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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin xu Jingyi Yang Li Zhou Lin Liu Min Li Shasha wang mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

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Effect of exogenous free N^(ε)-(carboxymethyl)lysine on diabetes-associated cognitive dysfunction:neuroinflammation,and metabolic disorders

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Food Science and Human Wellness 2024年第5期13卷 2970-2981页

作者： Huang Zhang Lan Mo Xi Chen mei Li Maiquan Li Yang xu Maomao Zeng Zhiyong He Qingwu Shen Jie Chen Wei Quan College of Food Science and Technology Hunan Agricultural UniversityChangsha 410128China Henan University of Animal Husbandry and Economy Zhengzhou 450046China College of Food Science and Engineering Northwest A&F UniversityYangling 712100China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China

Diabetes-associated cognitive dysfunction has already been attracted considerable *** glycation end products(AGEs)from daily diets are thought to be a vital contributor to the development of this ***,the effect of one of the best-characterized exogenous AGEs N^(ε)-(carboxymethyl)lysine(CML)on cognitive function is not fully *** the present study,diabetical Goto-Kakizaki(GK)rats were treated with free CML for *** was found that oral consumption of exogenous CML significantly aggravated diabetes-associated cognitive dysfunction in behavioral *** details,exogenous CML increased levels of oxidative stress,promoted the activation of glial cells in the brain,up-regulated the release of inflammatory cytokines interleukin-6,inhibited the protein expression of the brain-derived neurotrophic factor and thus led to ***,exogenous CML promoted the amyloidogenesis in the brain of GK rats,and inhibited the expression of ***,several tricarboxylic acid cycle and glutamate-glutamine/γ-aminobutyric acid cycle intermediates including pyruvate,succinic acid,glutamine,glutamate were significantly changed in brain of GK rats treated with exogenous free *** conclusion,exogenous free CML is a potentially noxious compounds led to aggravated diabetes-associated cognitive dysfunction which could be possibly explained by its effects on neuroinflammation,energy and neurotransmitter amino acid homeostasis.

关键词： Diabetes Cognitive dysfunction N^(ε)-(carboxymethyl)lysine Neuroinflammation Metabolomic

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Brain development in newborns and infants after ECMO

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World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan Lu-Kun Tang Fei-Fan Xiao Peng Zhang Guo-Qiang Cheng Lai-Shuan wang Chun-mei Lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng Zhou Tian-Tian Xiao Yan xu Zhao-Qing Yin Gang-Feng Yan Guo-Ping Lu Qi Li Wen-Hao Zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

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虾青素口服纳米制剂的研究进展

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食品工业科技 2024年第10期45卷 395-400页

作者：仲晨刘梅高焱徐科凤王颖山东省海洋科学研究院山东青岛266104 青岛市水产生物品质评价工程研究中心山东青岛266104

虾青素(Astaxanthin,AST)是一种脂溶性叶黄素类胡萝卜素,具有良好的抗氧化、抗炎和免疫调节活性。然而,因其口服生物利用度较差,临床应用有限。近年来,为了提高虾青素的生物利用度,各种类型的纳米制剂被广泛研究。其中纳米乳液、脂质体... 详细信息

虾青素(Astaxanthin,AST)是一种脂溶性叶黄素类胡萝卜素,具有良好的抗氧化、抗炎和免疫调节活性。然而,因其口服生物利用度较差,临床应用有限。近年来,为了提高虾青素的生物利用度,各种类型的纳米制剂被广泛研究。其中纳米乳液、脂质体、固体脂质纳米颗粒、壳聚糖纳米颗粒和聚乳酸-羟基乙酸聚合物(poly(lactic-co-glycolic acid),PLGA)纳米颗粒已被证明可有效提高虾青素的口服生物利用度。本综述中,基于体外和体内研究数据和结果,总结了不同类型的纳米制剂对于提高虾青素口服生物利用度的研究进展,为今后虾青素口服剂型的开发提供参考,实现其在临床中的应用价值。

关键词：虾青素口服制剂纳米颗粒生物利用度

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Modulated noble metal/2D MOF heterostructures for improved hydrogen storage of MgH_(2)

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Rare Metals 2024年第4期43卷 1672-1685页

作者： Zeng-Yi Li Li-Xian Sun Fen xu Yu-mei Luo Yong-Peng Xia Sheng Wei Chen-Chen Zhang Ri-Guang Cheng Chao-Feng Ye Meng-Yuan Liu Ju-Lan Zeng Zhong Cao Hong-Ge Pan School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of Chemistry and Chemical Engineering Changsha University of Science and TechnologyChangsha410114China Institute of Science and Technology for New Energy Xi’an Technological UniversityXi’an710021China

The conjugation of external species with twodimensional(2D)materials has broad application *** this study,we have explored the potential of noble metal/2D MOF heterostructures in hydrogen ***,the MgH_(2)-Ni-MOF@Pd system has shown remarkable hydrogen desorption/sorption performances,starting to liberate hydrogen at 1810C,which is 2300C lower than that of pristine *** the catalytic effect of Ni-MOF@Pd,the dehydrogenation apparent activation energy of MgH2 is noticeably decreased from(133.5±17.5)to(34.58±1.87)kJ·moL^(-1),and the hydrogenation apparent activation energy is reduced from(70.41±7.43)to(25.78±4.64)kJ·moL^(-1),which is lowered by 63.4%.The fully-dehydrogenated MgH2-NiMOF@Pd composite rapidly uptakes hydrogen,with 2.62wt%at 100℃and 6.06 wt%at 150℃within 300 s,*** mechanism analysis of MgH2 catalyzed by Ni-MOF@Pd has revealed that the transformation of Mg_2Ni and Mg_2NiH_4 could act as a"hydrogen pump",providing numerous channels for fast diffusion and transport of hydrogen ***,in the dehydrogenation process,the element Pd reacts with MgH_(2)to form the MgPd alloy phase,which makes MgH_(2)take precedence to decompose through the Mg-Pd alloy rather than self-decomposition,further reducing thermal stability and improving de/hydrogenation *** synergistic effect of Mg-Pd,Mg_2Ni,and the special ultra-thin 2D sheet structure of the additive is the main reason for the good hydrogen storage property of MgH_(2)-Ni-MOF@*** findings provide inspiration for designing efficient multifunctional additives with unique morphologies to optimize the hydrogen desorption/sorption behaviors of hydrogen storage materials.

关键词： Hydrogen storage Magnesium hydride 2D metal-organic framework nanosheets Ni/Pd Synergistic catalysis

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A comparison of the effect of alendronate and You-Gui-Wan on osteoporosis in female rats with kidney-yang deficiency

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Traditional Medicine Research 2024年第6期9卷 31-41页

作者： mei-mei Wu Xing-Peng He Wan-Ting Wu Wen-Jie Lu Yan-Yang Mai Kun-Cai xu Yao-Feng Zhi Hai-Xin Mo Jia-Di He Xin Zhang Peng-Fei Li Clinical Experimental Center Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational ResearchJiangmen Central HospitalJiangmen 529030China Traumatic Orthopedics Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510470China Department of Intelligent Engineering Guiyang Institute of Information Science and TechnologyGuiyang 550025China

Background:In traditional Chinese medicine,You-Gui-Wan(YGW)is typically used to treat osteoporosis associated with kidney-yang ***,there have been few mechanistic studies on the effectiveness of kidney-yang deficiency-type osteoporosis with *** further clarify the role of YGW in the effect of osteoporosis with kidney-yang deficiency,the study analyzed the therapeutic advantages of YGW by comparing the therapeutic effects of YGW and alendronate(ALN)on osteoporosis with kidney-yang ***:SPF female SD rats were randomly divided into control,osteoporosis,osteoporosis with kidney-yang deficiency,osteoporosis with kidney-yang deficiency+YGW and osteoporosis with kidney-yang deficiency+ALN *** for the control group,osteoporosis was induced by the removal of bilateral *** 12 weeks,rats with osteoporosis in the kidney-yang deficiency group had kidney-yang deficiency syndrome triggered by hydrocortisone for 14 *** were treated with YGW or ALN for 12 *** weights of rats were ***-eosin staining staining was used to observe pathological changes in bone trabeculae,liver,spleen,and kidneys of *** of the growth plate cartilage of rats in different groups was observed by safranine-O *** expression of osteoclast key indices(ACP)and osteoblast key indices(ALP)in the bone tissue of rats in the different groups was observed by immunohistochemical *** expression of bone resorption-related indicators(TRAP and NXT-1),bone formation-related indicators(BALP,BGP,and P1NP),and major indicators of kidney-yang deficiency(ACTH,T3,T4,cAMP,and cGMP)were observed using an ELISA detection *** expression levels of the main indices of liver function(ALT and AST)were detected in different ***:The differences between the osteoporosis with kidney-yang deficiency group and osteoporosis group were that the weight of rats and the expression of ACTH,T3,T4,and cAMP decreased significantl

关键词： osteoporosis kidney-yang deficiency You-Gui-Wan alendronate

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Experimental and simulation study on shear stress-induced erythrocyte damage based on vortex oscillator

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Biomedical Engineering Communications 2024年第1期3卷 23-30页

作者： xu.mei Li-Pu Zhao Lian Hou Ying-Ying Zhong State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Mechanical and Electrical Engineering Silicon Lake Vocational and Technical CollegeSuzhou 215006China College of Education Central China Normal UniversityWuhan 430079China

Background:Shear stress-induced erythrocyte damage,namely hemolysis,is an important problem in the development of blood-contacting medical devices such as mechanical circulatory support *** fluid dynamics simulation combined with hemolysis prediction models have been widely used to predict *** the development of hemolysis prediction models,the new hemolysis prediction model requires more experimental data to *** addition,the difference of in vitro blood-shearing device also affect the accuracy of hemolysis ***:To address these problems,a new in vitro blood-shearing device(vortex oscillator)was used to further verify the accuracy of the hemolysis prediction models,and to guide the optimal design of blood-contacting medical devices such as mechanical circulatory support ***,the flow field information such as wall stress and velocity of the vortex oscillator under different speeds was ***,different hemolysis prediction models were used to calculate hemolysis,and the predicted data was compared with the experimental *** and Conclusion:In this study,the flow field information inside the vortex oscillator at high rotational speeds was systematically investigated,and the prediction of hemolysis was carried *** results showed that the predicted data of hemolysis was significantly different from the experimental data,which indicated that it was urgent to establish a standardized in vitro blood-shearing platform to provide a reference for accurate hemolysis prediction.

关键词： CFD Hemolysis prediction model Vortex oscillator Shear stress

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Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

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Oncology Research 2024年第2期32卷 339-351页

作者： JUAN SHEN WEIYU ZHANG QINQIN JIN FUYU GONG HEPING ZHANG HONGLIANG xu JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE mei YANG SONG SHUGUANG ZHOU School of Big Data and Artificial Intelligence Anhui Xinhua UniversityHefei230088China Department of Gynecology and Obstetrics Maternity and Child Healthcare Hospital Affiliated to Anhui Medical UniversityAnhui Province Maternity and Child Healthcare HospitalHefei230001China Department of Gynecology and Obstetrics The Fifth Clinical College of Anhui Medical UniversityHefei230032China Departments of Breast Surgery Fuyang Women and Children’s HospitalFuyang236000China Departments of Pathology Anhui Province Maternity and Child Health HospitalHefei230001China Department of Pain The First Affiliated Hospital of Anhui Medical UniversityHefei230032China Department of Gynecology and Obstetrics Linquan Maternity and Child Healthcare HospitalFuyang236400China

Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of ***,it is critical to identify novel biomarkers for the prognostic assessment of ***:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO ***1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western *** sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell ***,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA *** application of the nomogram was further validated in an immunotherapy ***:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA ***,PLK1 expression level,age and stage were identified as independent prognostic factors of *** the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low *** also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA *** addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive ***:PLK1 expression and immune cell infiltration can predict post-immunotherapy pr

关键词： Breast invasive carcinoma(BRCA) Polo-like kinase 1(PLK 1) Random forest(RF) Support vector machine(SVM) Immune infiltration

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Blastic plasmacytoid dendritic cell neoplasm:Two case reports

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World Journal of Clinical Oncology 2024年第9期15卷 1207-1214页

作者： Yi-Qian Ma Zhan Sun Yu-mei Li Hui xu Department of Dermatology The Affiliated Hospital of Jiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND Blastic plasmacytoid dendritic cell tumor(BPDCN)is a rare and highly invasive lymphohematopoietic tumor that originates from plasmacytoid dendritic *** has an extremely poor *** lesions are usually the first manifestation of BPDCN,although the tumor may also invade the bone marrow,lymph nodes,peripheral blood,and other parts of the body,leading to several other manifestations,requiring further differentiation through skin biopsy and *** SUMMARY In the present paper,the cases of 2 patients diagnosed with BPDCN are *** immunohistochemistry analysis of these 2 patients revealed positivity for CD4,CD56,and ***,no standard chemotherapy regimen is available for ***,intensive therapy for acute lymphoblastic leukemia was applied as the treatment method for these 2 *** Although allogeneic bone marrow transplantation could be further effective in prolonging the median survival the ultimate prognosis was *** treatment modalities tailored for elderly patients will help prolong survival.

关键词： Blastic plasmacytoid dendritic cell neoplasm Skin CD4 CD56 CD123 Venetoclax Case report

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2023:A year of accomplishments for the 13 Science Citation Index Expanded-and Emerging Sources Citation Index-indexed Baishideng journals

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World Journal of Gastroenterology 2024年第1期30卷 9-16页

作者： Jin-Lei wang Jia-Ping Yan Jia-Ru Fan Xiang Li xu Guo Jia-Wei Li Yun-Xiaojian Wu Jing-Jie wang Yu-Lu Chen Li Li Cong Lin Xin-Liang Qu Ji-Hong Liu Yan-Liang Zhang Ying-Yi Yuan Hua-Ge Yu Yu-Xi Chen Yi-xuan Cai Xiang-Di Zhang Si Zhao Zi-Hang xu Li Ma Na Ma Diao-mei Guo Lian-Sheng Ma Baishideng Publishing Group Inc PleasantonCA 94566United States

In 2023,Baishideng Publishing Group(Baishideng)routinely published 47 openaccess journals,including 46 English-language journals and 1 Chinese-language *** successes were accomplished through the collective dedicated efforts of Baishideng staffs,Editorial Board Members,and Peer *** these 47 Baishideng journals,7 are included in the Science Citation Index Expanded(SCIE)and 6 in the Emerging Sources Citation Index(ESCI).With the support of Baishideng authors,company staffs,Editorial Board Members,and Peer Reviewers,the publication work of 2023 is about to be successfully *** editorial summarizes the 2023 activities and accomplishments of the 13 SCIEand ESCI-indexed Baishideng journals,outlines the Baishideng publishing policy changes and additions made this year,and highlights the unique advantages of Baishideng journals.

关键词： Baishideng Publishing Group Journal Impact Factor Open access Policy changes Policy additions Unique advantages Anxiety disorders Colorectal cancer Inflammatory bowel disease Hepatocellular carcinoma Gut microbes Atrial fibrillation

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