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Glycnsisitin A:A promising bicyclic peptide against heart failure that facilitates TFRCmediated uptake of iron in cardiomyocytes

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3125-3139页

作者： Jichao Zhou Yuanyuan Liu Xiaoli Wei Meng Yuan xu Zhang Lingfeng Qin Bing cui Pingping Li Jing Zhang Ziming Feng Jianshuang Jiang Xiang Yuan Ruibing xu Zhimeng Zhang Peicheng Zhang Xiaowei Zhang Yanan yang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Zhigancao decoction is a traditional prescription for treating irregular pulse and palpitations in *** the monarch drug of Zhigancao decoction,the bioactive molecules of licorice against heart diseases remain *** established the HRESIMS-guided method leading to the isolation of three novel bicyclic peptides,glycnsisitins A-C(1-3),with distinctive C-C and C-O-C side-chain-toside-chain linkages from the roots of Glycyrrhiza uralensis(Licorice).Glycnsisitin A demonstrated stronger cardioprotective activity than glycnsisitins B and C in an in vitro model of doxorubicin(DOX)-induced cardiomyocyte *** A treatment not only reduced the mortality of heart failure(HF)mice in a dose-dependent manner but also significantly attenuated DOX-induced cardiac dysfunction and myocardial *** set enrichment analysis(GSEA)of the differentially expressed genes indicated that the cardioprotective effect of glycnsisitin A was mainly attributed to its ability to maintain iron homeostasis in the ***,glycnsisitin A interacted with transferrin and facilitated its binding to the transferrin receptor(TFRC),which caused increased uptake of iron in *** findings highlight the key role of bicyclic peptides as bioactive molecules of Zhigancao decoction for the treatment of HF,and glycnsisitin A constitutes a promising therapeutic agent for the treatment of HF.

关键词： Glycyrrhiza uralensis Bicyclic peptides Myocardial energy metabolism Iron homeostasis TFRC

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High-resolution remote thermometry based on Bi^(3+)-doped 0D zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： cui-Mi Shi Shu-Hua xue Jin-Yun Wang Liang-Jin xu Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating Bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through Bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQY) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi^(3+)is mainly responsible for the blue emission. Single crystals of Bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K^(-1), representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids Bi^(3+)doping blue emission temperature sensing

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Differentially-grown cobalt regulators cooperatively involved in the tandem catalysis for high-yield production of second amines

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Nano Research 2024年第4期17卷 2444-2450页

作者： Jinhui xu Xiao Wang Ying Wang Fei Wang Lingling Zhang Wenjie cui Shuyan Song Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China

One-pot tandem catalysis has been regarded as one of the most atomic economic ways to produce secondary amines,the important platform molecules for chemical synthesis and pharmaceutical manufacture,but it is facing serious issues in overall *** promotional effects are highly desired for boosting the activity and regulating the selectivity of conventional tandem *** this work,we report a high-performance tandem catalyst with maximized synergistic effect among each counterpart by preciously manipulating the spatial structure,which involves the active CeO_(2)/Pt component as kernel,the densely-coated N-doped C(NC)layer as selectivity controller,and the differentially-grown Co species as catalytic performance *** comprehensive investigations,the unique growth mechanism and the promotion effect of Co regulators are ***,the surface-landed Co clusters(Cocs)are crucial to selectivity by altering the adsorption configuration of benzylideneaniline ***,the inner Co particles(Cops)are essential for activity by denoting their electrons to neighboring *** from the unique promotion effect,a remarkably-improved catalytic efficiency(100%nitrobenzene conversion with 94%N-benzylaniline selectivity)is achieved at a relatively low temperature of 80℃,which is much better than that of CeO_(2)/Pt(100%nitrobenzene conversion with 12%N-benzylaniline selectivity)and CeO_(2)/Pt/NC(35%nitrobenzene conversion with 94%benzylideneaniline selectivity).

关键词： tandem catalysis CeO_(2) hierarchical structure heterogeneous catalyst dual-site materials

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Body-coupled smart fibers:Enhancing seamless integration and efficiency in medical human-machine interaction

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The Innovation 2024年第5期5卷 19-20页

作者： Lei Xiang Yihan Li Ding Zhao Yiru xu Wenguo cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China The International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China

Human-machine interaction(HMI)has always been at the frontier of technological innovation,making our interactions with technology more intuitive and effi-cient,as well as driving much of the research interest in this *** electronic systems can seamlessly and accurately receive,store,process,and output *** endows them with tremendous potential applications ranging from daily life interactions to monitoring physiological signals and clinical medical *** upon this foundation,researchers have embarked on a series of innovations concerning textile fibers’materials,manufacturing techniques,and further functional payloads.

关键词： fibers interaction frontier

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Finger-actuated wireless-charging wearable multifunctional sweatsensing system for levodopa and vitamin C

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Nano Research 2024年第4期17卷 3096-3106页

作者： Qihong Ning Shaoqing Feng Qingwen Sun Ruoyao Yu Tangan Li Hao xu Daxiang cui Kan Wang School of Sensing Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityKey Laboratory of Thin Film and Microfabrication Technology(Ministry of Education)Shanghai 200240China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Efficient portable wearable sweat sensors allow the long-term monitoring of changes in the status of biomarkers in sweat,which can be useful in diagnosis,medication,and nutritional *** this study,we designed and tested a wireless,battery-free,flexible,self-pumping sweat-sensing system that simultaneously tracks levodopa and vitamin C levels in human sweat and detects body *** system includes a microfluidic chip with a self-driven pump and anti-reflux valve,a flexible wireless circuit board,and a purpose-designed smartphone *** microfluidic chip is used for the efficient collection of sweat and the drainage of excess *** dual electrochemical sensing electrodes in the chip are modified with functional materials and appropriate enzymatic reagents,achieving excellent selectivity and *** sensitivities of the levodopa sensor and the vitamin C sensor are 0.0073 and 0.0018μA·μM^(-1),respectively,and the detection correlation coefficients of both exceed *** sensors have a wide linear detection range of 0–100 and 0–1000μM,respectively,and low detection limits of 0.28 and 17.9μM,*** flexible wireless circuit board is equipped with the functions of wireless charging,electrical signal capture and processing,and wireless *** data recorded from each sensor are displayed on a smartphone via a self-developed app.A series of experimental results confirmed the reliability of the sweat-sensing system in noninvasively monitoring important biomarkers in the human body and its potential utility in the comprehensive assessment of biological health.

关键词： self-pumping microfluidic channel wireless charging wearable sensor health monitoring

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Sn-decorated CeO_(2) with different morphologies for direct dehydrogenation of ethylbenzene

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Journal of Rare Earths 2024年第1期42卷 102-109,I0004页

作者： Kai Zhang Guoju cui Mengzhen Yuan Huiwen Huang Ning Li Jiale xu Guowei Wang Chunyi Li State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao266580China Petrochemical Plant of Sinopec Shengli Oilfield Company Dongying257237China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao266590China

Three Sn-decorated ceria catalysts with various morphologies(rods,particles,and cubes)were prepared and applied to the direct dehydrogenation of ***-technology characterizations,including X-ray photoelectro n spectroscopy(XPS),H_(2)-tempe rature programmed reduction(H_(2)-TPR),and Raman spectroscopy,prove that the oxygen vacancies are the active sites for ethylbenzene dehydrogenation,which can be regulated by engineering CeO_(2) morphology and enhanced via introducing metal *** the results of activity test,the catalytic activities for ethylbenzene dehydrogenation over different samples are closely dependent on the amount of oxygen *** reduced Sn-decorated CeO_(2) catalyst with nanoparticles morphology exhibits better dehydrogenation performance than the other two studied catalysts at 600℃.This work provides an effective approach to regulate the active oxygen vacancies and further enhance the dehydrogenation activities through engineering the surface morphology of the catalyst and introducing suitable additives.

关键词： Ethylbenzene dehydrogenation CeO_(2) Sn Morphology Oxygen vacancy Rare earths

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Exploring the molecular mechanism of Epimedium brevicornu *** treating breast cancer via network pharmacology and in vitro experiments Author links open overlay panel

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 207-221页

作者： xuan Wang Bin cui Liuyan xu Xiaohua Pei Breast Department Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing100029China Emergency Department People's Hospital of Ningxia Hui Autonomous RegionYinchuan750002China

Objective To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin yang Huo)on breast cancer using network pharmacology and in vitro *** also aimed to explore the novel targets and mechanisms of EBM in the treatment of breast cancer to facilitate the discovery of new drugs and their clinical *** Network pharmacology was used to identify and screen the components and targets of EBM for breast cancer *** docking was further screened the effective components and targets of ***-healing assays and flow cytometry analysis were used to detect the ability of two compounds to intervene in the migration and apoptosis of MDA-MB-231 cells,and their mechanism of action was further explored using western blotting *** EBM contained 19 active *** them wereβ-anhydroicaritin(Anhy)and isoliquiritigenin(Iso),which were selected for in vitro *** resulted in a dose-dependent suppression of MDA-MB-231 cell viability,with an IC50 of 23.73μmol/L for Iso and 21.28μmol/L for *** the wound healing assay,cells in Anhy and Iso groups exhibited considerable inhibition of migration at 48 *** flow cytometry analysis,treatment with Iso(20μmol/L)for 96 h resulted in significantly higher levels of both early and late apoptosis in the Iso group than that in the control group(P=.004 and P=.014,respectively).Additionally,both Iso(20μmol/L)and Anhy(10 and 20μmol/L)induced cell necrosis at 96 *** blotting revealed that Anhy and Iso increased the expression of Bax and TBK1/*** These findings suggested that Anhy and Iso,the two components of EBM,inhibit MDA-MB-231 cell proliferation and migration of and induce their apoptosis,providing substantial support for future studies on breast cancer.

关键词： Breast cancer Epimedium brevicornu Maxim Molecular docking β-Anhydroicaritin Isoliquiritigenin Flow cytometry MDA-MB-231

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Inverse design of mechanical metamaterial achieving a prescribedconstitutive curve

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 16-22页

作者： Zongliang Du Tanghuai Bian Xiaoqiang Ren Yibo Jia Shan Tang Tianchen cui xu Guo State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDepartment of Engineering MechanicsDalian University of TechnologyDalian 116023China Ningbo Institute of Dalian University of Technology Ningbo 315016China

Besides exhibiting excellent capabilities such as energy absorption,phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive *** is facilitated by switching between different patterns under ***,the related inverse design problem is quite challenging,due to the lack of appropriate mathematical formulation and the convergence issue in the post-buckling analysis of intermediate *** this work,periodic unit cells are explicitly described by the moving morphable voids method and effectively analyzed by eliminating the degrees of freedom in void ***,by exploring the Pareto frontiers between error and cost,an inverse design formulation is proposed for unit *** formulation aims to achieve a prescribed constitutive curve and is validated through numerical examples and experimental *** design approach presented here can be extended to the inverse design of other types of mechanical metamaterials with prescribed nonlinear effective properties.

关键词： Metamaterial Pattern-transformation Constitutive curve Inverse design

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Transmission Energy Allocation for Over-the-Air Computation with Energy Harvesting

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Journal of Communications and Information Networks 2024年第2期9卷 126-136页

作者： Siyao Zhang Zixiang Ren Xinmin Li Yin Long Jie xu Shuguang cui School of Computer Science and Technology Southwest University of Science and TechnologyMianyang 621010China Shenzhen Future Network of Intelligence Institute(FNii-Shenzhen) The Chinese University of Hong KongShenzhenGuangdong 518172China School of Information Science and Technology University of Science and Technology of ChinaHefei 230027China FNii-Shenzhen The Chinese University of Hong KongShenzhenGuangdong 518172China College of Computer Science Chengdu UniversityChengdu 610100China School of Science and Engineering FNii-Shenzhenand Guangdong Provincial Key Laboratory of Future Networks of IntelligenceThe Chinese University of Hong KongShenzhenGuangdong 518172China

Over-the-air computation(AirComp)has recently emerged as a promising multiple-access technique for fast wireless data aggregation(WDA)from distributed wireless devices(WDs). This paper investigates an energy harvesting (EH) AirComp system, in which multiple EH-powered single-antenna WDs simultaneously send wireless signals to a single-antenna access point (AP) with conventional energy supply for WDA via AirComp. Under this setup, we minimize the average computation mean square error(MSE)over a particular time period, by jointly optimizing the transmit energy allocation at the WDs and the AirComp denoising factors at the AP over time, subject to the energy causality constraints at individual WDs. First, we consider the offline scenario by assuming that the energy state information(ESI)and channel state information (CSI) are non-causally known at the beginning of the period, in which the formulated average MSE minimization corresponds to a non-convex optimization problem. We present a high-quality converged solution by using the techniques of alternating optimization and convex optimization. It is shown that for each WD,if the EH rate is sufficiently high,then the channel inversion power allocation is adopted;while if the EH rate is low, then all the harvested energy should be used up for transmission with proper energy allocation over time. Next, we consider the online scenario with causal ESI and CSI,in which the MSE minimization becomes a stochastic optimization *** this scenario, we present an offline-inspired online algorithm to obtain efficient online energy allocation designs by utilizing the obtained offline solutions. Finally,numerical results show that the proposed designs significantly outperform two benchmark schemes with power-halving and full-power transmission,respectively.

关键词： over-the-air computation(AirComp) power allocation energy harvesting(EH) optimization

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Themechanism of resistance to CDK4/6 inhibition and novel combination therapy with RNR inhibition for chemo-resistant bladder cancer

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Cancer Communications 2024年第6期44卷 700-704页

作者： Zhichao tong Yubo Zhao Shiyu Bai Benedikt Ebner lou Lienhard Yuling Zhao Ziqi Wang Qi Pan Pengyu Guo Thilo Bracht Barbara Sitek Jürgen E.Gschwend Wanhai xu Roman Nawroth Department of Urology Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Urology Klinikum rechts der IsarTechnical university of MunichMunichGermany Department of Urology The Fourth Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Urology Ludwig-Maximilians-University of MunichMunichGermany Department of Urology Shanghai General HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Medizinisches Proteom-Center Ruhr-Universität BochumBochumGermany Clinic for Anesthesiology Intensive Care and Pain TherapyUniversity Medical Center Knappschaftskrankenhaus BochumBochumGermany

Bladder cancer(BCa)is the most prevalent urological cancer worldwide[1].A significant proportion of BCa(89%)exhibits molecular alterations in the cell cycle pathway,and targeting cyclin-dependent kinases 4 and 6(CDK4/6)is deemed as a promising therapeutic strategy[2].Selective inhibitors of CDK4/6(CDK4/6is)have been approved by the US Food and Drug Administration(FDA)[3].

关键词： bladder CDK4 alterations

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