检索结果-南通市图书馆

Spatiotemporal changes in frequency and intensity of high-temperature events in China during 1961-2014

Journal of Geographical Sciences 2017年第9期27卷 1027-1043页

作者： ZHANG ming DU Shiqiang WU Yanjuan WEN Jiahong WANG Congxiao xu ming WU Shuang-Ye Department of Geography Shanghai Normal University Shanghai 200234 China Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and Limnology CAS Nanjing 210008 China Shanghai Typhoon Institute China Meteorological Administration Shanghai 200030 China Department of Geology University of Dayton Dayton OH 45469 USA

In this study, we explored spatial patterns and the temporal trends in high-temperature events （HTEs） for the mainland of China dudng 1961-2014 based on a dailymaximum surface-air-temperature dataset of 494 stations and nonparametric trend detection methods. With three thresholds of 35℃ （HTE35）, 37℃ （HTE37）, and 40℃ （HTE40）, HTEs occurred in 82%, 71%, and 37% of the surveyed stations and showed an overall increasing trend in both frequency and intensity during 1961-2014. In northern and southeastem China, HTEs showed a significant increasing trend in both frequency and intensity, whilst a decreasing trend for both was observed in central China. Despite such regional heterogeneity, HTEs overwhelmingly presented three-phase characteristics in all three representative regions and throughout China; the phases are 1961-1980, 1980-1990, and 1990-2014. Both frequency and intensity of HTEs have strongly increased during 1990-2014 at 54.86%, 48.38%, and 23.28% of the investigated stations for HTE35, HTE37 and HTE40, respectively. These findings implied that HTEs adaptation should be paid further attention in the future over China because the wide spread distribution of HTEs and their increasing trends in both frequency and intensity during recent decades might pose challenges to the sustainability of human society and the ecosystem.

关键词： high temperature heat waves extreme events climate change hiatus warming hole

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

脂肪因子PAMM的生物学功能及其临床应用前景

引用

广东医科大学学报 2024年第1期42卷 93-98页

作者：杨欣欣何月敬马佳仪叶轩轩史玉仓徐明锋梁杰吴志远孙雪荣广东医科大学广东省医学分子诊断重点实验室衰老研究所广东东莞523808 广东医科大学第二临床医学院广东东莞523808 东莞市第八人民医院临床检验科广东东莞523321 广东医科大学附属医院整形外科广东湛江524001 广东医科大学生理学教研室广东湛江524023

PAMM(Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes)是一种氧化还原调节蛋白,在脂肪组织中高表达,具有广泛的生物学作用,是脊髓损伤的标志物及某些肿瘤治疗的候选靶点。该文就PAMM的生物学功能及其临床应用前景作一... 详细信息

PAMM(Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes)是一种氧化还原调节蛋白,在脂肪组织中高表达,具有广泛的生物学作用,是脊髓损伤的标志物及某些肿瘤治疗的候选靶点。该文就PAMM的生物学功能及其临床应用前景作一综述。

关键词： PAMM 脂肪因子抗氧化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alphaherpesvirus-vectored vaccines against animal diseases: Current progress

引用

Journal of Integrative Agriculture 2020年第8期19卷 1928-1940页

作者： HU yang WANG ming-shu CHENG An-chun JIA Ren-yong yang Qiao WU Ying LIU Ma-feng ZHAO Xin-xin ZHU De-kang CHEN Shun ZHANG Sha-qiu WANG Yin GAO Qun OU xu-min MAO Sai WEN Xing-jian xu Zhi-wen CHEN Zheng-li ZHU Ling LUO Qi-hui TIAN Bin PAN Lei-chang Mujeeb Ur REHMAN LIU Yun-ya YU Yan-ling ZHANG Ling CHEN Xiao-yue Institute of Preventive Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130P.R.China Key Laboratory of Animal Disease and Human Health of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China Avian Disease Research Center College of Veterinary MedicineSichuan Agricultural UniversityChengdu 611130P.R.China

Recombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity,are multivalent and multieffective,and have high safety *** alphaherpesviruses have a large genome,contain multiple nonessential regions that do not affect viral replication and are capable of accepting the insertion of an exogenous gene and expressing the antigen ***,animal alphaherpesviruses have a wide host spectrum,can replicate in the host and continuously stimulate the animal to produce immunity to the corresponding pathogen,thus making them ideal carriers for recombinant virus-vectored *** the development of gene-editing technology,recombinant viruses capable of expressing foreign genes can be constructed by various ***,studies on recombinant virusvectored vaccines constructed based on animal alphaherpesviruses have involved poultry,pigs,cattle,sheep,and companion *** have shown that the construction of recombinant animal alphaherpesviruses enables the acquisition of immunity to multiple *** article mainly summarizes the current progress on animal alphaherpesvirus-vectored vaccines,aiming to provide reference for the development of new animal alphaherpesvirus-vectored vaccines.

关键词： recombinant vectored-vaccine recombinant alphaherpesviruses immunity gene-editing exogenous gene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genome-wide association study reveals novel loci for adult type 1 diabetes in a 5-year nested case-control study

引用

World Journal of Diabetes 2021年第12期12卷 2073-2086页

作者： Yan Gao Shi Chen Wen-Yong Gu Chen Fang Yi-Ting Huang Yue Gao Yan Lu Jian Su ming Wu Jun Zhang ming xu Zeng-Li Zhang Department of Occupational and Environmental Health School of Public HealthMedical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina Institute of Suzhou Biobank Suzhou Center for Disease Prevention and ControlSuzhou 215004Jiangsu ProvinceChina Department of Public Health Sciences University of North Carolina CharlotteNC 28223United States School of Data Science University of North Carolina CharlotteNC 28223United States Department of Ultrasound The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Endocrinology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Clinical Nutrition The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Clinical Nutrition Department The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Occupational Disease Prevention Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009Jiangsu ProvinceChina Public Health Research Institute of Jiangsu Province Nanjing 210009Jiangsu ProvinceChina Department of Chronic Disease Prevention and Control Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009Jiangsu ProvinceChina

BACKGROUND Type 1 diabetes(T1D)is a severe and prevalent metabolic *** to its high heredity,an increasing number of genome-wide association studies have been performed,most of which were from hospital-based case-control studies with a relatively small sample *** association of single nucleotide polymorphisms(SNPs)and T1D has been less studied and is less understood in natural *** To investigate the significant variants of T1D,which could be potential biomarkers for T1D prediction or even *** A genome-wide association study(GWAS)of adult T1D was performed in a nested case-control study(785 cases vs 804 controls)from a larger 5-year cohort study in Suzhou,*** harmful or protective SNPs were evaluated for *** expression and splicing quantitative trait loci(eQTL and sQTL)analyses were carried out to identify target genes modulated by these *** A harmful SNP for T1D,rs3117017[odds ratio(OR)=3.202,95%confidence interval(CI):2.296-4.466,P=9.33×10-4]and three protective SNPs rs55846421(0.113,0.081-0.156,1.76×10-9),rs75836320(0.283,0.205-0.392,1.07×10-4),rs362071(0.568,0.495-0.651,1.66×10-4)were ***-two genes were further identified as potential candidates for T1D *** We identified a potential genetic basis of T1D,both protective and harmful,using a GWAS in a larger nested case-control study of a Chinese population.

关键词： Type 1 diabetes Genome-wide association study Nested case-control study Polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

穿心莲活性成分提取工艺及其在动物养殖中的应用研究

引用

饲料研究 2024年第5期47卷 155-160页

作者：徐兰程包雨明韦信求牙英红谭海敏周芳芳卢成淑辛桂瑜玉林师范学院生物与制药学院广西玉林537000 广西高校亚热带生物资源保护与利用重点实验室广西玉林537000

穿心莲是一种常见中草药,常用于治疗感冒发热、喉咙肿痛、口舌生疮等。穿心莲具有多种化学成分,包括酯类、黄酮类和生物碱等,具有抗肿瘤、抗炎、抗菌、抗病毒等多种生物活性。穿心莲作为饲料添加剂能够提高动物免疫力,促进生长发育,改... 详细信息

穿心莲是一种常见中草药,常用于治疗感冒发热、喉咙肿痛、口舌生疮等。穿心莲具有多种化学成分,包括酯类、黄酮类和生物碱等,具有抗肿瘤、抗炎、抗菌、抗病毒等多种生物活性。穿心莲作为饲料添加剂能够提高动物免疫力,促进生长发育,改善畜产品品质,预防和治疗动物疾病。文章介绍了穿心莲的主要活性成分提取方法、生物活性功能及其在动物生产中的应用研究进展,以期为穿心莲在动物生产中的应用研究提供参考。

关键词：穿心莲化学成分生物活性动物养殖

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Molecular phylogeny and taxonomy of four Remanella species(Protozoa, Ciliophora): A flagship genus of karyorelictean ciliates, with descriptions of two new species

引用

Zoological Research 2022年第5期43卷 827-842页

作者： ming-Zhen Ma Yu-Jie Liu Yuan xu Bo-Rong Lu Yu-Qing Li Saleh AAL-Farraj Giulio Petroni Wei-Bo Song Ying Yan Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdaoShandong 266003China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China Zoology Department College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Biological University of PisaPisa 56100Italy Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China

During faunal studies of psammophilic ciliates along the coast of Qingdao, China, several marine karyorelictean species were isolated. Among them,four species within the genus Remanella were investigated, including two species new to science:i.e., R. rugosa, Remanella elongata sp. nov.,Remanella aposinica sp. nov.,and ***. Remanella rugosa has been reported several times, but this study is the first to provide detailed morphological characters and phylogenetics. Remanella elongata sp. nov. can be distinguished from its congeners by the presence of complex cortical granules, fewer macronuclei, and longer body size. Remanella aposinica sp. *** from its congeners by having 14–17 right lateral ciliary rows and 24–37 dikinetids of intrabuccal kinety. Poorly known Remanella rugosa var. unicorpusculata(Kahl, 1933) Foissner, 1996should be elevated from subspecies to species level,Remanella unicorpusculata(Foissner, 1996) ***., based on detailed redescriptions with statistical data, living morphology, infraciliature, and species definitions. Small subunit(SSU) rDNA was sequenced for the four species, and phylogenetic analysis revealed that all known taxa in Remanella formed the outline branch to the genus Loxodes with moderate to high bootstrap support among Remanella lineages.

关键词： Marineciliates Morphology Infraciliature Phylogeny

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insufficiency of Mrpl40 disrupts testicular structure and semen parameters in a murine model

引用

Asian Journal of Andrology 2023年第5期25卷 627-631页

作者： Ying Liu Long-Long Fu Hui-Zhong xu Yi-ming Zheng Wei-Xi Li Guang-Hui Qian Wen-Hong Lu Hai-Tao Lv Institute of Pediatric Research Children's Hospital of Soochow UniversitySuzhou 215025China National Health Commission Key Laboratory of Male Reproductive Health National Research Institute for Family PlanningBeijing 100081China Institute for Advanced Study and School of Physical Science and Technology Soochow UniversitySuzhou 215006China

Approximately 31%of patients with 22q11.2 deletion syndrome(22q11.2DS)have genitourinary system disorders and 6%of them have undescended *** of genes on chromosome 22q11.2 might contribute to the risk of *** this study,we used mice with single-allele deletion in mitochondrial ribosomal protein L4o(Mrpl40-)as models to investigate the function of Mrpl40 in testes and spermatozoa *** penetrance of cryptorchidism in Mrpl40+-mice was found to be higher than that in wild-type(WT)*** the weight of testes was not significantly different between the WT and Mrpl40+-mice,the structure of seminiferous tubules and mitochondrial morphology was altered in the Mrpl40+-***,the concentration and motility of spermatozoa were significantly decreased in the Mrpl4O+-*** addition,data-independent acquisition mass spectrometry indicated that the expression of genes associated with male infertility was altered in Mrpl40+-*** study demonstrated the important role of Mrpl40 in testicular structure and spermatozoa motility and *** findings suggest that Mrpl4o is potentially a novel therapeutic target for cryptorchidism and decreased motility and count of spermatozoa.

关键词： cryptorchidism DiGeorge syndrome semen analysis spermatozoa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于机器学习筛选骨关节炎坏死性凋亡的特征基因RHOB及实验验证

引用

生物骨科材料与临床研究 2024年第5期21卷 1-8页

作者：徐文飞明春玉段戡袁长深郭锦荣胡琪曾超梅其杰广西中医药大学第一附属医院四肢骨伤科广西南宁530023 广西中医药大学附属瑞康医院老年病科广西南宁530011

目的运用机器学习方法筛选骨关节炎坏死性凋亡的特征基因RHOB并加以验证,以期为OA治疗提供新的思路与方法。方法从GEO数据库下载GSE55235、GSE1919、GSE82107、GSE98918微阵列数据集及GeneCard网站获取坏死性凋亡相关基因,采用R语言... 详细信息

目的运用机器学习方法筛选骨关节炎坏死性凋亡的特征基因RHOB并加以验证,以期为OA治疗提供新的思路与方法。方法从GEO数据库下载GSE55235、GSE1919、GSE82107、GSE98918微阵列数据集及GeneCard网站获取坏死性凋亡相关基因,采用R语言对OA数据进行批次校正,提取OA坏死性凋亡基因及差异分析,并对DEGs进行功能GO分析及KEGG信号通路分析,同时运用机器学习(LASSO回归、SVM-RFE、random Forest)筛选OA坏死性凋亡的特征基因,进一步运用荧光定量PCR试验验证。结果经批次校正及PCA分析后共获得OA基因8 492个,同时获得坏死性凋亡相关基因657个,经分析后得到48个OA坏死性凋亡DEGs,其中上调基因18个,下调基因30个;主要涉及调节炎症反应、白细胞细胞间黏附等生物过程;涉及膜筏、膜微区等细胞组分;涉及细胞因子活性、整合素结合等分子功能;同时与TNF、IL-17、AGE-RAGE等信号通路有关。运用机器学习(LASSO回归、SVM-RFE、Random Forest)分别筛选出8个基因、11个基因及8个基因。其交集后获得特征基因RHOB,验证后发现RHOB作为OA坏死性凋亡特征基因准确性较高(AUC>0.5),且滑膜组织中试验组RHOB表达高于对照组(P=0.36),而半月板组织中试验组RHOB表达高于对照组(P=0.033)。同时运用体外软骨细胞培养及荧光定量PCR试验进一步证实,试验组RHOB mRNA的表达高于对照组(P=0.001)。结论运用机器学习方法获得OA坏死性凋亡的特征基因及潜在因素,从新型细胞死亡角度为阐明其发病机制,为临床上更好治疗OA提供新方向。

关键词：机器学习骨关节炎坏死性凋亡特征基因

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

双重荧光逆转录-聚合酶链式反应与荧光逆转录-重组酶介导等温扩增快速检测食源性GⅠ型、GⅡ型诺如病毒

引用

食品安全质量检测学报 2024年第12期15卷 151-157页

作者：邓迎春郭旭光牛会敏任宝红韩小改郭瑞国家市场监管重点实验室(食品安全快速检测与智慧监管技术) 郑州450000 河南省食品和盐业检验技术研究院郑州450003 郑州中道生物技术有限公司郑州450001

目的建立双重荧光逆转录-聚合酶链式反应(reverse transcription polymerase chain reaction,RT-PCR)与荧光逆转录-重组酶介导等温扩增(reverse transcription recombinase-aided amplification,RT-RAA)快速有效地检测食品中食源性GⅠ型和GⅡ型诺如病毒的方法。方法根据GⅠ型、GⅡ型诺如病毒基因组保守序列设计引探,经过一系列引探浓度筛选,建立了双重荧光RT-PCR和恒温荧光RT-RAA两种检测方法,分别从敏感性、特异性、稳定性、重复性等方面进行了比较研究;同时将这两种方法应用于实际临床样本检测中,并与GB4789.42—2016《食品安全国家标准食品微生物学检验诺如病毒检验》进行比对验证。结果建立的两种方法特异性良好,敏感性均可达10 copies/μL;双重荧光RT-PCR方法质粒梯度变异系数(coefficient of variation,CV)值在0.1%~1.5%区间,恒温荧光RT-RAA方法CV值在1.0%~10.0%区间,稳定性和重复性显示双重荧光RT-PCR优于恒温荧光RT-RAA检测方法;31份诺如病毒阳性食品核酸样本均能检出,且50份食品盲样检测结果与国标一致。结论本研究成功建立了双重荧光RT-PCR与恒温荧光RT-RAA快速检测食源性GⅠ型、GⅡ型诺如病毒方法,两种方法各有优缺点,双重荧光RT-PCR稳定性和重复性好,恒温荧光RT-RAA检测时间短,仅20 min就能完成扩增,可根据不同需求选择一种或两种作为食源性GⅠ型、GⅡ型诺如病毒的检测方法。

关键词：荧光逆转录-聚合酶链式反应恒温荧光逆转录-重组酶介导等温扩增 GⅠ型诺如病毒 GⅡ型诺如病毒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Seismic monitoring network based on MEMS sensors

引用

Earthquake Science 2019年第3期32卷 179-185页

作者： Zhen-xuan Zou ming Zhang xu-dong He Sheng-fa Lin Zheng-yao Dong Kan Sun Zhejiang Earthquake Agency Hangzhou 310013China Zhoushan Science and Technology Bureau Zhoushan 316000China

This paper provides a brief introduction to the application of the sensor monitoring network of micro-electro-mechanical systems(MEMS)to Zhejiang *** the Wenzhou Shanxi reservoir and other areas,MEMS and traditional intensity-monitoring instruments have been deployed with complementary functions to implement hybrid *** low-cost MEMS network can continuously monitor areas at high risk of earthquakes at a high ***,it can quickly collect the parameters of earthquakes and records of the near-field acceleration of strong *** can be also used to rapidly generate earthquake intensity reports and provide early warning of *** used the MEMS sensors for the first time in 2016,and it has helped promote the development and application of seismic intensity instruments since then.

关键词： MEMS sensor seismic intensity instrument hybrid networking rapid intensity reports early warning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：