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Effects of laser photocoagulation on serum angiopoietin-1, angiopoietin-2, angiopoietin-1/angiopoietin-2 ratio, and soluble angiopoietin receptor Tie-2 levels in type 2 diabetic patients with proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2014年第4期7卷 648-653页

作者： Qiao-Ying You Fu-Yuan Zhuge Qi-Qian Zhu xu-wei si Department of Endocrine and Metabolism Shaoxing People's Hospital

·AIM: To determine the effects of laser photocoagulation on serum levels of angiopoietin-1(Ang-1),angiopoietin-2(Ang-2), soluble angiopoietin receptor Tie-2(Tie-2), Ang-1/Ang-2 ratio and vascular endothelial growth factor(VEGF) in patients with type 2diabetes mellitus(T2DM) and proliferative diabetic retinopathy(PDR). We also explored the role of the Ang/Tie system in PDR.·METHODS:Totally 160patientswithT2 DM, including50 patients with non-diabetic retinopathy(NDR), 58 patients with non-proliferative diabetic retinopathy(NPDR), and52 patients with PDR were enrolled in this study. Serum Ang-1, Ang-2, Tie-2 receptor and VEGF levels were measured using enzyme-linked immunosorbent assays for all patients and were repeated in 26 patients who underwent laser photocoagulation two months after the procedure.·RESULTS:ThemedianlevelsofAng-2andVEGFinserum were significantly higher in the NPDR group(4.23 ng/mL and 303.2 pg/mL, respectively) compared to the NDR group(2.67 ng/mL and 159.8 pg/mL, respectively, P significantly higher in the NPDR group(10.77ng/mL) compared to the NDR group(9.31 ng/mL) and the PDR groups(9.54 ng/mL)(P significantly different among three groups(P >0.05).Ang-2 was positively correlated with VEGF and Tie-2 in the PDR and NPDR groups(both P significantly decreased(both P 0.05). The median levels of Ang-2 and VEGF in serum were highest in PDR group,however, Ang-1/Ang-2 ratio of PDR group was lowest in three groups.·CONCLUsiON: Laser p

关键词： angiopoietin receptor protein tyrosine kinase diabetes mellitus type 2 retinopathy laser photocoagulation

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Observations on Therapeutic Effect of Back-Shu Acupoint in Treatment of Asthma

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Journal of Acupuncture and Tuina Science 2008年第1期6卷 32-35页

作者：徐斯伟蒯乐 Department of Acupuncture and Moxibustion First People's Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 200080P.R.China

Objective： To investigate the therapeutic effect of Back-Shu acupoint in treating asthma. Methods： sixty-one patients were randomly divided into a Back-Shu acupoint group, a acupuncture-moxibustion group and a acupuncture group. All the three groups were treated twice a week, 10 times made up a treatment course. The therapeutic effect was evaluated after three courses of treatment. Results and conclusion： The control and marked effective rate were significantly higher in the Back-Shu acupoint group and acupuncture-moxibustion groups than in the acupuncture group （P〈0.05）. They were slightly higher in the acupuncture-moxibustion group than in the Back-Shu acupoint group, but there was no statistically significant difference. The results indicated that the Back-Shu acupoints have a good therapeutic effect in treating asthma.

关键词： Electroacupuncture Moxa Stick Moxibustion Acupuncture Therapy Points, Back-Shu Asthma

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Clinical Study on Point-toward-Point Needling for Asthenopia

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Journal of Acupuncture and Tuina Science 2013年第2期11卷 96-100页

作者： Liu Jian xu si-wei Zhang Ren Han Chou-ping Department of Acupuncture Branch of Shanghai First People's Hospital Shanghai First People's Hospital Shanghai Literature Institute of Traditional Chinese Medicine

Objective:To observe the effect of point-toward-point needling on ***:A total of 60 asthenopia cases were randomized into an observation group and a control group,30 cases in each ***-point needling was used in the observation group;whereas point injection was used in the control *** signs and symptoms including visual tasks and eye fatigue were observed before and after *** was followed by an inter-group comparison of eye discomfort symptom score and therapeutic ***:After treatment,the symptoms and signs in both groups were significantly improved,showing a statistical significance(Psion:Both treatment protocols can help alleviate the clinical symptoms of asthenopia;point-toward-point needling can obtain better effect than point injection.

关键词： Point-toward-point Method Acupuncture Therapy Hydro-acupuncture Asthenopia

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Efficacy Observation of Tuina Therapy for Fibromyalgia Syndrome

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Journal of Acupuncture and Tuina Science 2014年第6期12卷 383-388页

作者： Zhang Kai-yong Yang Yang xu si-wei Zhan Hong-sheng Zhang Bi-meng Hong Jue First People’s Hospital School of Medicine Shanghai Jiaotong University Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Objective： To observe the efficacy of tuina manipulations for fibromyalgia syndrome （FMS）. Methods： sixty eligible FMS patients were randomized into two groups, 30 in each group. Patients in the observation group were intervened by tuina manipulations to the corresponding segment of the spine based on the detection of disorders of the spine-related bones and tendons; patients in the control group were directed to practice functional exercises. Before and after intervention, the fibromyalgia impact questionnaire （FIQ） and visual analogue scale （VAS） were adopted for evaluation. Results： After intervention, the FIQ and VAS scores dropped significantly in both groups （all P〈O.05）, and there were significant differences between the two groups （both P〈0.05）. The total effective rate was 86.7% in the observation group versus 63.3% in the control group, and the difference was statistically significant （P〈0.05）. Conclusion： Spinal tuina manipulations are effective and safe in treating FMS, for significantly promoting the quality of life of the FMS patients.

关键词： Fibromyalgia Tuina Massage Chiropractic Exercise

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Experimental Observation on Antithrombotic Property of A New Bileaflet Mechanical Heart Valve in Sheep

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Chinese Journal of Biomedical Engineering(English Edition) 2008年第4期17卷 161-165页

作者： LOU Hai-fang xu si-wei The 2nd Affiliated Hospital of Medical College of Zhejiang University Hangzhou 310009 China

Objective ： To observe the antithrombotic property of a new all-pyrolytic carbon bileaflet mechanical heart valve so as to provide evidence for clinical practice. Methods： 15 sheep underwent mitral valve replacement （MVR） with this new mechanical valve. Each animal was placed on cardiopulmonary bypass. All of the sheep were given in an anticoagulation protocol and followed for three months. Final studies were performed on all animals surviving for more than 12 weeks. Results ： 10 sheep died within 48 h after operation, 5 sheep survived. The long-term survivors were killed for autopsies,2 sheep were killed after 1 week, 1 after 12 weeks and 2 after two and half years. Pathological examination of 10 sheep which died early after operation revealed that there was neither evidence of thrombosis nor any failure of the mechanical valve. Autopsy studies in the 5 long-term survivors revealed that the sewing ring was covered by a thin layer of microthrombi consisted most of platelets and fibrin after 1 week. The sewing ring was covered by a tissue layer, with partial organized microthrombi and endothelialization after 12 weeks. Two and half years after operation, the complete endothelialization presented around the sewing ring without restriction of bileaflet motion. The tissue ingrowth tends to stop at the pyrolytic earbon-fabric interface on both surfaces of left atrium and ventricle. This study demonstrated that the new prosthetic heart valve had not promoted thrombosis and thrombembolism.

关键词： antithrombotic property mechanical heart valve cardiopulmonary bypass

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结合高分辨率X射线光电子能谱和拉曼散射研究Ge_(x)Ga_(8)S_(92-x)玻璃结构

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物理学报 2023年第1期72卷 238-245页

作者：许思维王训四沈祥湖南文理学院数理学院常德415000 宁波大学高等技术研究院浙江省光电探测材料及器件重点实验室宁波315211

本文在固定Ga原子含量为8%的情况下,结合高分辨率X射线光电子能谱和拉曼散射光谱对硫系玻璃Ge_(x)Ga_(8)S_(92-x)(x=24%,26.67%,29.6%,32%和36%)的结构进行了研究.通过分析玻璃结构中各单元结构的演变情况,发现玻璃内部网络结构主要为S... 详细信息

本文在固定Ga原子含量为8%的情况下,结合高分辨率X射线光电子能谱和拉曼散射光谱对硫系玻璃Ge_(x)Ga_(8)S_(92-x)(x=24%,26.67%,29.6%,32%和36%)的结构进行了研究.通过分析玻璃结构中各单元结构的演变情况,发现玻璃内部网络结构主要为S原子桥接GeS_(4)和GaS_(4)四面体结构.随着Ge含量的逐渐增大,S链状或环状结构单元迅速减少,并消失于Ge_(26.67)Ga_(8)S_(65.33)玻璃组分中;而类乙烷结构S_(3)Ge-GeS_(3)中的Ge—Ge同极键和S_(3)Ge/Ga-Ga/GeS_(3)结构中的M—M(Ge—Ge,Ga—Ga或Ge—Ga)同极键同时出现于Ge_(29.6)Ga_(8)S_(62.4)玻璃中,并且其结构数量随着Ge含量的增大而逐渐增加.由此可以判定,首先,在硫系玻璃Ge_(x)Ga_(8)S_(92-x)结构中Ge和Ga原子均主要以4配位的形式出现,而S原子则主要以2配位的形式出现.其次,M—M键的存在导致纳米相分离,玻璃网络结构的有序化程度降低.

关键词：硫系玻璃结构 X射线光电子能谱拉曼散射

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元素取代对Ge-As(Sb)-Se玻璃转变阈值行为的影响

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物理学报 2024年第5期73卷 297-303页

作者：许思维王训四沈祥湖南文理学院数理学院常德415000 宁波大学高等技术研究院浙江省光电探测材料及器件重点实验室宁波315211

本文针对Sb取代As元素对Ge_(x)As(Sb)_(20)Se_(80-x)玻璃阈值行为的影响进行研究.对理想共价网络玻璃GexAs20Se80-x的玻璃转变温度、密度和折射率等物理参数进行了系统测量,在其平均配位数为2.4和2.67处验证了转变阈值的存在,这两个转... 详细信息

本文针对Sb取代As元素对Ge_(x)As(Sb)_(20)Se_(80-x)玻璃阈值行为的影响进行研究.对理想共价网络玻璃GexAs20Se80-x的玻璃转变温度、密度和折射率等物理参数进行了系统测量,在其平均配位数为2.4和2.67处验证了转变阈值的存在,这两个转变分别代表玻璃内部的共价网络结构从欠限制的松散状态到过限制的紧致状态的转变和从二维到三维紧致状态的转变.但是,当金属性更强的Sb取代As时,得到的非理想共价网络玻璃Ge_(x)Sb_(20)Se_(80-x)则会引起转变阈值的变化,转变阈值改变为化学计量组成.进一步利用拉曼散射技术对其结构进行表征,并将拉曼光谱通过分峰拟合分解成不同的结构单元的特征峰,它们各自的强度变化表现出相同的行为,这归因于As和Sb的原子半径差异较大所引起的化学效应以及Sb元素具有较强的离子特性.

关键词：硫系玻璃玻璃转变拉曼散射

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Ge_xSb_(20)Se_(80-x)玻璃的拉曼光谱和X射线光电子能谱

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物理学报 2015年第22期64卷 117-123页

作者：许思维王丽沈祥北京工业大学应用数理学院北京100124 宁波大学信息科学与工程学院宁波315211

用拉曼散射光谱和X射线光电子能谱研究了GexSb20Se80-x(x=5 mol%,10 mol%,15 mol%,17.5 mol%,20 mol%和25 mol%)玻璃的结构.通过对拉曼光谱和X射线光电子能谱(Ge 3d,Sb 4d和Se 3d谱)进行分解,发现当硫系玻璃处于富Se状态下时,玻璃结构... 详细信息

用拉曼散射光谱和X射线光电子能谱研究了GexSb20Se80-x(x=5 mol%,10 mol%,15 mol%,17.5 mol%,20 mol%和25 mol%)玻璃的结构.通过对拉曼光谱和X射线光电子能谱(Ge 3d,Sb 4d和Se 3d谱)进行分解,发现当硫系玻璃处于富Se状态下时,玻璃结构中会出现Se—Se—Se结构单元,其数量随着Ge含量的增加而迅速减少,并最终在Ge15Sb20Se65玻璃结构中消失;Ge和Sb原子分别以Ge Se4/2四面体和SbSe3/2三角锥结构单元在玻璃结构中出现,GeSe4/2四面体结构单元的数量会随着Ge浓度的增加而增加,而SbSe3/2三角锥结构单元的数量基本保持稳定.另一方面,在缺Se的硫系玻璃中,玻璃会有Ge—Ge和Sb—Sb同极键产生,随着Ge含量的增大,这种同极键的数量会越来越多;而GeSe4/2四面体和SbSe3/2三角锥结构的数量则相应减少.在所有玻璃样品的结构中均有同极键Se—Se的存在.当玻璃组分越接近完全化学计量配比时,异质键Ge—Se和Sb—Se将占据玻璃结构中的主导地位,同极键Ge—Ge,Sb—Sb和Se—Se的比例降为最小.

关键词：拉曼光谱 X射线光电子能谱结构硫系玻璃

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Distinctive Drug-resistant Mutation Profiles and Interpretations of HIV-1 Proviral DNA Revealed by Deep Sequencing in Reverse Transcriptase

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Biomedical and Environmental Sciences 2016年第4期29卷 239-247页

作者： YIN Qian Qian LI Zhen Peng ZHAO Hai PAN Dong WANG Yan xu wei si XING Hui FENG Yi JIANG Shi Bo SHAO Yi Ming MA Li Ying State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention (NCAIDS) Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Chinese Center for Disease Control and Prevention State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Chinese Center for Disease Control and Prevention Key Laboratory of Medical Molecular Virology (Ministries of Education and Health) Shanghai Medical College and Institute of Medical Microbiology Fudan University

Objective To investigate distinctive features in drug-resistant mutations （DRMs） and interpretations for reverse transcriptase inhibitors （RTIs） between proviral DNA and paired viral RNA in HIV-l-infected patients. Methods Forty-three HIV-l-infected individuals receiving first-line antiretroviral therapy were recruited to participate in a multicenter AIDS Cohort Study in Anhui and Henan Provinces in China in 2004. Drug resistance genotyping was performed by bulk sequencing and deep sequencing on the plasma and whole blood of 77 samples, respectively. Drug-resistance interpretation was compared between viral RNA and paired proviral DNA. Results Compared with bulk sequencing, deep sequencing could detect more DRMs and samples with DRMs in both viral RNA and proviral DNA. The mutations M1841 and M2301 were more prevalent in proviral DNA than in viral RNA （Fisher＇s exact test, P〈0.05）. Considering ＇majority resistant variants＇, 15 samples （19.48%） showed differences in drug resistance interpretation between viral RNA and proviral DNA, and 5 of these samples with different DRMs between proviral DNA and paired viral RNA showed a higher level of drug resistance to the first-line drugs. Considering ＇minority resistant variants＇, 22 samples （28.57%） were associated with a higher level of drug resistance to the tested RTIs for proviral DNA when compared with paired viral RNA. Conclusion Compared with viral RNA, the distinctive information of DRMs and drug resistance interpretations for proviral DNA could be obtained by deep sequencing, which could provide more detailed and precise information for drug resistance monitoring and the rational design of optimal antiretroviral therapy regimens.

关键词： HIV-1 drug-resistant mutation Drug-resistance interpretation Proviral DNA Viral RNA Deep sequencing

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Experimental Observation on the Effects of Different Chitosan on Preventing Traumatic Peritoneal Adhesion in Rats

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Chinese Journal of Biomedical Engineering(English Edition) 2005年第3期14卷 130-138页

作者： ZHANG Zhi-liang xu si-wei ZHOU Xie-lai The schoo of clinical medicine of hangzhou normal college Hangzhou 310018China Department of cardiovascular surgery The 2nd affiliated hospital of medical college of zhejiang university 88 Jiefang RoadHangzhou 310009 China Correspondence to ：Dr. xu si-wei

objective:The effects of different chitosan on preventing traumatic peritoneal adhesion in rats was studied in this paper. METHODS: 96 SD rats with injured vermiform process were randomly divided into 4 groups as follows: group A without any treatment as control, group B treated with chitosan gel, group C treated with pure chitosan film and group D treated with chiston film containing 50% gelatin. 2 and 4 weeks after surgery, 12 rats in each group were respectively belly opened to observe chitosan degradation and evaluate peritoneal adhesion, and the adhesive vermiform processes tissues were histopathologically observed. RESULTS: *** in the group D was faster than that in the group C but slower than that in the group B. 2. 2 weeks after surgery the adhesion in the group B was milder than that in the control group(goup A) (Psion in the group B was milder than that in the control group (Psignificant difference between adhesion in the group C and group D (P>0.05). *** examinaiton indicated that: 2 weeks after surgery ,inflammatory cell infiltration and fibroplastic proliferation dominated in local lesion and the response was most severe on the serous coat, furthermore, the response in the control group was more severe than that in the group B, but milder than that in the group C and D; 4 weeks after surgery, fibroplastic proliferation dominated in local lesion in each group , moreover, the response in the control group was more severe than that in the group B but milder than that in the group C and D. What’s more, integrated fibrous membrane formed around implanted materials in the group C and D, and the fibrous membranes were thinner in the group C than that in the group D. CONCLUsiON:

关键词： Chitosan Gel Gelatin peritoneal adhesion Film protecting adhesion

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