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Acta Pharmaceutica Sinica B 2022年第3期12卷 1054-1067页

作者： xu Zhang Yuxiang wang Linghua meng Division of Anti-tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China

Esophageal cancer is one of the most lethal cancers worldwide because of its rapid progression and poor *** squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC)are two major subtypes of esophageal *** predominantly affects African and Asian populations,which is closely related to chronic smoking and alcohol *** typically arises in Barrett’s esophagus with a predilection for Western *** surgical operation and chemoradiotherapy have been applied to combat this deadly cancer,molecularly targeted therapy is still at the early *** the development of large-scale next-generation sequencing,various genomic alterations in ESCC and EAC have been revealed and their potential roles in the initiation and progression of esophageal cancer have been *** therapeutic targets have been identified and novel approaches have been developed to combat esophageal *** this review,we comprehensively analyze the genomic alterations in EAC and ESCC and summarize the potential role of the genetic alterations in the development of esophageal *** in the therapeutics based on the different tissue types and molecular signatures have also been reviewed and discussed.

关键词： Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Next-generation sequencing Genomic alteration Somatic mutation Copy number variation Molecularly targeted therapy

Continuous synthesis of few-layer MoS_(2) with highly electrocatalytic hydrogen evolution

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Green Energy & Environment 2021年第6期6卷 858-865页

作者： meng Shao Peican wang Yimeng wang Baoguo wang Yundong wang Jianhong xu The State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China

As one of the most promising alternative fuels,hydrogen is expected with high *** electrolysis of water is regarded as the cleanest and most efficient method of hydrogen *** disulfide(MoS_(2))is deemed as one of the most promising alternatives HER catalysts owing to its high catalytic activity and low *** continuous production and efficient preparation become the key problems in future industrial *** this work,we first developed a continuous micro-reaction approach with high heat and mass transfer rates to synthesize few-layer MoS_(2)nanoplates with abundant active *** defective MoS_(2)ultrathin nanoplates exhibit excellent HER performance with an overpotential of 260 m V at a current density of 10 m A cm^(-2),small Tafel slope(53.6 m V dec^(-1))and prominent durability,which are comparable to most reported MoS_(2)based *** the existence of continuous devices,it's suitable for the synthesis of MoS_(2)as highperformance electrocatalysts for the industrial water *** novel preparation method may open up a new way to synthesize all two-dimension materials toward HER.

关键词： MoS_(2) Micro-reactor Ultrathin Nanoplates Hydrogen evolution reaction

The Recent Advances of Fluorescent Sensors Based on Molecularly Imprinted Fluorescent Nanoparticles for Pharmaceutical Analysis

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Current Medical Science 2020年第3期40卷 407-421页

作者： Yi-fan wang meng-meng PAN xu YU Li xu School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Fluorescent nanoparticles have good chemical stability and photostability,controllable optical properties and larger stokes *** light of their designability and functionability,the fluorescent nanoparticles are widely used as the fluorescent probes for diverse *** enhance the sensitivity and selectivity,the combination of the fluorescent nanoparticles with the molecularly imprinted polymer,*** imprinted fluorescent nanoparticles(MIFN),was an effective *** sensor based on MIFN(the MIFN sensor)could be more compatible with the complex sample matrix,which was especially widely adopted in medical and biological *** this mini-review,the construction method,detective mechanism and types of MIFN sensors are *** current applications of MIFN sensors in pharmaceutical analysis,including pesticides/herbicide,veterinary drugs/drugs residues and human related proteins,are highlighted based on the literature in the recent three ***,the research prospect and development trend of the MIFN sensor are forecasted.

关键词： fluorescent sensor molecularly imprinted polymer pharmaceutical analysis fluorescent nanoparticles

Regulating the mesogenic properties of imidazolium salts by modifying N3-substituents

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Science China Chemistry 2015年第12期58卷 1884-1890页

作者： meng wang xu Pan Jian Chen Songyuan Dai Anhui Electric Power Design Institute Key Laboratory of Novel Thin Film Solar Cells Institute of Plasma Physics Chinese Academy of Sciences Beijing Key Laboratory of Novel Thin Film Solar Cells North China Electric Power University

In this study, a series of imidazolium salts with different N3-substituents(3-position: methyl, vinyl, ethyl, n-propyl, n-butyl)-based ionic-liquid crystals with iodide as counterion(ILCs) are synthesized and characterized, with the aim of regulating the mesogenic properties of imidazolium salts. The imidazolium salts-based ionic-liquid crystals are characterized by thermal analysis, polarized optical microscopy, X-ray powder diffraction, and single-crystalline diffraction. Liquid crystalline phase with a Smectic A phase interdigitated bilayer structure is observed. The mesophase temperature range decreases with the increase of the alkyl chain length of N3-substituent. While when vinyl is attached to the N3 position, intermolecular ?-? interactions are formed in adjacent layers, which exert a positive effect on the formation of mesophase. The layer-spacing of imidazolium salts keeps increasing with the increase of the alkyl chain length attached to both the N1 and N3 positions, and gradually decreases with the increasing temperature in liquid crystalline phase. The 1-alkyl-3-vinylimidazolium salt has the smallest layer-spacing, due to the intermolecular ?-? interactions between the vinyl and imidazolium rings in adjacent layers.

关键词： ionic liquid crystals mesogenic properties regulate N3-substituents

Multi-objective energy management system for DC microgrids based on maximum membership degree principle

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Journal of Modern Power Systems and Clean Energy 2018年第4期6卷 668-678页

作者： Panbao wang Wei wang Nina meng Dianguo xu School of Electrical Engineering and Automation Harbin Institute of Technology

With the increasing quantity of DC electrical equipment, DC microgrids have been paid more and more attention. This paper proposes an approach to multi-objective optimisation of an energy management system(EMS) for a DC microgrid that includes a hybrid energy storage system(HESS). The operating and maintenance cost and the loss of power supply probability(LPSP) of the system are used as optimisation targets. The power flows of all distributed generators(DGs) in the DC microgrid during operating period are optimized. Based on the improved differential evolution(DE) algorithm, and by using the multi-objective non-dominated sorting method and the maximum membership degree principle(MMDP) of fuzzy control, the overall satisfaction degree of Pareto solutions to power flow optimization can be obtained. Simulation results verify the effectiveness of the proposed EMS optimization scheme, which is able to achieve an effective trade-off between the economy and the reliability of microgrid operation.

关键词： DC microgrids Energy management system Multi-objective optimization Differential evolution algorithm Maximum membership degree

Recent progress on the synthesis of 2-deoxy glycosides

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Science China Chemistry 2017年第9期60卷 1162-1179页

作者： Jing Zeng Yang xu Hao wang Lingkui meng Qian Wan 0030 China Institute of Brain Research Huazhong University of Science and TechnologyWuhan 410030China

2-Deoxy glycosides are widely presented in natural products and clinical *** presence of 2-deoxy glycosides is essential for bioactivities of these *** report provides an overview of the recent advances in the stereoselective synthesis of 2-deoxy ***,the contents of this review covered the work published since the earlier reviews on this topic by Marzabadi(2000),Lowary(2009),Ding(2012) and Nagorny(2012).

关键词： 2-deoxy glycosides, glycosylation, stereoselective synthesis, oligosaccharides

自适应变分模态分解算法在高温高压水空化特性分析中的应用

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西安交通大学学报 2025年第1期59卷 56-67页

作者：许博胡鸿飞王海军西安交通大学能源与动力工程学院西安710049

针对高温高压流动工况下,空化状态判断困难、传统分析方法难以有效提取压力脉动信号中的有效信息的问题,以孔板为对象,开展了高温高压水的空化实验,并提出了一种基于遗传算法的自适应变分模态分解(AVMD)算法。该算法通过结合中心频率法... 详细信息

针对高温高压流动工况下,空化状态判断困难、传统分析方法难以有效提取压力脉动信号中的有效信息的问题,以孔板为对象,开展了高温高压水的空化实验,并提出了一种基于遗传算法的自适应变分模态分解(AVMD)算法。该算法通过结合中心频率法、遗传算法、功率谱熵和相对能量等技术,自适应地确定变分模态分解算法中的超参数并有效去除信号中的噪声成分,提高了空化特征的提取精度。结果表明:AVMD算法能够精确捕捉到高温高压水流经孔板时空化现象的发生和发展,识别空化起始点、转捩点以及空化强度的变化;当高温高压水流经孔板后,压力脉动的无量纲频率在0.04~0.35、压力脉动的无量纲幅值在0.014~0.067时,空化现象开始出现;随着空化强度增加,管内压力脉动幅值和频率整体呈增大趋势;空化起始转捩点及空化严重转捩点与入口压力和工质入口过冷度密切相关。AVMD算法能够有效提高空化特性分析的精度,尤其是在复杂流动条件下的空化预测,为压水堆核电站冷却剂系统和高压蒸汽系统的稳定运行提供理论依据和参考。

关键词：高温高压水空化特性自适应变分模态分解孔板

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基于计算机筛选与分子模拟技术的宁夏肉牛血红蛋白源抗氧化肽的鉴定

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食品科学 2025年第2期46卷 108-117页

作者：徐斐然王玉王晓静崔伟王永坤周辉王兆明蔡克周章宝徐宝才合肥工业大学食品与生物工程学院动物源食品绿色制造与资源挖掘安徽省重点实验室安徽合肥230601 宁夏农产品质量标准与检测技术研究所宁夏银川750002

采用3种酶解法(碱性蛋白酶(E1组)、胃蛋白酶+胰蛋白酶(E2组)、碱性蛋白酶+胃蛋白酶+胰蛋白酶(E3组))制备宁夏肉牛血红蛋白酶解产物,并筛选出抗氧化活性最佳组分;利用氨基酸分析和液相色谱-串联质谱鉴定分子质量<3 kDa酶解产物的氨基酸... 详细信息

采用3种酶解法(碱性蛋白酶(E1组)、胃蛋白酶+胰蛋白酶(E2组)、碱性蛋白酶+胃蛋白酶+胰蛋白酶(E3组))制备宁夏肉牛血红蛋白酶解产物,并筛选出抗氧化活性最佳组分;利用氨基酸分析和液相色谱-串联质谱鉴定分子质量<3 kDa酶解产物的氨基酸组成和序列,利用计算机分析技术筛选出潜在的抗氧化肽,并验证其活性;通过分子模拟技术进一步研究宁夏肉牛血红蛋白抗氧化肽的作用机理。结果表明,E3组酶解效果最佳,超滤后<3 kDa的组分表现出更佳的抗氧化活性(1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基和2,2’-联氮-双(3-乙基苯并噻唑啉-6-磺酸)(2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid),ABTS)阳离子自由基清除率的半数抑制浓度(half maximal inhibitory concentration,IC_(50))分别为(18.382±0.023)mg/mL和(0.246±0.012)mg/mL);E3(分子质量<3 kDa)组富含疏水性和芳香族氨基酸,且鉴定和筛选出4条活性最佳的抗氧化肽,氨基酸序列分别为DWGHSW、VFYPW、GTGW和TYFPHF;其中,VFYPW表现出最高的DPPH自由基清除率(IC_(50):(0.350±0.013)mg/mL)和ABTS阳离子自由基清除率(IC_(50):(9.482±0.122)μg/mL),其次为DWGHSW;氢键和疏水作用使DWGHSW和VFYPW与Keap1蛋白(PDB ID:2FLU)形成稳定的复合物。该研究可为宁夏肉牛血红蛋白肽作为天然源抗氧化补充剂的应用提供理论依据,有助于宁夏肉牛血液资源的高值化利用。

关键词：计算机筛选分子模拟宁夏肉牛血红蛋白抗氧化肽鉴定

Research on electronic word-ofmouth for product and service quality improvement:bibliometric analysis and future directions

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International Journal of Intelligent Computing and Cybernetics 2023年第1期16卷 68-98页

作者： Yajun wang Xinyu meng Chang xu meng Zhao School of Business Administration Northeastern UniversityShenyangChina and Northeastern University at QinhuangdaoQinhuangdaoChina School of Business Administration Northeastern UniversityShenyangChina Northeastern University at Qinhuangdao QinhuangdaoChina and Sichuan UniversityChengduChina

Purpose-This paper aims to analyze high-quality papers on the research of electronic word-of-mouth(eWOM)for product and service quality improvement from 2009 to 2022,in order to fully understand theirhistorical progress,current situation and future development ***/Methodology/Approach-This paper adopts the bibliometrics method to analyze the relevantliterature,including publishing trend and citation status,regional and discipline area distribution,andinfluential ***,the VOSviewer is used for literature co-citation analysis and keywordco-occurrence analysis to obtain the basic literature and research hotspots in this research ***-Firstly,the study finds that the number of publications basically shows an increasing trend,and thosepublications are mainly published in tourism *** addition,among these papers,China has the largestnumber of publications,followed by the USA and South *** co-citation analysis of literature andkeyword co-occurrence analysis,22 foundational papers and six main research topics are obtained in this ***,this paper elaborates on the development trend of the research topic and future research directions in ***/value-This is the first paper that uses bibliometrics to analyze and review relevant researcheson eWOM for product and service quality improvement,which is helpful for researchers to quickly understandits development status and *** review also provides some future research directions and provides areference for further research.

关键词： Electronic word-of-mouth Product improvement Service quality improvement Bibliometric analysis VOSviewer

Density Perturbation and Energy Flux of Internal Waves from Velocity Data

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Journal of Ocean University of China 2018年第4期17卷 727-732页

作者： wang Shuya wang Jinhu CHEN xu meng Jing wang Huan Key Laboratory of Physical Oceanography Ocean University of China College of Information Science and Engineering Ocean University of China

Internal waves play a crucial role in ocean mixing, and density perturbation and energy flux are essential quantities to investigate the generation and propagation of internal waves. This paper presents a methodology for calculating density perturbation and energy flux of internal waves only using a velocity field that is based on linearized equations for internal waves. The method was tested by numerical simulations of internal waves generated by tidal flowing over a Gaussian topography in a stratified fluid. The density perturbations and energy fluxes determined using our method that only used velocity data agreed with density perturbations and energy fluxes determined by the equation of state based on temperature data. The mean relative error(MRE) and root mean square error(RMSE) between the two methods were lower than 5% and 10% respectively. In addition, an experiment was performed to exam our method using the velocity field measured by Particle Image Velocimetry(PIV), and the setup of the experiment is consistent with the numerical model. The results of the experiments calculated by the methods using PIV data were also generally equal to those of the numerical model.

关键词： internal waves density perturbation energy flux velocity field PIV