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Thin-section Computed Tomography Detects Long-term Pulmonary Sequelae 3 Years after Novel Influenza A Virus-associated Pneumonia

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Chinese Medical Journal 2015年第7期128卷 902-908页

作者： Zhi-Heng Xing Xin sun Long xu Qi Wu Li Li Xian-Jie Wu xu-Guang Shao Xin-Qian Zhao Jing-Hua Wang Long-Yan Ma Kai Wang Department of Radiology Tianjin Institute of Respiratory Diseases Tianjin Haihe Hospital Tianjin 300350 China Department of Respiratory Tianjin Institute of Respiratory Diseases Tianjin Haihe Hospital Tianjin 300350 China TCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine Tianjin China Department of Neurology Tianjin Medical University General Hospital Tianjin China Department of Epidemiology Tianjin Neurological Institute Tianjin China

Background： The aim of this research was to evaluate long-term pulmonary sequelae on paired inspiration-expiration thin-section computed tomograpby （CT） scans 3 years after influenza A （H 1 N1 ） virus-associated pneumonia, and to analyze the affecting factors on pulmonary fibrosis. Methods： Twenty-four patients hospitalized with H 1N 1 virus-associated pneumonia at our hospital between September 2009 and January 2010 were included. The patients underwent thin-section CT 3 years after recovery. Abnonnal pulmonary lesion pattems （ground-glass opacity, consolidation, parenchymal bands, air trapping, and reticulation） and evidence of fibrosis （architectural distortion, traction bronchiectasis, or honeycombing） were evaluated on follow-up thin-section CT. Patients were assigned to Group 1 （with CT evidence of fibrosis） and Group 2 （without CT evidence of fibrosis）. Demographics, rate of mechanical ventilation therapy, rate of intensive care unit admission, cumulative prednisolone-equivalent dose, laboratory tests results （maximum levels of alanine aminotransferase, aspartate transaminase [AST], lactate dehydrogenase [LDH], and creatine kinase [CK]）, and peak radiographic opacification of 24 patients during the course of their illness in the hospital were compared between two groups. Results： Parenchymal abnormality was present in 17 of 24 （70.8%） patients and fibrosis occurred in 10 of 24 （41.7%） patients. Patients in Group 1 （ 10/24; 41.7%） had a higher rate of mechanical ventilation therapy （Z- -2.340, P- 0.019）, higher number of doses of cumulative prednisolone-equivalent （Z = -2.579, P = 0.010）, higher maximum level of laboratory tests results （AST [Z = -2.140, P = 0.032], LDH [Z = -3.227, P = 0.001 ], and CK [Z= -3.345, P = 0.019]）, and higher peak opacification on chest radiographs （Z- -2.743, P = 0.006） than patients in group 2 （14/24; 58.3%）. Conclusions： H 1N 1 virus-associated pneumonia tYequently is followed by long-term pulmonary sequelae, including fibrotic

关键词： Computed Tomography Influenza A Pulmonary infection Viral Pneumonia

Synthesis of tetrasubstituted thiophenes from pyridinium 1,4-zwitterionic thiolates and modified activated alkynes

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Chinese Chemical Letters 2021年第12期32卷 3972-3975页

作者： Taimin Wang xuecheng Zhu Qingqing Tao Wei xu Haiyan sun Ping Wu Bin Cheng Hongbin Zhai Institute of Marine Biomedicine/Hoffmann Institute of Advanced Materials Shenzhen PolytechnicShenzhen 518055China State Key Laboratory of Chemical Oncogenomics Shenzhen Engineering Laboratory of Nano Drug Slow-ReleasePeking University Shenzhen Graduate SchoolShenzhen 518055China Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong Dezhou CollegeDezhou 253023China

Pyridinium 1,4-zwitterionic thiolates were applied to a formal [3+2] annulation reaction with modified activated alkynes, affording various tetrasubstituted thiophenes with aryl, alkenyl, alkyl or silyl group at the special position. The structural modification of alkyne substrates enabled the synthesis of diverse thiophenes to be achieved using the pyridinium 1,4-zwitterionic thiolates as the sulfur-containing building blocks. This approach is metal-free and catalyst-free.

关键词： 1,4-Zwitterionic thiolate Activated alkyne Formal[3+2] Thiophene Metal-free Catalyst-free

Primary structure of helix C to helix G of a new retinal protein in ***515

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Chinese Science Bulletin 2000年第12期45卷 1108-1113页

作者： Hui Wang Shuxuan Zhan Qingan sun Deqiang xu Wei Zhao Weida Huang Qingguo Li Fudan Univ Sch Life Sci Shanghai 200433 Peoples R China

The gene fragment encoding the retinal protein from helix C to helix G in a new strain of halobacteria, ***515 has been amplified by PCR method. The nucleotide sequence of this fragment has been determined. The deduced amino acid sequence has been compared with halobium br and other two br-like proteins, ar-1 and ar-2. Results show that those amino acid residues in br, essential for proton pumping and binding to retinal, are conserved. The residue M145 in br may be important for isomerization reaction of retinal.

关键词： halohactcria claret membrane archaerhodopsin PCR sequence.

In situ redox growth of mesoporous Pd-Cu2O nanoheterostructures for improved glucose oxidation electrocatalysis

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Science Bulletin 2019年第11期64卷 764-773页

作者： Ying Guo Jianwen Liu Yi-Tao xu Bo Zhao xuewan Wang Xian-Zhu Fu Rong sun Ching-Ping Wong Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences. Shenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong KongChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518055China National Supercomputing Center in Shenzhen Shenzhen 518055China Department of Electronics Engineering The Chinese University of Hong KongHong KongChina School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Interfaces of metal-oxide heterostructured electrocatalyst are critical to their catalytic activities due to the significant interfacial effects. However, there are still obscurities in the essence of interfacial effects caused by crystalline defects and mismatch of electronic structure at metal-oxide nanojunctions. To deeply understand the interfacial effects, we engineered crystalline-defect Pd-Cu2O interfaces through nonepitaxial growth by a facile redox route. The Pd-Cu2O nanoheterostructures exhibit much higher electrocatalytic activity toward glucose oxidation than their single counterparts and their physical mixture,which makes it have a promising potential for practical application of glucose *** study and density functional theory(DFT) calculations demonstrated that the interfacial electron accumulation and the shifting up of d bands center of Cu-Pd toward the Fermi level were responsible for excellent electrocatalytic activity. Further study found that Pd(3 1 0) facets exert a strong metaloxide interface interaction with Cu2O(1 1 1) facets due to their lattice mismatch. This leads to the sinking of O atoms and protruding of Cu atoms of Cu2O, and the Pd crystalline defects, further resulting in electron accumulation at the interface and the shifting up of d bands center of Cu-Pd, which is different from previously reported charge transfer between the interfaces. Our findings could contribute to design and development of advanced metal-oxide heterostructured electrocatalysts.

关键词： Metal-oxide interfaces Crystalline defects Interfacial electron accumulation Electrocatalysts Density functional theory

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从胆分型论治情志病

南京中医药大学学报 2024年第3期40卷 309-314页

作者：吴易俊孙永康徐方飚宋研博刘文博姜爽廖豪豪王新志河南中医药大学第一附属医院河南郑州450046 河南中医药大学第一临床医学院河南郑州450046

总结名老中医王新志教授从胆论治情志病的独特观点和经验运用。根据胆的中医学生理功能和特性,提出“心神-胆-脏腑”轴主导情志的产生和变化,认为胆失决断是情志病的关键病机。倡导临证从胆分型论治,根据临床表现将情志病分为胆气不升... 详细信息

总结名老中医王新志教授从胆论治情志病的独特观点和经验运用。根据胆的中医学生理功能和特性,提出“心神-胆-脏腑”轴主导情志的产生和变化,认为胆失决断是情志病的关键病机。倡导临证从胆分型论治,根据临床表现将情志病分为胆气不升型、少阳不利型、胆实热盛型、胆怯不足型和心胆失决型;以调整心、脾、肝、胆、肾等脏腑功能为基本原则,运用补脾益肾、升提胆气、和解少阳、清泄胆热、温阳益气、重镇安神及化痰逐瘀等治法,强调心胆共治、肝胆同调,使得心神安位、胆复决断、情志和畅。

关键词：情志病胆主决断 “心神-胆-脏腑”轴名医经验

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致雏鹅痛风新型鹅星状病毒研究进展

广东畜牧兽医科技 2024年第2期49卷 1-7页

作者：向勇唐铮李林林徐志宏孙敏华广东省农业科学院动物卫生研究所/农业农村部禽流感等家禽重大疾病防控重点实验室/广东省畜禽疫病防治研究重点实验室/农业农村部兽用药物与诊断技术广东科学观测实验站广东广州510640 华南农业大学兽医学院广东广州510642

鹅星状病毒(Gooseastrovirus,GAstV)是我国近年来新发现的一种星状病毒属成员,主要危害3周龄以下雏鹅。雏鹅感染后以内脏器官表面和关节腔中显著的尿酸盐沉积为特征;其感染率高达80%,死亡率可达50%;未死亡雏鹅则出现生长抑制和免疫水平... 详细信息

鹅星状病毒(Gooseastrovirus,GAstV)是我国近年来新发现的一种星状病毒属成员,主要危害3周龄以下雏鹅。雏鹅感染后以内脏器官表面和关节腔中显著的尿酸盐沉积为特征;其感染率高达80%,死亡率可达50%;未死亡雏鹅则出现生长抑制和免疫水平降低等现象,更易受到其他病原的侵害。GAstV既够能通过粪口途径水平传播,也可垂直传播,同时还具备跨宿主传播的能力。目前该病毒致病机制的研究进展较为缓慢且尚无针对该病的商品化生物制品,使得在制定该病的科学防控措施时仍缺乏充分的理论依据和健全的药物配套,导致该疾病的防控形势依然严峻,给我国养鹅业造成了巨大的经济损失。该文围绕GAstV的病原学、流行情况、致病性、免疫应答及其致病机制等方面进行了简要综述,以期为GAstV的深入研究和防控措施的初步制定提供参考。

关键词：鹅星状病毒病原学流行病学致病性免疫应答致病机制

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江苏省与新加坡深层地热资源潜力分析

中国煤炭地质 2024年第7期36卷 35-40页

作者：李丹孙少川毛翔罗璐许振华张海雄中石化新星江苏华东新能源开发有限责任公司江苏南京210000 中国石化集团新星石油有限责任公司北京100083

中国江苏省和新加坡均面临着能源紧张的问题,受地理位置限制迫切需要向深层地热资源转型,而深层干热岩开发利用是其中的重要方向之一。通过对中国江苏省苏北盆地和新加坡构造和沉积等基础地热地质进行对比分析,认为二者均位于环太平洋... 详细信息

中国江苏省和新加坡均面临着能源紧张的问题,受地理位置限制迫切需要向深层地热资源转型,而深层干热岩开发利用是其中的重要方向之一。通过对中国江苏省苏北盆地和新加坡构造和沉积等基础地热地质进行对比分析,认为二者均位于环太平洋地热异常带周缘,且断裂体系和火成岩广泛发育,指示了优异的深部地热背景。通过对地温场的分析,揭示出二者的大地热流和地温梯度均高于大陆平均水平,其中新加坡更是具有世界级的高温背景。近年来,在苏北盆地成功探获的寒武系—奥陶系干热岩,为新加坡深部地热资源开发提供了重要的启示。干热岩的形成与板块俯冲作用密切相关,热流通过断裂向上传递,同时加热地表水和/或地下水,并最终在断裂交汇处出露温泉。研究成果不仅阐明了苏北盆地和新加坡的基础地热地质和地温场特征,还为实现区域能源自给自足提供理论支撑。

关键词：深层地热资源干热岩地热背景苏北盆地新加坡

结合CNN和BiGRU的双通道短文本意图识别算法

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计算机系统应用 2024年第5期33卷 136-143页

作者：王超孙喁喁徐飞马媛媛文雯汪露西安工业大学计算机科学与工程学院西安710021

在短文本意图识别领域,卷积神经网络(CNN)因其在局部信息提取方面的优异性能而备受关注.然而,由于其难以捕捉短文本语料的全局特征,因此存在一定局限性.针对该问题,本文结合TextCNN和BiGRU-att的优点提出一个双通道短文本意图识别模型,... 详细信息

在短文本意图识别领域,卷积神经网络(CNN)因其在局部信息提取方面的优异性能而备受关注.然而,由于其难以捕捉短文本语料的全局特征,因此存在一定局限性.针对该问题,本文结合TextCNN和BiGRU-att的优点提出一个双通道短文本意图识别模型,利用局部特征和全局特征更好地识别短文本的意图,弥补模型对文本整体特征的不足.AB-CNN-BGRU-att模型首先利用ALBERT多层双向Transformer结构对输入的文本向量化,再将向量分别送入TextCNN和BiGRU网络模型以获取局部和全局特征.将这两种特征进行融合,并通过全连接层并输入Softmax函数得到意图标签.实验结果表明,在THUCNews_Title数据集上,本文提出的AB-CNN-BGRU-att算法准确率(Acc)达到了96.68%,F1值达到了96.67%,相较于其他常用意图识别模型表现出更佳的性能.

关键词：意图识别 ALBERT BiGRU 双通道

Efficacy of Quxie Capsule in Metastatic Colorectal Cancer:Long-Term Survival Update of A Double-Blind,Randomized,Placebo Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第11期28卷 971-974页

作者： ZHANG Tong xu Yun sun Ling-yun HE Bin HAO Jie ZHANG Da YANG Yu-fei Department of Oncology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China

Objective:To verify the efficacy of Quxie Capsule in patients with metastatic colorectal cancer(m CRC).Methods:It was a block randomized,double-blind,placebo-controlled *** patients with m CRC were randomized into 2 groups at a 1:1 *** patients in the treatment group received conventional therapy including chemotherapy,radiotherapy,targeted therapy and supportive care,and Chinese herbal medicine combined with Quxie Capsule(each capsule of 0.4 g was orally administered at 50 mg/kg,twice daily,day 1–20,in a 30-day course)for 3 *** patients in the control group received conventional therapy and Chinese herbal medicine combined with placebo for 3 *** outcome measures were overall survival(OS)and progression-free survival(PFS).Subgroup analysis was performed according to therapy lines,right or left-sided colon,targeted therapy and RAS gene status to determine the differences in PFS and OS between the two *** were followed up every 3 months until December 31st,***:Median follow-up time was 19.4 *** median OS was 23.9 months in the treatment group[95%confidence interval(CI)15.9-28.5]vs.14.3 months in the control group(95%CI 11.3-21.4,P0.05).In the subgroups of second-line therapy,non-targeted therapy,RAS gene wild type and left-sided colon,the treatment group showed a significant survival benefit compared with the control group(P<0.05 or P<0.01),***:Quxie Capsule can reduce the risk of death and prolong the OS of patients with m CRC.(Registration *** CTR-IOR-16009733).

关键词： Quxie capsule metastatic colorectal cancer randomized controlles trial Chinese medicine