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Distribution of serotonin 5-HT_(2A) and 5-HT_7 receptors in the Onuf’s nucleus of the rat spinal cord

Neural Regeneration Research 2008年第8期3卷 853-857页

作者： Fanqing Zeng Chen xu ge xu Laboratory of Electron Microscopy Chongqing Medical University Chongqing 400016 China

BACKGROUND：Motoneurons from the Onuf’s nucleus of the spinal cord, which innervate the striated muscle of the pelvic floor, play an important role in erection, ejaculation, and urine control. Serotonin （5-hydroxytryptamine, 5-HT） regulates motoneuron activity from the Onuf’s nucleus of the spinal cord. However, few studies exist that describe 5-HT receptor distribution in the Onuf’s nucleus. In addition, the nature of the effects of 5-HT receptor on the innervating striated muscle of the pelvic floor is controversial. OBJECTIVE： To investigate the distribution of serotonin 5-HT2A and 5-HT7 receptors in motoneurons of Onuf’s nucleus in the spinal cord of male rats, and to analyze the relationship of 5-HT2A and 5-HT7 receptor to central modulation of urogenital function. DESIGN, TIME AND SETTING： The neural morphology experiment was performed at the Ultramicro-structure Laboratory of Reproductive Medicine, Basic Medical College, Chongqing Medical University, China from April to December 2007. MATERIALS： Ten adult, Sprague Dawley rats （eight males and two females） were randomly divided into gender control group （n = 4, 50% male and 50% female） and a retrograde tracing group （n = 6, 100% male） Recombinant pseudorabies virus （PRV-152） was provided by Professor LW Enquist from Princeton University, USA. Rabbit anti-5-HT2A and 5-HT7 receptor antibodies were purchased from Diasorin, France. METHODS： In the gender control group, the spinal L5-6 segments were harvested, sliced, and then incubate antibodies specific against 5-HT2A or 5-HT7 receptors for immunohistochemical staining. In the retrograde tracing group, PRV-152 was separately injected into the right ischiocavernosus （ischiocavernosus subgroup, n = 3） and the right external urethral sphincter （external urethral sphincter subgroup, n = 3）. Four days after injection, L5-6 segments were harvested, sliced, and incubated with antibodies specific against 5-HT2A or 5-HT7 receptors for double-labeling immunofluorescence sta

关键词： 5-hydroxytryptamine receptor Onuf's nucleus retrograde tracing urogenital reflex

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Hochschild (Co)homology of a Class of Nakayama Algebras

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1097-1106页

作者： Yun ge xu Dan WANG Faculty of Mathematics & Computer Science Hubei University Wuhan 430062 P. R. China

Let A = kQ/I be a finite-dimensional Nakayama algebra, where Q is an Euclidean diagram An for some n with cyclic orientation, and I is an admissible ideal generated by a single monomial relation. In this note we determine explicitly all the Hochschild homology and cohomology groups of A based on a detailed description of the Bardzell complex. Moreover, the cyclic homology of A can be calculated in the case that the underlying field is of characteristic zero.

关键词： Nakayama algebra Hochschild homology cyclic homology Hochschild cohomology

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Asymmetric Synthesis and Antitumor Activity of Spiro- Oxadiazole Derivatives from 1,4：3,6-Dianhydro-D-fructose

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Chinese Journal of Chemistry 2017年第9期35卷 1437-1444页

作者： Wenke xu Yongxun ge Yu Hou Yingju Liu Yingchun hua Weiwei Han Zhiyan Qin Fengwu Liu School of Pharmaceutical Sciences Zhengzhou University Zhengzhou Henan 450001 China Collaborative Innovation Center of Henan New Drug Research and Safety Evaluation Zhengzhou Henan 450001 China Zhengzhou Central Hospital Affiliated to Zhengzhou University Zhengzhou Henan 450007 China Oepartment of Medicine Kaifeng University Kaifeng Henan 475000 China

A series of spiro-oxadiazoles were synthesized from 1,4：3,6-dianhydro-D-fructose and hydrazides via a stereoselective two-step reaction sequence. The structures of newly synthesized compounds were established by spectral analysis. The absolute configuration of compound 2a was further confirmed by single crystal X-ray analysis. All the synthesized compounds were screened for their in vitro antitumor activity, showing that these compounds have poor inhibitory activities against A549, MGC-803 tumor cells.

关键词： 1,4:3,6-dianhydro-D-froctose spiro-oxadiazole single crystal X-ray analysis antitumor activity

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Hochschild(Co)homology of Galois Coverings of Grassmann Algebras

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Acta Mathematica Sinica,English Series 2009年第10期25卷 1693-1702页

作者： Yun ge xu Xin TANG School of Mathematics and Computer Science Hubei University Wuhan 430062 P.R. China Department of Mathematics and Computer Science Fayetteville State University Fayetteville NC 28301 USA

Let ∧ be the Z2-Galois covering of the Grassmann algebra A over a field k of characteristic not equal to 2. In this paper, the dimensional formulae of Hochschild homology and cohomology groups of ∧ are calculated explicitly. And the cyclic homology of∧ can also be calculated when the underlying field is of characteristic zero. As a result, we prove that there is an isomorphism from i≥1 HH^i（∧） to i≥1 HH^i（∧）.

关键词： Galois covering Grassmann algebra Hochschild (co)homology minimal projective resolution

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Azide-functionalization of carbon nanotubes by electrochemical oxidation of N_3^-in situ

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Chinese Chemical Letters 2014年第2期25卷 292-294页

作者： Xiao-Tang Ji Zhong-xue ge Jian-hua Bu Qing Liu Wei Wang Cheng xu Xi'an Modern Chemistry Research Institute

Azide-functionalization of single-walled carbon nanotubes （SWCNTs） was achieved by electrochemical oxidation of N3 in situ. The functionalized nanotubes were characterized in details by single internal reflection infrared spectroscopy （ATR-FTIR） and thermogravimetic analysis （TGA/MS）. The results revealed that a covalent C-N bond had formed and this might provide an effective method for the preparation of azide-functionalized materials, especially carbon materials. The degree of functionaliza- tion was measured by X-ray photoelectron spectroscopy （XPS）.

关键词： Electrochemical treatment Carbon nanotubes Azide Eunctionalization

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Structural understanding of T cell receptor triggering

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Cellular & Molecular Immunology 2020年第3期17卷 193-202页

作者： Xinyi xu hua Li Chenqi xu State Key Laboratory of Molecular Biology Shanghai Science Research CenterCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang Road200031 ShanghaiChina School of Life Science and Technology ShanghaiTech University100 Haike Road201210 ShanghaiChina

The T cell receptor(TCR)is one of the most complicated receptors in mammalian cells,and its triggering mechanism remains *** an octamer complex,TCR comprises an antigen-binding subunit(TCRαβ)and three CD3 signaling subunits(CD3ζζ,CD3δε,and CD3γε).Engagement of TCRαβwith an antigen peptide presented on the MHC leads to tyrosine phosphorylation of the immunoreceptor tyrosine-based activation motif(ITAM)in CD3 cytoplasmic domains(CDs),thus translating extracellular binding kinetics to intracellular signaling *** conformational change plays an important role in the transmembrane signal transduction of TCR is under *** by the complexity and functional importance of TCR,many groups have been studying TCR structure and triggering for decades using diverse biochemical and biophysical ***,we synthesize these structural studies and discuss the relevance of the conformational change model in TCR triggering.

关键词： T Cell Receptor Structure Conformational change Triggering

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Effects of Spatial Noncommutativity on Energy Spectrum of a Trapped Bose-Einstein Condensate

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Communications in Theoretical Physics 2006年第6X期46卷 966-968页

作者： LUO You-hua ge Zi-Ming Institute for Theoretical Physics and Department of Physics East China University of Science and Technology Shanghai 200237 China

In noncommutative space, we examine the problem of a noninteracting and harmonically trapped Bose- Einstein condensate, and derive a simple analytic expression for the effect of spatial noncommutatlvity on energy spectrum of the condensate, it indicates that the ground-state energy incorporating the spatial noncommutativity is reduced to a lower level, which depends upon the noncommutativity parameter 8. The gap between the noncommutative space and commutative one for the ground-state level of the condensate should be a signal of spatial noncommutativity.

关键词： spatial noncommutativity energy spectrum Bose Einstein condensate

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genetic and geographic Patterns of Duplicate DPL genes Causing genetic Incompatibility Within Rice:Implications for Multiple Domestication Events in Rice

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Rice science 2021年第1期28卷 58-68页

作者： xu xun ge Song Zhang Fumin State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Strong genetic incompatibilities exist between two primary rice subspecies,indica and ***,the wild ancestors of rice,*** Sharma et Shastry and *** Griff.,are genetically *** this genetic incompatibility became established has not been clearly *** provide insights into the process,we analyzed a pair of hybrid sterility genes in rice,DOPPELGANgeR 1(DPL1)and DOPPELGANgeR 2(DPL2).Either of the two loci can have one defective allele(DPL1-and DPL2-).Hybrid pollen carrying both DPL1-and DPL2-alleles is *** explore the origination of DPL1-and DPL2-,we sequenced the DPL1 and DPL2 genes of 811 individual plants,including Oryza sativa(132),***(296)and ***(383).We then obtained 20 DPL1 and 34 DPL2 sequences of *** from online *** these sequences,we analyzed the genetic and geographic distribution patterns of DPL genes in modern rice and its wild *** with the ancestral populations,DPL1-and DPL2-showed reduced diversity but increased frequency in modern *** speculated that the diversity reduction was due to a historic genetic bottleneck,and the frequency had likely increased because the defective alleles were preferred following this artificial *** results indicated that standing variances in ancestral lines can lead to severe incompatibilities among *** analysis indicated that the DPL1-haplotype of rice emerged from an *** population in India,whereas the DPL2-haplotype emerged from *** in South ***,the evolutionary history of DPLs conforms to the presumed multiple domestication events of modern rice.

关键词： rice DPL gene domestication genetic incompatibility phylogeography

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Innate immunity in tuberculosis: host defense vs pathogen evasion

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Cellular & Molecular Immunology 2017年第12期14卷 963-975页

作者： Cui hua Liu Haiying Liu Baoxue ge CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 101408China MOH Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biologyand Center for Tuberculosis ResearchChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176China Shanghai Key Lab of Tuberculosis Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China

The major innate immune cell types involved in tuberculosis(TB)infection are macrophages,dendritic cells(DCs),neutrophils and natural killer(NK)*** immune cells recognize the TB-causing pathogen Mycobacterium tuberculosis(Mtb)through various pattern recognition receptors(PRRs),including but not limited to Toll-like receptors(TLRs),Nod-like receptors(NLRs)and C-type lectin receptors(CLRs).Upon infection by Mtb,the host orchestrates multiple signaling cascades via the PRRs to launch a variety of innate immune defense functions such as phagocytosis,autophagy,apoptosis and inflammasome *** contrast,Mtb utilizes numerous exquisite strategies to evade or circumvent host innate *** we discuss recent research on major host innate immune cells,PRR signaling,and the cellular functions involved in Mtb infection,with a specific focus on the host’s innate immune defense and Mtb immune evasion.A better understanding of the molecular mechanisms underlying host–pathogen interactions could provide a rational basis for the development of effective anti-TB therapeutics.

关键词： host–pathogen interactions immune evasion innate immune defense Mycobacterium tuberculosis tuberculosis

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Influence of Ag content on the microstructure, mechanical, and tribological properties of TaVN–Ag films

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International Journal of Minerals,Metallurgy and Materials 2018年第1期25卷 110-115页

作者： Tong Chen Li-hua Yu Jun-hua xu School of Material Science and Engineering Jiangsu University of Science and Technology

A series of TaVN-Ag nanocomposite films were deposited using a radio-frequency magnetron sputtering system. The micro- structure, mechanical properties, and tribological performance of the films were investigated. The results showed that TaVN-Ag films were composed of face-centered cubic （fcc） TaVN and fcc-Ag. With increasing Ag content, the hardness of TaVN-Ag composite films first in- creased and then decreased rapidly. The maximum hardness value was 31.4 GPa. At room temperature, the coefficient of friction （COF） of TaVN-Ag films decreased from 0.76 to 0.60 with increasing Ag content from 0 to 7.93at%. For the TaVN-Ag films with 7.93at% Ag, COF first increased and then decreased rapidly from 0.60 at 25℃ to 0.35 at 600℃, whereas the wear rate of the film increased continuously from 3.91 × 10^-7 to 19.1 × 10^7 mm3/（N·mm）. The COF of the TaVN-Ag film with 7.93at% Ag was lower than that of the TaVN film, and their wear rates showed opposite trends with increasing temperature.

关键词： TaVN-Ag films RF magnetron sputtering microstructure mechanical properties tribological performances

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