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Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

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Food Science and Human Wellness 2024年第4期13卷 2116-2131页

作者： Yu peng Xiaoao Xiao Tingting Ji Xinyuan Wang Yixuan xu Jianbo Xiao Hui Cao Zhiyong chen Huifan Liu Yuanqing Gao Hongxun Tao Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China Department of Analytical Chemistry and Food Science Faculty of ScienceUniversity of VigoVigo 36310Spain CISPAC Fontan BuildingCity of CultureSantiago de Compostela 15707Spain Shaanxi Academy of Traditional Chinese Medicine Xi'an 710003China Guangdong Key Laboratory of Science and Technology of Lingnan Specialty Food Zhongkai University of Agriculture and EngineeringGuangzhou 510550China State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu 610075China

Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in ***,our previous work has found that *** extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced ***,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against *** chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were ***,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable *** decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of *** metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid ***,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

关键词： Rhodiola crenulate Colitis Chemical characterization Plasma pharmacochemistry Metabolomics

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Unmanned autonomous air-to-air refueling intelligent docking technology

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Chinese Journal of Aeronautics 2024年第5期37卷 1-5页

作者： peng LIN Yakun HE Yuanze chen Chinese Aeronautical Establishment Beijing 100029China

Unmanned autonomous Air-to-Air Refueling(AAR)capability is the key guarantee to support the distant-field,high-intensity and durable operations of the penetration counterair combat *** the future,the long-range unmanned reconnaissance and attack platform can reach the maximum flight range requirement through *** present,large transport aircraft platforms in China are still equipped with probe-and-drogue systems,and the refueling mode is gradually changing from manned to unmanned autonomous *** docking process is the riskiest and most important part,and there are strict safety,precision,and efficiency requirements for refueling operation,especially during close-distance docking and formation maintenance *** this paper,five issues that need to be solved to achieve autonomous AAR docking are *** this basis,five key technology development needs are proposed to solve these engineering ***,some prospects are given.

关键词： Air-to-air refueling Probe-and-drogue Unmanned aerial vehicles Docking Perception Collaborative control

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Global analysis of basic leucine zipper transcription factors in trifoliate orange and the function identification of PtbZIP49 in salt tolerance

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Horticultural Plant Journal 2024年第1期10卷 115-130页

作者： Yuanyuan xu Qiuling Hui Meng Li Hongxian peng Yizhong He Changpin Chun Liangzhi peng Xingzheng Fu National Citrus Engineering Research Center Citrus Research InstituteSouthwest UniversityChongqing 400712China

As one of the most widely distributed and highly conserved transcription factors in eukaryotes,basic leucine zipper proteins(bZIPs)are involved in a variety of biological processes in plants,but they are largely unknown in *** this study,56 bZIP family members were identified genome-wide from an important citrus rootstock,namely trifoliate orange(Poncirus trifoliata ***.),and these putative bZIPs were named PtbZIP1—*** PtbZIPs were classified into 13 subgroups by phylogenetic comparison with Arabidopsis thaliana bZIPs(AtbZIPs),and they were randomly distributed on nine known(50 genes)chromosomes and one unknown(6 genes)*** analysis revealed the detailed characteristics of PtPZIPs,including their amino acid length,isoelectric point(pI),molecular weight(MW),predicted subcellular localization,gene structure,and conserved *** of promoter elements suggested the presence of drought,low-temperature,wound,and defense and stress responsive elements,as well as multiple hormone-responsive cis-acting *** expression analysis showed the transcriptional patterns of PtbZIPs in different tissues and under dehydration,high salt,ABA,and IAA *** addition,21 PtbZIPs were predicted to have direct or indirect protein—protein *** these,PtbZIP49 was experimentally proven to interact with PtbZIP1 or PtbZIP11 by using a yeast two-hybrid assay and bimolecular fluorescence complementation(BiFC).Subcellular localization analysis further revealed that PtbZIP1,PtbZIP11,and PtbZIP49 were localized in the ***,PtbZIP49 was functionally identified as having an important role in salt stress via ectopic expression in *** and silenced in trifoliate orange using virus-induced gene silencing(VIGS).This study provided comprehensive information on PtbZIP transcription factors in citrus and highlights their potential functions in abiotic stress.

关键词： bZIP Citrus Trifoliate orange Abiotic stress Expression pattern

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Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong xu Benyan Lu chengpeng Tao Weiming chen Wen Hou Kui cheng Huichang Bi Wanyi Pan Jianjun chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

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Numerical Investigation of the Angle of Attack Effect on Cloud Cavitation Flow around a Clark-Y Hydrofoil

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2947-2964页

作者： Di peng Guoqing chen Jiale Yan Shiping Wang College of Engineering Peking UniversityBeijing100871China College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China

Cavitation is a prevalent phenomenon within the domain of ship and ocean engineering,predominantly occurring in the tail flow fields of high-speed rotating propellers and on the surfaces of high-speed underwater *** re-entrant jet and compression wave resulting from the collapse of cavity vapour are pivotal factors contributing to cavity ***,these phenomena significantly modulate the evolution of cavitation *** this paper,numerical investigations into cloud cavitation over a Clark-Y hydrofoil were conducted,utilizing the Large Eddy Simulation(LES)turbulence model and the Volume of Fluid(VOF)method within the OpenFOAM *** analysis of results obtained at different angles of attack is undertaken.A discernible augmentation in cavity thickness is observed concomitant with the escalation in attack angle,alongside a progressive intensification in pressure at the leading edge of the hydrofoil,contributing to the suction *** results can serve as a fundamental point of reference for gaining a deeper comprehension of cloud cavitation dynamics.

关键词： Cloud cavitation re-entrant jet compression wave clark-Y hydrofoil

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Stochastic Flexibility Evaluation for Virtual Power Plants by Aggregating Distributed Energy Resources

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 988-999页

作者： Siyuan Wang Wenchuan Wu Qizhan chen Junjie Yu peng Wang Department of Electrical Engineering Tsinghua UniversityBeijing 100084China Zhongshan Power Supply Bureau of the Guangdong Power Grid Corporation Zhongshan 528400China Beijing Qingda Gaoke System Control Company Beijing 102208China CSEE IEEE

To manage a large amount of flexible distributed energy resources(DERs)in the distribution networks,the virtual power plant(VPP)is introduced into the *** VPP can optimally dispatch these resources in a cluster manner and provide flexibility for the power system operation as a *** existing studies formulate the equivalent power flexibility of the aggregating DERs as deterministic optimization models without considering their *** this paper,we introduce the stochastic power flexibility range(PFR)and timecoupling flexibility(TCF)to describe the power flexibility of *** this model,both operational constraints and the randomness of the DERs’output are incorporated,and a combined model and data-driven solution is proposed to obtain the stochastic PFR,TCF,and cost function of *** aggregating model can be easily incorporated into the optimization model for the power system operator or market bidding,considering ***,a numerical test is *** results show that the proposed model not only has higher computational efficiency than the scenario-based methods but also achieves more economic benefits.

关键词： Chance constrained optimization combined model and data-driven stochastic power flexibility virtual power plant

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Ultrahigh strength and improved electrical conductivity in an aging strengthened copper alloy processed by combination of equal channel angular pressing and thermomechanical treatment

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Journal of Central South University 2024年第6期31卷 1823-1837页

作者： WANG xu LI Zhou MENG Xiang-peng XIAO Zhu School of Materials Science and Engineering Central South UniversityChangsha 410083China Ningbo Boway Alloy Material Co. Ltd.Ningbo 315135China Key Laboratory of Non-ferrous Metal Materials Science and Engineering(Ministry of Education) Changsha 410083China

In this paper,equal channel angular pressing and thermomechanical treatment was employed to improve the strength and electrical conductivity of an aging strengthened Cu-Ti-Cr-Mg alloy,and the microstructure and properties of the alloy were investigated in *** results showed that the samples deformed by the combination of cryogenic equal channel angular pressing(ECAP)and rolling had good comprehensive properties after aging at 400℃.The tensile strength of the peak-aged and over-aged samples was 1120 MPa and 940 MPa,with their corresponding electrical conductivity of 14.7%IACS and 22.1%IACS,*** and cryogenic rolling introduced high density dislocations,leading to the inhibition of the softening effects and refinement of the *** a long time aging at 400℃,the alloy exhibited ultra-high strength with obvious increasing electrical *** high strength was attributed to the synergistic effect of work hardening,grain refinement strengthening and precipitation *** precipitation of a large amount of Ti atoms from the matrix led to the high electrical conductivity of the over-aged sample.

关键词： Cu-Ti alloy equal channel angular pressing rolling aging treatment high strength

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Microstructure Evolution and Mechanical Properties of Friction Stir Welded Al-Cu-Li Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 855-871页

作者： peng chen Wenhao chen Jiaxin chen Zhiyu chen Yang Tang Ge Liu Bensheng Huang Zhiqing Zhang School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Sichuan Provincial Engineering Research Center of Advanced Materials Manufacturing Technology for Shale Gas High-Efficient Exploitation Southwest Petroleum UniversityChengdu 610500China College of Materials Science and Engineering Chongqing UniversityChongqing 400045China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China School of Robot Engineering Yangtze Normal UniversityChongqing 408100China

The investigation concentrates on friction stir welded(FSW)Al-Cu-Li alloy concerning its local microstructural evolution and mechanical *** grain features were characterized by electron back scattered diffraction(EBSD)technology,while precipitate characterization was conducted by using transmission electron microscopy(TEM)aligned along[011]Al and[001]Al zone *** mechanical properties are evaluated through micro-hardness and tensile *** can be found that nugget zones exhibit finely equiaxed grains evolved through complete dynamic recrystallization(DRX),primarily occurring in continuous dynamic recrystallization(CDRX)and discontinuous dynamic recrystallization(DDRX).In the thermal-mechanically affected zone(TMAZ),numerous sub-structured grains,exhibiting an elongated morphology,were created due to partial DRX,signifying the dominance of CDRX,DDRX,and geometric dynamic recrystallization(GDRX)in this region.T_(1)completely dissolves in the nugget zone(NZ)leading to the formation of Guinier-Preston zones and increase ofδ′,β′and S′.Conversely,T_(1)partially solubilizes in TMAZ,the lowest hardness zone(LHZ)and heat affected zone(HAZ),and the residual T_(1)undergoes marked coarsening,revealing various T_(1)*** solubilization and coarsening of T_(1)are primary contributors to the degradation of hardness and strength.θ′primarily dissolves and coarsens in NZ and TMAZ,whilst this precipitate largely coarsens in HAZ and LHZ.σ,TB,grain boundary phases(GBPs)and precipitate-free zone(PFZ)are newly generated during FSW.σexists in the TMAZ,LHZ and HAZ,whereas TB nucleates in *** and PFZ mostly develop in LHZ and HAZ,which can cause strain localization during tensile deformation,potentially leading to LHZ joint fracture.

关键词： Al-Cu-Li alloy Friction stir welding Microstructure evolution Mechanical properties

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Mucosal immune responses to Ichthyophthirius multifiliis in the ocular mucosa of rainbow trout(Oncorhynchus mykiss,Walbaum),an ancient teleost fish

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Marine Life Science & Technology 2024年第2期6卷 266-279页

作者： Weiguang Kong Guangyi Ding Gaofeng cheng peng Yang Zhen xu Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Department of Aquatic Animal Medicine College of FisheriesHuazhong Agricultural UniversityWuhan 430070China

The eye,as a specialized visual organ,is directly exposed to the external environment,and,therefore,it faces constant chal-lenges from external pathogenic organisms and *** the ocular mucosa(OM)of mammals,mucosal-associated lymphoid tissues(MALTs)constitute the primary line of ***,the immune defense role of the OM remains unknown in aquatic *** gain insights into the immune processes within the OM of teleost fish,we developed an infection model of rainbow trout(Oncorhynchus mykiss)OM using a parasite,Ichthyophthirius multifiliis(Ich).Immunofluorescence,qPCR,and H&E staining revealed that Ich successfully infiltrates the OM of rainbow trout,leading to pathological struc-tural changes,as evidenced by A&B ***,the qPCR results indicate an up-regulation of immune-related genes following Ich infection in the ***,transcriptome analyses were conducted to detect immune responses and impairments in eye function within the OM of rainbow trout with Ich *** results of the transcriptome analysis that Ich infection can cause an extensive immune response in the OM,ultimately affecting ocular *** the best of our knowledge,our findings represent for the first time that the teleost OM could act as an invasion site for parasites and trigger a strong mucosal immune response to parasitic infection.

关键词： Ocular mucosa Mucosal immunity Transcriptome analysis Oncorhynchus mykiss Ichthyophthirius multifiliis

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Tetrathiafulvalene esters with high redox potentials and improved solubilities for non-aqueous redox flow battery applications

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Green Energy & Environment 2024年第5期9卷 899-908页

作者： Weikang Hu Jiaqi xu Nanjie chen Zongcai Deng Yuekun Lai Dongyang chen College of Materials Science and Engineering Fuzhou UniversityFuzhou350116China College of Chemical Engineering Fuzhou UniversityFuzhou350116China

The exploitation of high performance redox-active substances is critically important for the development of non-aqueous redoxﬂow ***,three tetrathiofulvalene(TTF)derivatives with different substitution groups,namely TTF diethyl ester(TTFDE),TTF tetramethyl ester(TTFTM),and TTF tetraethyl ester(TTFTE),are prepared and their energy storage properties are *** has been found that the redox potential and solubility of these TTF derivatives in conventional carbonate electrolytes increases with the number of ester *** battery with a catholyte of 0.2 mol L^(-1) of TTFTE delivers a speciﬁc capacity of more than 10 Ah L^(-1) at the current density of 0.5 C with two discharge voltage platforms locating at as high as 3.85 and 3.60 V ***/Liþ.Its capacity retention can be improved from 2.34 Ah L^(-1) to 3.60 Ah L^(-1) after 100 cycles by the use of an anion exchange membrane to block the crossover of TTF *** excellent cycling stability of the TIF esters is supported by their well-delocalized electrons,as revealed by the density function theory ***,the introduction of more and larger electron-withdrawing groups is a promising strategy to simultaneously increase the redox-potential and solubility of redox-active ma-terials for non-aqueous redoxﬂow batteries.

关键词： Non-aqueous redox flow batteries Tetrathiofulvarene Redox potential Solubility Substituent effect

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