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Pancreatic encephalopathy and Wernicke encephalopathy in association with acute pancreatitis: A clinical study

World Journal of Gastroenterology 2006年第26期12卷 4224-4227页

作者： Guo-Hui Sun Yun-sheng Yang Qing-Sen Liu Liu-Fang Cheng xu-sheng huang Department of Gastroenterology Chinese PLA General Hospital Beijing 100853 China Department of Neurology Chinese PLA General Hospital Beijing 100853 China

AIM： To investigate clinical characteristics and therapy of pancreatic encephalopathy （PE） and Wernicke encephalopathy （WE）. METHODS： In a retrospective study of 596 patients with acute pancreatitis （AP）, patients with PE were compared to those with WE in regards to history, clinical manifestation, diagnosis, treatment and outcome. RESULTS： There were 93 patients with severe acute pancreatitis （SAP）. Encephalopathies were discovered in 10 patients （1.7%）. Six patients with PE all developed in SAP （6.5%）, and three of them died （3% of SAP, 50% of PE）. Four patients with WE developed in AP （0.7%）, and two of them died （0.3% of AP, 50% of WE）. Two patients with WE were treated with parenteral thiamine and survived. Global confusions were seen in all patients with encephalopathy. Ocular abnormalities were found. Conjugate gaze palsies were seen in 1 of 6 （16.7%） patients with PE. Of 4 patients with WE, one （25%） had conjugate gaze palsies, two （50%） had horizontal nystagmus, three （75%） had diplopia, and one （25%） had myosis. Ataxia was not seen in all patients. None of patients with WE presented with the classic clinical triad. CSF examinations for 2 patients with WE showed lightlyincreased proteins and glucose. CT and MRI of the brain had no evidence of characteristic abnormalities. CONCLUSION： PE occurs in early or reiteration stage of SAP, and WE in restoration stage of SAP/AP. Ocular abnormalities are the hallmarks of WE, and horizontal nystagmus is common. It is difficult to diagnose earlier an encephalopathy as PE or WE, as well as differentiate one from the other. Long fasting, hyperemesis and total enteral nutrition （TPN） without thiamine are main causes of thiamine deficiency in the course of pancreatitis.

关键词： Pancreatic encephalopathy Wernicke encephalopathy Acute pancreatitis Thiamine Total parenteral nutrition

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Construction of a new regular LDPC code for optical transmission systems

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Optoelectronics Letters 2013年第3期9卷 204-207页

作者： YUAN Jian-guo TONG Qing-zhen xu Liang huang sheng Key Lab. of Optical Fiber Communications Technology Chongqing University of Posts and TelecommunicationsChongqing 400065 China

A novel construction method of the check matrix for the regular low density parity check （LDPC） code is proposed. The novel regular systematically constructed Gallager （SCG）-LDPC（3969,3720） code with the code rate of 93.7% and the redundancy of 6.69% is constructed. The simulation results show that the net coding gain （NCG） and the distance from the Shannon limit of the novel SCG-LDPC（3969,3720） code can respectively be improved by about 1.93 dB and 0.98 dB at the bit error rate （BER） of 10s, compared with those of the classic RS（255,239） code in ITU-T G.975 recommendation and the LDPC（32640,30592） code in ITU-T G.975.1 recommendation with the same code rate of 93.7% and the same redundancy of 6.69%. Therefore, the proposed novel regular SCG-LDPC（3969,3720） code has excellent performance, and is more suitable for high-speed long-haul optical transmission systems.

关键词：规则LDPC码光传输系统低密度奇偶校验 ITU-T 代码率校验矩阵正规系统仿真结果

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Mutation Analysis of Gap Junction Protein Beta 1 and Genotype-Phenotype Correlation in X-linked Charcot-Marie- Tooth Disease in Chinese Patients

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Chinese Medical Journal 2016年第9期129卷 1011-1016页

作者： Bo Sun Zhao-HuiChen Li Ling Yi-Fan Li Li-Zhi Liu Fei Yang xu-sheng huang Department of Neurology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background： Among patients with Charcot-Marie-Tooth disease （CMT）, the X-linked variant （CMTX） caused by gap junction protein beta 1 （GJB1） gene mutation is the second most frequent type, accounting for approximately 90% of all CMTX. More than 400 mutations have been identified in the GJB1 gene that encodes connexin 32 （CX32）. CX32 is thought to form gap junctions that promote the diffusion pathway between cells. GJB1 mutations interfere with the formation of the functional channel and impair the maintenance of peripheral myelin, and novel mutations are continually discovered. Methods： We included 79 unrelated patients clinically diagnosed with CMT at the Department of Neurology of the Chinese People＇s Liberation Army General Hospital from December 20, 2012, to December 31, 2015. Clinical examination, nerve conduction studies, and molecular and bioinformatics analyses were performed to identify patients with CMTX 1. Results： Nine GJBI mutations （c.283G〉A, c.77C〉T, c.643C〉T, c.515C〉T, c.191G〉A, c.610C〉T, c.490C〉T, c.491G〉A, and c.44G〉A） were discovered in nine patients. Median motor nerve conduction velocities of all nine patients were 〈 38 m/s, resembling CMT Type 1. Three novel mutations, c.643C〉T, c.191G〉A, and c.610C〉T, were revealed and bioinformatics analyses indicated high pathogenicity. Conclusions： The three novel missense mutations within the GJB1 gene broaden the mutational diversity ofCMT1X. Molecular analysis of family members and bioinformatics analyses of the afflicted patients confirmed the pathogenicity of these mutations.

关键词： Connexin 32 Electrophysiology Gap Junction Protein Beta 1 Genetic Mutation X-linked Charcot-Marie-Tooth Disease

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Prognostic value of time to generalization in 71 Chinese patients with sporadic amyotrophic lateral sclerosis

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Chinese Medical Journal 2019年第9期132卷 1023-1027页

作者： Qiong-Hua Sun Yan-Ran Li Wen-Jie Lan Fei Yang Fang Cui xu-sheng huang Department of Neurology Chinese People's Liberation Army General HospitalBeijing 100853China College of Medicine Nankai UniversityTianjin 300071China

Background:It is important to determine prognostic factors for the outcome of amyotrophic lateral sclerosis (ALS) at an early *** time taken for symptoms to spread from spinal or bulbar regions to both (time to generalization;TTG) is considered a strong predictor of survival;however,this has rarely been studied in Asian *** aim of this retrospective study was to evaluate potential factors affecting prognosis in Chinese patients with sporadic ALS,with a focus on the association between TTG and overall ***:Seventy-one patients with sporadic ALS who were hospitalized at Chinese PLA General Hospital from 2009 to 2016 were followed up until December *** analysis was performed using univariate Kaplan-Meier log-rank and multivariate Cox proportional hazards *** clinical data of the patients were recorded and *** studied were age at symptom onset,sex,site of symptom onset,diagnostic latency,TTG,diagnostic category,ALS Functional Rating Scale-revised score,percent predicted forced vital capacity (FVC%),and disease progression rate (DPR) at ***:The mean age at onset was 54 (SD = 10.2) years,and the median survival time from symptom onset was 41 months (95% confidence interval:34–47).By univariate analysis,factors independently affecting survival were age at symptom onset (Log rank = 15.652,P<0.0001),TTG (Log rank = 14.728,P<0.0001),diagnostic latency (Log rank = 11.997,P = 0.001),and DPR (Log rank = 6.50,P = 0.011).In the Cox multivariate model,TTG had the strongest impact on survival time (hazard ratio = 0.926,P = 0.01).Conclusions:TTG can be used as an effective indicator of prognosis in patients with sporadic ALS.

关键词： Amyotrophic lateral sclerosis Time to generalisation (TTG) Prognosis Survival

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Effects of Head-down Tilt on Nerve Conduction in Rhesus Monkeys

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Chinese Medical Journal 2017年第3期130卷 323-327页

作者： Bo Sun Xiao-Yun Zhang Li-Zhi Liu Zhao-Hui Chen Zhong-Quan Dai xu-sheng huang Department of Neurology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Neurology 306th Hospital of People's Liberation Army Beijing 100101 China Department of Biomedical Engineering China Astronaut Research and Training Center Beijing 100101 China

Background： Few studies have focused on peripheral nerve conduction during exposure to microgravity. The -6° head-down tilt （HDT） comprises an experimental model used to simulate the space flight environment. This study investigated nerve conduction characteristics of rhesus monkeys before and alter prolonged exposure to H DT. Methods： Six rhesus monkeys （3-4 years old） were tilted backward 6° from the horizontal. Nerve conduction studies （NCSs） were performed on the median, ulnar, tibial, and fibular motor nerves. Analysis of variance with a randomized block design was conducted to compare the differences in the NCS belbre and 7, 2 l, and 42 days alter the 6° HDT. Results： The proximal amplitude of the CMAP of the median nerve was significantly decreased at 21 and 42 days of HDT compared with the amplitude before HDT （4.38 ± 2.83 vs. 8.40 ±2.66 mV, F = 4.85, P = 0.013 and 3.30± 2.70 vs. 8.40± 2.66 mV, F = 5.93, P = 0.004, respectively）. The distal amplitude of the CMAP of the median nerve was significantly decreased at 7, 21, and 42 days of HDT compared with the amplitude before HDT （7.28 ± 1.27 vs. 10.25 ± 3.40 mV, F= 4.03, P = 0.039; 5.05 ± 2.01 vs. 10.25 ± 3.40 mV, F = 6.25, P = 0.04; and 3.95 ± 2.79 vs. 10.25 ± 3.40 mV, F = 7.35, F=- 0.01; respectively）. The proximal amplitude of the CMAP of the tibial nerve was significantly decreased at 42 days of HDT compared with the amplitude betbre HDT （6.14± 1.94 vs. 11.87± 3.19 mV, F = 5.02, P = 0.039）. Conclusions： This study demonstrates that the compound muscle action potential amplitudes of nerves are decreased under simulated microgravity in rhesus monkeys. Moreover, rhesus monkeys exposed to HDT might be served as an experimental model for the study of NCS under microgravity.

关键词： Compound Muscle Action Potential Head-down Tilt Microgravity Nerve Conduction Nerve Conduction Velocity

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Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China Earth Sciences 2025年第1期68卷 74-93页

作者： Ye YANG Steven A.BINNIE sheng xu Cong-Qiang LIU Tibor J.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

关键词： 10Be-derived denudation rate Climate change Tectonic uplift Topographic gradient Asian mountains

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Clinical Characteristics, Electrophysiology, and Skin Biopsy of 38 Peripheral Neuropathy Cases with Small Fiber Involvement of Various Etiologies

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Chinese Medical Journal 2017年第14期130卷 1683-1688页

作者： Bo Sun Li-Zhi Liu Yi-Fan Li Zhao-Hui Chen Li Ling Fei Yang Fang Cui xu-sheng huang Department of Neurology Chinese People's Liberation Army General HospitalBeijing 100853China

Background：In small fiber neuropathy （SFN）,thinly myelinated Aδ and unmyelinated C fibers are primarily affected,resulting in sensory and/or autonomic *** etiologies have been shown to be associated with *** study was aimed to analyze a variety of features in peripheral neuropathy （PN） with small fiber *** to compare disease severity among patients with idiopathic PN,PN associated with impaired glucose tolerance （IGT）,and metabolic syndrome （MS） ***：Thirty-eight PN patients with small fiber involvement were enrolled from December 20,2013 to May 31,*** were divided into idiopathic PN,IGT-related PN,and MS-related PN *** medical history and small fiber neuropathy were investigated,and symptom inventory questionnaire was conducted,as well as the visual analog *** conduction studies and skin biopsies were also *** differences among the groups were analyzed using analysis of variance and Kruskal-Wallis ***：Eight patients were diagnosed with pure *** nerve fiber density （I ENFD） weakly correlated with motor conduction velocity （MCV）（r =0.372,P =0.025）,and proximal （r =0.383,P =0.021） and distal （r =0.358,P 0.032） compound muscle action potential （CMAP） of the tibial *** also weakly correlated with MCV of the peroneal nerve （r=0.399,P =0.016）.IENFD was shown to be significantly different among all groups （x2 =9.901,P-0.007）.IENFD was significantly decreased （x2 =23.000,P=0.003） in the MS-related PN group compared to the idiopathic PN *** MCV of the tibial nerve was significantly different among all groups （x2 =8.172,P 〈 0.017）.The proximal （F =4.336,P =0.021） and distal （F =3.262,P =0.049） CMAP of the tibial nerve was also significantly different among all ***：IENFD of patients included in the present study weakly correlated with various electrophysiological *** and large fibers are more involved in patients with MS-related PN than

关键词： Impaired Ghicose Tolerance: lntraepidermal Nerve Fiber Density Metabolic Syndrome Nerve Conduction Studies:Small Fiber Neuropathy

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Contact heat evoked potentials in knowledge workers and unskilled labors

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Chinese Medical Journal 2020年第5期133卷 537-541页

作者： Bo Sun Yan-Ran Li Hong-Fen Wang Fang Cui Li Ling Fei Yang Zhao-Hui Chen xu-sheng huang Geriatric Neurological Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China Neurological Department of the First Medical Center Chinese People’s Liberation Army General HospitalBeijing 100853China

Background:Whether occupation has an impact on contact heat evoked potential(CHEP)results has not been *** this study,we investigated the difference of CHEP parameters between knowledge workers and unskilled ***:A total of 137 healthy participants were recruited between November 20,2014 and December 31,*** participants underwent neurologic examination,laboratory examination,and nerve conduction *** was performed on four body sites:the upper border of the distal third of the volar forearm,the upper border of the distal third of the lateral leg,the spinous process of seventh cervical vertebrae(C7),and the spinous process of 12th thoracic vertebrae(T12).Independent t test and nonparametric test were performed using SPSS software to compare the difference of the CHEP parameters between knowledge workers and unskilled ***:The“N2 latency/height”(Z=-2.290,P=0.022)and“P2 latency/height”(Z=-2.020,P=0.043)on the volar forearm of unskilled labors significantly increased than those of knowledge ***“N2 latency/height”(F=6.348,P=0.016)and“P2 latency/height”(F=5.920,P=0.018)in the distal leg of unskilled labors significantly prolonged than those of knowledge *** N2-P2 amplitude(F=5.797,P=0.020)in the distal leg of unskilled labors significantly decreased than those of knowledge ***:Our study found that significantly prolonged N2 latency and P2 latency and significantly decreased N2-P2 amplitude in the distal leg and the volar forearm in unskilled labors as to knowledge workers.

关键词： Contact heat evoked potential Occupation Nerve conduction studies

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Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第1期68卷 257-263页

作者： Jiapian huang Chenxin Wang xu Wang Xiaoyu Zhou Wei Xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

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Repetitive Nerve Stimulation in Amyotrophic Lateral Sclerosis

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Chinese Medical Journal 2018年第18期131卷 2146-2151页

作者： Xiao-Sun Sun Wen-Xiu Liu Zhao-Hui Chen Li Ling Fei Yang Hong-Fen Wang Fang Cui xu-sheng huang Department of Neurology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background： Nowadays, it is widely known that decremental responses in low-frequency repetitive nerve stimulation （LF-RNS） are frequently observed in patients with amyotrophic lateral sclerosis （ALS）. The pathological mechanism of this phenomenon remains unknown. This study aimed to illuminate the features of RNS in Chinese patients with ALS. Methods： Clinical and electrophysiological data of 146 probable and definite ALS patients who underwent RNS were retrospectively enrolled and analyzed. LF-RNS （3 Hz） was performed in trapezius, deltoid, abductor digiti minimi （ADM）, quadriceps femoris, and tibialis anterior. High-frequency RNS （HF-RNS, 10 Hz） was performed only in ADM. The two-sample t-test and Chi-squared test were used for statistical ***： Decremental responses to LF-RNS （≥ 10%） in at least one muscle were detected in 83 （56.8%） of the cases and were most commonly seen in trapezius and deltoid. The incidence ofdecremental response was higher in patients with upper limb onset. Incremental responses to HF-RNS （≥60%） in ADM were observed in 6 （5.6%） of the cases. In 106 muscles with decremental response, 62 （57.4%） muscles had a continuous decremental pattern, more than a U-shape pattern （37 cases, 34.3%）. Nineteen cases showed definite decrements in LF-RNS tests in trapezius, while no abnormalities were found in the electromyography and neurological examination of the sternocleidomastoid muscle, supplied by the accessory nerve as ***： Decremental responses in the RNS are commonly observed in ALS patients. The findings regarding the trapezius indicated that some ALS onsets could be initiated by a ＂dying back＂ process, with destruction of neuromuscular junctions （NMJs） before motor neurons. Incremental responses in the ADM implied damage of the NMJs involved both the post and presynaptic membranes.

关键词： Amyotrophic Lateral Sclerosis Decremental Response Dying Back Repetitive Nerve Stimulation

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