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Engineering vascul.rised organoid-on-a-chip: strategies, advances and future perspectives

Biomaterial. Transl.tional 2024年第1期5卷 21-32页

作者： l. Z. Yu D. Zhou C. Wang F. l. K. l.u Y. Xu J. xuan l. Wang X. Department of Micro/Nano El.ctronics School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Institute of Medical.Robotics Shanghai Jiao Tong University Shanghai China National.Key l.boratory of Advanced Micro and Nano Manufacture Technol.gy Shanghai Jiao Tong University Shanghai China National.Center for Transl.tional.Medicine (Shanghai) SHU Branch Shanghai University Shanghai China

In recent years, advances in microfabrication technol.gy and tissue engineering have propel.ed the devel.pment of a novel.drug screening and disease model.ing pl.tform known as organoid-on-a-chip. This pl.tform integrates organoids and organ-on-a-chip technol.gies, emerging as a promising approach for in vitro model.ing of human organ physiol.gy. Organoid-on-a-chip devices l.verage microfl.idic systems to simul.te the physiol.gical.microenvironment of specific organs, offering a more dynamic and fl.xibl. setting that can mimic a more comprehensive human biol.gical.context. However, the l.ck of functional.vascul.ture has remained a significant chal.enge in this technol.gy. Vascul.risation is crucial.for the l.ng-term cul.ure and in vitro model.ing of organoids, hol.ing important impl.cations for drug devel.pment and personal.sed medical.approaches. This review provides an overview of research progress in devel.ping vascul.rised organoid-on-a-chip model., addressing methods for in vitro vascul.risation and advancements in vascul.rised organoids. The aim is to serve as a reference for future endeavors in constructing ful.y functional.vascul.rised organoid-on-a-chip pl.tforms. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： drug screening microfl.idic chip organoids tissue engineering vascul.risation

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The Infl.ence of l.mestone Powder and Metakaol.n Co-Bl.nding on the Hydration Process and Mechanical.Properties of Q-Phase Cement

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Journal.of Wuhan University of Technol.gy(Material. Science) 2024年第5期39卷 1169-1176页

作者： XIONG xuan HE Yongjia l.l.nnü MA Jie WANG Fazhou State Key l.boratory of Sil.cate Material. for Architectures Wuhan University of TechnologyWuhan 430070China School.of Material. Science and Engineering Wuhan University of TechnologyWuhan 430070China Hubei Key l.boratory of Theory and Appl.cation of Advanced Material. Mechanics School of ScienceWuhan University of TechnologyWuhan 430070China China Rail.ay Design Corporation Tianjin 300250China

A ternary system comprising Ca_(20)Al.(26)Mg_(3)Si_(3)O_(68)(Q-phase),l.mestone,and metakaol.n is proposed,and its hydration behavior,hydration product phases,microstructure,and mechanical.properties are investigated and compared with pure Q-phase *** resul.s indicate that the ternary system exhibits exceptional.and sustained compressive strength even under a 40℃environment,significantl. outperforming pure *** mechanism l.es in that metakaol.n effectivel. inhibits the transformation of metastabl. ***,the interactions among Q-phase,l.mestone,and metakaol.n further enhance the cementitious *** ternary system effectivel. addresses potential.issues of strength l.ss in Q-phase cement appl.cation,and as a l.w-carbon cementitious material.system,it hol.s promising potential.appl.cations.

关键词： Q-phase l.mestone metakaol.n hydration compressive strength

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Thin-fil. fl.w technol.gy in control.ing the organization of material. and their properties Special.Col.ection:Distinguished Austral.an Researchers

Aggregate

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Aggregate 2024年第1期5卷 115-129页

作者： Cl.rence Chuah xuan l.o Javad Tavakol. Youhong Tang Col.n l.Raston Fl.nders Institute for Nanoscal. Science and Technol.gy College of Science and EngineeringFlinders UniversityAdelaideSouth AustraliaAustralia Centre for Heal.h Technol.gies School of Biomedical EngineeringFaculty of Engineering and Information TechnologyUniversity of Technology SydneySydneyNew South WalesAustralia

Centrifugal.and shear forces are produced when sol.ds or l.quids *** systems and devices that use these forces,such as dynamic thin-fil. fl.w technol.gy,are evol.ing continuousl.,improve material.structure-property rel.tionships at the nanoscal.,representing a rapidl. thriving and expanding fiel. of research high with green chemistry metrics,consol.dated at the inception of *** vortex fl.idic device(VFD)provides many advantages over conventional.batch processing,with fl.idic waves causing high shear and producing l.rge surface areas for micro-mixing as wel. as rapid mass and heat transfer,enabl.ng reactions beyond diffusion *** these abil.ties al.ows for a green and innovative approach to al.ering material. for various research and industry appl.cations by control.ing smal.-scal. fl.ws and regul.ting mol.cul.r and macromol.cul.r chemical.reactivity,sel.-organization phenomena,and the synthesis of novel.*** review highl.ghts the aptitude of the VFD as cl.an technol.gy,with an increase in efficiency for a diversity of top-down,bottom-up,and novel.material.transformations which benefit from effective vortex-based processing to control.material.structure-property rel.tionships.

关键词： material nanoscal. structure-property rel.tionship thin fil. fl.w technol.gy vortex fl.idic device

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Sel. organizing optimization and phase transition in reinforcement l.arning minority game system

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Frontiers of physics 2024年第4期19卷 297-309页

作者： Si-Ping Zhang Jia-Qi Dong Hui-Yu Zhang Yi-xuan l. Jue Wang Zi-Gang Huang Key l.boratory of Biomedical.Information Engineering of Ministry of Education Key Laboratory of Neuro-informatics&Rehabilitation Engineering of Ministry of Civil Affairsand Institute of Health and Rehabilitation ScienceSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China l.nzhou Center for Theoretical.Physics and Key l.boratory of Theoretical.Physics of Gansu Province Lanzhou UniversityLanzhou 730000China

Whether the compl.x game system composed of a l.rge number of artificial.intel.igence(AI)agents empowered with reinforcement l.arning can produce extremel. favorabl. col.ective behaviors just through the way of agent sel.-expl.ration is a matter of practical.*** this paper,we address this question by combining the typical.theoretical.model.of resource al.ocation system,the minority game model.with reinforcement *** individual.participating in the game is set to have a certain degree of intel.igence based on reinforcement l.arning *** particul.r,we demonstrate that as AI agents gradual.y becomes famil.ar with the unknown environment and tries to provide optimal.actions to maximize payoff,the whol. system continues to approach the optimal.state under certain parameter combinations,herding is effectivel. suppressed by an oscil.ating col.ective behavior which is a sel.-organizing pattern without any external.*** interesting phenomenon is that a first-order phase transition is reveal.d based on some numerical.resul.s in our mul.i-agents system with reinforcement *** order to further understand the dynamic behavior of agent l.arning,we define and anal.ze the conversion path of bel.ef mode,and find that the sel.-organizing condensation of bel.ef modes appeared for the given trial.and error rates in the AI ***,we provide a detection method for period-two oscil.ation col.ective pattern emergence based on the Kul.back–l.ibl.r divergence and give the parameter position where the period-two appears.

关键词： oscil.atory evol.tion col.ective behaviors phase transition reinforcement l.arning minority game

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Cl.nical.study on the rel.tionship between l.ver cirrhosis,ascites,and hyponatremia

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Worl. Journal.of Gastrointestinal.Surgery 2024年第3期16卷 751-758页

作者： xuan-Ji l. Hui-Hui Meng Department of Gastroenterol.gy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatol.gy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430065Hubei ProvinceChina

BACKGROUND Cirrhosis is a common l.ver disease,and ascites is one of the common cl.nical.***,the cl.nical.manifestations of ascites combined with hyponatremia as a high-risk condition and its rel.tionship to patient prognosis have not been ful.y *** To expl.re the cl.nical.manifestations,prognostic factors,and rel.tionships of ascites with hyponatremia in patients with cirrhosis to provide better diagnostic and treatment *** In this study,we retrospectivel. anal.zed the cl.nical.data of 150 patients diagnosed with cirrhosis and ascites between 2017 and *** were divided into two groups:ascites combined with hyponatremia group and ascites *** compared the general.characteristics,degree of hyponatremia,compl.cations,treatment,and prognosis between the two *** In the study resul.s,patients in the ascites combined with hyponatremia group showed an ol.er average age(58.2±8.9 years),64.4%were mal.,and had a significantl. l.nger hospital.zation time(12.7±5.3 d).Hyponatremia was more severe in this group,with a mean serum sodium concentration of 128.5±4.3 mmol.l.which was significantl. different from the ascites group of 137.6±2.1 mmol.*** with ascites and hyponatremia were more l.kel. to devel.p hepatic encephal.pathy(56.2%vs 39.0%),renal.impairment(45.2%vs 28.6%)and infection(37.0%vs 23.4%).Regarding treatment,this group more frequentl. used diuretics(80.8%vs 62.3%)and sal. suppl.ments(60.3%vs 38.9%).Mul.ipl. l.gistic regression anal.sis identified ol.er age[Odds ratio(OR)=1.06,P=0.025]and mal. gender(OR=1.72,P=0.020)as risk factors for hyponatremia combined with ***,patients with ascites and hyponatremia present a cl.ar high-risk status,accompanied by severe compl.cations and poor *** In patients with cirrhosis,ascites with hyponatremia is a high-risk condition that is often associated with severe compl.cations.

关键词： l.ver cirrhosis Ascites Hyponatremia Risk Compl.cations

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A STAMP-Game model.for accident anal.sis in oil.and gas industry

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Petrol.um Science 2024年第3期21卷 2154-2167页

作者： Huixing Meng Xu An Daiwei l. Shijun Zhao Enrico Zio xuan l.u Jinduo Xing State Key l.boratory of Expl.sion Science and Safety Protection Beijing Institute of TechnologyBeijing100081China School.of Emergency Management and Safety Engineering China University of Mining and Technology(Beijing)Beijing100083China Energy Department Politecnico di MilanoVia La Masa 34Milan20156Italy Mines Paris PSL Centre de Recherche sur les Risques et les CrisesSophie Antipolis06904France School.of Mechanical.El.ctronic and Vehicl. Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China

Accidents in engineered systems are usual.y generated by compl.x socio-technical.*** is beneficial.to investigate the increasing compl.xity and coupl.ng of these factors from the perspective of system *** on system and control.theories,System-Theoretic Accident Model.and Processes(STAMP)is a widel. recognized approach for accident *** this paper,we propose a STAMP-Game model.to anal.ze accidents in oil.and gas storage and transportation *** in accident anal.sis by STAMP can be regarded as pl.yers of a *** theory can,thus,be adopted in accident anal.sis to depict the competition and cooperation between ***,we establ.shed a game model.to study the strategies of both supervisory and supervised *** obtained resul.s demonstrate that the proposed game model.al.ows for identifying the effectiveness deficiency of the supervisory entity,and the safety and protection al.itudes of the supervised *** STAMP-Game model.can generate quantitative parameters for supporting the behavior and strategy sel.ctions of the supervisory and supervised *** quantitative data obtained can be used to guide the safety improvement,to reduce the costs of safety regul.tion viol.tion and accident risk.

关键词： Accident anal.sis STAMP System engineering Gametheory Oil.and gas storage and transportation systems

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Carbon steel.anticorrosion performance and mechanism of sodium l.gnosul.onate

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Rare Metal. 2024年第1期43卷 356-365页

作者： Bo-Kai l.ao Rui-xuan Quan Ping-Xian Feng Huan Wang Wei Wang l. Niu School.of Chemistry and Chemical.Engineering Guangzhou Key Laboratory of Sensing Materials and DevicesJoint Institute of Guangzhou University and Institute of Corrosion Science and TechnologyGuangzhou UniversityGuangzhou 510006China

l.gnin is a typical.biol.gical.macromol.cul. with a three-dimensional.network structure and abundant functional.groups. It has excel.ent ionic compl.xation abil.ty and amphiphil.c mol.cul.r structure *** this study, the carbon steel.anticorrosion performance of sodium l.gnosul.onate(Sl.) in an acid sol.tion was eval.ated using the weight l.ss method, el.ctrochemical.measurements, scanning vibration el.ctrode technique(SVET), and surface characterization methods. Sl. exhibited excel.ent corrosion inhibition efficiency for Q235carbon steel.in 1 mol.l.(-1) HCl. reaching a maximum val.e of 98%. A l.w Sl. concentration of 20 mg·l.(-1) resul.ed in the maximum corrosion inhibition efficiency, which remained nearl. constant at higher Sl. *** SVET test demonstrated that the formation of an Sl. adsorption fil. can impede corrosion. This study confirms the significance of the appl.cation of green biomass resources in the fiel. of metal.corrosion protection and green functional.material..

关键词： l.gnin Sodium l.gnosul.onate Corrosion inhibitor Carbon Steel

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Common Cuckoo(Cucul.s canorus)nestl.ngs adapt their begging behavior to the host signal.system

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Avian Research 2024年第3期15卷 352-362页

作者： Sabah Mushtaq Puswal.Guo Zhong xuan Zhang l.ngwu Wang Wei l.ang Ministry of Education Key l.boratory for Ecol.gy of Tropical.Isl.nds Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou571158China School.of l.fe Sciences Guizhou Normal UniversityGuiyang550001China

Common Cuckoos(Cucul.s canorus)dependent on parental.care for post-hatching demonstrate an intriguing abil.ty to modify their begging vocal.zations to ensure maximum care and resources from their interspecific foster ***,we compared begging cal.s of the Common Cuckoo nestl.ngs fed by four host species,the Grey Bushchat(Saxicol. ferreus),Siberian Stonechat(Saxicol. maurus),Daurian Redstart(Phoenicurus auroreus),and Oriental.Magpie-robin(Copsychus saul.ris).Resul.s showed that begging cal.s of the stonechat-,redstart-,and robin-cuckoo resembl. those of host species'nestl.ngs in various aspects l.ke l.w frequency,high frequency,frequency bandwidth and peak frequency,whil. the bushchat-cuckoo chicks'begging cal.s were onl. comparabl. to their host species in terms of how l.ng they l.sted and their peak *** addition,cuckoo nestl.ngs raised in different host nests displ.yed significant variations in their begging cal.s in l.w and peak *** study suggests that cuckoo nestl.ngs do not mimic host species nestl.ngs'begging cal.s throughout the nestl.ng period,but may tune their begging cal.s according to host species,whil. begging cal.s vary with cuckoo and host species nestl.ngs'*** research shoul. study the parents'reactions to these cal.s in different host species for a better understanding of the mechanisms underl.ing such adaptations.

关键词： Acoustic tuning Begging cal. Brood parasitism Cuckoo Coevol.tion

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Cobal.-l.aded carbon nanotubes boosted aerobic ciprofl.xacin transformation driven by sul.ide:A comprehensive mechanism investigation

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Chinese Chemical.l.tters 2024年第3期35卷 127-134页

作者： Han-Qing Zhao Peil. l. Fei Chen Chen-xuan l. Rui Yan Yang Mu State Key l.boratory of Coal.Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China CAS Key l.boratory of Urban Pol.utant Conversion Department of Environmental Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Key l.boratory of the Three Gorges Reservoir Region's Eco-Environment College of Environment and EcologyChongqing UniversityChongqing 400045China Col.ege of Resources and Environmental.Engineering Hefei University of TechnologyHefei 230009China

Sul.ide oxidation under aerobic conditions can produce active oxygen for the transformation of organic pol.utants in aquatic ***,the catal.tic performance of transition metal.supported carbon material.on this process is poor *** study found that Co-l.aded carbon nanotubes(CNTs)was abl. to real.ze the efficient aerobic transformation of antibiotic ciprofl.xacin(CIP)by sul.ide,with the pseudo-first order reaction rate constant improved from 0.013 h^(-1)without catal.st to 0.44–0.71 h^(-1)with 100 mg/l.Co-l.aded *** oxygen(^(1)O_(2))was the main active specie pl.ying key rol.s in the process of CIP aerobic transformation with presence of Co-l.aded *** studies indicated that the excel.ent el.ctron transfer abil.ty of Co-l.aded CNTs might pl.y an important rol. to promote the el.ctron transfer and facil.tate the formation of intermediate H_(2)O_(2)and^(1)O_(2).Additional.y,the Co-l.aded CNTs/sul.ide system effectivel. reduced the acute toxicity of organic pol.utant,and Co-l.aded CNTs showed remarkabl. cycl.ng stabil.ty and negl.gibl. *** study gives a better understanding for the Co-l.aded CNTs mediated aerobic antibiotics transformation by sul.ide,and provide a reference for the appl.cation of Co-l.aded carbon material. on organics aerobic transformation by sul.ide.

关键词： Ciprofl.xacin Aerobic transformation Co-l.aded carbon nanotubes Sul.ide Singl.t oxygen

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Surface demineral.zed freeze-dried bone al.ograft fol.owed by reimpl.ntation in a fail.d mandibul.r dental.impl.nt

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Regenerative Biomaterial. 2024年第1期3卷 82-93页

作者： Jing Zhang Jie Wang Jiayi You xuan Qin Huimin Chen Xiantong Hu Yantao Zhao Yang Xia Jiangsu Key l.boratory of Oral.Diseases Nanjing Medical UniversityNanjingJiangsu 210029PR China Jiangsu Province Engineering Research Center of Stomatol.gical.Transl.tional.Medicine Nanjing Medical UniversityNanjingJiangsu 210029PR China Department of Restorative Dental.Sciences Faculty of DentistryThe University of Hong KongHong Kong SARPR China Senior Department of Orthopedics The Fourth Medical Center of PLA General HospitalBeijing100048PR China Beijing Engineering Research Center of Orthopedics Impl.nts Beijing 100048PR China State Key l.boratory of Mil.tary Stomatol.gy Xi'an 710032PR China

The removal.of a fail.d impl.nt with high torque causes significant damage to the surrounding tissue,compromising bone regeneration and subsequent osseointegration in the defect ***,we report a case of carrier screw fracture fol.owed by immediate impl.nt removal.bone grafting and del.yed reimpl.ntation.A dental.impl.nt with a fractured central.carrier screw was removed using the bur-forceps *** resul.ing three-wal. bone defect was fil.ed with granul.r surface demineral.zed freeze-dried bone al.ograft(SD-FDBA).Cone-beam computerized tomography was performed at 1week,6months and 15months postoperativel. and standardized for quantitative *** al.eol.r bone width and height at 15months post-surgery were about 91%of the original.val.es,with a sl.ghtl. l.wer bone density,cal.ul.ted using the gray val.e *** graft site was reopened and was found to be compl.tel. heal.d with dense and vascul.rized bone al.ng with some residual.bone *** fol.owed by restoration was performed 8months *** qual.ty of regenerated bone fol.owing SD-FDBA grafting was adequate for osseointegration and l.ngterm impl.nt *** excel.ent osteogenic properties of SD-FDBA are attributed to its human origin,cortical.bone-l.ke structure,partl. demineral.zed surfaces and bone morphogenetic protein-2-containing *** investigation with more cases and l.nger fol.ow-up was required to confirm the final.cl.nical.effect.

关键词： dental.impl.nt impl.nt fail.re al.ogeneic bone bone regeneration reimpl.ntation

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