVD,FVD,CPD,IPD,and FPD,and positively with the FAZ perimeter,CST,CV,and *** aqueous ANGPTL6 levels correlated negatively with the IVD,FVD,IPD,FPD,FAZCI and positively with CST,CV,***:ANGPTL4 and ANGPTL6 may be associated with vascular leakage in DME and may represent good targets for DME *** addition,OCT

关键词： diabetic retinopathy diabetic macular edema optical coherence tomography angiography angiopoietin-like vascular leakage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Network Diffusion Framework to Simulate Spreading Processes in Complex Networks

引用

Big Data Mining and Analytics 2024年第3期7卷 637-654页

作者： MichałCzuba Mateusz Nurek Damian Serwata yu-xuan qiu Mingshan Jia Katarzyna Musial Radosław Michalski Piotr Bródka Department of Artificial Intelligence Wrocław University of Science and TechnologyWrocław 50-370Poland Data Science Institute University of Technology SydneyUltimoNSW 2007Australia

With the advancement of computational network science,its research scope has significantly expanded beyond static graphs to encompass more complex *** introduction of streaming,temporal,multilayer,and hypernetwork approaches has brought new possibilities and imposed additional *** instance,by utilising these advancements,one can model structures such as social networks in a much more refined manner,which is particularly relevant in simulations of the spreading ***,the pace of advancement is often too rapid for existing computational packages to keep up with the functionality *** results in a significant proliferation of tools used by researchers and,consequently,a lack of a universally accepted technological stack that would standardise experimental methods(as seen,e.g.,in machine learning).This article addresses that issue by presenting an extended version of the Network Diffusion ***,a survey of the existing approaches and toolkits for simulating spreading phenomena is shown,and then,an overview of the framework ***,we report four case studies conducted with the package to demonstrate its usefulness:the impact of sanitary measures on the spread of COVID-19,the comparison of information diffusion on two temporal network models,and the effectiveness of seed selection methods in the task of influence maximisation in multilayer *** conclude the paper with a critical assessment of the library and the outline of still awaiting challenges to standardise research environments in computational network science.

关键词： computational framework seed selection influence maximisation spreading models temporal networks multilayer networks network science network control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cross-subcarrier precoder design for massive MIMO-OFDM downlink with symplectic optimization

引用

Science China(Information Sciences) 2025年

作者： yu-xuan ZHANG An-An LU Xiang-Gen XIA Xi-Qi GAO National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Department of Electrical and Computer Engineering University of Delaware

We propose a cross-subcarrier precoder design(CSPD) for massive multiple-input multiple-output(MIMO) orthogonal frequency division multiplexing(OFDM) downlink. This work aims to significantly improve the channel estimation and signal detection performance by enhancing the smoothness of the frequency domain effective channel. This is accomplished by designing a few vectors known as the transform domain precoding vectors(TDPVs), which are then transformed into the frequency domain to generate the precoders for a set of subcarriers. To combat the effect of channel aging, the TDPVs are optimized under imperfect channel state information(CSI). The optimal precoder structure is derived by maximizing an upper bound of the ergodic weighted sum-rate(WSR) and utilizing the a posteriori beam-based statistical channel model(BSCM). To avoid the large-dimensional matrix inversion, we propose an algorithm with symplectic optimization. Simulation results indicate that the proposed cross-subcarrier precoder design significantly outperforms conventional methods.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

市域社会治理现代化:现实描述与优化路径——基于试点城市湖州的实证分析

引用

湖州职业技术学院学报 2023年第4期21卷 87-92页

作者：铉玉秋中共湖州市委党校法学教研室浙江湖州313000

党的十九届四中全会强调“加快推进市域社会治理现代化”,这一要求具有实践和理论双重面向。市域社会治理现代化的现有研究尚缺乏对典型案例的探讨和试点的关注。通过对社会治理基础较好、全国市域社会治理现代化第一批试点城市湖州的研... 详细信息

党的十九届四中全会强调“加快推进市域社会治理现代化”,这一要求具有实践和理论双重面向。市域社会治理现代化的现有研究尚缺乏对典型案例的探讨和试点的关注。通过对社会治理基础较好、全国市域社会治理现代化第一批试点城市湖州的研究,发现湖州虽然在治理体制、工作布局、治理方式现代化等方面开展了诸多创新实践,但是在试点过程中也存在政策工具选择单一、重点任务推进不均衡、法治引领保障作用有待提升、“地域性”和“示范性”不突出等局限性。文章认为,要进一步推进市域社会治理现代化,必须科学把握“市域社会治理”的内涵与外延,厘清市域社会治理与市域治理、县乡基层治理、城市治理之间的关系,更加注重市域社会治理建设的整体性、法治性和地域性。

关键词：湖州市域社会治理现实描述优化路径

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanograting‑Based Dynamic Structural Colors Using Heterogeneous Materials

引用

Nano-Micro Letters 2025年第3期17卷 138-151页

作者： Jingang Wang Haibo yu Jianchen Zheng yuzhao Zhang Hongji Guo Ye qiu Xiaoduo Wang Yongliang Yang Lianqing Liu State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Dynamic structuralcolors can change in response todifferent environmental *** ability remains effectiveeven when the size of the speciesresponsible for the structural coloris reduced to a few micrometers,providing a promising sensingmechanism for solving microenvironmentalsensing problems inmicro-robotics and ***, the lack of dynamicstructural colors that can encoderapidly, easily integrate, and accuratelyreflect changes in physical quantities hinders their use in microscale sensing applications. Herein, we present a 2.5-dimensionaldynamic structural color based on nanogratings of heterogeneous materials, which were obtained by interweaving a pH-responsive hydrogelwith an IP-L photoresist. Transverse gratings printed with pH-responsive hydrogels elongated the period of longitudinal grating in the swollenstate, resulting in pH-tuned structural colors at a 45° incidence. Moreover, the patterned encoding and array printing of dynamic structuralcolors were achieved using grayscale stripe images to accurately encode the periods and heights of the nanogrid structures. Overall, dynamicstructural color networks exhibit promising potential for applications in information encryption and in situ sensing for microfluidic chips.

关键词： Dynamic structural colors Four-dimensional printing pH-responsive Nanogrid Heterogeneous materials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

引用

Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang yuntao Liu Beibei Du xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

引用

Science China Chemistry 2025年

作者： yuan Tian Jiang-Bo Chen Jie Ying Ge Tian yu-xuan Xiao Yi Lu Si-Ming Wu Wei Geng Ling Shen Xiao-yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

社区法治在法治进程中的价值

引用

行政与法 2007年第10期 26-28页

作者：铉玉秋胡志宏中共湖州市委党校浙江湖州313000

社区法治既是国家法治建设全局中的重要领域,又是能够催生和促进法治的新生社会空间,社区产生发展的历史背景、社区自身的特点属性、以及社区法治化社会实践,都带有法治社会建设"试验田"、"示范区"和"战略区"的特征和功能。

关键词：社区自治社区法治价值

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

法治视角下的群体性事件——以当前群体性事件的三个热点为例

引用

行政与法 2006年第8期 42-45页

作者：铉玉秋胡志宏中共浙江省湖州市委党校浙江湖州313003

法的功能在于调节、调和与调解各种错杂和冲突的利益。本文以当前群体性事件的三个热点为例,分析了由于法律缺失和不完善,不依法行政、滥用权力,司法不公及司法权威受损与群体性事件的发生的关系。提出一方面我们应当教育群众通过合法... 详细信息

法的功能在于调节、调和与调解各种错杂和冲突的利益。本文以当前群体性事件的三个热点为例,分析了由于法律缺失和不完善,不依法行政、滥用权力,司法不公及司法权威受损与群体性事件的发生的关系。提出一方面我们应当教育群众通过合法途径保护自身的合法权益,另一方面应通过加强法制建设,约束行政权力、规范行政行为,采取切实可行的政策措施,保护群众的利益不受侵害。

关键词：群体事件利益法治司法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：