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Biliary tract intraductal papillary mucinous neoplasm: Report of 19 cases

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World Journal of Gastroenterology 2015年第14期21卷 4261-4267页

作者： Xing Wang Yun-Qiang Cai Yong-Hua Chen xu-bao liu Department of Hepatopancreatobiliary Surgery West China HospitalSichuan University

AIM: To gain a better understanding of biliary tract intraductal papillary mucinous neoplasm(BT-IPMN).METHODS: From January 2000 to December 2013, 19cases of BT-IPMN were retrospectively identified from a total of 343 biliary tract tumors resected in our single *** characteristics, clinical data, pathology, surgical strategies, and long-term follow-up were ***: The mean age of the 19 BT-IPMN cases was 53.8 years(range: 25-74 years).The most common symptom was abdominal pain(15/19; 78.9%), followed by jaundice(7/19; 36.8%).Cholangitis was associated with most(16/19; 84.2%) of the BT-IPMN *** visible mucin was detected in all 19 patients, based on original surgical *** most common abnormal preoperative imaging findings for BT-IPMN were bile duct dilation(19/19; 100%) and intraluminal masses(10/19; 52.6%).Thirteen(68.4%) cases involved the intrahepatic bile duct and *** performed left hepatectomy in 11/19(57.9%), right hepatectomy in 2/19(10.5%), bile duct resection in 4/19(21.1%), and pancreatoduodenectomy in 1/19(5.3%) ***(5.3%) patient was biopsied and received a choledochojejunostomy because of multiple tumors involving the right extrahepatic and left intrahepatic bile *** showed malignancy in 10/19(52.6%) *** overall median survival was 68 *** benign cases showed a non-significant trend towards improved survival compared to malignant cases(68 mo vs 48 mo, P = 0.347).The patient without tumor resection died of liver failure 22 mo after palliative ***: BT-IPMN is a rare biliary *** resection of the tumor is associated with good survival, even in patients with malignant disease.

关键词： Biliary tract Cystic tumor Intraductal papillary m

Synthesis of 2-Arylimidazo[l, 2-a]pyrimidines in Ionic Liquids

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Chinese Chemical Letters 2003年第10期14卷 1002-1004页

作者： Dan Qian xu, bao You liu, Zhen Yuan xu Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310032 Catalytic Hydrogenation Res. Center Zhejiang University of Technology Hangzhou 310032 China

Room temperature ionic liquids were used as a "green" recyclable alternative to conventional solvents in the synthesis of pharmaceutically useful compounds 2-arylimidazo[1, 2-a] pyrimidines through Tschotschibabin rea... 详细信息

关键词： Room temperature ionic liquids Tschotschibabin reaction 2-aminopyrimidine a-bromoacetophenones 2-arylimidazo[1,2-a]pyrimidines.

Duodenum and ventral pancreas preserving subtotal pancreatectomy for low-grade malignant neoplasms of the pancreas: An alternative procedure to total pancreatectomy for low-grade pancreatic neoplasms

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World Journal of Gastroenterology 2017年第35期23卷 6457-6466页

作者： Xing Wang Chun-Lu Tan Hai-Yu Song Qiang Yao xu-bao liu Department of Pancreatic Surgery West China HospitalSichuan University West China School of Public Health Sichuan University

AIM To describe the indications, technique and outcomes of the novel surgical procedure of duodenum and ventral pancreas preserving subtotal pancreatectomy(DVPPSP).METHODS Data collected retrospectively from 43 patients who underwent DVPPSP and TP between 2009 and 2015 in our single centre were analysed. For enrolment, only patients with low-grade pancreatic neoplasms, such as pancreatic neuroendocrine tumors, intraductal papillary mucinous neoplasms(IPMNs), and solid pseudopapillary tumors, were included. Ten DVPPSP(group 1) and 13 TP(group 2) patients were selected in this *** There were no significant differences in age, gender, comorbidities, preoperative symptoms, American Society of Anesthesiologists score or indications for surgery between the two groups. The most common indication was IPMN for DVPPSP and TP(60% vs 85%, P = 0.411). Compared with the TP group, the DVPPSP group had comparable postoperative morbidities(P = 0.405) and mortalities(both nil), but significantly shorter operative time(232 ± 19.6 min vs 335 ± 32.3 min, P < 0.001). DVPPSP preserved better long-term pancreatic function with less supplementary therapy(P < 0.001) and better quality of life(Qo L) after surgery, including better scores in social(P = 0.042) and global health(P = 0.047) on functional scales and less appetite loss(P = 0.049) on the symptom scale. CONCLUSION DVPPSP is a feasible and safe procedure that could be an alternative to TP for low-grade neoplasms arising from the body and tail region but across the neck region of the pancreas; DVPPSP had better metabolic function and Qo L after surgery.

关键词： Low-grade malignant neoplasm Ventral pancreas preserving Subtotal pancreatectomy Quality of life

Mesenterico-portal vein invasion should be an important factor in TNM staging for pancreatic ductal adenocarcinoma: Proposed modification of the 8th edition of the American Joint Committee on Cancer staging system

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World Journal of Gastroenterology 2019年第46期25卷 6752-6766页

作者： Hong-Yu Chen Xing Wang Hao Zhang xu-bao liu Chun-Lu Tan Department of Pancreatic Surgery West China HospitalSichuan University

BACKGROUND The 8^th edition of the American Joint Committee on Cancer(AJCC)staging system for pancreatic ductal adenocarcinoma(PDAC)excludes extrapancreatic extension from the assessment of T stage and restages tumors with mesenterico-portal vein(MPV)invasion into T1-3 diseases according to tumor ***,MPV invasion is believed to be correlated with a poor *** To analyze whether the inclusion of MPV invasion can further improve the 8th edition of the AJCC staging system for *** This study retrospectively included 8th edition AJCC T1-3N0-2M0 patients undergoing pancreaticoduodenectomy/total pancreatectomy from two cohorts and analyzed survival *** the first cohort,a total of 7539 patients in the surveillance,epidemiology,and end results database was included,and in the second cohort,689 patients from the West China Hospital database were *** Cox regression analysis showed that MPV invasion is an independent prognostic factor in both *** the MPV-group,all pairwise comparisons between the survival functions of patients with different stages were significant except for the comparison between patients with stage IIA and those with stage ***,in the MPV+group,pairwise comparisons between the survival functions of patients with stage IA,stage IB,stage IIA,stage IIB,and stage III were not significant.T1-3N0 patients in the MPV+group were compared with the T1N0,T2N0,and T3N0 subgroups of the MPV-group;only the survival of MPV-T3N0 and MPV+T1-3N0 patients had no significant *** comparisons of patients with stage IIA and subgroups of stage IIB showed(1)no significant difference between the survival of T2N1 and T3N0 patients;(2)a longer survival of T1N1 patients that was shorter than the survival of T2N0 patients;and(3)and a shorter survival of T3N1 patients that was similar to that of T1-3N2 *** The modified 8th edition of the AJCC staging system for PDAC proposed in this study,which i

关键词： Pancreatic ductal adenocarcinoma Portal vein Mesenteric veins Neoplasm staging Pancreaticoduodenectomy

Prospects and applications of enucleation in solid pseudopapillary neoplasms of the pancreas

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1227-1238页

作者： Rui Wang Jing Li Chun-Lu Tan xu-bao liu Yong-Hua Chen Department of Pancreatic Surgery West China Hospital of Sichuan UniversityChengdu 610037Sichuan ProvinceChina Department of Operating Room West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610037Sichuan ProvinceChina

Solid pseudopapillary neoplasms(SPNs)of the pancreas are rare,low-grade,malignant neoplasms that are mostly seen in young women in the second and third decades of life and are quite uncommon in *** resection for benign and borderline neoplasms of the pancreas is associated with a substantial risk of postoperative morbidity and long-term functional impairment,whereas enucleation leads to less morbidity and preserves healthy parenchyma as well as exocrine and endocrine *** of SPNs has been increasingly reported to be feasible and safe for preserving the normal physiological function of the pancreas,especially in teenagers and *** review summarizes findings published in recent years on the enucleation of SPNs as well as potential future developments and *** has undoubtedly come to stay as an alternative surgical procedure for ***,many questions remain unresolved,and future directions toward the best surgical indication,the prevention and intervention of complications,especially pancreatic fistula,intraoperative resection margin safety assessment,and long-term oncology prognosis remain to be evaluated and should be explored in future clinical trials.

关键词： Solid pseudopapillary neoplasm Enucleation Pancreatic tumor Distal pancreatectomy Pancreaticoduodenectomy

Laparoscopic splenectomy for splenic littoral cell angioma

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World Journal of Gastroenterology 2015年第21期21卷 6660-6664页

作者： Yun-Qiang Cai Xing Wang xun Ran xu-bao liu Bing Peng Department of Hepatopancreatobiliary Surgery West China HospitalSichuan University

AIM:To establish the safety and feasibility of laparoscopic splenectomy(LS) for littoral cell angioma(LCA).METHODS:From September 2003 to November 2013,27 patients were diagnosed with LCA in our *** patients were divided into two groups based on operative procedure:LS(13 cases,Group 1) and open splenectomy(14 cases,Group 2).Data were collected retrospectively by chart *** were performed between the two groups in terms of demographic characteristics(sex and age); operative outcomes(operative time,estimated blood loss,transfusion,and conversion); postoperative details(length of postoperative stay and complications); and follow-up ***:LS was successfully carried out in all patients except one in Group 1,who required conversion to hand-assisted LS because of perisplenic *** average operative time for patients in Group 1 was significantly shorter than that in Group 2(127 ± 34 min vs 177 ± 25 min,P = 0.001).The average estimated blood loss in Group 1 was significantly lower than in Group 2(62 ± 48 m L vs 138 ± 64 m L,P < 0.01).No patient in Group 1 required a blood transfusion,whereas one in Group 2 required a *** patients in Group 1 and four in Group 2 suffered from postoperative *** the complications were cured by conservative *** were no deaths in our *** patients were followed up and no recurrence or abdominal metastasis were ***:LS for patients with LCA is safe and feasible,with preferable operative outcomes and longterm tumor-free survival.

关键词： Laparoscopy Minimal invasiveness Splenictumor Splenectomy Littoral cell angioma

Solid pseudopapillary tumor of the pancreas in male patients: Report of 16 cases

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World Journal of Gastroenterology 2014年第22期20卷 6939-6945页

作者： Yun-Qiang Cai Si-Ming Xie xun Ran Xing Wang Gang Mai xu-bao liu Department of Hepatopancreatobiliary Surgery West China HospitalSichuan University

AIM: To investigate the clinical characteristics, surgical strategies and prognosis of solid pseudopapillary tumors (SPTs) of the pancreas in male patients. METHODS: From July 2003 to March 2013, 116 patients were diagnosed with SPT of the pancreas in our institution. Of these patients, 16 were male. The patients were divided into two groups based on gender: female (group 1) and male (group 2). The groups were compared with regard to demographic characteristics, clinical presentations, surgical strategies, complications and follow-up outcomes. RESULTS: Male patients were older than female patients (43.1 +/- 12.3 years vs 33.1 +/- 11.5 years, P = 0.04). Tumor size, location, and symptoms were comparable between the two groups. All patients, with the exception of one, underwent complete surgical resection. The patients were regularly followed up. The mean follow-up period was 58 mo. Two female patients (1.7%) developed tumor recurrence or metastases and required a second resection, and two female patients (1.7%) died during the follow-up period. CONCLUSION: Male patients with SPT of the pancreas are older than female patients. There are no significant differences between male and female patients regarding surgical strategies and prognosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Frantz tumor Pancreas neoplasm Solid pseudopapillary tumor

Role of original and modified Frey's procedures in chronic pancreatitis

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World Journal of Gastroenterology 2016年第47期22卷 10415-10423页

作者： Chun-Lu Tan Hao Zhang Min Yang Shao-Jun Li xu-bao liu Ke-Zhou Li Department of Pancreatic Surgery West China Hospital of Sichuan University

AIM To retrospectively review patients with chronic pancreatitis(CP) treated with Frey's procedures between January 2009 and January *** A retrospective review was performed of patients with CP treated with Frey's procedures between January 2009 and January 2014 in the Department of Pancreatic Surgery. A cross-sectional study of postoperative pain relief, quality of life(Qo L), and alcohol and nicotine abuse was performed by clinical interview, letters and telephone interview in January 2016. Qo L of patients was evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30) version 3.0. The patients were requested to fill in the questionnaires by themselves via correspondence or clinical *** A total of 80 patients were enrolled for analysis, including 44 who underwent the original Frey's procedure and 36 who underwent a modified Frey's procedure. The mean age was 46 years in the original group and 48 years in the modified group. Thirtyfive male patients(80%) were in the original group and 33(92%) in the modified group. There were no differences in the operating time, blood loss, and postoperative morbidity and mortality between the two groups. The mean follow-up was 50.3 mo in the original group and 48.7 mo in the modified group. There were no differences in endocrine and exocrine function preservation between the two groups. The original Frey's procedure resulted in significantly betterpain relief, as shown by 5-year follow-up(P = 0.032), better emotional status(P = 0.047) and fewer fatigue symptoms(P = 0.028). When stratifying these patients by the M-ANNHEIM severity index, no impact was found on pain relief after the two types of *** The original Frey's procedure is as safe as the modified procedure, but the former yields better pain relief. The severity of CP does not affect postoperative pain relief.

关键词： Chronic pancreatitis Frey’s procedure M-ANNHEIM severity index Pain relief Quality of life

Neoadjuvant therapy in resectable pancreatic cancer:A promising curative method to improve prognosis

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 1903-1917页

作者： Hao-Qi Zhang Jing Li Chun-Lu Tan Yong-Hua Chen Zhen-Jiang Zheng xu-bao liu Department of Pancreatic Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Operating Room/West China School of Nursing West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Currently,15 randomized controlled trials(RCTs)have been designed to investigate whether neoadjuvant therapy(NAT)benefits patients with resectable pancreatic adenocarcinoma(R-PA)compared to surgery *** of them have acquired results so far;however,corresponding conclusions have not been *** speculated that the reason for this phenomenon could be that some prognostic factors had proven to be adverse through upfront surgery curative patterns,but some of them were not regarded as independent baseline characteristics,which is important to obtaining comparability between the NAT and upfront surgery *** fact could cause bias and lead to the difference in the outcomes of *** this review,we collate data about risk factors(such as tumor size,resection margin,and lymph node status)influencing the prognoses of patients with R-PA from five RCTs and discuss the possible reasons for the varying outcomes.

关键词： Neoadjuvant therapy Resectable Pancreatic cancer Prognosis