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Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants

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Cancer Biology & Medicine 2024年第6期21卷 473-483页

作者： Shuyi chen Jing Gu Kaichun wu Xiaodi Zhao Yuanyuan Lu State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’an 710032China School of Basic Medical Sciences Fourth Military Medical UniversityXi’an 710032China

Targeted therapy is crucial for advanced colorectal cancer(CRC) positive for genetic drivers. With advances in deep sequencing technology and new targeted drugs, existing standard molecular pathological detection systems and therapeutic strategies can no longer meet the requirements for careful management of patients with advanced CRC. Thus, rare genetic variations require diagnosis and targeted therapy in clinical practice. Rare gene mutations, amplifications, and rearrangements are usually associated with poor prognosis and poor response to conventional therapy. This review summarizes the clinical diagnosis and treatment of rare genetic variations, in genes including erb-b2 receptor tyrosine kinase 2(ERBB2), B-Raf proto-oncogene, serine/threonine kinase(BRAF), ALK receptor tyrosine kinase/ROS proto-oncogene 1, receptor tyrosine kinase(ALK/ROS1), neurotrophic receptor tyrosine kinases(NTRKs), ret proto-oncogene(RET), fibroblast growth factor receptor 2(FGFR2), and epidermal growth factor receptor(EGFR), to enhance understanding and identify more accurate personalized treatments for patients with rare genetic variations.

关键词： Genetic variation gene mutation gene amplification gene rearrangement targeted therapy

Distribution, bioaccumulation, trophic transfer and risk assessment of trace elements in fish from a typical shallow outflow lake basin, China

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 141-156页

作者： Miao He Guijian Liu Xiaodan Shi Lei wu Qiang chen CAS Key Laboratory of Crust-Mantle Materials and Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Anhui Academy of Environmental Sciences Hefei 230022China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Fish are important food sources for humans,and the availability of appropriate amount of trace elements(TEs)plays a crucial role in fish ***,due to large volumes of sewage discharge,high levels of certain elements are present in aquatic environments,and these elements accumulate in fish and potentially affect human *** this study,the distribution and bioaccumulation capacity of trace elements in six dominant fish species from Chaohu Lake(China)were *** results showed that the bioaccumulation capacity of fish for Zn was greater than other *** the source of the TEs in the fish were explored along with the concentration of the TEs in the aquatic environment,which indicated that TEs in fish were mainly obtained through ingestion and indirectly affected by the industrial activities in the ***,stable carbon and nitrogen isotopes were used to classify the trophic levels and explore the biological magnification of TEs of the *** was found that Sb and Sr showed biomagnification with the increase of trophic level of *** on the above analyses,the environmental biogeochemical cycle model of TEs in the lake was distinguished and established,which can offer valuable insights for sustainable fishery management in the downstream Yangtze River Delta ecosystem.

关键词： Trophic level Bioaccumulation Risk assessment Trace elements

Effect of dietary supplement of inactivated Lactobacillus plantarum Ep-M 17 on growth performance,immune response,disease resistance,and intestinal microbiota in Penaeus vannamei

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Journal of Oceanology and Limnology 2024年第2期42卷 676-694页

作者： Ting wu Xiaoman HU Wenlong XU Yang DU Jiong chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingbo 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingbo 315211China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Ningbo UniversityNingbo 315211China

Our previous study found that feeding with Lactobacillus plantarum Ep-M17 could effectively affect the growth performance,immune response,and gut microbiota of Penaeus ***,high temperature and pressure during feed pelletizing is the main problem that can lead to a decrease in the activity of probiotics or cause their *** investigation needs to investigate whether inactivated Ep-M17 can exert similar effects as live ***,we evaluated the effects of inactivated *** Ep-M17 on growth performance,immune response,disease resistance,and gut microbiota in *** show that adding inactivated Ep-M17 to the feed also promoted body weight gain and increased relative immune protection in ***,histological examination revealed that the administration of inactivated Ep-M17 led to improvements in the density and distribution of microvilli in the intestines and enhancements in the abundance of B and R cells in the ***,the inactivated Ep-M17 supplementation resulted in increased activity levels of nutrient immune-related enzymes in both the shrimp hepatopancreas and ***,it stimulated the expression of Lvlec,PEN-3a,Crustin,LGBP,Lysozyme,and proPo genes in both the hepatopancreas and ***,the inactivated Ep-M17 also increased bacterial diversity in the gut of shrimp and promoted the abundance of specific flora,facilitating the host organism’s metabolism and immunity to improve the disease resistance of ***,supplementation of inactivated *** Ep-M17 in shrimp diets can exert similar effects as live *** Ep-M17 effectively improving growth performance,gut microbiota,immune response,and disease resistance in ***.

关键词： Penaeus vannamei Lactobacillus plantarum Ep-M17 inactivated probiotics immune response gut flora

Layered Coded Cache Placement and Cooperative Delivery with Sharing Links in Satellite-Terrestrial Integrated Networks

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China Communications 2024年第3期21卷 217-229页

作者： Gu Shushi chen Zihan wu Yaonan Zhang Qinyu Wang Ye School of Electronic and Information Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Guangdong Provincial Key Laboratory of Aerospace Communication and Networking Technology Shenzhen 518055China Broadband Communications Research Department Pengcheng LaboratoryShenzhen 518052China

Cooperative utilization of multidimensional resources including cache, power and spectrum in satellite-terrestrial integrated networks(STINs) can provide a feasible approach for massive streaming media content delivery over the seamless global coverage area. However, the on-board supportable resources of a single satellite are extremely limited and lack of interaction with others. In this paper, we design a network model with two-layered cache deployment, i.e., satellite layer and ground base station layer, and two types of sharing links, i.e., terrestrial-satellite sharing(TSS) links and inter-satellite sharing(ISS) links, to enhance the capability of cooperative delivery over STINs. Thus, we use rateless codes for the content divided-packet transmission, and derive the total energy efficiency(EE) in the whole transmission procedure, which is defined as the ratio of traffic offloading and energy consumption. We formulate two optimization problems about maximizing EE in different sharing scenarios(only TSS and TSS-ISS),and propose two optimized algorithms to obtain the optimal content placement matrixes, *** results demonstrate that, enabling sharing links with optimized cache placement have more than 2 times improvement of EE performance than other traditional placement schemes. Particularly, TSS-ISS schemes have the higher EE performance than only TSS schemes under the conditions of enough number of satellites and smaller inter-satellite distances.

关键词： coded content placement cooperative delivery energy efficiency sharing links STINs

Spherical Bi_(2)O_(3)/ATO catalyst with N_(2)pre-reduction electrocatalytic reduction of CO_(2)to formic acid

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Journal of Environmental Sciences 2024年第6期140卷 331-340页

作者： Junying Yi Yuli chen Dongze Lai Bihong Lv Xiaomin wu Guohua Jing Department of Environmental Science&Engineering College of Chemical EngineeringHuaqiao UniversityXiamenFujian 361021China

To achieve carbon neutrality,the Chinese government needs to gain a comprehensive understanding of the sources and drivers of greenhouse gas(GHG)emissions,particularly at the county *** County in eastern China is a typical example of an industrial transformation from quarrying to a low-carbon *** study analyzed the decoupling types and structural characteristics of GHG emissions and the driving factors of carbon dioxide(CO_(2))emissions in the Anji from 2006 to 2019,and explored the differences between countylevel and provincial-level or city-level *** was observed that energy-related activities are the main source of GHG emissions in Anji and that economic development is the driving factor behind the increasing CO_(2)***,industrial transformation and upgradation coupled with the alternative use of clean energy limit the growth of GHG *** study details the GHG emissions of county during the industrial transformation stage and provides corresponding policy recommendations for county governments.

关键词： N_(2)prereduction CO_(2)electroreduction Bi_(2)O_(3)/ATO catalyst Formate

TibetanGoTinyNet:a lightweight U-Net style network for zero learning of Tibetan Go

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Frontiers of Information Technology & Electronic Engineering 2024年第7期25卷 924-937页

作者： Xiali LI Yanyin ZHANG Licheng wu Yandong chen Junzhi YU Key Laboratory of Ethnic Language Intelligent Analysis and Security Governance Ministry of EducationMinzu University of ChinaBeijing 100081China School of Information Engineering Minzu University of ChinaBeijing 100081China Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

The game of Tibetan Go faces the scarcity of expert knowledge and research ***,we study the zero learning model of Tibetan Go under limited computing power resources and propose a novel scaleinvariant U-Net style two-headed output lightweight network *** lightweight convolutional neural networks and capsule structure are applied to the encoder and decoder of TibetanGoTinyNet to reduce computational burden and achieve better feature extraction *** autonomous self-attention mechanisms are integrated into TibetanGoTinyNet to capture the Tibetan Go board’s spatial and global information and select important *** training data are generated entirely from self-play *** achieves 62%–78%winning rate against other four U-Net style models including Res-UNet,Res-UNet Attention,Ghost-UNet,and Ghost *** also achieves 75%winning rate in the ablation experiments on the attention mechanism with embedded positional *** model saves about 33%of the training time with 45%–50%winning rate for different Monte–Carlo tree search(MCTS)simulation counts when migrated from 9×9 to 11×11 *** for our model is available at https://***/paulzyy/TibetanGoTinyNet.

关键词： Zero learning Tibetan Go U-Net Self-attention mechanism Capsule network Monte-Carlo tree search

Identification of high oxygen-consuming substances in stormwater drainage systems illicitly connected with sewage system

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Journal of Environmental Sciences 2024年第4期138卷 132-140页

作者： chen Xu Zuxin Xu Wenhai Chu Shanshan wu Rong Xiao Lei Su State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Ministry of Education Key Laboratory of Yangtze River Water Environment Tongji UniversityShanghai 200092China Guangzhou Resource Environmental Protection Technology Co. Ltd.Guangzhou 510030China

The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the ecological *** a water body is anoxic,the activity of anaerobic microorganisms increases and organic matter is decomposed to produce a large number of blackening and odorizing substances,resulting in black and odorous water bodies,which is a very common and typical phenomenon in ***,there is still a relatively universal occurrence of illicitly connected stormwater and sewage pipes in the urban drainage pipe network in China,which makes oxygen-consuming substances be directly discharged into rivers through stormwater pipes and consume the dissolved oxygen in the water bodies,resulting in an oxygen deficiency of the *** induces seasonal or year-round black and stink phenomena in urban ***,identifying high oxygen-consuming substances,which lays the foundation for the subsequent removal of oxygen-consuming substances,is *** a series of comparisons of water quality indicators and analysis of organic characteristics,it was found that the oxygen consumption capacity of domestic sewage was higher than that of industrial wastewater in the selected area of this study,and the oxygen-consuming substances of domestic sewage were small molecular amino *** comparing 20 conventional free amino acids,it was found that seven of them consumed oxygen easily,and compared with chemical oxygen consumption,biological oxygen consumption was in a leading position.

关键词： Urban drainage system Oxygen-consuming substances Domestic sewage Amino acid

Two material removal modes in chemical mechanical polishing:mechanical plowing *** bonding

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Friction 2024年第5期12卷 897-905页

作者： Yuan wu Liang JIANG Wenhui LI Jiaxin ZHENG Yushan chen Linmao QIAN Tribology Research Institute State Key Laboratory of Rail Transit Vehicle SystemSouthwest Jiaotong UniversityChengdu610031China

With the rapid development of semiconductors,the number of materials needed to be polished sharply *** material properties vary significantly,posing challenges to chemical mechanical polishing(CMP).Accordingly,the study aimed to classify the material removal *** on the CMP and atomic force microscopy results,the six representative metals can be preliminarily classified into two groups,presumably due to different material removal *** the tribology perspective,the first group of Cu,Co,and Ni may mainly rely on the mechanical plowing *** adding H_(2)O_(2),corrosion can be first enhanced and then suppressed,affecting the surface mechanical ***,the material removal rate(MRR)and the surface roughness increase and *** comparison,the second group of Ta,Ru,and Ti may primarily depend on the chemical bonding *** H_(2)O_(2)can promote oxidation,increasing interfacial chemical ***,the MRR increases,and the surface roughness decreases and levels *** addition,CMP can be regulated by tuning the synergistic effect of oxidation,complexation,and dissolution for mechanical plowing,while tuning the synergistic effect of oxidation and ionic strength for chemical *** findings provide mechanistic insight into the material removal mechanism in CMP.

关键词： Chemical mechanical polishing corrosion wear material removal mode mechanical plowing chemical bonding

Adsorption of trichlorphon on phyllosilicate minerals:Effect of low-molecular-weight organic acids

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Pedosphere 2024年第1期34卷 78-87页

作者： Hongfeng chen Zhouyang HE Mingxia HOU Cilai TANG Yonghong wu College of Hydraulic&Environmental Engineering China Three Gorges UniversityYichang 443002China Hubei Field Observation and Scientific Research Stations for Water Ecosystem in Three Gorges Reservoir China Three Gorges UniversityYichang 443002China Engineering Research Center of Eco-Environment in Three Gorges Reservoir Region China Three Gorges UniversityYichang 443002China State Key Laboratory of Soi and Sustainable Agriculture Institute of Soil SciencesChinese Academy of SciencesNanjing 210008China

The use of trichlorphon in large quantities causes a large number of organic pollutants to enter water, sediments, and soils. Phyllosilicate minerals are considered effective adsorbents for organic pollutants. However, the adsorption behavior of organic pollutants on soil minerals affected by low-molecular-weight organic acids(LMWOAs) is not fully understood. In this study, the effect of LMWOAs on the adsorption behavior of trichlorphon on phyllosilicate minerals was investigated using a combination of adsorption measurements and molecular spectroscopic techniques(attenuated total reflection-Fourier transform infrared spectroscopy(ATR-FTIR) and X-ray photoelectron spectroscopy(XPS)). The adsorption of trichlorphon onto kaolinite(KAO) and montmorillonite(MON) was suppressed by increasing pH, indicating that electrostatic interaction played a key role in adsorption, especially at low pH. In the presence of citric acid(CA), there was an obvious promotion of trichlorphon adsorption on KAO and MON. In the presence of oxalic acid(OA), the adsorption of trichlorphon on KAO was promoted, whereas the adsorption on MON was inhibited, especially at pH 4.0. The presence of CA and OA increased the adsorption by increasing the exposure of hydrophobic sites of KAO and MON. The results from ATR-FTIR and XPS also indicated that the hydrophobic Si–O sites of phyllosilicate minerals were the preferred adsorption sites for trichlorphon in the presence of CA and OA, probably driven by the hydrophobic effect. However, the weak effect of OA on MON caused an increase in the electrostatic repulsion between MON and trichlorphon molecules, thus inhibiting adsorption. This study is significant for a deeper understanding of self-purification of soil and sediment systems in the presence of organic pollutants.

关键词： adsorption behavior citric acid hydrophobic effect organic pesticide organic pollutant organochlorine oxalic acid