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Partially substituting alfalfa hay with hemp forage in the diet of goats improved feed efficiency, ruminal fermentation pattern and microbial profiles

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Animal Nutrition 2024年第2期17卷 49-60页

作者： tao Ran Zhipeng xu Wenzhu Yang Dalin Liu Duanqin Wu College of Pastoral Agriculture Science and Technology Lanzhou University State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems Changshu Center for Animal Disease Prevention and Control Lethbridge Research and Development Centre Agriculture and Agri-Food Canada College of Animal Science and Technology Yangzhou University Institute of Bast Fiber Crops Chinese Academy of Agricultural Sciences

The use of hemp as a forage source in livestock diets has been less studied because bioactive residues in animal tissues may pose a risk to consumers. This study investigated the effects of partial substitution of alfalfa hay(AH) with hemp forage(HF) in growing goat diets on growth performance, carcass traits, ruminal fermentation characteristics, rumen microbial communities, blood biochemistry, and antioxidant *** Xiangdong black goats with body weight(BW) 7.82 ± 0.57 kg(mean ± SD) were grouped by BW and randomly assigned into one of the four treatment diets(n = 10/treatment) in a completely randomized design. The goats were fed ad libitum total mixed rations containing 60% forage and 40% concentrate(DM basis). The diets included control(CON; 60% AH and 40% concentrate), 55% AH and 5% HF(HF5), 50% AH and10% HF(HF10), and 40% AH and 20% HF(HF20). Increasing the substitution of HF for AH linearly decreased(P = 0.004) DM intake and improved feed conversion efficiency. However, final BW, average daily gain,carcass traits, meat quality, and most blood biochemistry indices did not differ among treatments. The ruminal NH3-N concentration(P = 0.003) and blood urine nitrogen(P = 0.050) linearly increased(P < 0.01)with increasing substitution rate of HF, whereas the total volatile fatty acids concentration quadratically changed(P = 0.007). Substitution of AH with HF had no effect on the diversity and richness of ruminal microbes, though it linearly decreased(P = 0.040) Prevotella＿1 and linearly increased(P = 0.017) Rikenellaceae＿RC9＿gut＿group. The cannabinoids and/or their metabolites were detected in both ruminal filtrates(8) and plasma(4), however, no detectable cannabinoid-related residues were observed in *** results indicate that the HF could be used to partially substitute AH in goat diets, whereas the effects vary between substitution rates of HF for AH. Although no cannabinoid-related residues were detected in meat, the presence of cannabinoids resid

关键词： Alfalfa hay Hemp forage Growth performance Ruminal microbiota Cannabinoid metabolism Goat

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High-frequency magnetic properties of biphase Ce_(2)Fe_(17)N_(3)/α-Fe microflakes with easy-plane anisotropy

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Journal of Rare Earths 2024年第1期42卷 110-115,I0004页

作者： Ke Wang Hang Zhang yuandong Huang Zhibiao xu Fashen Li tao Wang Key Laboratory for Magnetism and Magnetic Materials of MOE Lanzhou UniversityLanzhou730000China Key Laboratory of Special Function Materials and Structure Design Ministry of EducationLanzhou UniversityLanzhou730000China

Soft magnetic composites(SMCs)are effective as magnetic powder cores in an *** to high saturation magnetization,large magnetocrystalline anisotropy and high operating frequency of M(metal)-RE(rear earth)soft magnetic composites,it is possible to miniaturize inductor cores by reducing total loss,especially eddy current loss and excess loss at high *** this article,the characteristics of Ce_(2)Fe_(17)N_(3)/α-Fe(CFN/F)loss per volume and effective permeability reaching a high frequency of 3 MHz are *** biphase CFN/F composite exhibits a high permeability of 16 at 70 MHz,which is two times greater than that of pure Ce_(2)Fe_(17)N_(3)(CFN)*** total loss is as low as 545 mW/cm^(3)at 3 MHz and 6 *** direct current(DC)-bias properties have a percent of permeability exceeding 65% at H=7960 A/*** phenomenon indicates that our material has a higher working frequency and lower core loss than other materials;the biphase CFN/F structure is a promising and efficient approach for developing the miniaturized radio frequency(RF)inductor core.

关键词： High frequency Soft magnetic composites Easy-plane anisotropy Permeability spectra Core loss Rare earths

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Preparation and characterization of Rb-doped TiO_(2) powders for photocatalytic applications

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Rare Metals 2024年第2期43卷 555-561页

作者： Lu Jia Li-Mei Yang Wei Wang Song-tao Huang Zheng xu National Engineering Laboratory of Biohydrometallurgy General Research Institute for Nonferrous MetalsBeijing100088China

TiO_(2)nanoparticles doped with different concentrations of Rb were prepared by sol–gel *** crystal structures of samples were characterized by X-ray diffraction(XRD)and transmission electron microscopy(TEM).It was confirmed by the Rietveld refinement method that the as-prepared samples crystallize in anatase phase and Rb doping induces expansion and distortion of the crystal *** with the pure TiO_(2),the Rb-doped nanoparticles have smaller crystal size and better *** rate of methylene blue was used to evaluate the photocatalytic activity of Rb–TiO_(2).It indicated that doping Rb into TiO_(2)can effectively improve the photocatalytic activity of TiO_(2)and the mechanisms were discussed in *** using the sample doped with 0.20%Rb,methylene blue degraded with the fastest rate(97%within 60 min).

关键词： Rb doping TiO_(2) Photocatalysis Sol-gel

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Generic load regulation strategy for enhancing energy efficiency of chiller plants

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Building Simulation 2024年第8期17卷 1273-1287页

作者： Hang Wan yuyang Gong Shengwei Wang Yongjun Sun tao xu Gongsheng Huang Department of Architecture and Civil Engineering City University of Hong KongHong KongChina Department of Building Environment and Energy Engineering Hong Kong Polytechnic UniversityHong KongChina School of Civil Engineering Guangzhou UniversityGuangzhouChina Shenzhen Research Institute of City University of Hong Kong ShenzhenChina

In many chiller plants,high coefficient of performance(COP)is only achieved at a few favorable part load ratios(PLRs),while the COP is low at many other non-favorable *** address this issue,this study proposes a generic load regulation strategy that aims to maintain chiller plants operating at high COP,particularly under non-favorable *** is achieved by incorporating thermal energy storage(TES)units and timely optimizing the charging and discharging power of the integrated TES *** optimal charging and discharging power is determined by solving a dynamic optimization problem,taking into account the performance constraints of the TES units and the chiller *** provide an overview of the energy-saving potential of the proposed strategy,a comprehensive analysis was conducted,considering factors such as building load profiles,COP/PLR curves of chillers,and attributes of the TES *** analysis revealed that the proposed load regulation strategy has the potential to achieve energy savings ranging from 5.7%to 10.8%for chiller plants with poor COPs under unfavorable PLRs,particularly in buildings with significant load variations.

关键词： load regulation thermal energy storage chiller plants building energy efficiency

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A Two-Layer Encoding Learning Swarm Optimizer Based on Frequent Itemsets for Sparse Large-Scale Multi-Objective Optimization

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1342-1357页

作者： Sheng Qi Rui Wang tao Zhang xu Yang Ruiqing Sun Ling Wang College of Systems Engineering National University of Defense TechnologyChangsha 410073China Xiangjiang Laboratory Changsha 410205China College of Computer National University of Defense TechnologyChangsha 410073China Department of Automation Tsinghua UniversityBeijing 100084China IEEE

Traditional large-scale multi-objective optimization algorithms(LSMOEAs)encounter difficulties when dealing with sparse large-scale multi-objective optimization problems(SLM-OPs)where most decision variables are *** a result,many algorithms use a two-layer encoding approach to optimize binary variable Mask and real variable Dec ***,existing optimizers often focus on locating non-zero variable posi-tions to optimize the binary variables ***,approxi-mating the sparse distribution of real Pareto optimal solutions does not necessarily mean that the objective function is *** data mining,it is common to mine frequent itemsets appear-ing together in a dataset to reveal the correlation between *** by this,we propose a novel two-layer encoding learning swarm optimizer based on frequent itemsets(TELSO)to address these *** mined the frequent terms of multiple particles with better target values to find mask combinations that can obtain better objective values for fast ***-mental results on five real-world problems and eight benchmark sets demonstrate that TELSO outperforms existing state-of-the-art sparse large-scale multi-objective evolutionary algorithms(SLMOEAs)in terms of performance and convergence speed.

关键词： Evolutionary algorithms learning swarm optimiza-tion sparse large-scale optimization sparse large-scale multi-objec-tive problems two-layer encoding.

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Sustainable and practical semi-heterogeneous photosynthesis of 5-amino-1,2,4-thiadiazoles over WS_(2)/TEMPO

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Chinese Chemical Letters 2024年第8期35卷 250-253页

作者： Jia-Cheng Hou Hong-tao Ji yu-Han Lu Jia-Sheng Wang Yao-Dan xu Yan-Yan Zeng Wei-Min He School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China

An eco-friendly and practical method for the clean preparation of 5-amino-1,2,4-thiadiazoles was *** WS_(2)as the semiconductor photocatalyst,both TEMPO and O_(2)(in air)as the redox catalysts,a variety of thiadiazoles were semi-heterogeneously formed in high to quantitative yields and could be easily collected by CPME extraction and ***,the catalytic system can be reusable for at least 5 reaction runs.

关键词： Green chemistry Thiadiazoles Heterogeneous catalyst Redox catalyst Extraction

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Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

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Food Science and Human Wellness 2024年第4期13卷 2116-2131页

作者： yu Peng Xiaoao Xiao Tingting Ji Xinyuan Wang Yixuan xu Jianbo Xiao Hui Cao Zhiyong Chen Huifan Liu yuanqing Gao Hongxun tao Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China Department of Analytical Chemistry and Food Science Faculty of ScienceUniversity of VigoVigo 36310Spain CISPAC Fontan BuildingCity of CultureSantiago de Compostela 15707Spain Shaanxi Academy of Traditional Chinese Medicine Xi'an 710003China Guangdong Key Laboratory of Science and Technology of Lingnan Specialty Food Zhongkai University of Agriculture and EngineeringGuangzhou 510550China State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu 610075China

Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in ***,our previous work has found that *** extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced ***,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against *** chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were ***,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable *** decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of *** metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid ***,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

关键词： Rhodiola crenulate Colitis Chemical characterization Plasma pharmacochemistry Metabolomics

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Aging Mongolian pine plantations face high risks of drought-induced growth decline:evidence from both individual tree and forest stand measurements

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Journal of Forestry Research 2024年第2期35卷 109-120页

作者： Mingyong Li Leilei Yang yu Cao Dedong Wu Guangyou Hao CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016People’s Republic of China Key Laboratory of Terrestrial Ecosystem Carbon Neutrality Liaoning ProvinceShenyang 110016People’s Republic of China Daqinggou Ecological Research Station Institute of Applied EcologyChinese Academy of SciencesShenyang 110016People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Research Institute of Sand Control and Utilization Liaoning ProvinceFuxin 123000People’s Republic of China

Discerning vulnerability differences among different aged trees to drought-driven growth decline or to mortality is critical to implement age-specific countermeasures for forest management in water-limited *** important species for afforestation in dry environments of northern China,Mongolian pine(Pinus sylvestris *** Litv.)has recently exhibited growth decline and dieback on many sites,particularly pronounced in old-growth ***,changes in response to drought stress by this species with age as well as the underlying mechanisms are poorly *** this study,tree-ring data and remotely sensed vegetation data were combined to investigate variations in growth at individual tree and stand scales for young(9-13 years)and aging(35-52 years)plantations of Mongolian pine in a water-limited area of northern China.A recent decline in tree-ring width in the older plantation also had lower values in satellited-derived normalized difference vegetation indices and normalized difference water indices relative to the younger *** addition,all measured growth-related metrics were strongly correlated with the self-calibrating Palmer drought severity index during the growing season in the older *** of growth to drought of the older plantation might be attributed to more severe hydraulic limitations,as reflected by their lower sapwood-and leaf-specific hydraulic *** study presents a comprehensive view on changes of growth with age by integrating multiple methods and provides an explanation from the perspective of plant hydraulics for growth decline with *** results indicate that old-growth Mongolian pine plantations in water-limited environments may face increased growth declines under the context of climate warming and drying.

关键词： Tree age Drought stress Mongolian pine plantation Tree rings Remote sensing Plant hydraulics

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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu yu-Ya Wang Gui-tao Huo Yan-Wei Yang Nan xu Hong Wang Yong Wu yu-Fa Miao Rui Fu yu-Wei Zhao Chang-Fa Fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

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Crosstalk between RNA m^(6)A modification and epigenetic factors in plant gene regulation

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Plant Communications 2024年第10期5卷 45-58页

作者： Jianzhong Hu tao xu Hunseung Kang Guangdong Provincial Key Laboratory for Plant Epigenetics Longhua Bioindustry and Innovation Research InstituteCollege of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong 518060China Jiangsu Key Laboratory of Genomics School of Life SciencesJiangsu Normal UniversityXuzhouJiangsu Province 221116China Department of Applied Biology College of Agriculture and Life SciencesChonnam National UniversityGwangju 61186Korea

N^(6)-methyladenosine(m^(6)A)is the most abundant modification observed in eukaryotic *** in transcriptome-wide m^(6)A mapping and sequencing technologies have enabled the identification of several conserved motifs in plants,including the RRACH(R=A/G and H=A/C/U)and UGUAW(W=U or A)***,the mechanisms underlying deposition of m^(6)A marks at specific positions in the conserved motifs of individual transcripts remain to be *** from plant and animal studies suggests that m^(6)A writer or eraser components are recruited to specific genomic loci through interactions with particular transcription factors,5-methylcytosine DNA methylation marks,and histone *** addition,recent studies in animal cells have shown that microRNAs play a role in depositing m^(6)A marks at specific sites in transcripts through a base-pairing mechanism.m^(6)A also affects the biogenesis and function of chromatin-associated regulatory RNAs and long noncoding *** we have less of an understanding of the link between m^(6)A modification and epigenetic factors in plants than in animals,recent progress in identifying the proteins that interact with m^(6)A writer or eraser components has provided insights into the crosstalk between m^(6)A modification and epigenetic factors,which plays a crucial role in transcript-specific methylation and regulation of m^(6)A in plants.

关键词： RNA methylation DNA methylation histone modification epigenetics microRNA long noncoding RNA

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