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Catheter ablation versus medical therapy for atrial fibrillation with prior stroke history:a prospective propensity score-matched cohort study

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Journal of Geriatric Cardiology 2023年第10期20卷 707-715,I0006页

作者： Wen-Li DAI Zi-xu ZHAO Chao JIANG Liu HE Ke-Xin YAO Yu-Feng WANG ming-yang GAO Yi-Wei LAI Jing-Rui ZHANG ming-Xiao LI Song ZUO xue-Yuan GUO Ri-Bo TANG Song-Nan LI Chen-Xi JIANG Nian LIU De-Yong LONG Xin DU Cai-Hua SANG Jian-Zeng DONG Chang-Sheng MA Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Center for Cardiovascular DiseasesBeijingChina Heart Health Research Center BeijingChina Department of Cardiovascular Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

BACKGROUND Patients with atrial fibrillation(AF)and prior stroke history have a high risk of cardiovascular events despite anticoagulation *** is unclear whether catheter ablation(CA)has further benefits in these *** AF patients with a previous history of stroke or systemic embolism(SE)from the prospective Chinese Atrial Fibrillation Registry study between August 2011 and December 2020 were included in the *** were matched in a 1:1 ratio to CA or medical treatment(MT)based on propensity *** primary outcome was a composite of all-cause death or ischemic stroke(IS)/*** During a total of 4.1±2.3 years of follow-up,the primary outcome occurred in 111 patients in the CA group(3.3 per 100 person-years)and in 229 patients in the MT group(5.7 per 100 person-years).The CA group had a lower risk of the primary outcome compared to the MT group[hazard ratio(HR)=0.59,95%CI:0.47–0.74,P<0.001].There was a significant decreasing risk of all-cause mortality(HR=0.43,95%CI:0.31–0.61,P<0.001),IS/SE(HR=0.73,95%CI:0.54–0.97,P=0.033),cardiovascular mortality(HR=0.32,95%CI:0.19–0.54,P<0.001)and AF recurrence(HR=0.33,95%CI:0.30–0.37,P<0.001)in the CA group compared to that in the MT *** analysis generated consistent results when adjusting for time-dependent usage of *** In AF patients with a prior stroke history,CA was associated with a lower combined risk of all-cause death or IS/*** clinical trials are warranted to confirm the benefits of CA in these patients.

关键词： prospective fibrillation matched

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Characterization of low-resistance ohmic contacts to heavily carbon-doped n-type InGaAsBi films treated by rapid thermal annealing

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Chinese Physics B 2021年第2期30卷 472-475页

作者： Shu-Xing Zhou Li-Kun Ai ming Qi An-Huai xu Jia-Sheng Yan Shu-Sen Li Zhi Jin Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Hubei Key Laboratory of High Power Semiconductor Technology Xiangyang 441021China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China

Carbon-doped In Ga As Bi films on In P:Fe(100)substrates have been grown by gas source molecular beam epitaxy(GSMBE).The electrical properties and non-alloyed Ti/Pt/Au contact resistance of n-type carbon-doped In Ga As Bi films were characterized by Van der Pauw-Hall measurement and transmission line method(TLM)with and without rapid thermal annealing(RTA).It was found that the specific contact resistance decreases gradually with the increase of carrier *** electron concentration exhibits a sharp increase,and the specific contact resistance shows a noticeable reduction after *** RTA,the In Ga As Bi film grown under CBr4 supply pressure of 0.18 Torr exhibited a high electron concentration of 1.6×10^(21) cm^(-3) and achieved an ultra-low specific contact resistance of 1×10^(-8)Ω·cm^(2),revealing that contact resistance depends greatly on the tunneling effect.

关键词： InGaAsBi electrical properties contact resistance rapid thermal annealing

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双创时代背景下构建创新教育生态圈培育实践创新型康复人才的探索

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中国中医药现代远程教育 2024年第3期22卷 178-181页

作者：许明艾坤何运生彭荧荧祁芳周予婧秦爽张泓湖南中医药大学针灸推拿与康复学院湖南长沙410208 湖南中医药大学教务处湖南长沙410208 湖南中医药大学信息科学与工程学院湖南长沙410208

康复是一门多学科交叉的新兴应用型学科,康复从业人员掌握理论知识的同时,更需注重实践运用和综合创新能力的培养,而康复高等教育是培养康复专业人才的基本途径。此文分析了“双创”时代背景下,强化培养康复专业大学生实践创新能力的必... 详细信息

康复是一门多学科交叉的新兴应用型学科,康复从业人员掌握理论知识的同时,更需注重实践运用和综合创新能力的培养,而康复高等教育是培养康复专业人才的基本途径。此文分析了“双创”时代背景下,强化培养康复专业大学生实践创新能力的必要性与存在的问题;探索构建“创新教育生态圈”,培养具有较强实践能力及创新性思维的实践创新型康复专业人才,旨在为构建培养符合时代要求、符合行业需要、符合学生发展的实践创新型康复专业人才的实践模式提供参考。

关键词：创新创业康复教育生态圈

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Clinical Efficacy and Safety Analysis of Laparoscopic- assisted Vaginal Surgery and Laparoscopic-alone Surgery in Treatment of Endometrial Cancer

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International Journal of Technology Management 2014年第10期 91-93页

作者： HU Duoduo xu ming-juan Department of Gynecology Xinhua HospitalSchool of MedicineShanghai Jiao Tong University Shanghai 200092China Department of Obestetrics and Gynecology Changhai HospitalSecond Military Medical University Shanghai200433China

Objective： Assess clinical efficacy and safety analysis of laparoscopic-assisted vaginal surgery and laparoscopic-alone surgery in treatment of endometrial cancer. Methods： select 76 cases of endometrial cancer patients, divided into two groups, 40 in laparoscopic-alone group and 36 in laparoscopic-assisted group, and compare operation time, intraoperative blood loss, intraoperative complications, postoperative complications, lymph node number, anal exhaust time, indwelling catheter days and hospitalization days by group. Result： compared with laparoscopic-alone surgery, laparoscopic-assisted vaginal surgery has certain advantages in reducing intraoperative blood loss, intraoperative and postoperative complications, anal exhaust time, indwelling catheter days and hospitalization days. Discussion： laparoscopic-assisted vaginal surgery is a relatively safe, effective and good economic benefit surgical method in treatment of endometrial cancer.

关键词： Clinical Efficacy Laparoscopic Surgery Vaginal Surgery Endometrial Cancer

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阵列雷达中快速目标截获的几个关键问题研究

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北京航空航天大学学报 2000年第3期26卷 278-281页

作者：徐斌杨晨阳屈剑明李少洪北京航空航天大学电子工程系

研究了阵列雷达中快速目标截获的两个关键问题 :角度测量和角度预测 .首先 ,从测角原理、要求的波位排布、鉴别特性和测角性能等几个方面研究了阵列雷达中快速目标截获的两种测角算法 :幅度比较类单脉冲和幅度加权平均 ,提出了这两种算... 详细信息

研究了阵列雷达中快速目标截获的两个关键问题 :角度测量和角度预测 .首先 ,从测角原理、要求的波位排布、鉴别特性和测角性能等几个方面研究了阵列雷达中快速目标截获的两种测角算法 :幅度比较类单脉冲和幅度加权平均 ,提出了这两种算法在工程应用中的引导和非线性校正方法 ;然后 ,分析了利用跟踪滤波器的角度预测算法 ,提出了SDF跟踪滤波器 ;最后 ,在某阵列雷达仿真系统中进行了仿真研究 .

关键词：阵列雷达目标截获角度测量角度预测

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High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study

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Infectious Diseases of Poverty 2016年第1期5卷 753-763页

作者： Jun-Jie xu Wei-ming Tang Hua-Chun Zou Tanmay Mahapatra Qing-Hai Hu Geng-Feng Fu Zhe Wang Lin Lu ming-Hua Zhuang Xi Chen Ji-Hua Fu Yan-Qiu Yu Jin-Xin Lu Yong-Jun Jiang Wen-Qing Geng Xiao-xu Han Hong Shang Key Laboratory of AIDS Immunology of National Health and Family Planning Commission Department of Laboratory MedicineThe First Affiliated HospitalChina Medical UniversityShenyang 110001People’s Republic of China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouPeople’s Republic of China University of North Carolina at Chapel Hill Project-ChinaNo.2 Lujing RoadGuangzhou 510085People’s Republic of China Guangdong Provincial Center for Skin Diseases and STIs Control Guangzhou 510085People’s Republic of China Kirby Institute the University of New South WalesSydneyNSW 2052Australia Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos Angeles 90095USA Jiangsu Provincial Centers for Disease Control and Prevention NanjingChina He’nan Provincial Centers for Disease Control and Prevention ZhengzhouChina Yunnan Provincial Centers for Disease Control and Prevention KunmingChina Shanghai Municipal Centers for Disease Control and Prevention ShanghaiChina Hu’nan Provincial Centers for Disease Control and Prevention ChangshaChina Shandong Provincial Centers for Disease Control and Prevention JinanChina

Background:Recent upsurge of new HIV infections among men who have sex with men(MSM)is a major concern in *** of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric,timely and comprehensive ***:Mixed methods were used to recruit MSM from seven cities in China between 2012 and *** and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme *** and herpes simplex virus-2(HSV-2)were also ***:A total of 4496 eligible MSM were *** majority was aged≤35 years(77.5%),migrants(60.3%),never married(69.8%),and played receptive role in anal sex(70.5%).The HIV prevalence was 9.9%,and 41.9%were recently infected,with sensitivity/specificity adjusted HIV incidence of 8.9(95%CI:7.6-10.2)/100 *** prevalence of history HSV-2 and syphilis were 12.5%and 8.5%,*** HIV infection was associated with having multiple male partners(aOR=1.4,95%CI 1.1-1.9),recreational drug use(aOR=2.2,95%CI 1.6-3.0),anal bleeding(aOR=2.1,95%CI 1.4-3.0),syphilis infection(aOR=2.8,95%CI 1.9-4.3)and history HSV-2 infection(aOR=2.3,95%CI 1.5-3.3).Conclusion:High rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in *** interventions to address high-risk MSM including those having multiple partners,history of recreational drug use and syphilis or HSV-2 infection seemed to be the need of the hour.

关键词： Men who have sex with men(MSM) HIV Incidence BED HIV-1 capture enzyme immunoassay(BED-CEIA)

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Optimization of Supercritical Fluid Extraction and Rapid Resolution LC-MS/ESI Identification of Chromones from Saposhnikoviae Radix through Orthogonal Array Design

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Chinese Herbal Medicines 2016年第4期8卷 314-322页

作者： Zhong-ming Han xue Wang Miao-miao xu Yun-he Wang Li-min yang Mei Han College of Chinese Medicinal Materials Jilin Agricultural University

Objective To establish a rapid and effective supercritical fluid extraction（SFE） and rapid resolution liquid chromatography method coupled with diode-array detector（RRLC-DAD） to quantify the chromones in a species. Methods The effects of four parameters including ethanol concentration（50%-90%）, pressure（25-45 MPa）, temperature（40-60 ℃）, and time（30-90 min） on the chromones yields, namely prim-O-glucosylcimifugin, cimifugin, 5-O-methylvisammioside, and sec-O-glucosylhamaudol, were investigated using SFE system with orthogonal array design（OAD）. Furthermore, the extracts were analyzed using rapid resolution liquid chromatography coupled with diode-array detector（RRLC-DAD） system to confirm the results. Results Under the optimized conditions, i.e., 35 MPa of pressure, 60 ℃ of temperature, 70% ethanol, and 60 min of time, the yields of prim-O-glucosylcimifugin, cimifugin, 5-O-methylvisammioside, sec-O-glucosylhamaudol, and total chromones were 3.514, 0.132, 6.242, 0.342, and 10.231 mg/g, respectively. In comparison with ultrasonic assisted extraction（UAE）, SFE was able to yield a 20.7% increase in the total chromones from Saposhnikoviae Radix. Conclusion SFE is an alternative and promising method to extract chromones from this species, and the established RRLC-DAD method could serve as a rapid and effective method for the identification of chromones from Saposhnikoviae Radix.

关键词： orthogonal array design RRLC Saposhnikoviae Radix supercritical fluid extraction

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Agent- oriented Software Engineering

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Journal of Systems Science and Systems Engineering 2001年第1期13卷 44-49页

作者： GUAN xu, CHENG ming, LIU Bao School of Management, Tianjin University, Tianjin 300072, China School of Management Tianjin University Tianjin 300072 China

：An increasing number of computer systems are being viewed in terms of autonomous *** people believe that agent-oriented approach is well suited to design and build complex systems. Yet. todate, little effort had been devoted to discuss the advantages of agent-oriented approach as a mainstreamsoftware engineering paradigm. Here both of this issues and the relation between object-oriented and agent-oriented will be argued. we describe an agent-oriented methodology and provide a quote for designing anauction system.

关键词： agent-oriented approach software engineering multi-agent systems

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Successful response to camrelizumab in metastatic bladder cancer: A case report

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World Journal of Clinical Cases 2022年第1期10卷 254-259页

作者： Chen Xie Xia Yuan Shu-Hui Chen Zhi-Yong Liu Di-La Lu Feng xu Zhi-Qiu Chen Xiao-ming Zhong Department of Radiotherapy Jiangxi Provincial Tumour HospitalNanchang 330029Jiangxi ProvinceChina Department of Radiotherapy The Affiliated Cancer Hospital of Nanchang UniversityNanchang 330029Jiangxi ProvinceChina Faculty of Medicine Burning Rock BiotechGuangzhou 510300Guangdong ProvinceChina

BACKGROUND There has been no report to use camrelizumab with chemotherapy for advanced bladder cancer patients with positive programmed death-ligand 1(PD-L1)expression and high tumor mutational burden(TMB).More effective predictors of bladder cancer immunotherapy have yet to be explored,and the combination of multiple factors may be more predictive than a single *** SUMMARY We report the case of a 74-year-old male patient with recurrent metastatic bladder cancer,which demonstrated positive PD-L1 expression and high *** immune checkpoint inhibitor camrelizumab was administered to the patient in combination with gemcitabine and *** patient achieved a partial response with a progression-free survival of 11 *** This is the first report to use camrelizumab with chemotherapy for advanced bladder cancer patients with positive PD-L1 expression and high TMB.

关键词： Programmed death-ligand 1 Tumor mutational burden Bladder cancer Camrelizumab Next-generation sequencing Case report

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Exploring New Methods for Facile Synthesis of Some Biologically Interesting Molecules

Exploring New Methods for Facile Synthesis of Some Biologica...

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中国化学会第十一届全国天然有机化学学术会议

作者： ming-Hua xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences

＜正＞Exploration of attractive strategies and methods with emphasis on selectivity,practicality,and efficiency for the preparation of bioactive compounds,natural products,and pharmaceutical agents is a sempiternal subject of great interest in the field of organic synthesis and medicinal *** recent years,we have been particularly involved in the development of new efficient synthetic approaches for rapid or facile construction of a

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