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World Journal of Clinical Oncology 2025年第2期16卷 165-172页

作者： xuan guo Yan Liu Yu-Ting Wang Kan Liu Hui Ding Department of Pulmonary and Critical Care Medicine Yixing People’s Hospital of Jiangsu UniversityYixing 214200Jiangsu ProvinceChina

BACKGROUND Through deeper understanding of targetable driver mutations in non-small-cell lung cancer(NSCLC)over the past years,some patients with driver mutations have benefited from the targeted molecular *** the anaplastic lymphoma kinase and BRAF mutations are not frequent subtypes in NSCLC,the availability of several targeted-drugs has been confirmed through a series of clinical *** little is clear about the proper strategy in rare BRAF G469A mutation,not to mention co-exhibition of anaplastic lymphoma kinase and BRAF G469A mutations,which is extremely rare in *** SUMMARY We present a patient to stage IVA lung adenocarcinoma with coexisting echinoderm microtubule associated protein like-4 rearrangement and BRAF G469A *** received several targeted drugs with unintended resistance and suffered from unbearable adverse *** Due to the rarity of co-mutations,the case not only enriches the limited literature on NSCLC harbouring BRAF G469A and echinoderm microtubule associated protein like-4 mutations,but also suggests the efficacy and safety of specific multiple-drug therapy in such patients.

关键词： Non-small-cell lung cancer Driver mutation Rearrangement Resistance Case report

Pointer-prototype fusion network for few-shot named entity recognition

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The Journal of China Universities of Posts and Telecommunications 2023年第5期30卷 32-41页

作者： Zhao Haiying guo xuan School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China School of Computer Science Beijing University of Posts and TelecommunicationsBeijing 100876China

Few-shot named entity recognition(NER)aims to identify named entities in new domains using a limited amount of annotated *** methods divided this task into entity span detection and entity classification,achieving good *** these methods are limited by the imbalance between the entity and non-entity categories due to the use of sequence labeling for entity span *** this end,a point-proto network(PPN)combining pointer and prototypical networks was ***,the pointer network generates the position of entities in sentences in the entity span detection *** prototypical network builds semantic prototypes of entity types and classifies entities based on their distance from these prototypes in the entity classification ***,the low-rank adaptation(LoRA)fine-tuning method,which involves freezing the pre-trained weights and injecting a trainable decomposition matrix,reduces the parameters that need to be trained and *** experiments on the few-shot NER Dataset(Few-NERD)and Cross-Dataset demonstrate the superiority of PPN in this domain.

关键词： few-shot named entity recognition(NER) pointer network prototypical network low-rank adaptation

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BAM: A Block-Based Bayesian Method for Detecting Genome-Wide Associations with Multiple Diseases

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Tsinghua Science and Technology 2020年第5期25卷 678-689页

作者： Guanying Wu xuan guo Baohua Xu the Dental Center of China-Japan Friendship Hospital Beijing 100029China the Department of Computer Science and Engineering University of North TexasDentonTX 76203USA

Many human diseases involve multiple genes in complex *** Genome-Wide Association Studies (GWASs) have been considered to hold promise for unraveling such ***,statistic tests for high-order epistatic interactions (≥2 Single Nucleotide Polymorphisms (SNPs)) raise enormous computational and analytical *** is well known that the block-wise structure exists in the human genome due to Linkage Disequilibrium (LD) between adjacent *** this paper,we propose a novel Bayesian method,named BAM,for simultaneously partitioning SNPs into LD-blocks and detecting genome-wide multi-locus epistatic interactions that are associated with multiple *** results on the simulated datasets demonstrate that BAM is powerful and *** also applied BAM on two GWAS datasets from WTCCC,i.e.,Rheumatoid Arthritis and Type 1 Diabetes,and accurately recovered the LD-block ***,we believe that BAM is suitable and efficient for the full-scale analysis of multi-disease-related interactions in GWASs.

关键词： disease association study epistasis Linkage Disequilibrium(LD)block Bayesian methods

Water and partial melting of Earth's mantle

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Science China Earth Sciences 2016年第4期59卷 720-730页

作者： NI HuaiWei ZHANG Li guo xuan Chinese Academy of Sciences Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of China

Water plays a crucial role in the melting of Earth's mantle. Mantle magmatisms mostly occur at plate boundaries(including subduction zones and mid-ocean ridges) and in some intraplate regions with thermal anomaly. At oceanic subduction zones, water released by the subducted slab may induce melting of the overlying mantle wedge or even the slab itself, giving rise to arc magmatism, or may evolve into a supercritical fluid. The physicochemical conditions for the formation of slab melt and supercritical fluid are still under debate. At mid-ocean ridges and intraplate hot zones, water and CO_2 cause melting of the upwelling mantle to occur at greater depths and in greater extents. Low degree melting of the mantle may occur at boundaries between Earth's internal spheres, including the lithosphere-asthenosphere boundary(LAB), the upper mantletransition zone boundary, and the transition zone-lower mantle boundary, usually attributed to contrasting water storage capacity across the boundary. The origin for the stimulating effect of water on melting lies in that water as an incompatible component has a strong tendency to be enriched in the melt(i.e., with a mineral-melt partition coefficient much smaller than unity), thereby lowering the Gibbs free energy of the melt. The partitioning of water between melt and mantle minerals such as olivine, pyroxenes and garnet has been investigated extensively, but the effects of hydration on the density and transport properties of silicate melts require further assessments by experimental and computational approaches.

关键词： Water Mantle Partial melting Silicate melts Partition coefficient Supercritical fluid

Electrical conductivity of hydrous silicate melts and aqueous fluids: Measurement and applications

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Science China Earth Sciences 2016年第5期59卷 889-900页

作者： guo xuan CHEN Qi NI HuaiWei CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space Sciences University of Science and Technology of China

The combination of magnetotelluric survey and laboratory measurements of electrical conductivity is a powerful approach for exploring the conditions of Earth's deep interior. Electrical conductivity of hydrous silicate melts and aqueous fluids is sensitive to composition, temperature, and pressure, making it useful for understanding partial melting and fluid activity at great depths. This study presents a review on the experimental studies of electrical conductivity of silicate melts and aqueous fluids, and introduces some important applications of experimental results. For silicate melts, electrical conductivity increases with increasing temperature but decreases with pressure. With a similar Na^+ concentration, along the calc-alkaline series electrical conductivity generally increases from basaltic to rhyolitic melt, accompanied by a decreasing activation enthalpy. Electrical conductivity of silicate melts is strongly enhanced with the incorporation of water due to promoted cation mobility. For aqueous fluids, research is focused on dilute electrolyte solutions. Electrical conductivity typically first increases and then decreases with increasing temperature, and increases with pressure before approaching a plateau value. The dissociation constant of electrolyte can be derived from conductivity data. To develop generally applicable quantitative models of electrical conductivity of melt/fluid addressing the dependences on temperature, pressure, and composition, it requires more electrical conductivity measurements of representative systems to be implemented in an extensive P-T range using up-to-date methods.

关键词： Silicate melts Aqueous fluids Electrical conductivity Laboratory measurement Partial melting

A Survey of SNP Data Analysis

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Big Data Mining and Analytics 2018年第3期1卷 173-190页

作者： Xiaojun Ding xuan guo School of Computer Science and Engineering Yulin Normal University School of Information Engineering Jiangxi University ofScience and Technology Department of Computer Science and Engineering University of North Texas

Every person differs from every other person regarding their physical appearance, susceptibility to disease, response to medications, and so on. However, 99.9 percent of human DNA is the same. As such,differences in human genomes are very worthy of study. Single-Nucleotide Polymorphisms(SNPs) are the simplest form and most common source of genetic polymorphism. SNPs have been used to successfully identify defective genes that cause Mendelian diseases. However, most common human diseases are complex and are caused by multiple SNPs. Each SNP explains only a small fraction of genetic causes. Experiments on individual SNPs may reveal their non-detectable effects on complex diseases. Pathogenesis is a complicated topic, and it is difficult to correctly predict multiple SNPs. As such, the analysis of SNP data is a critical task in the study of genetic *** this paper, we divide the methods for genome-wide SNP data analysis into two categories: single-trait GenomeWide Association Studies(GWAS) in which pathology is mined from data of a single phenotype, and multiple-trait GWAS which identifies cross-phenotype associations. For single-trait GWAS, we review methods ranging from the simple to the complex, including TEAM, BOOST, AntEpiSeeker, SNPRuler, EDCF, HiSeeker, ORF, MLR-tagging,MSCD, and MIC. For multiple-trait GWAS, we describe methods in terms of their employed regression models,dimension-reduction methods, and meta-analysis methods. We also list the advantages and disadvantages of these methods. Finally, we discuss the future directions of SNP data analysis for genome-wide association.

关键词： SNP interactions SNP combinations GWAS case-control study disease association analysis cross phenotype association studies

Evaluation of the Interface Between Two Plates by the Lamb Wave

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Chinese Physics Letters 2001年第11期18卷 1483-1486页

作者： WANG Xiao-Min LIAN guo-xuan LI Ming-xuan Institute of Acoustics Chinese Academy of SciencesBeijing 100080

A new expression of the dispersion equation of the Lamb wave in an adhesive two-layered plate is presented. The bond rigidity of the adhesive plate is accounted for in terms of a spring model. The influence of the variations of the compliance constants of the spring on the dispersion feature of Lamb modes is numerically studied. The numerical results indicate that the deterioration of the bond rigidity may cause the phase velocity decrease and the frequency-shift for a given Lamb mode, thus having a possibility for the evaluation of the bonding state of the adhesive plate by using ultrasonic wave velocity measurements. The phase-tracing method is used to measure the phase velocities experimentally and the results for an adhesive plate of aluminium-aluminium are given to verify the theoretical predictions.

关键词： plate rigidity dispersion

Electrical conductivity of melts: implications for conductivity anomalies in the Earth's mantle

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National Science Review 2021年第11期8卷 133-151页

作者： Bao-Hua Zhang xuan guo Takashi Yoshino Qun-Ke Xia Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province School of Earth Sciences Zhejiang University CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space Sciences University of Science and Technology of China Institute for Planetary Materials Okayama University

Magmatic liquids,including silicate and carbonate melts,are principal agents of mass and heat transfer in the Earth and terrestrial planets,and they play a crucial role in various geodynamic processes and in Earth’s *** conductivity data of these melts elucidate the cause of electrical anomalies in Earth’s interior and shed light on the melt *** the improvement in high-pressure experimental techniques and theoretical simulations,major progress has been made on this front in the past several *** review aims to summarize recent advances in experimental and theoretical studies on the electrical conductivity of silicate and carbonate melts of different compositions and volatile contents under high temperature and *** electrical conductivity of silicate melts depends strongly on temperature,pressure,water content and the ratio of non-bridging oxygens to tetrahedral cations(NBO/T).By contrast,the electrical conductivity of carbonate melts exhibits a weak dependence on temperature and pressure due to their fully depolymerized *** electrical conductivity of carbonate melts is higher than that of silicate melts by at least two orders of *** can increase electrical conductivity significantly and reduce the activation energy of silicate ***,this effect is weak for carbonate *** addition,the replacement of alkali-earth elements(Ca2+or Mg2+) with alkali elements causes a significant decrease in the electrical conductivity of carbonate melts.A distinct compensation trend is revealed for the electrical conductivity of silicate and carbonate melts under anhydrous and hydrous *** important applications of laboratory-based melt conductivity are introduced in order to understand the origin of high-conductivity anomalies in the Earth’s *** for future studies are also provided.

关键词： electrical conductivity silicate melt carbonate melt high-conductivity anomaly Earth's mantle

A DUAL-SURFACE DAMAGE MODEL AND EVALUATION FOR NATURAL SOILS WITHIN THE THERMOMECHANICAL FRAMEWORK

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Acta Mechanica Solida Sinica 2008年第1期21卷 85-94页

作者： xuan guo Chenggang Zhao Dajun Yuan Mengshu Wang Tunnel and Underground of Engineering Experienmental Research Center Beijing Jiaotong University Beijing 100044 China School of Civil Engineering ＆ Architecture Beijing Jiaotong University Beijing 100044 China

Naturally deposited or residual soils exhibit more complicated behavior than remolded clays. A dual-surface damage model for structured soils is developed based on the thermodynamics framework established in our first paper. The shift stresses and the transformation between the generalized dissipative stress space and actual stress space are established following a systematic procedure. The corresponding constitutive behavior of the proposed model is determined, which reflects the internal structural configuration and damage behavior for geomaterials. Four evolution variables κj^i（i=D, R;j=V, S） and the basic parameters λ, s, v and e0 are introduced to account for the progressive loss of internal structure for natural clays. A series of fully triaxial tests and isotropic compression tests are performed for structured and reconstituted samples of Beijing and Zhengzhou natural clays. The validation of the proposed model is examined by comparing the numerical results with the experimental data.

关键词： dual-surface damage model triaxial tests structured soils thermomechanical approach compressibility

A THERMOMECHANICAL DAMAGE APPROACH TO CONSTITUTIVE MODELS FOR RATE-INDEPENDENT DISSIPATIVE GEOMATERIALS

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Acta Mechanica Solida Sinica 2008年第1期21卷 73-84页

This paper builds the formulations of hyperplastic damage theory for rate-independent geomaterials to describe the bulk and the likely damage behavior of granular materials. Using 2 kinematic internal variables and the conjugates, dissipative and yield function can be reasonably introduced. A systematic constitutive presentation of 32 possible ways within the thermodynamical damage framework is presented, which entirely formulates the constitutive behavior through two scalar thermodynamic potentials. Combining the four common thermodynamical energy functions, two independent kinematic internal variables and the accordingly generalized stress are introduced to describe the damage behavior and structural rearrangement of the granules for any bulk deformation. A few Legendre transformations are used to establish the links between energy functions so that the complex incremental response of geomaterials can be entirely established from these four energy functions. The constitutive relations are built with the thermodynamics laws, which account for the important structural aspects of geomaterials. Some examples axe provided in the appendix to validate the applicability and implementation of the framework. This theory is based on previous work by Houlsby et al., and extends to the multi-mechanisms description. This framework paves a way in developing models for specific geomaterials with an examinable basis.

关键词： thermomechanical damage approach hyperplastic energy dissipation