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冲击拦阻力计算及车架结构的瞬态分析

机械设计与制造 2024年第4期398卷 71-76,80页

作者：许云华张建永丰申王发展西安建筑科技大学机电工程学院陕西西安710055

针对采用撞击试验法来测试钢索拦阻系统的可靠性问题,这里首次基于能量法建立了轨道车拦阻动力学模型。对不同指标及不同运行速度下冲击拦阻力的变化规律进行了分析,并给出了用于描述轨道车冲击拦阻力的具体表达式。在此基础上,对不同... 详细信息

针对采用撞击试验法来测试钢索拦阻系统的可靠性问题,这里首次基于能量法建立了轨道车拦阻动力学模型。对不同指标及不同运行速度下冲击拦阻力的变化规律进行了分析,并给出了用于描述轨道车冲击拦阻力的具体表达式。在此基础上,对不同工况下的车架进行瞬态响应分析。结果表明:在撞击初期,冲击拦阻力Fx增长迅速,当轨道车位移一定距离后,Fx增长缓慢或保持不变,直到轨道车被安全拦停;车架的前心盘以及中梁与撞击梁交界处是应力集中的区域,容易出现破坏;车架在相同撞击初速度下,使拦停距离最短的车架形变量比使最大钢索拉力值为最小的车架形变量明显要大。

关键词：能量法轨道车冲击拦阻力瞬态响应分析

资源赋能国有企业关键核心技术突破的机制与路径——基于资源编排理论视角下的探索性案例研究

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湖北经济学院学报 2024年第1期22卷 54-66页

作者：王文海黄紫微许云华安徽财经大学工商管理学院安徽蚌埠233000

基于资源编排理论,采用纵向单案例研究方法,对中建材玻璃新材料研究总院2000-2023年从技术追随者到领导者的关键核心技术攻关实践展开深入研究。研究发现:案例企业经历了技术跟跑、技术并跑和技术领跑3个阶段,在不同阶段,由不同的动因... 详细信息

基于资源编排理论,采用纵向单案例研究方法,对中建材玻璃新材料研究总院2000-2023年从技术追随者到领导者的关键核心技术攻关实践展开深入研究。研究发现:案例企业经历了技术跟跑、技术并跑和技术领跑3个阶段,在不同阶段,由不同的动因需求驱动资源编排行动,进而构建价值共创模式,最后支撑案例企业实现角色身份的演变。具体而言:(1)技术跟跑阶段,案例企业在为实现国产制造的动因需求下,进行资源建构化,建立起调配式价值共创模式,成为技术追随者;(2)技术并跑阶段,案例企业在为实现国产替代的动因需求下,进行资源能力化,建立起整合式价值共创模式,成为技术参与者;(3)技术领跑阶段,案例企业在为实现国产领导的动因需求下,进行资源杠杆化,建立起共享式价值共创模式,成为技术领导者。由此构建资源赋能国有企业关键核心技术突破的理论框架,不仅推进了资源编排与关键核心技术两个领域的理论研究,还为国有企业实现关键核心技术攻关提供实践启示。

关键词：国有企业资源编排价值共创模式关键核心技术突破

Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

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Neural Regeneration Research 2022年第4期17卷 806-811页

作者： Jie Ma xu-yun hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the ***,most studies are volume-based which may lead to inaccurate anatomical positioning of functional *** methods that work on the cortical surface may be more sensitive than those using the full brain volume and thus be more suitable for map plasticity *** this prospective cross-sectional study performed in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,20 patients with osteonecrosis of the femoral head(12 males and 8 females,aged 56.80±13.60 years)and 20 healthy controls(9 males and 11 females,aged 54.56±10.23 years)were included in this *** of resting-state functional magnetic resonance imaging were *** results revealed that compared with healthy controls,compared with the healthy controls,patients with osteonecrosis of the femoral head(ONFH)showed significantly increased surface-based regional homogeneity(Re Ho)in areas distributed mainly in the left dorsolateral prefrontal cortex,frontal eye field,right frontal eye field,and the premotor cortex and decreased surface-based Re Ho in the right primary motor cortex and primary sensory *** showing significant differences in surfacebased Re Ho values between the healthy controls and patients with ONFH were defined as the regions of ***-based functional connectivity was performed to investigate interregional functional *** the areas with decreased surface-based Re Ho in the frontal eye field and right premotor cortex were used as the regions of interest,compared with the healthy controls,the patients with ONFH displayed increased functional connectivity in the right middle frontal cortex and right inferior parietal cortex and decreased functional connectivity in the right precentral cortex and right middle occipital ***

关键词： cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei

Effects of paired associative magnetic stimulation between nerve root and cortex on motor function of lower limbs after spinal cord injury:study protocol for a randomized controlled trial

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Neural Regeneration Research 2022年第11期17卷 2459-2464页

作者： Ting-Ting Sun Guang-Yue Zhu Ya Zheng Ye-Ran Mao Qi-Long Hu Gong-Ming Song Rong xu Qi Yang Dan Zhao xu-yun hua Dong-Sheng xu Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghaiChina Rehabilitation Medical Center Tongji Hospital Affiliated to Tongji University School of MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina

Classic paired associative stimulation can improve synaptic plasticity,as demonstrated by animal expe riments and human clinical trials in spinal cord injury *** associative magnetic stimulation(dual-target peripheral and central magnetic stimulation)has been shown to promote neurologic recove ry after ***,it remains unclear whether paired associative magnetic stimulation can promote recovery of lower limb motor dysfunction after spinal cord *** hypothesize that the curre nt caused by central and peripheral magnetic stimulation will conve rge at the synapse,which will promote synapse function and improve the motor function of the relevant ***,this study aimed to examine the effects of paired associative magnetic stimulation on neural circuit activation by measuring changes in motor evoked and somatosensory evoked potentials,motor and sensory function of the lower limbs,functional health and activities of daily living,and depression in patients with spinal co rd *** will recruit 110 thora cic spinal trauma patients treated in the Department of Spinal Cord Injury,China Rehabilitation Hospital and randomly assign them to expe rimental and control groups in a 1:1 *** trial group(n=55)will be treated with paired associative magnetic stimulation and conventional rehabilitation *** control group(n=55)will be treated with sham stimulation and co nventional rehabilitation *** will be measured at four time points:baseline and 4,12,and 24 wee ks after the start of inte rvention(active or sham paired associative magnetic stimulation).The primary outcome measure of this trial is change in lower limb American Spinal Injury Association Impairment Scale motor function score from baseline to last *** outcome measures include changes in lower limb American Spinal Injury Association sensory function sco re,motor evoked potentials,sensory evoked potentials,modified Ashwo rth scale score,Masl

关键词： interstimulus interval motor-evoked potentials Modified Ashworth Scale Maslach Burnout Inventory paired-associative magnetic stimulation plasticity repetitive transcranial magnetic stimulation sensory-evoked potential spinal cord injury spike timing-dependent plasticity

Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第7期17卷 1545-1555页

作者： Si-Si Li xu-yun hua Mou-Xiong Zheng Jia-Jia Wu Zhen-Zhen Ma Xiang-Xin Xing Jie Ma Chun-Lei Shan Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina

Electroacupuncture(EA)has been widely used for functional restoration after ***,its role in post-stroke rehabilitation and the associated regulatory mechanisms remain poorly *** this study,we applied EA to the Zusanli(ST36)and Quchi(LI11)acupoints in rats with middle cerebral artery occlusion and *** found that EA effectively increased the expression of brain-derived neurotrophic factor and its receptor tyrosine kinase B,synapsin-1,postsynaptic dense protein 95,and microtubule-associated protein 2 in the ischemic penumbra of rats with middle cerebral artery occlusion and ***,EA greatly reduced the expression of myelin-related inhibitors Nogo-A and NgR in the ischemic *** kinase B inhibitor ANA-12 weakened the therapeutic effects of *** findings suggest that EA can improve neurological function after middle cerebral artery occlusion and reperfusion,possibly through regulating the activity of the brain-derived neurotrophic factor/tyrosine kinase B signal *** procedures and experiments were approved by the Animal Research Committee of Shanghai University of Traditional Chinese Medicine,China(approval ***200110002)on January 10,2020.

关键词： brain-derived neurotrophic factor dendritic electroacupuncture ischemia/reperfusion motor function neurite outgrowth inhibitor-A neurological outcomes Nogo receptor synapse tyrosine kinase B

Altered intra- and inter-network brain functional connectivity in upper-limb amputees revealed through independent component analysis

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Neural Regeneration Research 2022年第12期17卷 2725-2729页

作者： Bing-Bo Bao Hong-Yi Zhu Hai-Feng Wei Jing Li Zhi-Bin Wang Yue-hua Li xu-yun hua Mou-Xiong Zheng Xian-You Zheng Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Although cerebral neuroplasticity following amputation has been observed, little is understood about how network-level functional reorganization occurs in the brain following upper-limb amputation. The objective of this study was to analyze alterations in brain network functional connectivity(FC) in upper-limb amputees(ULAs). This observational study included 40 ULAs and 40 healthy control subjects;all participants underwent resting-state functional magnetic resonance imaging. Changes in intra-and inter-network FC in ULAs were quantified using independent component analysis and brain network FC analysis. We also analyzed the correlation between FC and clinical manifestations, such as pain. We identified 11 independent components using independent component analysis from all subjects. In ULAs, intra-network FC was decreased in the left precuneus(precuneus gyrus) within the dorsal attention network and left precentral(precentral gyrus) within the auditory network;but increased in the left Parietal_Inf(inferior parietal, but supramarginal and angular gyri) within the ventral sensorimotor network, right Cerebelum_Crus2(crus Ⅱ of cerebellum) and left Temporal_Mid(middle temporal gyrus) within the ventral attention network, and left Rolandic_Oper(rolandic operculum) within the auditory network. ULAs also showed decreased inter-network FCs between the dorsal sensorimotor network and ventral sensorimotor network, the dorsal sensorimotor network and right frontoparietal network, and the dorsal sensorimotor network and dorsal attention network. Correlation analyses revealed negative correlations between inter-network FC changes and residual limb pain and phantom limb pain scores, but positive correlations between inter-network FC changes and daily activity hours of stump limb. These results show that post-amputation plasticity in ULAs is not restricted to local remapping;rather, it also occurs at a network level across several cortical regions. This observation provides addit

关键词： amputation functional connectivity functional magnetic resonance imaging independent component analysis neuroimaging phantom pain phantom sensation resting-state networks

Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury:a resting-state functional MRI study

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Neural Regeneration Research 2023年第2期18卷 410-415页

作者： Cheng-Cheng Sun Yu-Wen Zhang Xiang-Xin Xing Qi Yang Ling-yun Cao Yu-Feng Cheng Jing-Wang Zhao Shao-Ting Zhou Dan-Dan Cheng Ye Zhang xu-yun hua He Wang Dong-Sheng xu Department of Rehabilitation Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina Institute of Rehabilitation Medicine School of Rehabilitation ScienceShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Rehabilitation Tongren HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Rehabilitation Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Yangzhi Rehabilitation HospitalTongji UniversityShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina

Modified constraint-induced movement therapy(mCIMT)has shown beneficial effects on motor function improvement after brain injury,but the exact mechanism remains *** this study,amplitude of low frequency fluctuation(ALFF)metrics measured by resting-state functional magnetic resonance imaging was obtained to investigate the efficacy and mechanism of mCIMT in a control co rtical impact(CCI)rat model simulating traumatic brain *** 3 days after control co rtical impact model establishment,we found that the mean ALFF(mALFF)signals were decreased in the left motor cortex,somatosensory co rtex,insula cortex and the right motor co rtex,and were increased in the right corpus *** 3 weeks of an 8-hour daily mClMT treatment,the mALFF values were significantly increased in the bilateral hemispheres compared with those at 3 days *** mALFF signal valu es of left corpus callosum,left somatosensory cortex,right medial prefro ntal cortex,right motor co rtex,left postero dorsal hippocampus,left motor cortex,right corpus callosum,and right somatosensory cortex were increased in the mCIMT group compared with the control cortical impact ***,we identified brain regions with significantly decreased mALFF valu es at 3 days *** correlation coefficients with the right forelimb sliding score indicated that the improvement in motor function of the affected upper limb was associated with an increase in mALFF values in these brain *** findings suggest that functional co rtical plasticity changes after brain injury,and that mCIMT is an effective method to improve affected upper limb motor function by promoting bilateral hemispheric co rtical *** values correlate with behavio ral changes and can potentially be used as biomarkers to assess dynamic cortical plasticity after traumatic brain injury.

关键词： amplitude of low frequency fluctuation cortical plasticity functional magnetic resonance imaging modified constraint-induced movement therapy traumatic brain injury

High-resolution remote thermometry based on Bi^(3+)-doped 0D zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： Cui-Mi Shi Shu-hua xue Jin-yun Wang Liang-Jin xu Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating Bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through Bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQY) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi^(3+)is mainly responsible for the blue emission. Single crystals of Bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K^(-1), representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids Bi^(3+)doping blue emission temperature sensing

Development of antibody-drug conjugates in cancer:Overview and prospects

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Cancer Communications 2024年第1期44卷 3-22页

作者： Dan-yun Ruan Hao-Xiang Wu Qi Meng Rui-hua xu Department of Clinical Research Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhouGuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China

In recent years,remarkable breakthroughs have been reported on antibody-drug conjugates(ADCs),with 15 ADCs successfully entering the market over the past *** substantial development has positioned ADCs as one of the fastest-growing domains in the realm of anticancer drugs,demonstrating their efficacy in treating awide array of ***,there is still an unmet clin-ical need forwider application,better efficacy,and fewer side effects of *** ADC generally comprises an antibody,a linker and a payload,and the combina-tion has profound effects on drug structure,pharmacokinetic profile and ***,optimization of the key components provides an opportunity to develop ADCs with higher potency and fewer side *** this review,we comprehen-sively reviewed the current development and the prospects of ADC,provided an analysis of marketed ADCs and the ongoing pipelines globally as well as in China,highlighted several ADC platforms and technologies specific to different pharmaceutical enterprises and biotech companies,and also discussed the new related technologies,possibility of next-generation ADCs and the directions of clinical research.

关键词： companies breakthrough payload