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气-固两相流边界层双向耦合模型及其应用

水动力学研究与进展（A辑） 1995年第1期10卷 61-67页

作者：伊景海王运良徐忠上海交通大学动力机械工程系上海200030 西安交通大学西安710049

本文提出了一种稀相的气-固两相流边界层的双向耦合模型,在对固壁附近的粒子源项作了特殊处理后,利用此模型研究了流经平面叶栅的气-固两相流中的固体粒子穿越边界层时受到的影响以及粒子存在对边界层内气体流动的反影响。其中粒子运动... 详细信息

本文提出了一种稀相的气-固两相流边界层的双向耦合模型,在对固壁附近的粒子源项作了特殊处理后,利用此模型研究了流经平面叶栅的气-固两相流中的固体粒子穿越边界层时受到的影响以及粒子存在对边界层内气体流动的反影响。其中粒子运动特性的计算结果与试验进行了对比分析。

关键词：两相流边界层双向耦合模型

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积极情绪对条件性恐惧泛化的抑制作用

心理学报 2017年第3期49卷 317-328页

作者：冯彪徐亮张蔚欣陈婷王文清郑希付华南师范大学心理学院广州510631 华南师范大学心理应用研究中心广州510631 广东省心理健康与认知科学重点实验室广州510631 广东交通职业技术学院心理健康教育中心广州510650

恐惧的过度泛化是焦虑障碍的核心症状之一,表现为患者对与原危险刺激极不相似的安全刺激也产生恐惧反应。本研究采用经典条件恐惧范式,以US主观预期、回溯性恐惧评定、回溯性效价评定和皮电反应作为恐惧反应的指标,通过"最好自我"训练... 详细信息

恐惧的过度泛化是焦虑障碍的核心症状之一,表现为患者对与原危险刺激极不相似的安全刺激也产生恐惧反应。本研究采用经典条件恐惧范式,以US主观预期、回溯性恐惧评定、回溯性效价评定和皮电反应作为恐惧反应的指标,通过"最好自我"训练来诱发被试的积极情绪,考察了恐惧习得后的积极情绪对于恐惧泛化的影响。本研究发现,积极情绪能有效地抑制条件性恐惧的泛化,增强被试对安全信号的学习,并对消退后的恐惧重建现象起到预防作用。研究同时显示,恐惧泛化在主观评定指标和生理指标间出现了分离,这表明积极情绪对恐惧泛化的抑制作用是一个综合的过程,可能涉及到不同的作用机制。本研究结果提示可以通过诱发积极情绪,抑制条件性恐惧的泛化,对临床干预有一定的启发意义。

关键词：恐惧泛化积极情绪安全学习抑制作用

Chondrogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells Induced by Cartilage-derived Morphogenetic Protein-2 In Vitro

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第4期27卷 429-432页

作者：田洪涛杨述华徐亮张宇坤许伟华 Department of Orthopedics Union Hospital Tongji Medical College Huazhong University of Science and Technology

To study the cartilage differentiation of mouse mesenchymal stem cells （MSCs） induced by cartilage-derived morphogenetic proteins-2 in vitro, the MSCs were isolated from mouse bone marrow and cultured in vitro. The cells in passage 3 were induced into chondrogenic differentiation with different concentrations of recombinant human cartilage-derived morphogenetic proteins-2 （0, 10, 20, 50 and 100 ng/mL）. After 14 days of induction, morphology of cells was observed under phase-contrast microscope. Collagen Ⅱ mRNA and protein were examined with RT-PCR, Western blotting and immunocytochemistry respectively and the sulfate glycosaminoglycan was measured by Alcian blue staining. RT-PCR showed that CDMP-2 could promote expression of collagen Ⅱ mRNA in an dose-dependant manner, especially at the concentration of 50 ng/mL and 100 ng/mL. Immunocytochemistry and Western blotting revealed a similar change. Alcian blue staining exhibited deposition of typical cartilage extracellular matrix. Our results suggest that mouse bone marrow mesencymal stem cells can differentiate into chondrogenic phonotype with the induction of CDMP-2 in vitro, which provides a basis for further research on the role of CDMP-2 in chondrogenesis.

关键词： cartilage-derived morphogenetic proteins-2 bone marrow mesenchymal stem cell chondrogenic differentiation mouse

EUK001 improved age-related memory deficit

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EUK001 improved age-related memory deficit

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： xu-liang zhang Wen SI Ru-Qing LIU Xiao-Hua CAO~* Shanghai Institute of Brain Functional Genomics the Key Laboratories of Ministry of Education of China and Shanghai Municipality East China Normal University Shanghai 200062 China

＜正＞Objective The M1/ M4 muscarinic acetylcholine receptor agonist xanomeline can significantly improve the cognitive function,but the intolerable side effects limit its clinical *** present study is to investigate the function of a novel derivative of xanomeline,3-(3-（3- florophenyl- 2- propyn-1 - ylthio） -1,2,5- thiadiazol- 4- yl]-1,2,5,6- tetrahydro-1- methylpyridine Oxalate（EUK1001）,in memory and synaptic plasticity in aged *** Behavioral and electrophysiological techniques were utilized in the present *** behavior test,aged mice（14-15 months） were randomly assigned into five experimental groups:vehicle control group（0.9%saline,i.p.）,EUK1001-treated groups（0.1mg/ kg,0.5mg/kg and 1.0mg/kg,i.p.）,and Xanomeline-treated group（1mg/kg,i.p.） as positive *** 10-day treatment, fear conditioning and passive avoidance task were *** addition,effect of EUK 1001 on hippocampal CA3-CA1 LTP was measured by in vitro electrophysiological technique on hippocampal ***（1） EUK1001（0.1mg/kg, 0.5mg/kg and 1.0mg/kg,i.p.） significantly enhanced the freezing performance in contextual fear conditioning task and prolonged the escape latency of passive avoidance,without influencing the locomotor activity and footshock sensitivity of aged mice.（2） Hippocampal LTP in EUK1001（0.5mg/kg） group was significantly larger than that of ***, bath application of EUK1001（0.01μM） also directly enhanced hippocampal LTP in aged *** enhancement was blocked by 0.25μM pirenzepine,a Ml selective antagonist,but not by 0.25μM methoctramine,a M2/M4 selective *** Taken together,our results demonstrate that EUK 1001 can enhance synaptic plasticity and memory function via the activation of Ml muscarinic acetylcholine ***,EUK1001 represents a promising lead compound for the treatment of Alzheimer’s disease and age-related cognitive deficits.

关键词： EUK1001 Xanommeline hippocampal long-term potentiation memory

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旋转填充床分离沼气中的CO_2

化工环保 2016年第6期36卷 671-675页

作者：许碧璇张良王奎升李秀金北京化工大学机电工程学院北京100029 北京化工大学化学工程学院北京100029

以水为吸收液,采用旋转填充床分离微生物厌氧发酵沼气中的CO_2,考察了工艺条件对CO_2吸收效果的影响。实验结果表明:进液量越大、气液比越小、进口CO_2体积分数越小、操作压力越大、进液温度越低则CO_2的吸收效果越好,而床转速以适中为... 详细信息

以水为吸收液,采用旋转填充床分离微生物厌氧发酵沼气中的CO_2,考察了工艺条件对CO_2吸收效果的影响。实验结果表明:进液量越大、气液比越小、进口CO_2体积分数越小、操作压力越大、进液温度越低则CO_2的吸收效果越好,而床转速以适中为宜;在进液量60 L/h、气液比3.3、床转速1 000 r/min、进口CO_2体积分数40%、操作压力1.2 MPa、进液温度5℃的条件下,CO_2吸收率为57.4%,提纯后气体的CO_2体积分数为17%。

关键词：旋转填充床沼气 CO2 分离

Deciphering Water Oxidation Catalysts: The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： An, Li Li, Jianyi Sun, Yuanmiao Zhu, Jiamin Seow, Justin Zhu Yeow zhang, Hong zhang, Nan Xi, Pinxian xu, Zhichuan J. Yan, Chun-Hua Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Key Lab Nonferrous Met Chem & Resources Utilizat G State Key Lab Appl Organ ChemColl Chem & Chem Eng Lanzhou 730000 Peoples R China Nanyang Technol Univ Sch Mat Sci & Engn Singapore 639798 Singapore Chinese Acad Sci Fac Mat Sci & Energy Engn Shenzhen Inst Adv Technol Inst Technol Carbon Neutral Shenzhen 518055 Peoples R China Yunnan Univ Natl Ctr Int Res Photoelect & Energy Mat Electron Microscopy Ctr Sch Mat & EnergyKey Lab Electromagnet Mat & Devic Kunming 650091 Peoples R China Baotou Res Inst Rare Earths State Key Lab Baiyunobo Rare Earth Resource Res & Baotou 014030 Peoples R China Peking Univ Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Chem Beijing 100871 Peoples R China

Demonstrate that the key factor to determine the activity of reconstructed surfaces is the surface chemistry, instead of reconstruction degree using the popular perovskite LaNi1-xFexO3 oxides as model *** content can influence both the surface reconstruction degree, the activation degree, and the activity of reconstructed *** oxygen evolution reaction activity of reconstructed catalysts is primarily governed by the chemistry of the reconstructed surface species. Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution reaction. The surface reconstruction has been widely observed in perovskite catalysts, and the reconstruction degree has been often correlated with the activity enhancement. Here, a systematic study on the roles of Fe substitution in activation of perovskite LaNiO3 is reported. The substituting Fe content influences both current change tendency and surface reconstruction degree. LaNi0.9Fe0.1O3 is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi1-xFexO3 (x = 0.00, 0.10, 0.25, 0.50, 0.75, 1.00) series. The reconstructed LaNi0.9Fe0.1O3 shows a higher intrinsic activity than most reported NiFe-based catalysts. Besides, density functional theory calculations reveal that Fe substitution can lower the O 2p level, which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term stability. Furthermore, it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction degree. The effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface reconstruction. This finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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研究生教育中的学术规范和学术诚信问题研究

北京化工大学学报（社会科学版） 2016年第4期 83-87页

作者：徐军张亮李海勇北京化工大学科学技术发展研究院北京化工大学文法学院北京100029

本文采用问卷调查和专家访谈的方式,结合作者的研究生管理工作实践,通过对某211高校文理科研究生学术规范和学术诚信现状的分析,挖掘研究生学术失范与学术不端行为的根源、内在联系以及学术诚信教育中存在的问题,对高校如何开展常态化... 详细信息

本文采用问卷调查和专家访谈的方式,结合作者的研究生管理工作实践,通过对某211高校文理科研究生学术规范和学术诚信现状的分析,挖掘研究生学术失范与学术不端行为的根源、内在联系以及学术诚信教育中存在的问题,对高校如何开展常态化的学术规范和学术诚信教育有借鉴意义。

关键词：研究生教育学术规范学术诚信

Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： Fang, Lei Lin, Xiaoqi xu, Ruian Liu, Lu zhang, Yu Tian, Feng Li, Jiao Jiao xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing xuyun Hua Yuwen zhang Xin xue Jiajia Wu Mouxiong Zheng He Wang Jianguang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity