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Abnormal Innervation,Demyelination,and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice

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Neuroscience Bulletin 2024年第8期40卷 1093-1103页

作者： Yue Qiu le Xie Xiaohui Wang Kai xu xue bai Sen Chen Yu Sun Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Otolaryngology Nanchang UniversityNanchang 330006China

GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary *** individuals suffering from severe to profound GJB2-related deafness,cochlear implants have emerged as the sole remedy for auditory *** previous studies have highlighted the crucial role of preserving cochlear neural components in achieving favorable outcomes after cochlear ***,we generated a conditional knockout mouse model(Cx26-CKO)in which Cx26 was completely deleted in the cochlear supporting cells driven by the Sox2 *** Cx26-CKO mice showed severe hearing loss and massive loss of hair cells and Deiter’s cells,which represented the extreme form of human deafness caused by GJB2 gene *** addition,multiple pathological changes in the peripheral auditory nervous system were found,including abnormal innervation,demyelination,and degeneration of spiral ganglion neurons as well as disruption of heminodes in Cx26-CKO *** findings provide invaluable insights into the deafness mechanism and the treatment for severe deafness in Cx26-null mice.

关键词： Spiral ganglion neurons Gjb2 Heminode Hearing loss

Qualitative Analyses of Correlations between Strong Ground Motions of the Three Large Earthquakes and Landslide Distributions

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Journal of Earth Science 2023年第2期34卷 369-380页

作者： Yuzhu bai Chong xu Institute of Geology China Earthquake AdministrationBeijing 100029China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of ChinaBeijing 100085China

In this work,the correlations between spatial distributions of landslide point density(LPD)and strong ground motions of the three strong earthquakes are qualitatively *** the qualitative relationship between the distribution of LPD and the fault rupture process is also *** strong events are the Lushan,Wenchuan,and Jiuzhaigou *** order to reconstruct the near filed strong ground motions and the fault processes of these earthquakes,the broadband ground simulation method of University of California Santa Barbara(UCSB)and the simplified crustal layer structures are *** show the rationality of the UCSB method,the fault slip distributions of the three earthquakes reconstructed by the kinematic rupture generator model in the UCSB method are compared with those by ***,the validation of the UCSB method for the three earthquakes is also carried according to the validation exercise of the Southern California Earthquake Center(SCEC)Broadband Platform(BBP).Lastly,the fields of peak ground acceleration(PGA)and peak ground velocity(PGV)in three mutually perpendicular directions of the three earthquakes are ***,the landslide distribution length of large LPD values along the fault strike is less than the fault strike ***,the slip modes of earthquake faults affect the distributions of *** the strike slip earthquakes,the distributions of large LPD values relate well to PGA and PGV components of the parallel and normal to the fault *** the reverse slip earthquakes,distributions of LPD relate to ground motion components in all ***,distributions of landslides in near fields of earthquakes are significantly affected by the focus parameters and fault scales.

关键词： Lushan earthquake Wenchuan earthquake Jiuzhaigou earthquake landslide ground motions engineering geology

Improved local amplification factor transport equation for stationary crossflow instability in subsonic and transonic flows

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Chinese Journal of Aeronautics 2020年第12期33卷 3073-3081页

作者： Jiakuan xu lei QIAO Junqiang bai School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Department of Mathematics Imperial College LondonLondon SW72AZUnited Kingdom

Transition prediction is a hot research topic of fluid *** subsonic and transonic aerodynamic flows,e^(N) method based on Linear Stability Theory(LST)is usually adopted reliably to predict *** 2013,Coder and Maughmer established a transport equation for Tollmien-Schlichting(T-S)instability so that the e^(N) method can be applied to general Reynolds-Average-Navier-Stokes(RANS)solvers ***,this equation focuses on T-S instability,and is invalid for crossflow instability induced transition which plays a crucial role in flow instability of three-dimensional boundary ***,a transport equation for crossflow instability was developed in 2016,which is restricted to wing-like ***,in 2019,this model was extended to arbitrarily shaped geometries based on local ***,there are too many tedious functions and parameters in this version,and it can only be used for incompressible ***,in this paper,after a large amount of LST analyses and parameter optimization,an improved version for subsonic and transonic boundary layers is *** present improved model is more robust and more concise,and it can be applied widely in aeronautical flows,which has great engineering application value and *** extensive validation study for this improved transition model will be performed.

关键词： Boundary layer transition Crossflow instability Linear stability theory Transition Model Transonic flows

The nonlinear theory for sediment ripple dynamic process of straight river

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Science China(Technological Sciences) 2012年第3期55卷 753-771页

作者： xu HaiJue bai YuChuan State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Institute for Sedimentation on River and Coastal Engineering Tianjin UniversityTianjin 300072China

There are various sand tipples in the natural world. The viewpoint of Yalin is that local disturbances result in laminar instability and in sand-tipple formation, namely, local disturbance^the instability of the laminar flow→the formation of sand ripples. Based on this viewpoint, a theoretical model of the resonant triad interaction and its nonlinear interaction with the sediment is established. The purpose of this model is to explain the formation and evolution of the sand-tipple and allow for analysis of the instability of open-channel flow caused by it and sand-tipple hydro-dynamic process. This model will not only pave a road to explore the mechanism of interaction between bed-form and turbulence, but also provide a good base for the study of aeolian sand-tipple formation.

关键词： straight river bed-forms symmetric sand-ripples perturbation method nonlinearity

Stability characteristics of the open channel flow above the asymmetrical irregular sand ripples

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Science China(Physics,Mechanics & Astronomy) 2010年第8期53卷 1515-1529页

作者： xu HaiJue bai YuChuan Institute for Sedimentation River and Coastal Engineering School of Civil EngineeringTianjin UniversityTianjin 300072China

Sandy bed cannot keep its original smoothness as the flows pass. With the increase of the flow intensity, the bed forms will appear as sand ripples and dune in turn. Among these morphologies, the sand ripple scale is the smallest, which is generally symmetrical when it just appears, but as time goes on, the asymmetrical form gradually develops. Just because of this sand ripples asymmetry, it manifests the influence of the flow on the bed morphology and also the impact on the laminar flow dynamical process, especially the stability characteristics. The stability features of laminar flow on open channels with the asymmetrical sand ripples are discussed, and also the results on the symmetrical sand ripples are compared in detail.

关键词： asymmetry open channel sand ripples stability

A study on the stability of laminar open-channel flow over a sandy rippled bed

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Science China(Technological Sciences) 2005年第1期48卷 83-103页

作者： bai Yuchuan xu Haijue Institute for Sedimentation River and Coastal Engineering Tianjin University Tianjin 300072 China Institute for Sedimentation River and Coastal Engineering Tianjin University Tianjin 300072 China

The bed of a river often features some kinds of bedform, such as sand ripples, dunes, and so on. Even if the bed is smooth initially, disturbances arising from the bed or other external sources will cause the laminar flow in an open channel to become unstable as soon as the flow develops, thereby leading to the formation of sand ripples on the bed. In return, the formation of the sand ripples will modfy the instability path of the laminar flow passing over them. The wavy character of the bed will induce further instability of the flow, which is essentially different from that on a smooth bed: the neutral curve will move forward and the critical Reynolds number will decrease. The flow is unstable in response to a wider range of the disturbance wave number, or the laminar flow instability can happen more easily. The propagation speed of the sand ripples also affects the flow instability, since the stability of open channel flow over a movable bed is fundamentally different from that on a rigid bed. These instability effects are discussed in detail in this paper.

关键词： bed with sand ripples, open channel, flow instability.

Stability characteristics of hyper-concentration flow in open channel

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Science China(Physics,Mechanics & Astronomy) 2008年第9期51卷 1316-1338页

作者： xu HaiJue bai YuChuan Institute for Sedimentation River and Coastal Engineering Tianjin UniversityTianjin 300072China

The flow instability is related to many engineering problems and belongs to a wide-ranging research field. When the problem on the transition from the laminar to the turbulence caused by the instability of the laminar is studied,the "neutral line" and the critical Reynolds number are always taken as the criterion to judge whether a certain kind of flow is stable,whose corresponding flow medium is the clear water,that is,the single-phase Newtonian fluid. And it is not studied in the traditional in-stability theory that the hyper-concentration flow widely exists in rivers. This shortage can be covered by this research. Study shows that the instability of non-Newtonian fluid such as hyper-concentration fluid,compared with Newtonian fluid such as clear water,is influenced by not only Reynolds number,the ratio of the inertia force and the viscous force,but also many other factors such as the sediment concentration,the concentration distribution,the grain size,the volu-metric weight of the sediment and so on,which make the mechanical principle even more complex. So the results of the research can supply the scientific basis for the explanations of "slurrying river",the turbulence intensity of the flow carrying sediment and the variance of the turbulence structure.

关键词： hyper-concentration stability turbulence mechanics of sediment motion

A SIMULATION STUDY ON DYNAMIC-SAMPLING-MODE FOR FLUORESCENCE MOleCULAR TOMOGRAPHY

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Journal of Innovative Optical Health Sciences 2009年第2期2卷 165-177页

作者： ZHUN xu JING bai Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084China

Fluorescence tomography can obtain a sufficient dataset and optimal three-dimensional imageswhen projections are captured over 360◦ by CCD camera. Herein a non-stop dynamic samplingmode for fluorescence tomography is proposed in an attempt to improve the optical measurementspeed of the traditional imaging system and stability of the object to be imaged. A series ofsimulations are carried out to evaluate the accuracy of dataset acquired from the dynamicsampling mode. Reconstruction with the corresponding data obtained in the dynamic-modeprocess is also performed with the phantom. The results demonstrate the feasibility of suchan imaging mode when the angular velocity is set to the appropriate value, thus laying thefoundation for real experiments to verify the superiority in performance of this new imagingmode over the traditional one.

关键词： Fluorescence molecular tomography dynamic sampling mode simulation

Boundary Behaviors for a Continuous-state Nonlinear Neveu’s Branching Process

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2005-2016页

作者： Lin Yu bai xu YANG School of Mathematics and Information Science North Minzu UniversityYinchuan 750021P.R.China

By generalizing a criterion of Mufa Chen for Markov jump processes,we establish the necessary and sufficient conditions for the extinction,explosion and coming down from infinity of a continuous-state nonlinear Neveu... 详细信息

关键词： Continuous-state branching process nonlinear branching Neveu’s branching extinction explosion coming down from infinity