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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui TAN Jin-hua SU Lian-lin yan Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(P<0.05 or P<0.01).Moreover,BXD suppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression

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Cancer Communications 2022年第9期42卷 868-886页

作者： Ye Yuan Li-Hong Wang Xian-Xian Zhao Jiao Wang Meng-Si Zhang Qing-Hua Ma Sen Wei Ze-xuan yan Yue Cheng Xiao-Qing Chen Hong-Bo Zou Jia Ge yan Wang Xia Zhang You-Hong Cui Tao Luo Xiu-Wu Bian Institute of Pathology and Southwest Cancer Center Southwest HospitalThird Military Medical University(Army Medical University)and Key Laboratory of Tumor ImmunopathologyMinistry of Education of ChinaChongqing 400038P.R.China Bio-Bank of Southwest Hospital Third Military Medical University(Army Medical University)Chongqing 400038P.R.China Department of Clinical Laboratory Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038P.R.China Department of Oncology the Third Affiliated Hospital of Chongqing Medical UniversityChongqing 401120P.R.China

Background:Elucidation of the post-transcriptional modification has led to novel strategies to treat intractable tumors,especially glioblastoma(GBM).The ubiquitin-proteasome system(UPS)mediates a reversible,stringent and stepwise post-translational modification which is closely associated with malignant processes of *** this end,developing novel therapeutic approaches to target the UPS may contribute to the treatment of this *** study aimed to screen the vital and aberrantly regulated component of the UPS in *** on the molecular identification,functional characterization,and mechanism investigation,we sought to elaborate a novel therapeutic strategy to target this vital factor to combat ***:We combined glioma datasets and human patient samples to screen and identify aberrantly regulated E3 ubiquitin *** database analysis and molecular and functional experiments in vivo and in vitro were used to evaluate the roles of HECT,UBA and WWE domain-containing E3 ubiquitin ligase 1(HUWE1)in ***9 synergistic activation mediator system and recombinant adeno-associated virus(rAAV)were used to endogenously overexpress full-length HUWE1 in vitro and in glioma orthotopic ***:Low expression of HUWE1 was closely associated with worse prognosis of GBM *** ubiquitination and subsequent degradation of N-Myc mediated by HUWE1,leading to the inactivation of downstream Delta-like 1(DLL1)-NOTCH1 signaling pathways,inhibited the proliferation,invasion,and migration of GBM cells in vitro and in vivo.A rAAV dual-vector system for packaging and delivery of dCas9-VP64 was used to augment endogenous HUWE1 expression in vivo and showed an antitumor activity in glioma orthotopic ***:The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress GBM *** activity of rAAV dual-vector delivering dCas9-HUWE1 system uncovers a promising therapeutic strategy for GBM.

关键词： DLL1 E3 ubiquitin ligase glioblastoma HUWE1 N-Myc NOTCH1 recombinant adenoassociated virus ubiquitin-proteasome system

急性高容量血液稀释对全麻患者维库溴铵肌松起效和恢复的影响

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中华麻醉学杂志 2008年第4期28卷 349-352页

作者：郑宏宣斐宣燕新疆医科大学第一附属医院麻醉科乌鲁木齐市830054 新疆医科大学附属肿瘤医院麻醉科

目的探讨急性高容量血液稀释（AHHD）对全麻患者维库溴铵肌松起效和恢复的影响。方法择期全麻下普通外科手术患者32例，ASAⅠ或Ⅱ级，随机分为2组（n=16）：对照组和AHHD组。AHHD组AHHD完成并稳定10min后、对照组气管插管完成后，静... 详细信息

目的探讨急性高容量血液稀释（AHHD）对全麻患者维库溴铵肌松起效和恢复的影响。方法择期全麻下普通外科手术患者32例，ASAⅠ或Ⅱ级，随机分为2组（n=16）：对照组和AHHD组。AHHD组AHHD完成并稳定10min后、对照组气管插管完成后，静脉注射维库溴铵负荷剂量0．1mg／kg。静脉输注维库溴铵维持L／L5％～15％。于AHHD前、后各时点测定血生化指标，记录维库溴铵起效时间和恢复时间。结果与对照组比较，AHHD组AHHD后Hct、Hb、血浆总蛋白及白蛋白浓度降低，维库溴铵起效时间和恢复时间均缩短（P〈0．05），肝、肾和凝血功能指标差异无统计学意义（P〉0．05）。结论急性高容量血液稀释可缩短全麻患者维库溴铵的肌松起效时间，加快肌松恢复。

关键词：血液稀释维库溴铵神经肌肉阻滞

预应力混凝土曲线连续梁桥施工及使用过程时效仿真分析

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中国铁道科学 2007年第4期28卷 61-65页

作者：石现峰宣言王澜石家庄铁道学院土木工程分院河北石家庄050043 铁道科学研究院铁道科学技术研究发展中心北京100081

根据BP-2理论,考虑混凝土的收缩徐变、预应力及其损失等因素的影响,采用按龄期调整的有效弹性模量法和有限单元步进法,编制预应力混凝土曲线连续梁桥的时效仿真分析软件,计算结构在整个施工过程及投入使用后任意时刻任意位置的内力和变... 详细信息

根据BP-2理论,考虑混凝土的收缩徐变、预应力及其损失等因素的影响,采用按龄期调整的有效弹性模量法和有限单元步进法,编制预应力混凝土曲线连续梁桥的时效仿真分析软件,计算结构在整个施工过程及投入使用后任意时刻任意位置的内力和变形,实现对预应力混凝土曲线连续梁桥施工过程进行实时控制的目的。应用该仿真分析软件对1座3跨曲线连续梁桥的分析表明,混凝土的收缩徐变和预应力对桥梁结构的内力和变形均有较大的影响,而且某些截面的控制内力往往发生在施工过程中而非成桥后。因此对于分阶段施工的预应力混凝土曲线连续梁桥,应该结合实际的施工过程进行相应阶段的内力计算,以确保各个施工阶段的内力值在安全范围内。

关键词：预应力混凝土曲线桥连续梁桥时效分析仿真

水体系中尿素卤化铵共晶合成及影响因素的理论研究

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高等学校化学学报 2018年第12期39卷 2700-2706页

作者：闫璇薛冰纯刘二保山西师范大学化学与材料科学学院临汾041001

通过缓慢蒸发技术合成尿素氯化铵、尿素溴化铵和尿素氟化铵3种尿素卤化铵共晶.采用第一性原理方法,在原尿素氯化铵晶胞结构基础上,构建同晶系的尿素氟化铵及尿素溴化铵共晶晶胞,并对3种尿素卤化铵共晶结构的稳定性、堆积系数和形成能、... 详细信息

通过缓慢蒸发技术合成尿素氯化铵、尿素溴化铵和尿素氟化铵3种尿素卤化铵共晶.采用第一性原理方法,在原尿素氯化铵晶胞结构基础上,构建同晶系的尿素氟化铵及尿素溴化铵共晶晶胞,并对3种尿素卤化铵共晶结构的稳定性、堆积系数和形成能、卤素离子半径和电负性及离子水合作用进行对比研究.结果表明,对于尿素溴化铵共晶,Br^-半径较大导致晶胞内部空腔变形,溴离子水合团簇稳定,均会阻碍Br^-进入尿素孔道内;对于尿素氟化铵共晶,F^-的强电负性使氟离子水合团簇F^-(H_2O)5稳定性很强,阻碍裸F-进入尿素空腔中;对于易于合成的尿素氯化铵共晶,由于Cl^-的电负性及半径大小都适中,水合离子团簇的稳定性适当,易于进入尿素空腔中.

关键词：尿素共晶卤化铵影响因素理论计算

客运专线曲线线路车线耦合系统动力学性能与无砟轨道结构振动响应的仿真研究

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中国铁道科学 2007年第5期28卷 136-138页

作者：宣言王澜铁道科学研究院铁道科学技术研究发展中心北京100081

Based on the thought of the system engineering theory,the questions about the dynamic characteristics of vehicle-track coupling system on curved track and the vibration response of ballastless track structure of passenger traffic railway are analyzed and are simulated *** main searches are as follows:(1) Depending on the theory of vehicle-track coupling dynamic and finite element method,the motion state of each part of the vehicle-track coupling system is analyzed in *** dynamic models of vehicle structure,curve ballasted track structure,ballastless track structure are built *** rail/wheel contact model adopting FEM to calculate the rolling contact progress is brought *** worn profiled wheel tread is *** part of the track structure model is built by real size and relation,and is simplified *** calculation about rail/wheel contact interaction is close to real *** wheel can roll on the track,or glide relative to track,or separate from ***,the phenomena of the vehicle’ climb on rail and derail are simulated. Through applying the wheel rotate velocity,the forward rolling of the wheel is realized,and then it is true more than giving a vehicle velocity.(2) Adopting ABAQUS software,the vehicle-track coupling system of Passenger Traffic Railway is simulated *** method and the contact penalty function method are used for *** the contact calculation,constraint enforcement methods is described the pressure-overclosure behavior,contact surface weighting method & tracking approach are used to judged contact state,contact tangent action is described by corresponding sliding *** calculate results show that adopting FEM to calculated rolling contact progress is feasible and the results is more exact.(3) Taking example by the engineering of rail traffic in a city,the dynamic characteristics of the vehicle-track coupling systems of ballasted track and ballastless track are

关键词：车线耦合系统曲线线路客运专线无砟轨道板式轨道振动响应计算机仿真

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浅谈减少多层住宅地基不均匀沉降的措施

煤炭工程 2005年第2期37卷 27-28页

作者：玄雁燕中煤国际工程集团南京设计研究院江苏南京210031

砖混结构房屋在我国住宅建筑中占的比例较大、分布较广 ,砖混结构中一般的细小裂缝虽不影响使用 ,却降低了墙体的质量 ,其中地基不均匀沉降是造成墙体裂缝的重要原因之一。论文针对多层住宅地基不均匀沉降产生的裂缝现象 ,从设计、施工... 详细信息

砖混结构房屋在我国住宅建筑中占的比例较大、分布较广 ,砖混结构中一般的细小裂缝虽不影响使用 ,却降低了墙体的质量 ,其中地基不均匀沉降是造成墙体裂缝的重要原因之一。论文针对多层住宅地基不均匀沉降产生的裂缝现象 ,从设计、施工等方面阐述了防治措施。

关键词：多层住宅砖混结构地基不均匀沉降墙体裂缝

A Series of 5-Azotetrazolyl Salicylic Acid Based Lanthanide Complexes:Syntheses,Structures and Magnetic Properties

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A Series of 5-Azotetrazolyl Salicylic Acid Based Lanthanide ...

The association between admission systolic blood pressure and 1-year mortality in patients with non-ST-segment elevation acute coronary syndrome

中国化学会第29届学术年会

作者： Wen-Bin Chen yan-xuan Qiu Yu-Zhi Su Wen Dong Department of Chemistry Guangzhou Key Laboratory for Environmentally Functional Materials and TechnologyGuangzhou University230 Wai Huan Xi RoadGuangZhou Higher Education Mega Center

Recently,the lanthanide complexes are attracting increasing attention for the large intrinsic magnetic anisotropy of Ln（III）ions and potential applications as high density magnetic memories,quantum computing devices,and molecular spintronics[1-6].The 5-azotetrazolyl salicylic acid（H3ASA）that contains azo,salicylic acid and tetrazole moieties should be an especially desirable ligand for assembling various metal-organic complexes because it not only can dissociate mono-,di-and tri-valent anions,but also is additionally bonded byπ–πinteractions and hydrogen bonding interactions.A series of dinuclear lanthanide complex[Ln2（H2ASA）2（HASA）2（H2O）8]·6H2O（Ln=Sm,Eu,Gd,Tb,Dy,Ho,Er）have been synthesized by slow evaporation of the mixed aqueous solution of H3ASA and LnCl3·*** structures and magnetic properties have been characterized by X-ray diffraction and SQUID *** result of AC magnetic susceptibility for dysprosium complex show that the in-phase（χ′）and out-of-phase（χ′′）signals show obvious frequency dependence at low temperature.

关键词： 5-azotetrazolyl salicylic acid lanthanide complexes magmetism

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South China Journal of Cardiology 2017年第3期18卷 175-179,187页

作者： xuan Hai-yan LUO si-ni LIU Hui-xia Department of Cardiology Guangdong Cardiovascu- lar Institute Guangdong General Hospital Guangdong Acade- my of Medical Sciences Guangdong Geriatrics Institute Guangdong General Hospital Guangdong Academy of Medi- cal Sciences Guangzhou 510080 China

Background In patients with acute coronary syndrome（ACS）, lower admission systolic blood pressure（SBP）levels infer a worse prognosis. However, the predictive potential of admission SBP on 1-year mortality has not fully elucidated in patients with non-ST-segment elevation ACS（NSTEACS）. Methods We enrolled 1325 patients to investigate the association between admission SBP in patients hospitalized for NSTEACS. We analyzed the association between admission SBP and 1-year mortality. Admission SBP was categorized as low（〈110 mm Hg）, normal（110-140 mm Hg）, high（141-160 mm Hg）, and very high（〉160 mm Hg）. Results Compared with patients with normal admission SBP, those with low SBP had a significantly increased hazard ratios（HRs） for 1-year mortality of 3.03（P〈0.05）, while patients with high and very high admission SBP had no significantly increased HRs for 1-year mortality. Conclusion Low admission SBP, but not elevated admission SBP, is a strong independent predictor of 1-year mortality in patients with NSTEACS.

关键词： non-ST-segment elevation acute coronary syndrome systolic blood pressure mortality