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Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2429-2442页

作者： dong liang Chen Yu Zhao Ma Xingye Yang Zhenzhen li Xuhui dong Xiaojun Qin Lupei Du Minyong li Key Laboratory of Chemical Biology(MOE) School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Head and neck squamous cell carcinoma(HNSCC) is one of the most common human cancers;however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map(cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and screened out parbendazole as a most promising compound, which had an excellent inhibitory effect on the proliferation of HNSCC cell lines. In addition, tubulin was identified as a primary target of parbendazole, and the direct binding between them was further verified. Parbendazole was further proved as an effective tubulin polymerization inhibitor, which can block the cell cycle, cause apoptosis and prevent cell migration, and it exhibited reasonable therapeutic effect and low toxicity in the in vivo and in vitro anti-tumor evaluation. Our study repositioned an anthelmintic parbendazole to treat HNSCC, which revealed a therapeutic utility and provided a new treatment option for human cancers.

关键词： HNSCC cMap Bioinformatics Parbendazole Drug repositioning Anti-tumor

考虑风光出力不确定性的新能源基地直流外送随机规划方法研究

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电网技术 2024年第7期48卷 2795-2803,I0049页

作者：李晖刘栋秦继朔韩晓男赵鹏飞孙一丁孙英云国网经济技术研究院有限公司北京市昌平区102209 华北电力大学电气与电子工程学院北京市昌平区102206

加快推进沙漠、戈壁、荒漠地区大型风电太阳能发电基地规划与建设,是我国实现“双碳”目标的重要举措。大规模新能源基地电力外送呈现强随机性、波动性特征,跨区送电特性与传统直流相比发生较大变化,亟需研究适用于不确定性环境的直流... 详细信息

加快推进沙漠、戈壁、荒漠地区大型风电太阳能发电基地规划与建设,是我国实现“双碳”目标的重要举措。大规模新能源基地电力外送呈现强随机性、波动性特征,跨区送电特性与传统直流相比发生较大变化,亟需研究适用于不确定性环境的直流外送输电曲线规划方法。考虑了新能源基地风电、光伏出力不确定性对电力外送的影响,针对新能源基地、直流通道和受端电网的运行特性分别建模,提出了基于场景分析法的新能源基地直流外送随机规划方法。算例结果表明,该方法得到的直流输电曲线可应对不同新能源出力场景下的直流外送需求,验证了所提方法的有效性。

关键词：随机规划新能源基地直流外送不确定性输电曲线

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新能源汽车用铝合金激光-电弧复合焊接研究进展(特邀)

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中国激光 2024年第4期51卷 23-40页

作者：王晓南陈夏明环鹏程李响董其鹏骆顺存长海博文苏州大学沙钢钢铁学院江苏苏州215021 江苏省新能源汽车用金属结构材料绿色制备与资源再生工程研究中心江苏苏州215021 东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110819 无锡锐科光纤激光技术有限责任公司江苏无锡214000

发展新能源汽车是我国从汽车大国迈向汽车强国的必由之路,是应对气候变化、推动绿色发展的战略举措。近年来,作为新能源汽车制造的重要结构材料,车用铝合金性能的不断提升给后续的焊接加工带来了全新的挑战。与传统弧焊热源相比,激光-... 详细信息

发展新能源汽车是我国从汽车大国迈向汽车强国的必由之路,是应对气候变化、推动绿色发展的战略举措。近年来,作为新能源汽车制造的重要结构材料,车用铝合金性能的不断提升给后续的焊接加工带来了全新的挑战。与传统弧焊热源相比,激光-电弧复合热源具有诸多优势,为抑制铝合金焊接缺陷并提升焊接接头系数提供了新途径。较为全面地总结了近年来国内外学者在铝合金焊接缺陷(如软化、气孔)等形成及调控方面的研究进展,分析了现有研究工作中存在的问题并给出了激光-电弧复合焊接铝合金未来的研究方向,旨在为后续研究及应用提供参考。

关键词：激光技术激光-电弧复合焊接铝合金软化气孔力学性能

Three-dimensional graphitic carbon sphere foams as sorbents for cleaning oil spills

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International Journal of Minerals,Metallurgy and Materials 2022年第3期29卷 513-520页

作者： Saisai li Haijun Zhang Longhao dong Haipeng liu Quanli Jia Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials Anhui University of TechnologyMa’anshan 243002China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China High Temperature Ceramic Institute Zhengzhou UniversityZhengzhou 450052China

Frequent offshore oil spill accidents, industrial oily sewage, and the indiscriminate disposal of urban oily sewage have caused seri- ous impacts on the human living environment and health. The traditional oil-water separation methods not only cause easily environmental secondary pollution but also a waste of limited resources. Therefore, in this work, three-dimensional (3D) graphitic carbon sphere (GCS) foams (collectively referred hereafter as 3D foams) with a 3D porous structure, pore size distribution of 25-200 μm, and high porosity of 62vol% were prepared for oil adsorption via gel casting using GCS as the starting materials. The results indicate that the water contact angle (WCA) of the as-prepared 3D foams is 130°. The contents of GCS greatly influenced the hydrophobicity, WCA, and microstructure of the as-prepared samples. The adsorption capacities of the as-prepared 3D foams for paraffin oil, vegetable oil, and vacuum pump oil were approximately 12-15 g/g, which were 10 times that of GCS powder. The as-prepared foams are desirable characteristics of a good sorbent and could be widely used in oil spill accidents.

关键词： graphitic carbon spheres three dimensional foams gel casting oil adsorption

Finite-horizon resilient state estimation for complex networks with integral measurements from partial nodes

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Science China(Information Sciences) 2022年第3期65卷 167-181页

作者： Nan HOU Jiahui li Hongjian liU Yuan GE Hongli dong Artificial Intelligence Energy Research Institute Northeast Petroleum University Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast Petroleum University Key Laboratory of Advanced Perception and Intelligent Control of High-end Equipment Ministry of EducationAnhui Polytechnic University School of Electrical Engineering Anhui Polytechnic University

This paper proposes a finite-horizon state estimation method for a kind of complex network that suffers from randomly occurring gain variations. The method involves utilizing integral measurements from a portion of nodes in such complex networks. Integral measurements are carried out to characterize time delays that occur in signal acquisition together with real-time signal processing. Measurements from only partial nodes reflect the fact that signals of several sensors are unacquirable. A Gaussian random variable is utilized to depict the random appearance of gain variations during the practical implementation of estimators. The aim of this paper is to construct finite-horizon resilient estimators for complex networks in view of integral measurements from a portion of nodes that fulfill the specified H∞ performance demand involving a specified disturbance attenuation level. Necessary and sufficient conditions are put forward to ensure that such ideal estimators exist by employing stochastic analysis as well as using the completing squares method. The gain parameters of the finite-horizon estimators are expressed by adopting the Moore-Penrose pseudoinverse and acquired through solving the solutions to a group of coupled backward recursive Riccati difference equations with constraint conditions. A confirmatory instance is carried out that demonstrates the feasibility of the newly developed estimation algorithm.

关键词： complex networks finite-horizon $H_{\infty}$ partial-nodes-based state estimation gain variations backward recursive Riccati difference equations integral measurements

不同剂量阿托伐他汀联合胰激肽原酶肠溶片治疗糖尿病动脉粥样硬化患者的疗效

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川北医学院学报 2024年第7期39卷 977-980页

作者：桑丽丽朱丽丽王海彦傅绪栋聊城市人民医院老年医学科·查体中心山东聊城252000 聊城市人民医院老年医学科山东聊城252000

目的:研究不同剂量阿托伐他汀与胰激肽原酶肠溶片结合治疗糖尿病动脉粥样硬化的疗效及其对炎症因子的影响。方法:选取146例糖尿病动脉粥样硬化患者作为研究对象,按照治疗方式不同将患者分为对照组和观察组,每组各73例。对照组接受低剂量... 详细信息

目的:研究不同剂量阿托伐他汀与胰激肽原酶肠溶片结合治疗糖尿病动脉粥样硬化的疗效及其对炎症因子的影响。方法:选取146例糖尿病动脉粥样硬化患者作为研究对象,按照治疗方式不同将患者分为对照组和观察组,每组各73例。对照组接受低剂量(20 mg/d)阿托伐他汀与胰激肽原酶肠溶片治疗;观察组接受高剂量(40 mg/d)阿托伐他汀与胰激肽原酶肠溶片治疗。对比两组在治疗前后的血糖、血脂、治疗效果、炎症指标、血管内皮功能、动脉粥样硬化状态及不良反应发生情况。结果:治疗后,观察组的甘油三酯(TG)、总胆固醇(TC)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、内皮素1(ET-1)水平、斑块面积及厚度均低于对照组,高密度脂蛋白胆固醇(HDL-C)、一氧化氮(NO)和6酮前列环素1α(6-Keto-PGF1α)水平高于对照组(P0.05)。结论:对于糖尿病导致的动脉粥样硬化,高剂量阿托伐他汀配合胰激肽原酶肠溶片能更有效地减轻症状,有助于降低血脂和炎症反应,同时有助于减小斑块和改善血管内皮功能,具有显著的临床疗效和良好的安全性。

关键词：阿托伐他汀糖尿病动脉粥样硬化疗效炎症

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基于分形理论的变齿厚齿轮接触应力分析

机械强度 2024年第1期46卷 169-175页

作者：刘永平魏帅董长斌魏永峭任忠涛李泽宇兰州理工大学机电工程学院兰州730050

为了更准确地反应变齿厚齿轮齿面真实接触应力,构建了变齿厚齿轮的齿面接触系数,并对其合理性进行了验证。基于分形接触理论和Hertz接触理论建立了综合考虑齿轮齿面粗糙形貌、接触点弹性变形、材料特性等参数的变齿厚齿轮接触模型,计算... 详细信息

为了更准确地反应变齿厚齿轮齿面真实接触应力,构建了变齿厚齿轮的齿面接触系数,并对其合理性进行了验证。基于分形接触理论和Hertz接触理论建立了综合考虑齿轮齿面粗糙形貌、接触点弹性变形、材料特性等参数的变齿厚齿轮接触模型,计算变齿厚齿轮的接触强度,并与有限元计算结果进行比较,验证了方法的有效性。通过分形理论得出齿轮啮合时载荷与面积的关系,并对4个基本参数进行仿真,分析分形接触模型的效果。结果表明,通过数值模拟和分析实际接触面积与载荷的关系图,验证了分形接触模型的准确性。基于有限元理论、Hertz接触理论和分形理论,对变齿厚齿轮的齿面接触强度进行了比较和分析,验证了分形接触模型计算变齿厚齿轮接触应力的正确性,该模型的建立为变齿厚齿轮的设计与强度校核提供了一定的理论依据。

关键词：变齿厚齿轮分形理论接触应力 Hertz 接触理论

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2022-2023年华北地区住院患者鼻咽部携带肺炎克雷伯菌的耐药特征分析

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中华预防医学杂志 2024年第3期58卷 306-314页

作者：高鹏芳陈延莹戈艳蕾杜小莉邢欢李嘉琛李跃龙汤雅婷韩肖李娟崔志刚周海健董爱英华北理工大学附属医院临床微生物科唐山063000 传染病溯源预警和智能决策全国重点实验室、中国疾病预防控制中心传染病预防控制所北京102206 华北理工大学附属医院呼吸科唐山063000

目的:分析2022-2023年华北地区住院患者鼻咽部携带肺炎克雷伯菌的耐药特征。方法:于2022年11月至2023年7月,采集华北理工大学附属医院100例住院患者的鼻咽拭子并进行肺炎克雷伯菌分离培养。同时收集患者的临床资料,包括性别、年龄、科... 详细信息

目的:分析2022-2023年华北地区住院患者鼻咽部携带肺炎克雷伯菌的耐药特征。方法:于2022年11月至2023年7月,采集华北理工大学附属医院100例住院患者的鼻咽拭子并进行肺炎克雷伯菌分离培养。同时收集患者的临床资料,包括性别、年龄、科室、临床诊断的疾病类型等。使用全自动细菌药敏系统检测菌株的最低抑菌浓度,通过全基因组测序和数据分析对菌株的耐药基因、ST型、荚膜血清型以及种群结构进行分析。结果:100例住院患者中,共计从55名住院患者鼻咽拭子中分离出肺炎克雷伯菌,占比55.00%。55名鼻咽部携带肺炎克雷伯菌的住院患者中以男性患者为主(70.91%,39/55),年龄分布集中在61~80岁(58.18%,32/55),科室分布集中在重症监护室(50.91%,28/55),患者基础疾病类型以神经系统疾病为主(49.09%,27/55)。药敏结果显示55株肺炎克雷伯菌对头孢菌素类、喹诺酮类、氨曲南、呋喃妥因的不敏感率均>80.00%;共检出碳青霉烯类耐药肺炎克雷伯菌28株(50.91%),产超广谱β-内酰胺酶47株(85.45%),多重耐药菌48株(87.27%);共检出碳青霉烯类(携带率76.36%)、超广谱β-内酰胺酶类(携带率96.36%)等11类抗生素耐药基因。55株菌可分为17种ST型别,ST11型最多(25.45%)。55株菌可分为18种荚膜血清型,K102型最多(23.64%)。OXA-1_ST307_K102(21.82%)和KPC-2_ST5492_K125(18.18%)为优势克隆群,分别分布于神经外科和重症监护室。全基因组序列分析显示55株菌中有4个同源性较高的簇,来源于重症监护室的菌株组成2个独立的簇,又分别与神经内科重症监护室和神经外科的菌株各组成1个簇。结论:住院患者鼻咽部肺炎克雷伯菌的携带率较高,菌株耐药情况严重,携带耐药基因种类多。

关键词：克雷伯菌肺炎鼻咽部横断面研究耐药全基因组测序

Generalization ability of a CNNγ-ray localization model for radiation imaging

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Nuclear Science and Techniques 2023年第12期34卷 53-65页

作者： Wei Lu Hai‑Wei Zhang Ming‑Zhe liu Hao‑xuan li Xian‑Guo Tuo Lei Wang Chengdu University of Technology Chengdu 610059China Sichuan University of Science and Engineering Zigong 643000China

Inγ-ray imaging,localization of theγ-ray interaction in the scintillator is *** neural network(CNN)techniques are highly promising for improvingγ-ray *** study evaluated the generalization capabilities of a CNN localization model with respect to theγ-ray energy and thickness of the *** model maintained a high positional linearity(PL)and spatial resolution for ray energies between 59 and 1460 *** PL at the incident surface of the detector was 0.99,and the resolution of the central incident point source ranged between 0.52 and 1.19 *** modified uniform redundant array(MURA)imaging systems using a thick crystal,the CNNγ-ray localization model significantly improved the useful field-of-view(UFOV)from 60.32 to 93.44%compared to the classical centroid localization ***,the signal-to-noise ratio of the reconstructed images increased from 0.95 to 5.63.

关键词： γ-Ray imaging γ-Ray localization model Convolutional neural network Spatial resolution