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冲击拦阻力计算及车架结构的瞬态分析

机械设计与制造 2024年第4期398卷 71-76,80页

作者：许云华张建永丰申王发展西安建筑科技大学机电工程学院陕西西安710055

针对采用撞击试验法来测试钢索拦阻系统的可靠性问题,这里首次基于能量法建立了轨道车拦阻动力学模型。对不同指标及不同运行速度下冲击拦阻力的变化规律进行了分析,并给出了用于描述轨道车冲击拦阻力的具体表达式。在此基础上,对不同... 详细信息

针对采用撞击试验法来测试钢索拦阻系统的可靠性问题,这里首次基于能量法建立了轨道车拦阻动力学模型。对不同指标及不同运行速度下冲击拦阻力的变化规律进行了分析,并给出了用于描述轨道车冲击拦阻力的具体表达式。在此基础上,对不同工况下的车架进行瞬态响应分析。结果表明:在撞击初期,冲击拦阻力Fx增长迅速,当轨道车位移一定距离后,Fx增长缓慢或保持不变,直到轨道车被安全拦停;车架的前心盘以及中梁与撞击梁交界处是应力集中的区域,容易出现破坏;车架在相同撞击初速度下,使拦停距离最短的车架形变量比使最大钢索拉力值为最小的车架形变量明显要大。

关键词：能量法轨道车冲击拦阻力瞬态响应分析

Supplementary motor area deactivation impacts the recovery of hand function from severe peripheral nerve injury

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Neural Regeneration Research 2016年第4期11卷 670-675页

作者： Ye-chen Lu Han-qiu Liu xu-yun hua yun-dong Shen Wen-dong xu Jian-guang xu Yu-dong Gu Department of Hand Surgery Huashan HospitalFudan University Department of Radiology Huashan HospitalFudan University State Key Laboratory of Medical Neuroscience Fudan University

Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve *** is believed that the capability of brain plasticity is crucial for the recovery of hand *** supplementary motor area may play a key role in brain remodeling after peripheral nerve *** this study,we explored the activation mode of the supplementary motor area during a motor imagery *** investigated the plasticity of the central nervous system after brachial plexus injury,using the motor imagery *** from functional magnetic resonance imaging showed that after brachial plexus injury,the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor *** result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task,thereby impacting brain *** of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing,initiating and executing certain movements,which may be partly responsible for the unsatisfactory clinical recovery of hand function.

关键词： nerve regeneration peripheral nerve injury brachial plexus injury neuronal plasticity supplementary motor area premotor area magnetic resonance imaging motor preparation motor imagery clinical restoration of hand function cortical remodeling block design neural regeneration

资源赋能国有企业关键核心技术突破的机制与路径——基于资源编排理论视角下的探索性案例研究

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湖北经济学院学报 2024年第1期22卷 54-66页

作者：王文海黄紫微许云华安徽财经大学工商管理学院安徽蚌埠233000

基于资源编排理论,采用纵向单案例研究方法,对中建材玻璃新材料研究总院2000-2023年从技术追随者到领导者的关键核心技术攻关实践展开深入研究。研究发现:案例企业经历了技术跟跑、技术并跑和技术领跑3个阶段,在不同阶段,由不同的动因... 详细信息

基于资源编排理论,采用纵向单案例研究方法,对中建材玻璃新材料研究总院2000-2023年从技术追随者到领导者的关键核心技术攻关实践展开深入研究。研究发现:案例企业经历了技术跟跑、技术并跑和技术领跑3个阶段,在不同阶段,由不同的动因需求驱动资源编排行动,进而构建价值共创模式,最后支撑案例企业实现角色身份的演变。具体而言:(1)技术跟跑阶段,案例企业在为实现国产制造的动因需求下,进行资源建构化,建立起调配式价值共创模式,成为技术追随者;(2)技术并跑阶段,案例企业在为实现国产替代的动因需求下,进行资源能力化,建立起整合式价值共创模式,成为技术参与者;(3)技术领跑阶段,案例企业在为实现国产领导的动因需求下,进行资源杠杆化,建立起共享式价值共创模式,成为技术领导者。由此构建资源赋能国有企业关键核心技术突破的理论框架,不仅推进了资源编排与关键核心技术两个领域的理论研究,还为国有企业实现关键核心技术攻关提供实践启示。

关键词：国有企业资源编排价值共创模式关键核心技术突破

Patterns of cortical reorganization in facial synkinesis:a task functional magnetic resonance imaging study

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Neural Regeneration Research 2018年第9期13卷 1637-1642页

作者： Yin Wang Wei-Wei Wang xu-yun hua Han-Qiu Liu Wei Ding Department of Radiology Huashan HospitalFudan University Shanghai Institution of Medical Imaging Zhongshan HospitalFudan University Department of Hand Surgery Huashan HospitalFudan University Department of Plastic and Reconstructive Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine

Facial synkinesis,a sequela of peripheral facial nerve palsy,is characterized by simultaneous involuntary facial movement during a voluntary desired *** cortical plasticity might be involved in the dysfunction of facial *** cohort study investigated the cortical functional alterations in patients with unilateral facial synkinesis,using the task functional magnetic resonance *** motor tasks,including blinking and smiling,were performed by 16 patients（aged 30.6 ± 4.5 years,14 females/2 males） and 24 age-and sex-matched healthy controls（aged 29.1 ± 4.2 years,19 females/5 males）.Results demonstrated that activation in the cortico-facial motor representation area was lower during tasks in patients with facial synkinesis compared with healthy *** movements on either side performed by patients caused more intensive activation of the supplementary motor area on the contralateral side of the affected face,than those on the unaffected *** results revealed that there was cortical reorganization in the primary sensorimotor area and the supplementary motor *** study was registered in Chinese Clinical Trial Registry（registration number： Chi CTR1800014630）.

关键词： nerve regeneration facial synkinesis functional magnetic resonance imaging neural plasticity cortical representation block design facial movement blinking smiling neural regeneration

Brain plasticity after peripheral nerve injury treatment with massage therapy based on resting-state functional magnetic resonance imaging

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Neural Regeneration Research 2021年第2期16卷 388-393页

作者： Xiang-Xin Xing Mou-Xiong Zheng xu-yun hua Shu-Jie Ma Zhen-Zhen Ma Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Medicine Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Yangzi Rehabilitation Hospital Tongji UniversityShanghaiChina

Massage therapy is an alternative treatment for chronic pain that is potentially related to brain ***,the underlying mechanism remains *** established a peripheral nerve injury model in rats by unilateral sciatic nerve transection and direct *** experimental rats were treated over the gastrocnemius muscle of the affected hindlimb with a customized massage instrument(0.45 N,120 times/min,10 minutes daily,for 4 successive weeks).Resting-state functional magnetic resonance imaging revealed that compared with control rats,the amplitude of low-frequency fluctuations in the sensorimotor cortex contralateral to the affected limb was significantly lower after sciatic nerve ***,amplitudes were significantly higher in the massage group than in a sham-massage *** findings suggest that massage therapy facilitated adaptive change in the somatosensory cortex that led to the recovery of peripheral nerve injury and *** study was approved by the Animal Ethics Committee of Shanghai University of Traditional Chinese Medicine of China(approval No.201701001)on January 12,2017.

关键词： injury massage model neuron peripheral nerve plasticity rat repair

Structural remodeling in related brain regions in patients with facial synkinesis

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Neural Regeneration Research 2021年第12期16卷 2528-2533页

作者： Jia-Jia Wu Ye-Chen Lu Mou-Xiong Zheng xu-yun hua Chun-Lei Shan Wei Ding Jian-Guang xu Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Wound Healing Center Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Trauma and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Facial synkinesis is a troublesome sequelae of facial nerve *** is difficult to recover from synkinesis,despite improved surgical techniques for isolating the peripheral facial nerve ***,it remains unclear whether long-term dysfunction of motor control can lead to irreversible plasticity-induced structural brain *** case-control study thus investigated the structural brain alterations associated with facial *** study was conducted at Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,*** patients with facial synkinesis(2 male and 18 female,aged 33.35±6.97 years)and 19 healthy volunteers(2 male and 17 female,aged 33.21±6.75 years)underwent magnetic resonance imaging,and voxel-based and surface-based morphometry techniques were used to analyze *** was no significant difference in brain volume between patients with facial synkinesis and healthy *** with facial synkinesis exhibited a significantly reduced cortical thickness in the contralateral superior and inferior temporal gyri and a reduced sulcal depth of the ipsilateral precuneus compared with healthy *** addition,sulcal depth of the ipsilateral precuneus was negatively correlated with the severity of *** findings suggest that there is a structural remodeling of gray matter in patients with facial synkinesis after facial nerve *** study was approved by the Ethics Review Committee of the Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,China(approval No.2017-365-T267)on September 13,2017,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR1800014630)on January 25,2018.

关键词： brain plasticity cortical thickness depression facial nerve paralysis facial synkinesis peripheral nerve injury sulcal depth structural remodeling surface-based morphometry voxel-based morphometry

Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

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Neural Regeneration Research 2022年第4期17卷 806-811页

作者： Jie Ma xu-yun hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the ***,most studies are volume-based which may lead to inaccurate anatomical positioning of functional *** methods that work on the cortical surface may be more sensitive than those using the full brain volume and thus be more suitable for map plasticity *** this prospective cross-sectional study performed in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,20 patients with osteonecrosis of the femoral head(12 males and 8 females,aged 56.80±13.60 years)and 20 healthy controls(9 males and 11 females,aged 54.56±10.23 years)were included in this *** of resting-state functional magnetic resonance imaging were *** results revealed that compared with healthy controls,compared with the healthy controls,patients with osteonecrosis of the femoral head(ONFH)showed significantly increased surface-based regional homogeneity(Re Ho)in areas distributed mainly in the left dorsolateral prefrontal cortex,frontal eye field,right frontal eye field,and the premotor cortex and decreased surface-based Re Ho in the right primary motor cortex and primary sensory *** showing significant differences in surfacebased Re Ho values between the healthy controls and patients with ONFH were defined as the regions of ***-based functional connectivity was performed to investigate interregional functional *** the areas with decreased surface-based Re Ho in the frontal eye field and right premotor cortex were used as the regions of interest,compared with the healthy controls,the patients with ONFH displayed increased functional connectivity in the right middle frontal cortex and right inferior parietal cortex and decreased functional connectivity in the right precentral cortex and right middle occipital ***

关键词： cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei

Effects of paired associative magnetic stimulation between nerve root and cortex on motor function of lower limbs after spinal cord injury:study protocol for a randomized controlled trial

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Neural Regeneration Research 2022年第11期17卷 2459-2464页

作者： Ting-Ting Sun Guang-Yue Zhu Ya Zheng Ye-Ran Mao Qi-Long Hu Gong-Ming Song Rong xu Qi Yang Dan Zhao xu-yun hua Dong-Sheng xu Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghaiChina Rehabilitation Medical Center Tongji Hospital Affiliated to Tongji University School of MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina

Classic paired associative stimulation can improve synaptic plasticity,as demonstrated by animal expe riments and human clinical trials in spinal cord injury *** associative magnetic stimulation(dual-target peripheral and central magnetic stimulation)has been shown to promote neurologic recove ry after ***,it remains unclear whether paired associative magnetic stimulation can promote recovery of lower limb motor dysfunction after spinal cord *** hypothesize that the curre nt caused by central and peripheral magnetic stimulation will conve rge at the synapse,which will promote synapse function and improve the motor function of the relevant ***,this study aimed to examine the effects of paired associative magnetic stimulation on neural circuit activation by measuring changes in motor evoked and somatosensory evoked potentials,motor and sensory function of the lower limbs,functional health and activities of daily living,and depression in patients with spinal co rd *** will recruit 110 thora cic spinal trauma patients treated in the Department of Spinal Cord Injury,China Rehabilitation Hospital and randomly assign them to expe rimental and control groups in a 1:1 *** trial group(n=55)will be treated with paired associative magnetic stimulation and conventional rehabilitation *** control group(n=55)will be treated with sham stimulation and co nventional rehabilitation *** will be measured at four time points:baseline and 4,12,and 24 wee ks after the start of inte rvention(active or sham paired associative magnetic stimulation).The primary outcome measure of this trial is change in lower limb American Spinal Injury Association Impairment Scale motor function score from baseline to last *** outcome measures include changes in lower limb American Spinal Injury Association sensory function sco re,motor evoked potentials,sensory evoked potentials,modified Ashwo rth scale score,Masl

关键词： interstimulus interval motor-evoked potentials Modified Ashworth Scale Maslach Burnout Inventory paired-associative magnetic stimulation plasticity repetitive transcranial magnetic stimulation sensory-evoked potential spinal cord injury spike timing-dependent plasticity

Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第7期17卷 1545-1555页

作者： Si-Si Li xu-yun hua Mou-Xiong Zheng Jia-Jia Wu Zhen-Zhen Ma Xiang-Xin Xing Jie Ma Chun-Lei Shan Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina

Electroacupuncture(EA)has been widely used for functional restoration after ***,its role in post-stroke rehabilitation and the associated regulatory mechanisms remain poorly *** this study,we applied EA to the Zusanli(ST36)and Quchi(LI11)acupoints in rats with middle cerebral artery occlusion and *** found that EA effectively increased the expression of brain-derived neurotrophic factor and its receptor tyrosine kinase B,synapsin-1,postsynaptic dense protein 95,and microtubule-associated protein 2 in the ischemic penumbra of rats with middle cerebral artery occlusion and ***,EA greatly reduced the expression of myelin-related inhibitors Nogo-A and NgR in the ischemic *** kinase B inhibitor ANA-12 weakened the therapeutic effects of *** findings suggest that EA can improve neurological function after middle cerebral artery occlusion and reperfusion,possibly through regulating the activity of the brain-derived neurotrophic factor/tyrosine kinase B signal *** procedures and experiments were approved by the Animal Research Committee of Shanghai University of Traditional Chinese Medicine,China(approval ***200110002)on January 10,2020.

关键词： brain-derived neurotrophic factor dendritic electroacupuncture ischemia/reperfusion motor function neurite outgrowth inhibitor-A neurological outcomes Nogo receptor synapse tyrosine kinase B