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基于高效分离不皂化物的傅里叶红外光谱结合化学计量学鉴定芝麻油

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光谱学与光谱分析 2021年第1期41卷 319-326页

作者：何文绚林棋闽江学院材料工程系中国漆新型材料工程研究中心福建福州350108

芝麻油是日常生活中常用食用油之一,掺假芝麻油会导致严重的健康问题。研究芝麻油鉴定方法是非常重要的。皂化植物油提取不皂化物是食用油鉴定的经济方法之一,现有植物油皂化方法需要较长时间,较高的温度,且不皂化物提取过程非常繁琐。... 详细信息

芝麻油是日常生活中常用食用油之一,掺假芝麻油会导致严重的健康问题。研究芝麻油鉴定方法是非常重要的。皂化植物油提取不皂化物是食用油鉴定的经济方法之一,现有植物油皂化方法需要较长时间,较高的温度,且不皂化物提取过程非常繁琐。采用超声技术替代常规回流加热法,提高了皂化效率,皂化时间缩短至10分钟,在此基础上采用专用固相萃取(SPE)小柱快速分离不皂化物。基于分离富集得到的植物油不皂化物红外光谱,结合化学计量学方法进行芝麻油鉴定。利用偏最小二乘判别分析(PLS-DA)和正交偏最小二乘判别分析(OPLS-DA)构建芝麻油鉴定模型。分析结果表明:所构建的芝麻油鉴定模型,OPLS-DA模型优于PLS-DA模型;OPLS-DA模型对芝麻油检验集样本预测准确率高。基于植物油不皂化物红外光谱结合化学计量学方法可以准确鉴定芝麻油。

关键词：芝麻油不皂化物鉴定 FT-IR PLS-DA OPLS-DA

Disposable circumcision suture device： clinical effect and patient satisfaction

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Asian Journal of Andrology 2014年第3期16卷 453-456页

作者： Bo-Dong Lv Shi-Geng Zhang xuan-wen Zhu Jie Zhang Gang Chen Min-Fu Chen Hong-Liang Shen Zai-Jun Pei Zhao-Dian Chen The First Affiliated Hospital of Zhejiang University Zhejiang Hangzhou Departments of Urology The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou Department of Urology People's Hospital of Anji County Huzhou Department of Urology Traditional Chinese Medical Hospital of Deqing County Huzhou Department of Urology Traditional Chinese Medical Hospital of Tongxiang County Jiaxing China

In our experience patients undergoing circumcision are mostly concerned about pain and penile appearances. We conducted a prospective randomized trial to assess the benefits of a new disposable circumcision suture device （DCSD）. A total of 942 patients were equally divided into three groups （conventional circumcision, Shang ring and disposable suture device group）. Patients in the DCSD group were anesthetized with compound 5% lidocaine cream, the others with a 2% lidocaine penile block. Operation time, intra-operative blood loss, incision healing time, intra-operative and post-operative pain, the penile appearance and overall satisfaction degree were measured. Operation time and intra-operative blood loss were significantly lower in the Shang ring and suture device groups compared to the conventional group （P 〈 0.001）. Intra-operative pain was less in the suture device group compared With the other two groups （P 〈 0.001）; whereas post-operative pain was higher in the conventional group compared to the other two groups （P 〈 0.001）. Patients in the suture device （80.57%） and Shang ring （73,57%） groups were more satisfied with penile appearances compared with the conventional circumcision group （20.06%, P 〈 0.05）. Patients in suture device group also healed markedly faster than the conventional group （P 〈 0.01）. The overall satisfaction rate was better in the suture device group （78.66%） compared with the conventional （47.13%） and Shang ring （50.00%） groups （P 〈 0.05）. The combination of DCSD and lidocaine cream resulted in shorter operation and incision healing times, reduced intra-operative and post-operative pain and improved patient satisfaction with the cosmetic appearances.

关键词： circumcision disposable circumcision suture device patient satisfaction penis appearance pre-operative and post-operative pain Shang ring ~

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中国企业跨国经营的模式转型与风险

国际经济合作 2007年第6期 18-21页

作者：文轩对外经济贸易大学

改革开放以来,中国企业经历了一段渐进式的主要是内向化的跨国经营后,正面临由内向化向外向化、由非股权性向股权性跨国经营的转型。这一转型是发展的必然结果,但我们同时要认识到,在这一过程中,想要“走出去”的中国企业将面临来自于... 详细信息

改革开放以来,中国企业经历了一段渐进式的主要是内向化的跨国经营后,正面临由内向化向外向化、由非股权性向股权性跨国经营的转型。这一转型是发展的必然结果,但我们同时要认识到,在这一过程中,想要“走出去”的中国企业将面临来自于目标国和母国,以及资本市场和企业自身的语言文化、法律习俗、政治和经济等方面的种种困难和风险。

关键词：跨国经营转型风险

COMPSTAT: An Effective Results-Based Public Management Strategy?

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COMPSTAT: An Effective Results-Based Public Management Strat...

Mass spectrometry profiling analysis enables the identification of new modifications in ribosomal RNA

2007 International Conference on Public Administration（ICPA 3rd）

作者： wen xuan-yu Byron E.PRICE Rutgers University Newark USA

Since 1990s, advocated by the proponents of NPM （New public Management）, private sector management techniques and strategies have been introduced and adopted in governments in the U.S and around the world. It is believed that techniques and strategies such as computerized information system, performance measurement, results-based strategic management and organizational decentralization can cure the pathologies of public bureaucracy, improve government efficiency, effectiveness, and restore public trust toward government. After 10 years’ adoption and implementation, systematic reflection and evaluation on the effectiveness of those techniques and strategies are emerging. In this article, COMPSTAT, a goal oriented, results based, strategic management system initiated and adopted in the New York Police Department （NYPD） and "the most successful manifestations and applications of the tenets of NPM", is examined. After introducing its history, its philosophy and principles, and its constitutive elements, controversies over COMPSTAT such as its paradigmatic status, its effectiveness, i.e., its actual contribution to the dramatic crime reduction in NYC and its management scandals, are presented and discussed. At the end, suggestions for the further improvement of COMPSTAT are provided. It is revealed that though with great potentials, without scrutiny, deliberation and scrupulous implementation techniques and management strategies recommended by NPM do not necessarily achieve what it is supposed to achieve in public sector.

关键词： COMPSTAT NPM Information technology Strategic management Policing innovation

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Chinese Chemical Letters 2023年第3期34卷 157-161页

作者： Xiao-Meng Tang Tian-Tian Ye Xue-Jiao You Xiao-Ming Yin Jiang-Hui Ding wen-xuan Shao Meng-Yuan Chen Bi-Feng Yuan Yu-Qi Feng Sauvage Center for Molecular Sciences Department of ChemistryWuhan UniversityWuhan 430072China School of Public Health Wuhan UniversityWuhan 430071China

Ribosomal RNAs(rRNAs) provide the structural framework of ribosomes and play critical roles in protein *** ribosome biogenesis,rRNAs acquire various modifications that can influence the structure and catalytic activity of ***,rRNA modifications in plants have yet to be fully ***,we proposed a method to purify rRNAs by a successive isolation with different strategies,including poly A-based m RNA depletion and agarose gel electrophoresis-based purification,with which highly pure rRNAs could be *** addition,we developed a liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS) method to systematically profile and characterize modifications from the isolated highly pure plant 18S rRNA and 25S ***-ESI-MS/MS analysis showed that 10 and 12 kinds of modifications were present in plant 18S rRNA and 25S rRNA,***,among these identified modifications,2 kinds of modifications of N^(2),N^(2)-dimethylguanosine(m^(2,2)G)and N^(6),N^(6)-dimethyladenosine(m^(6,6)A) in 18S rRNA,and 4 kinds of modifications of m^(2,2)G,m^(6,6)A,N7-methylguanosine(m^(7)G) and 3-methyluridin(m^(3)U) in 25S rRNA,were first reported to be present in ***,exposure of Arabidopsis thaliana to cadmium(Cd) led to significant changes of modifications in both 18S rRNA and 25S rRNA of plants,indicating that rRNA modifications play important roles in response to environmental *** discovery of new modifications in plant rRNAs improves the spectra of plant rRNA modifications and may promote the investigation of the functional roles of plant ribosomes in regulating gene expression.

关键词： Ribosomal RNA RNA modification Plant Arabidopsis thaliana Profiling Mass spectrometry

油中溶解丙酮的银纳米线-金纳米星SERS检测

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光谱学与光谱分析 2024年第12期44卷 3473-3479页

作者：罗文萱万福华北电力大学(保定) 河北保定071003 输变电装备技术全国重点实验室(重庆大学电气工程学院) 重庆400044

油纸绝缘设备是电力系统中的关键设备之一,准确掌握电气设备油纸绝缘老化状态,是保证电网安全生产的重要因素之一。丙酮是绝缘纸老化的重要指标,快速、灵敏、准确地测定绝缘油中溶解丙酮含量,对评估油-纸绝缘系统的老化具有重要意义。... 详细信息

油纸绝缘设备是电力系统中的关键设备之一,准确掌握电气设备油纸绝缘老化状态,是保证电网安全生产的重要因素之一。丙酮是绝缘纸老化的重要指标,快速、灵敏、准确地测定绝缘油中溶解丙酮含量,对评估油-纸绝缘系统的老化具有重要意义。通过离子溅射法成功在硅-金(Si-Au)膜表面制备了银纳米线(AgNWs)-金纳米星(AuNSts)表面增强拉曼散射(SERS)基底,并将其用于快速评估绝缘油中丙酮的含量。根据扫描电子显微镜显示的基底进行形貌表征表明:在比表面积较大的AgNWs表面溅射小尺寸的金纳米颗粒,形成的双金属星环绕结构既可以有效提高表面等离激元共振,又可以为AgNWs提供了一层保护屏障,使得基底整体的抗氧化性能显著增加。SERS检测结果表明:相较于Si-Au,Si-Au-AgNWs,Si-AgNWs-AuNSts基底,Si-Au-AgNWs-AuNSts的SERS性能更优异,采用水(H2O)萃取后,绝缘油中溶解丙酮的最低检测限为40 mg·L^(-1)。且基底具有较高的一致性和稳定性,RSD值为4.87%,30 d后目标峰信号仅仅衰减了6.14%。该方法为实现油中溶解丙酮高可靠现场检测提供了一种有效途径。

关键词：银纳米线金纳米星丙酮绝缘油 SERS

Surgical treatment of a rare case of penile squamous cell carcinoma in a 65-year-old man

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Asian Journal of Andrology 2007年第2期9卷 271-273页

作者： xuan-wen Zhu Fang-Yin Li Qing-Wei He Yi-Min Wang Department of Urology First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China

Penile squamous cell carcinoma has been commonly reported in the past decades. We describe a rare case of a huge squamous cell Carcinoma of the penis in a 65-year-old patient with a 4-year history of tumor growth, for which total penectomy, perineal urethrostomy and bilateral inguinal lymphadenectomy were carried out. We suggest that aggressive surgical intervention should be recommended for those with well-differentiated penile carcinoma regardless of the size of the tumor.

关键词： penis penile carcinoma inguinal lymphadenotomy

Discovery of 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine as Novel Cyclin-dependent Kinases 4 and 6 Dual Inhibitors via 3D-QSAR and Molecular Simulation

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Chinese Journal of Structural Chemistry 2022年第3期41卷 108-124,I0010页

作者： FU Le ZHAO Li-Nan GUO Hong-Mei YU Na QUAN wen-xuan CHEN Yi SHU Mao WANG Rui LIN Zhi-Hua School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Qianjiang Central Hospital of Chongqing Chongqing 409099China

Cyclin D dependent kinases 4/6 regulate the entry of cells into S phase and are effective target for the discovery of anticancer *** this article,3D-QSAR modeling including comparative molecular field analy-sis(CoMFA)and comparative molecular similarity indices analysis fields(CoMSIA)was implemented on 52 dual CDK4/6 *** a result,we obtained a pretty good 3D-QSAR model,which is CoMFACDK4 with q2 to be 0.543 and r^(2) to be 0.967;CoMSIACDK4 with q2 being 0.518 and r^(2) being 0.937;CoMFACDK6 with q2 to be 0.624 and r^(2) to be 0.984;CoMSIACDK6 with q2 being 0.584 and r^(2) being *** docking confirmed the important residues for *** dynamics simulation further confirmed binding affinity with key residues of protein,such as Lys22,Lys35,Val96 for CDK4 and Lys43,His100,Val101 for CDK6 at the active *** these results offered new directions to explore new inhibitors of CDK4/***,we designed 10 novel compounds with promising expected activity and ADME/T properties,and provided referable synthetic routes.

关键词： cyclin-dependent kinases 4 and 6 dual inhibitors 3D-QSAR drug design molecular simulation

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最小化预测残差的图像序列压缩感知

光学精密工程 2012年第9期20卷 2095-2102页

作者：石文轩李婕武汉大学电子信息学院湖北武汉430072

提出了一种最小化预测残差的图像序列压缩感知算法以实现高速相机输出图像的实时压缩。首先,在编码端仅使用映射矩阵对原始输出图像进行压缩,将压缩得到的观测向量通过信道传输到解码端。接着,在解码端对相邻帧进行运动估计和运动补偿,... 详细信息

提出了一种最小化预测残差的图像序列压缩感知算法以实现高速相机输出图像的实时压缩。首先,在编码端仅使用映射矩阵对原始输出图像进行压缩,将压缩得到的观测向量通过信道传输到解码端。接着,在解码端对相邻帧进行运动估计和运动补偿,得到一幅待重建图像的预测图像,利用压缩感知算法对原始图像和预测图像之间存在的预测残差图像进行重建。最后,用迭代的方法优化预测残差图像的重建结果,直到连续两次的重建结果之差小于设定阈值,从而获得重建的原始图像。采用DALSA公司的CR-GEN0-H6400相机进行的实验表明,该算法可以实现1 000frame/s图像的实时压缩,并且图像重建质量比独立地重建每张图像至少提高了2～6dB,有效地实现了对高速相机输出图像的实时压缩与高质量重建。

关键词：压缩感知实时压缩图像重建预测残差