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Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang xuan-guang ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain

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Synthesis and characterization of three new solid polyoxometalates based on Wells-Dawson-derived sandwich-type polyanions [Co_(4)(H_(2)O)_(2)(P_(2)W_(15)O_(56))_(2)]^(16-)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 268-274页

作者： Jjijie ye xuan XU Chuande WU Department of Chemistry Zhejiang UniversityHangzhou 310058China

Three polyoxometalate-based hybrid coordination materials,[Co_(8)(H_(2)O)_(34)(pz)_(2){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·16H_(2)O(compound 1),[H_(3)O]_(4)[Co_(6)(H_(2)O)_(22)(pz)_(2){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·21H_(2)(compound 2),and[H_(3)O]_(4)[Co_(6)(H_(2)O)_(22){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·29H_(2)O(compound 3)(pz-pyrazine),were built from the linkage of[Co_(4)(H_(2)O)_(2)(P_(2)W_(15)O_(56)_(2)]^(16-)-(abbreviated as{Co_(4)P_(4)W_(30})polyanions and pz and/or cobalt(II)*** compounds 1 and 2 consisted of the same components,their lamellar networks were quite *** inorganic lamellar network in compound 3 was constructed by connecting{Co_(4)P_(4)W_(30)}units with cobalt(I)*** work demonstrates that the coordination modes of{Co_(4)P_(4)W_(30)}are very sensitive to synthesis conditions,while the ring-belt tetrametals are easily substituted by different transition metal cations under mild reaction conditions.

关键词： Cobalt Crystal structure Cyclic voltammetry Hybrid Polyoxometalate

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A Review on Vibration Control of Multiple Cylinders Subjected to FlowInduced Vibrations

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China Ocean Engineering 2024年第2期38卷 183-197页

作者： XU Wan-hai MA ye-xuan State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300350China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China

The fatigue damage caused by flow-induced vibration(FIV)is one of the major concerns for multiple cylindrical structures in many engineering *** FIV suppression is of great importance for the security of many cylindrical *** active and passive control methods have been employed for the vibration suppression of an isolated cylinder undergoing vortex-induced vibrations(VIV).The FIV suppression methods are mainly extended to the multiple cylinders from the vibration control of the isolated *** to the mutual interference between the multiple cylinders,the FIV mechanism is more complex than the VIV mechanism,which makes a great challenge for the FIV *** efforts have been devoted to vibration suppression of multiple cylinder systems undergoing FIV over the past two *** control methods,such as helical strakes,splitter plates,control rods and flexible sheets,are not always effective,depending on many influence factors,such as the spacing ratio,the arrangement geometrical shape,the flow velocity and the parameters of the vibration control *** FIV response,hydrodynamic features and wake patterns of the multiple cylinders equipped with vibration control devices are reviewed and *** FIV suppression efficiency of the vibration control methods are analyzed and compared considering different influence *** research on the FIV suppression of multiple cylinders is suggested to provide insight for the development of FIV control methods and promote engineering applications of FIV control methods.

关键词： flow-induced vibration vibration control multiple cylinders tandem side-by-side staggered

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Significant contribution of carbonyls to atmospheric oxidation capacity(AOC)during the winter haze pollution over North China Plain

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Journal of Environmental Sciences 2024年第5期139卷 377-388页

作者： Xue Yang Gen Zhang guang Pan Guolan Fan Houyong Zhang xuan Ge Mingyue Du School of Municipal and Environmental Engineering Shandong Jianzhu UniversityJi’nan 250101China State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of China Meteorological Administration Chinese Academy of Meteorological SciencesBeijing 100081China Shandong Jinan Ecological Environment Monitoring Center Ji’nan 250101China

Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been clearly *** we measured carbonyl compounds and other trace gasses together with PM_(2.5)over urban Jinan in North China Plain during the *** higher carbonyl concentrations(average:14.63±4.21 ppbv)were found during wintertime haze pollution,about one to three-times relative to those on nonhaze days,with slight difference in chemical composition except formaldehyde(HCHO).HCHO(3.68 ppbv),acetone(3.17 ppbv),and acetaldehyde(CH_3CHO)(2.83 ppbv)were the three most abundant species,accounting for~75% of the total carbonylson both haze and non-haze *** from observational-based model(OBM)with atmospheric oxidation capacity(AOC)indicated that AOC significantly increased with the increasing carbonyls during the winter haze *** photolysis have supplied key oxidants such as RO_(2) and HO_(2),and thereby enhancing the formation of fine particles and secondary organic aerosols,elucidating the observed haze-carbonyls *** variation with carbonyls exhibiting peak values at early-noon and night highlighted the combined contribution of both secondary formation and primary diesel-fuel sources.1-butene was further confirmed to be the major precursor for *** study confirms the great contribution of carbonyls to AOC,and also suggests that reducing the emissions of carbonyls would be an effective way to mitigate haze pollution in urban area of the NCP region.

关键词： Carbonyls Haze Observation-based model Source apportionment Atmospheric oxidation capacity

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Design and construction of charged-particle telescope array for study of exotic nuclear clustering structure

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Nuclear Science and Techniques 2024年第8期35卷 114-123页

作者： Zheng‑Li Liao Xi‑guang Cao Yu‑xuan Yang Chang‑Bo Fu Xian‑Gai Deng Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Zhengzhou University Zhengzhou 450001China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan University Shanghai 200438China

The exploration of exotic shapes and properties of atomic nuclei,e.g.,αcluster and toroidal shape,is a fascinating field in nuclear *** study the decay of these nuclei,a novel detector aimed at detecting multipleα-particle events was designed and *** detector comprises two layers of double-sided silicon strip detectors(DSSD)and a cesium iodide scintillator array coupled with silicon photomultipliers array as light sensors,which has the advantages of their small size,fast response,and large dynamic *** coupled with cesium iodide crystal arrays are used to distinguish multipleα*** detector array has a compact and integrated design that can be adapted to different experimental *** detector array was simulated using Geant4,and the excitation energy spectra of someα-clustering nuclei were reconstructed to demonstrate the *** simulation results show that the detector array has excellent angular and energy resolutions,enabling effective reconstruction of the nuclear excited state by multipleαparticle *** detector offers a new and powerful tool for nuclear physics experiments and has the potential to discover interesting physical phenomena related to exotic nuclear structures and their decay mechanisms.

关键词： Cluster decay Toroidal structure Telescope array SiPM Energy resolution

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Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying Liu Shuai ye Xin-Ni Li Wei-guang Li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

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Corrosion behavior of Al_(2)O_(3)-C bricks in MnO-containing mold slag

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Journal of Iron and Steel Research International 2024年第6期31卷 1486-1492页

作者： Yi-jiang Zhao guang-qiang Li Yang Wu Cheng Yuan Ze Meng Xiao-xuan Deng Yu Liu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Research Institute of Technology Shougang Group Co.Ltd.Beijing 100043China

In order to explore the corrosion mechanism of Al_(2)O_(3)-C refractories in the mold flux bearing MnO,the immersion test of Al_(2)O_(3)-C refractories in CaO-SiO2-CaF2-MnO slag with different MnO contents was carried out at 1550℃.The results show that Mn particles were observed in the slag after experiment,due to the reduction of MnO by graphite in *** amounts of graphite were observed at the interface between refractories and slag,indicating that the oxidation of graphite is limited by the poor contact between graphite and molten ***,the oxidation of graphite is not the main cause of damage to refractories.A small quantity of CaO·2Al_(2)O_(3)(CA_(2))and CaO·6Al_(2)O_(3)(CA_(6))adjacent to Al_(2)O_(3) grain was detected at the slag/reaction layer ***_(2) and CA_(6) possess relatively high melting points,which is beneficial to hindering the further penetration of ***,the dissolution of Al_(2)O_(3) into slag is still the main cause for refractories *** increase in the MnO content of mold slag decreases the viscosity and then results in the severe corrosion of Al_(2)O_(3)-C bricks.

关键词： Al_(2)O_(3)-C refractory MnO-containing slag Graphite Corrosion

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SCIRD: Revealing Infection of Malicious Software in Edge Computing-Enabled IoT Networks

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Computers, Materials & Continua 2024年第5期79卷 2743-2769页

作者： Jiehao ye Wen Cheng Xiaolong Liu Wenyi Zhu xuan’ang Wu Shigen Shen School of Information Engineering Huzhou UniversityHuzhou313000China

The Internet of Things(IoT)has characteristics such as node mobility,node heterogeneity,link heterogeneity,and topology *** the face of the IoT characteristics and the explosive growth of IoT nodes,which brings about large-scale data processing requirements,edge computing architecture has become an emerging network architecture to support IoT applications due to its ability to provide powerful computing capabilities and good service ***,the defense mechanism of Edge Computing-enabled IoT Nodes(ECIoTNs)is still weak due to their limited resources,so that they are susceptible to malicious software spread,which can compromise data confidentiality and network service *** this situation,we put forward an epidemiology-based susceptible-curb-infectious-removed-dead(SCIRD)***,we analyze the dynamics of ECIoTNs with different infection levels under different initial conditions to obtain the dynamic differential ***,we establish the presence of equilibrium states in the SCIRD ***,we conduct an analysis of the model’s stability and examine the conditions under which malicious software will either spread or disappear within Edge Computing-enabled IoT(ECIoT)***,we validate the efficacy and superiority of the SCIRD model through MATLAB *** research findings offer a theoretical foundation for suppressing the propagation of malicious software in ECIoT *** experimental results indicate that the theoretical SCIRD model has instructive significance,deeply revealing the principles of malicious software propagation in ECIoT *** study solves a challenging security problem of ECIoT networks by determining the malicious software propagation threshold,which lays the foundation for buildingmore secure and reliable ECIoT networks.

关键词： Edge computing Internet of Things malicious software propagation model heterogeneity

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Case Report: Surgical Correction of Transposition of the Great Arteries with Aortopulmonary Window

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Congenital Heart Disease 2024年第3期19卷 275-278页

作者： Qiqi Shi xuan Lei Wenbo Zhang Ming ye Department of Cardiothoracic Surgery Children’s Hospital of Fudan UniversityShanghai201102China Department of Pediatrics Children’s Hospital of Fudan University(Xiamen Branch)Xiamen Children’s HospitalXiamen361006China

Introduction:Transposition of the great arteries(TGA)with aortopulmonary window is a rare type of congenital heart disease with limited *** reported a neonate aged 25 days receiving the arterial switch operation and assisted with extracorporeal membrane ***:TGA with aortopulmonary window can be safely correctly with the arterial switch operation.

关键词： Transposition of the great arteries aortopulmonary window arterial switch operation

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Dynamic manipulation of multimodal emission in Er^(3+)-activated non-core-shell structure for optical thermometry and information security

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Rare Metals 2024年第4期43卷 1702-1712页

作者： xuan Liu Zi-Xia Lin Yin-Biao Shi Xiao-Yan Wang Ming-ye Ding Xiao-Fei Yang College of Science Nanjing Forestry UniversityNanjing210037China Testing Center Yangzhou UniversityYangzhou225009China

Regulating luminescent dynamics of lanthanide-based luminescent materials via external stimuli is of great significance in the fields of optical thermometry and high-level ***,it is still a huge challenge to realize multimodal emissions with tunable color outputs from a single activator in simple structures via smart dynamic control of photon transition ***,we present a mechanistic strategy to achieve multimodal luminescence of Er^(3+)activators with color-switchable outputs in a non-core-shell *** the control of excitation dynamics(λ_(ex)=980,808,1532,377 nm),the population among the intermediate en ergy levels of Er^(3+)and the interaction between Er^(3+)and Yb^(3+)could be precisely modulated through energy transfer and migration processes,leading to the generation of colortunable multimodal luminescence upon diverse excitation modes(non-steady-state,single-/dual-wavelength steady,thermal activation).Inspired by its special luminescent performance,the as-obtained material exhibits great potential in noncontact thermometry,multimodal anticounterfeiting,and high-capacity information encryption by performing a series of proof-of-concept *** findings might provide a conceptual model to modulate the luminescent dynamics in a simple-structured system for the generation of color-adjustable multimodal emissions,which is convenient for the development of advanced luminescent materials toward versatile cuttingedge applications.

关键词： Lanthanide ions Multimodal emission Upconversion Downshifting Anti-counterfeiting Luminescent thermometry

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