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An in-plane low-noise accelerometer fabricated with an improved process flow

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1413-1420页

作者： xu-dong zheng Zhong-he JIN Yue-lin WANG Wei-jun LIN Xiao-qi ZHOU Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

We present a bulk micromachined in-plane capacitive accelerometer fabricated with an improved process flow,by etching only one-fifth of the wafer thickness at the back of the silicon while forming the bar-structure electrode for the sensing *** improved flow greatly lowers the footing effect during deep reactive ion etching(DRIE),and increases the proof mass by 54% compared to the traditional way,resulting in both improved device quality and a higher yield *** in the X direction is sensed capacitively by varying the overlapped area of a differential capacitor pair,which eliminates the nonlinear behavior by fixing the parallel-plate *** damping coefficient of the sensing motion is low due to the slide-film damping.A large proof mass is made using DRIE,which also ensures that dimensions of the spring beams in the Y and Z directions can be made large to lower cross axis coupling and increase the pull-in *** theoretical Brownian noise floor is 0.47 μg/Hz1/2 at room temperature and atmospheric *** tested frequency response of a prototype complies with the low damping design *** data for input acceleration from ?1 g to 1 g are recorded by a digital multimeter and show very good *** tested random bias of the prototype is 130 μg at an averaging time of around 6 s.

关键词： MEMS accelerometer, Deeo reactive ion etchin (DRIE), Footin effect, Canacitive sensing

Modeling and noise analysis of a fence structure micromachined capacitive accelerometer system

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第12期11卷 1009-1015页

作者： Xia ZHANG Hao WANG xu-dong zheng Shi-chang HU Zhong-he JIN Department of lnformation Science and Electronic Engineering Zhejiang University Hangzhou 310027 China Beijing Institute of Aerospace Control Devices Beijing 100854 China

We analyze the effects of possible noise sources on a fence structure micromachined capacitive accelerometer system by modeling and simulation to improve its performance. Simulation results show that a mismatch between the two initial sensing capacitors of the accelerometer or a mismatch between the two capacitance-voltage conversion circuits has a great effect on the output noise floor. When there is a serious mismatch, the noise induced by a sinusoidal carrier is the major noise source. When there is no or only a slight mismatch, the differential capacitance-voltage conversion circuits become the main noise source. The simulation results were validated by experiments and some effective approaches are proposed to improve the system resolution.

关键词： Capacitive accelerometer Micro-electromechanical system (MEMS) Noise Modeling Simulation

Standardized processes of biomass briquetting densification fuel

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Forestry Studies in China 2012年第1期14卷 80-84页

作者： ZHAO Fang ZHANG Ya-zhuo xu zheng-dong LI Li ZHANG Shuang-bao College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

Forest biomass resources are available in enormous quantities in China. The development of forest biomass briquetting densification fuel, which has a high calorific value, can ease the energy shortage in China. But the molding technology is still at the primary stage with many questions unresolved, such as unequal distribution of resources, imperfect technology and an inadequate mechanism of market supply and demand. There are no consistent production and quality standards to refer to, which seriously hinder the industrialization of biomass molding technology. Hence, it is imperative to speed up the formulation of production standards of biomass briquetting densification fuel which not only conform to international standards, but are in accordance with national condi- tions in China. Drawing on the standards of biomass briquetting densification fuel in Europe, a standard system should be concerned with raw material collection, transport and storage of the end products, terminology, denomination and classification of molding equipment, as well as with technical conditions, testing methods, safety and environmental protection. The establishment of a stan- dard system is useful for the development of a healthy, orderly and sustainable biomass fuel industry.

关键词： biomass briquetting densification fuel standardized process

State of research and trends in development of wood adhesives

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Forestry Studies in China 2011年第4期13卷 321-326页

作者： ZHAO Lei-feng LIU Yu xu zheng-dong ZHANG Ya-zhuo ZHAO Fang ZHANG Shuang-bao College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

We aim to present an overview of the status of adhesives in the wood industry, especially in the area of wood-based panels. The review summarizes the current state of research of two kinds of adhesives, i.e., synthetic adhesives and natural adhesives. Synthetic adhesives, consisting of urea-formaldehyde resins （UF）, phenol-formaldehyde resins （PF）, polyvinyl acetate emulsion （PVAc） and isocyanates, are widely used. For UF, most investigations are concerned with the reduction of free formaldehyde; for PF, most studies focus on finding new chemicals to replace phenol. PVAc has poor properties, but these can be improved by a blending reactions and copolymerization with other chemicals. Isocyanate is an environmentally friendly synthetic adhesive, but also suffers from inadequate properties. Natural adhesives, such as protein/starch, lignin and tannins, have poor bonding effect that limits their level of use, but their main advantages are that they are environmentally friendly and a renewable resource. Studies of modification can improve the bonding performances and gradually cause natural adhesives to become applied in industrial production. Some proposals for future development and the importance of environmentally friendly adhesives are provided, which will be helpful in future theoretical and experimental research.

关键词： synthetic adhesives natural adhesives main features development trend

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高效绿色的微波热解废旧轮胎方法（英文）

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第12期19卷 951-960页

作者： Yu-zhe ZHANG Ting-ting BIAN Yi ZHANG xu-dong zheng Zhong-yu LI School of Environmental and Safety Engineering Changzhou University Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology School of Petrochemical EngineeringChangzhou University Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

目的:废旧轮胎正成为一个日益严峻的环境问题。本文旨在研究发掘一个高效绿色的处理废旧轮胎的方法。本文探讨微波热解废旧轮胎的可能性,同时研究不同环境温度、微波频率以及样本大小对微波热解废旧轮胎效率的影响。方法:1.通过实验分析... 详细信息

目的:废旧轮胎正成为一个日益严峻的环境问题。本文旨在研究发掘一个高效绿色的处理废旧轮胎的方法。本文探讨微波热解废旧轮胎的可能性,同时研究不同环境温度、微波频率以及样本大小对微波热解废旧轮胎效率的影响。方法:1.通过实验分析,验证影响微波热解废旧轮胎的关键因素,同时找出微波热解废旧轮胎的最佳条件。2.理论设计多个与分解效率相关的变量,推导其计算公式,从而证明提高热解效率的关键因素。3.分析热解后产物,证明该方法是高效绿色的。结论:1.微波热解废旧轮胎的最佳条件是:轮胎样品厚度为5 mm、微波频率为915 MHz以及环境温度为592.1°C。2.分解产物中包含35%的炭黑、40%的原油以及25%的可燃性气体;这证明微波热解法是有效的。3.所有产物皆可重复利用,证明该方法是高效绿色的。

关键词：循环系统废旧轮胎微波热解炭黑油天然气

Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment

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World Journal of Stem Cells 2019年第9期11卷 705-721页

作者： Kinji Furuya Yun-Wen zheng Daisuke Sako Kenichi Iwasaki dong-xu zheng Jian-Yun Ge Li-Ping Liu Tomoaki Furuta Kazunori Akimoto Hiroya Yagi Hiromi Hamada Hiroko Isoda Tatsuya Oda Nobuhiro Ohkohchi Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Faculty of MedicineUniversity of TsukubaTsukubaIbaraki 305-8575Japan Institute of Regenerative Medicine and Affiliated Hospital Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Regenerative Medicine School of MedicineYokohama City UniversityYokohama 236-0004Japan Department of Medicinal and Life Sciences Faculty of Pharmaceutical SciencesTokyo University of ScienceNoda 278-8510Japan Department of Obstetrics and Gynecology Faculty of MedicineUniversity of TsukubaTsukuba 305-8575Japan Faculty of Life and Environmental Sciences University of TsukubaTsukuba 305-8572Japan

BACKGROUND To solve the problem of liver transplantation donor insufficiency,an alternative cell transplantation therapy was *** focused on amniotic epithelial cells(AECs)as a cell source because,unlike induced pluripotent stem cells,they are cost-effective and *** utilization of AECs in regenerative medicine,however,is in its infancy.A general profile for AECs has not been comprehensively ***,no hepatic differentiation protocol for AECs has yet been *** this end,we independently compiled human AEC libraries,purified amniotic stem cells(ASCs),and co-cultured them with mesenchymal stem cells(MSCs)and human umbilical vein endothelial cell(HUVECs)in a 3D system which induces functional hepatic *** To characterize AECs and generate functional hepatic organoids from ASCs and other somatic stem cells METHODS AECs,MSCs,and HUVECs were isolated from the placentae and umbilical cords of cesarean section *** and primary AEC stemness characteristics and heterogeneity were analyzed by immunocytochemistry,Alkaline phosphatase(AP)staining,and flow *** adherent AEC subpopulation was selected and evaluated for ASC purification quality by a colony formation *** transcriptomes were compared with those for other hepatocytes cell sources by *** 2D and 3D culture were compared by relative gene expression using several differentiation ***,MSCs,and HUVECs were combined in a 3D co-culture system to generate hepatic organoids whose structure was compared with a 3D AEC sphere and whose function was elucidated by immunofluorescence imaging,periodic acid Schiff,and an indocyanine green(ICG)*** AECs have certain stemness markers such as EPCAM,SSEA4,and *** AEC subpopulation was also either positive for AP staining or expressed the TRA-1-60 and TRA-1-81 stemness ***,it could form colonies and its frequency was enhanced ten-fold in the adherent subpo

关键词： 3D micropattern Amniotic epithelial cells Amniotic stem cells Hepatic differentiation Heterogeneity Human placental tissue Human umbilical vein endothelial cells Mesenchymal stem cells Multicellular microenvironment Organoid

Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong zheng Du Wang Rongjie Lin Weihong xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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新兴煤矿较软围岩中大断面硐室施工技术

煤炭科学技术 2007年第7期35卷 41-43页

作者：许正东龙煤矿业集团有限责任公司鹤岗分公司新兴煤矿黑龙江鹤岗154105

软岩、煤岩互层、断层带以及硐室群中施工特大断面硐室,采用锚索、锚杆、钢筋梯、钢筋网,联合支护方式,成功取代了以往采用的被动支护的砌碹支护,架棚支护工艺,为在破碎、煤岩断层中施工大断面硐室,总结摸索出一条成功的经验。

关键词：特大断面硐室锚杆锚索钢筋梯钢筋网联合支护

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan xu Jie Mu Yu Leng Lei Ma Yu zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions