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Nomogram for prediction of fatal outcome in patients with severe COVID-19:a multicenter study

Military Medical Research 2021年第4期8卷 535-545页

作者： Yun Yang Xiao-Fei Zhu Jian huang Cui Chen Yang Zheng Wei He Ling-Hao Zhao Qian Gao xuan-xuan huang Li-Juan Fu Yu Zhang Yan-Qin Chang Huo-Jun Zhang Zhi-Jie Lu The Third Affiliated Hospital of Second Military Medical University Shanghai 200438China. The Guanggu Branch of the Women and Children’s Hospital of Hubei Province Wuhan 430070China. The First Affiliated Hospital of Second Military Medical University Shanghai 200438China. 4904 Hospital of PLA Joint Logistic Support Force Wuxi 215000JiangsuChina. Tongji Taikang Hospital Wuhan 430050China. 6924 Hospital of PLA Joint Logistic Support Force Guilin 541002GuangxiChina. Huoshen Mountain Hospital Wuhan 430113China.

Background:To develop an effective model of predicting fatal outcomes in the severe coronavirus disease 2019(COVID-19)***:Between February 20,2020 and April 4,2020,consecutive confirmed 2541 COVID-19 patients from three designated hospitals were enrolled in this *** patients received chest computed tomography(CT)and serological examinations at *** tests included routine blood tests,liver function,renal function,coagulation profile,C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),and arterial blood *** SaO2 was measured using pulse oxygen saturation in room air at resting *** high-risk factors associated with death were analyzed using Cox proportional hazard model.A prognostic nomogram was constructed to predict the survival of severe COVID-19 ***:There were 124 severe patients in the training cohort,and there were 71 and 76 severe patients in the two independent validation cohorts,*** Cox analysis indicated that age≥70 years(HR=1.184,95%CI 1.061–1.321),panting(breathing rate≥30/min)(HR=3.300,95%CI 2.509–6.286),lymphocyte count10pg/ml(HR=3.029,95%CI 1.567–7.116)were independent high-risk factors associated with fatal *** developed the nomogram for identifying survival of severe COVID-19 patients in the training cohort(AUC=0.900,95%CI 0.841–0.960,sensitivity 95.5%,specificity 77.5%);in validation cohort 1(AUC=0.811,95%CI 0.763–0.961,sensitivity 77.3%,specificity 73.5%);in validation cohort 2(AUC=0.862,95%CI 0.698–0.924,sensitivity 92.9%,specificity 64.5%).The calibration curve for probability of death indicated a good consistence between prediction by the nomogram and the actual *** prognosis of severe COVID-19 patients with high levels of IL-6 receiving tocilizumab were better than that of those patients without tocilizumab both in the training and validation cohorts,but without diffe

关键词： Severe COVID-19 Nomogram Prediction Survival

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Total synthesis of(+)-taberdicatine B and(+)-tabernabovine B

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Chinese Chemical Letters 2025年第02期36卷 349-353页

作者： Tengfei xuan Xinyu Zhang Wei Han Yidong huang Weiwu Ren Molecular Synthesis Center&Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of China Laboratory for Marine Drugs and Bioproducts Laoshan Laboratory

The first total synthesis of(+)-taberdicatine B and(+)-tabernabovine B has been accomplished in 10steps with 26.9% overall yield and 15 steps with 7.3% overall yield, respectively. The prominent features of this efficient synthetic strategy include the following:(1)(+)-Taberdicatine B and(+)-tabernabovine B were accessed from common advanced intermediates by varying the substituents;(2) A one-pot asymmetric bromocyclization/hydrolysis was explored to assemble HPI skeleton;(3) Dieckmann condensation to form β-keto ester for the assembly of seven-membered ring;(4) An ester reduction/amide semireduction/cyclization sequence was applied to form the cage-like framework.

关键词： Asymmetric dearomatization Hexahydropyrrolo[2,3-b]indole Taberdicatine B Tabernabovine B Total synthesis

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An Efficient and Flexible Bifunctional Dual-Band Electrochromic Device Integrating with Energy Storage

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Nano-Micro Letters 2025年第4期17卷 419-434页

作者： Zekun huang Yutao Peng Jing Zhao Shengliang Zhang Penglu Qi Xianlin Qu Fuqiang Yan Bing Ding Yimin xuan Xiaogang Zhang Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China Key Laboratory of Thermal Management and Energy Utilization of Aviation Vehicles College of Energy and Power EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China Center for Microscopy and Analysis Nanjing University of Aeronautics and AstronauticsNanjing 211106People’s Republic of China

Dual-band electrochromic devices capable of the spectral-selective modulation of visible(VIS)light and near-infrared(NIR)can notably reduce the energy consumption of buildings and improve the occupants’visual and thermal ***,the low optical modulation and poor durability of these devices severely limit its practical ***,we demonstrate an efficient and flexible bifunctional dual-band electrochromic device which not only shows excellent spectral-selective electrochromic performance with a high optical modulation and a long cycle life,but also displays a high capacitance and a high energy recycling efficiency of 51.4%,integrating energy-saving with *** nanowires structure and abundant oxygen-vacancies of oxygen-deficient tungsten oxide nanowires endows it high flexibility and a high optical modulation of 73.1%and 85.3%at 633 and 1200 nm *** prototype device assembled can modulate the VIS light and NIR independently and effectively through three distinct modes with a long cycle life(3.3%capacity loss after 10,000 cycles)and a high energy-saving performance(8.8℃lower than the common glass).Furthermore,simulations also demonstrate that our device outperforms the commercial low-emissivity glass in terms of energy-saving in most climatic zones around the *** windows represent an intriguing potential technology to improve the building energy efficiency.

关键词： Electrochromic Dual-band electrochromic devices Spectral-selective modulation Flexible Energy storage

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Association of stent thrombectomy and conventional treatment with neuroprotection, complications, anxiety, and depression in acute ischemic stroke patients

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World Journal of Psychiatry 2025年第1期15卷 72-82页

作者： Kai-Jie Yang Jia-Jian huang Cai-Xia xuan Department of Neurology Qinzhou Second People's HospitalQinzhou 535000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Acute ischemic stroke(AIS)is an abrupt blood flow cessation to a specific brain region within a vascular zone,causing a subsequent decline in neurological *** thrombectomy is a recently established technique for treating *** provides the benefits of being a relatively simple and safe procedure,capable of partially enhancing a patient’s ***,some patients may experience endothelial damage and recurrent thrombosis,with clinical outcomes that are not always ***,the efficacy of this method remains *** To survey the association of stent thrombectomy vs standard treatment with neurological function protection,complications,and short-term prognosis in patients diagnosed with *** This study assigned 90 patients with AIS to the observation and control groups(n=45 patients)from December 2020 to December *** thrombectomy was conducted in the observation group,whereas routine treatment was provided to the control *** study assessed the therapeutic outcomes of two groups,including a comparison of their neurological function,living ability,anxiety and depression status,plaque area,serum inflammatory factors,serum Smur100βprotein,neuron-specific enolase(NSE),homocysteine(Hcy),and vascular endo-thelial ***,the incidence of complications was calculated and analyzed for each *** The total effective rate of treatment was 77.78%and 95.56%in the control and observation groups,*** 8 weeks of treatment,the scores on the National Institutes of Health Stroke Scale,Hamilton Anxiety Scale,and Hamilton Depression Scale decreased remarkably;the Barthel index increased remarkably,with better improvement effects of the scores in the observation group(P<0.05);total cholesterol,triglyceride,C-reactive protein,and plaque area lessened remarkably,with fewer patients in the observation group(P<0.05);S-100βprotein,NSE,and Hcy levels lessened remarkably,with fewer patients in

关键词： Stent thrombectomy Acute ischemic stroke Neurological function Complications Short-term prognosis

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Polysaccharide from large leaf yellow tea activates the LXRα-ABCA1/ABCG1 pathway to ameliorate type 2 diabetes by regulating gut microbiota

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Food Science and Human Wellness 2025年

作者： Hao Chen Zhuang Wang Xinxin Pei Jielin Chen Kaili xuan Lei Gong Xinyu Zhou Yuzhe huang Yan Chen School of Life Sciences， Anhui University Key Laboratory of Ecological Engineering and Biotechnology of Anhui Province Institutes of Physical Science and Information Technology， Anhui University Fugong Yuanlveda Puluo Tea Industry Co.， Ltd.

Type 2 diabetes mellitus （T2DM） is a multifaceted metabolic condition characterized by chronic hyperglycemia （elevated blood sugar levels） and insulin resistance （IR）. We have isolated a new homogeneous polysaccharide， LYTP-3， (7.22 × 105Da) with anti-diabetic activity， from large leaf yellow tea （LYT） by biological activity-guided sequential separation and activity evaluation. Using a T2DM mouse model， we demonstrate that oral administration of LYTP-3 can reduce blood lipid levels， alleviate hyperglycemia and glucose tolerance， and inhibit insulin resistance. LYTP-3 ameliorated T2DM treatment by activating the liver X receptor alpha （LXRα）-ATP-binding cassette （ABC） transporter （LXRα-ABCA1/ABCG1） signaling pathway， which is regulated by the gut microbiota. The strain Lachnospiraceae bacterium A4 is potentially the key to this improvement. Additionally， we have solved the molecular structure of LYTP-3 using nuclear magnetic resonance （NMR）， and methylation analyses. The main backbone of LYTP-3 consists of 1，2，4-α-L-Rhap， 1，4-α-D-Galp， 1，6-α-D-Glcp， with branches of 1，4-β-D-Galp， 1，6-β-D-GalpA， 1，3，6-β-D-Manp， 1，2-α-L-Rhap， T-β-Manp， and T-β-Galp. The findings of this study suggest that LYTP-3 may serve as a potential gut microbiota modulator in the treatment of T2DM.

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劳动力供求视角下绿色金融改革的就业效应研究

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江淮论坛 2025年第1期 107-114页

作者：黄明张璇复旦大学经济学院上海200433

绿色金融改革是推动我国生态文明建设、践行“两山论”的重要举措,在促进经济社会可持续发展的同时,有望成为提升就业水平、实现“稳就业”目标的新动力。从劳动力供求视角剖析绿色金融改革对就业的影响机理,基于绿色金融改革创新试验... 详细信息

绿色金融改革是推动我国生态文明建设、践行“两山论”的重要举措,在促进经济社会可持续发展的同时,有望成为提升就业水平、实现“稳就业”目标的新动力。从劳动力供求视角剖析绿色金融改革对就业的影响机理,基于绿色金融改革创新试验区的政策进行实证检验,结果表明绿色金融改革显著提升了劳动力就业水平,具有“稳就业”效应,尤其在劳动密集型企业和劳动力市场化程度较高的地区表现更为突出。机制分析进一步表明,该效应得益于绿色技术创新水平的提升、融资约束的缓解以及企业社会声誉的提高。据此提出,绿色金融改革应针对绿色技术扶持、融资生态优化以及企业声誉提升方面精准发力,为助力劳动力市场提供有效指引,实现在经济发展中促进绿色转型、在绿色转型中推动更好发展。

关键词：劳动力供求绿色金融改革就业效应

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生物安保保障水产养殖绿色高质量发展:回顾与展望

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渔业科学进展 2025年第1期46卷 161-182页

作者：董宣黄倢海水养殖生物育种与可持续产出全国重点实验室(中国水产科学研究院黄海水产研究所) 青岛海洋科技中心海洋渔业科学与食物产出过程功能实验室农业农村部海水养殖病害防治重点实验室青岛市海水养殖流行病学与生物安保重点实验室山东青岛266071

本文综述了生物安保在水产养殖业中的重要性及其对推动产业绿色高质量发展的作用。生物安保作为一种基于风险分析的战略性综合方法,其核心目标在于防控疫病风险,保障行业健康和可持续发展。文章首先阐述了生物安保的概念和发展历史,讨... 详细信息

本文综述了生物安保在水产养殖业中的重要性及其对推动产业绿色高质量发展的作用。生物安保作为一种基于风险分析的战略性综合方法,其核心目标在于防控疫病风险,保障行业健康和可持续发展。文章首先阐述了生物安保的概念和发展历史,讨论了这一概念与生物安全、疫病防控和健康养殖、动物卫生等概念的联系与差别,并提出生物安保、动物卫福和生态干预构成动物卫生三要素,探讨了生物安保体系构建的六大要素和生物安保计划的实施流程。随后,概述了生物安保概念所涉及的关键科学技术问题,介绍了国内外相关科技和政策领域的研究发展现状。接下来,文章讨论了全球和区域性组织在推动水产养殖生物安保战略中的作用,以及不同国家和地区在水产养殖生物安保法规体系构建方面的实践,特别介绍了联合国粮食及农业组织(FAO)和世界动物卫生组织(WOAH)等国际组织重视运用生物安保理念来推动水产养殖的可持续发展。文章进一步讨论了水产养殖企业生物安保分级及其技术内容,以无特定病原(SPF)虾苗培育为例介绍了国外企业生物安保的发展,描述了水产养殖企业生物安保体系构建方法和在对虾育苗场的实践。最后,文章重点指出了中国在水产养殖生物安保方面的挑战和机遇,展望了生物安保战略的发展方向,包括构建国家生物安保中长期发展战略的路线图、强化生物安保相关的研究与教育普及,优先发展种业生物安保,构建高标准生物安保水平上的种业体系,以保障中国水产养殖业的绿色高质量发展。

关键词：生物安保水产养殖疫病防控绿色发展

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The Influence of Microbial Community on Oil Reservoirs:A Case Study on the Mesozoic Natural Gas in the Pengyang Area,Southwestern Ordos Basin,China

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 144-158页

作者： SHANG Ting NIU Xiaobing LI Mingrui ZHANG Zhongyi huang xuan HAN Tianyou ZHANG Xiaolei LI Jihong CHU Meijuan LIU Xin School of Geography and the Environment Xianyang Normal UniversityXianyang712000China State Key Laboratory of Continental Dynamics Northwest UniversityXi'an 710069China PetroChina Changqing Oilfield Company Xi'an 710018China Exploration&Development Research Institute of PetroChina Changqing Oilfield Company Xi'an 710018China National Engineering Laboratory for Exploration and Development of Low-Permeability Oil&Gas Fields Xi'an 710018China Northwest University Xi’an 710069China

The formation of Mesozoic natural gas in the Pengyang area of southwestern Ordos Basin is discussed,from the perspective of microbial community characteristics,in order to clarify the relationship between the origin of natural gas and its associated indigenous microbial *** types and diversity of indigenous microbial communities associated with the oil reservoir were studied by means of collecting reservoir formation water samples from exploration *** indigenous microbial communities in the Chang 8 member of the Yanchang Formation were primarily distributed within Proteobacteria and Firmicutes,including the specific species and genera of Methylobacter,Pseudomonas,Haibacter,Toxobacillus,Acinetobacter and Adura *** results of diversity analysis shows that the number of common genes was 5448,while the number of unique genes and information was *** reflects the fact that the strata in the study area are relatively closed and not invaded by external water sources,which leads to the development of biological community *** conjunction with the analysis of geochemical characteristics of oil and gas reservoirs in this area,this indicates that the study area possesses the necessary geological conditions for microbial *** is the first time that the species and diversity of the indigenous microbial community in the Ordos Basin have been analyzed,showing that microbial degradation is the main cause of natural gas formation here,changes the characteristics of crude oil in this area and provides first-hand information on the impact of indigenous microorganisms on the reservoir.

关键词： microbial community source of natural gas Yanchang Formation Pengyang area Ordos Basin

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窟野河流域次降雨事件下水沙变化特征及其输移过程

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水土保持研究 2025年第2期32卷 52-60页

作者：杨晨佘冬立黄萱河海大学农业科学与工程学院南京211100

[目的]深入分析黄土高原粗沙区流域次降雨事件尺度下水沙动态变化特征及其输移过程,为黄土高原粗沙区流域的水沙管理和调控提供重要科学依据。[方法]以黄土高原中游粗沙多沙区窟野河流域为对象,收集2006—2019年间的160场次降雨事件水... 详细信息

[目的]深入分析黄土高原粗沙区流域次降雨事件尺度下水沙动态变化特征及其输移过程,为黄土高原粗沙区流域的水沙管理和调控提供重要科学依据。[方法]以黄土高原中游粗沙多沙区窟野河流域为对象,收集2006—2019年间的160场次降雨事件水沙数据。通过运用方差分析、水沙关系曲线、滞后分析等方法,比较位于窟野河及其子流域次降雨事件下产流输沙特征,构建了各流域次降雨事件尺度下水沙关系曲线,分析了水沙滞后关系及滞后指数的空间差异,以揭示次降雨尺度下窟野河流域的水沙输移过程。[结果](1)4个流域径流相关参数无显著差异,但泥沙相关参数差异显著;(2)位于窟野河上游东部的新庙流域水沙相关性强,表征外界人为干扰的参数(a)最大,位于上游西部的王道恒塔流域泥沙浓度低,水沙相关性弱,表征河流本身输沙能力的参数(b)最大;(3)新庙、王道恒塔和温家川3个流域的主要滞后模式为逆时针型,泥沙来源于上游区域,且高含沙降雨事件的滞后系数(HI)平均值多为负;而神木流域的主要滞后模式为“8”字型,指示泥沙来源相对接近流域出口,且高含沙降雨事件的HI平均值多为正。[结论]窟野河嵌套流域次降雨事件尺度下水沙变化空间差异显著,泥沙输移过程复杂,不同子流域滞后模式揭示了泥沙来源和输移机制的空间异质性。

关键词：次降雨事件尺度输移过程水沙关系滞后分析

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飞机轮胎-湿滑道面相互作用SPH算法仿真分析

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北京航空航天大学学报 2025年第1期51卷 53-62页

作者：蔡靖黄钰岱李琪李岳戴轩中国民航大学交通科学与工程学院天津300300

针对飞机在湿滑道面上的滑水问题,采用光滑粒子流体动力学(SPH)算法建立了飞机轮胎-湿滑道面有限元模型,与流固耦合算法(CEL)模型进行对比,显示了SPH算法的优越性,进而分析了不同轮胎速度及水膜厚度对轮胎与湿滑道面相互作用的影响规律... 详细信息

针对飞机在湿滑道面上的滑水问题,采用光滑粒子流体动力学(SPH)算法建立了飞机轮胎-湿滑道面有限元模型,与流固耦合算法(CEL)模型进行对比,显示了SPH算法的优越性,进而分析了不同轮胎速度及水膜厚度对轮胎与湿滑道面相互作用的影响规律。结果表明,SPH模型得到的临界滑水速度与CEL模型结果相差不超过5%;舰首波、侧向羽流等流体特征更为明显立体;平均运算效率较CEL模型提高36.5%。利用SPH模型分析可得,道面支撑力随轮胎速度增加呈先平缓下降再急速下降的趋势,水膜厚度为3~13 mm时,急速下降段所在轮胎速度区间为170~260 km/h,基本处于A320飞机的着陆滑跑速度范围内,应增强对飞机滑水事故风险的防范;位移阻力随着轮胎速度增加呈先增大后减小的趋势,且在轮胎达到临界滑水速度时取得最大值,进而提出利用位移阻力最大值确定临界滑水速度的方法;侧向羽流最大溅水高度随轮胎速度增加呈先升高后降低的趋势,在接近临界滑水速度时达到最大值;舰首波最大溅水高度低于侧向羽流最大溅水高度,且随轮胎速度增加而降低,达到临界滑水速度时舰首波接近消失,2种溅水特征的最大溅水高度值均低于A320飞机发动机的最小离地高度0.680 m,不会对发动机产生影响。

关键词：交通运输工程轮胎-道面相互作用光滑粒子流体动力学算法临界滑水速度道面支撑力位移阻力溅水高度

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