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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du wang Rongjie Lin Weihong xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi Lv Qian wang Yuzhen xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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氢对X80钢焊接接头在近中性pH值溶液中腐蚀行为的影响

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腐蚀科学与防护技术 2016年第5期28卷 415-422页

作者：范裕文吴明陈旭孟向楠王彦亮辽宁石油化工大学石油天然气工程学院抚顺113001

采用动电位极化和电化学阻抗技术研究了电化学充氢后X80钢母材和焊缝在近中性p H值溶液中的电化学行为,并结合光学显微镜对试样充氢前后的形貌进行了观察,测量了母材和焊缝的放氢量。结果表明,电化学充氢并没有改变钢的组织结构;相同电... 详细信息

采用动电位极化和电化学阻抗技术研究了电化学充氢后X80钢母材和焊缝在近中性p H值溶液中的电化学行为,并结合光学显微镜对试样充氢前后的形貌进行了观察,测量了母材和焊缝的放氢量。结果表明,电化学充氢并没有改变钢的组织结构;相同电化学充氢条件下,焊缝比母材吸收更多的氢。在近中性p H值溶液中,未充氢时母材比焊缝有更好的耐蚀性能。充氢促进母材和焊缝在近中性p H值溶液中的阳极溶解。随充氢时间增加,母材和焊缝的自腐蚀电位负移,腐蚀电流增大,腐蚀产物膜电阻和极化电阻减小,母材与焊缝电化学腐蚀行为均加剧。充氢后焊缝中位错缺陷浓度高,对氢起钉扎作用的,使焊缝的耐蚀性大于母材。

关键词： X80管线钢焊缝电化学充氢腐蚀

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含参集值向量均衡问题各种有效解映射的下半连续性

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数学的实践与认识 2017年第5期47卷 234-241页

作者：孟旭东王三华南昌航空大学科技学院江西南昌330034 南昌大学数学系江西南昌330031

在实Hausdorff拓扑向量空间中,引进含参集值向量均衡问题,给出各种有效解的概念.在锥-次类凸的条件下,得到各种有效解的标量化结果.结合集值映射的弱f-性,在适当假设条件下,得到含参集值向量均衡问题各种有效解映射的下半连续性.

关键词：有效解解映射下半连续性含参集值向量均衡问题

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不同形貌二水草酸钙晶体的合成、表征及其对肾上皮细胞的损伤作用

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人工晶体学报 2016年第9期45卷 2232-2239页

作者：余凯徐猛王建敏欧阳健明暨南大学化学系广州510632

合成了4种不同形貌和尺寸的二水草酸钙(COD)晶体,分别为尺寸20μm的花状、10μm的十字形、2μm的四方双锥形和1μm的棒状COD晶体。采用X射线衍射、傅立叶变换红外光谱、扫描电子显微镜(SEM)和比表面测试仪对上述4个COD晶体的理化性质进... 详细信息

合成了4种不同形貌和尺寸的二水草酸钙(COD)晶体,分别为尺寸20μm的花状、10μm的十字形、2μm的四方双锥形和1μm的棒状COD晶体。采用X射线衍射、傅立叶变换红外光谱、扫描电子显微镜(SEM)和比表面测试仪对上述4个COD晶体的理化性质进行了表征。花状和十字形COD晶体都具有尖锐的棱角;棒状、四方双锥形COD都具有完整的(100)面。随着晶体尺寸的降低和晶体表面正电荷密度高的(100)面比例增大,其Zeta电位绝对值不断减小。不同形貌COD晶体均对非洲绿猴肾上皮细胞(Vero)具有毒性作用,其细胞毒性大小与多因素相关,包括晶体的尺寸、晶面、尖锐程度、比表面积以及Zeta电位等。本研究有助于进一步阐明尿微晶形貌差异影响肾结石形成的分子和细胞机制。

关键词：二水草酸钙晶体形貌细胞毒性

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并购与企业研发:对中国制造业上市公司的研究

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中国工业经济 2017年第7期 137-155页

作者：任曙明许梦洁王倩董维刚大连理工大学管理与经济学部

本文扎根于中国制造业转型升级背景,探讨行业内的并购对企业研发的影响机制,从并购可能性和议价能力平均水平两个维度,揭示了并购通过改变企业对市场竞争条件变化的预期来影响其研发的机制。本文使用了行业内并购交易额与行业总资产之... 详细信息

本文扎根于中国制造业转型升级背景,探讨行业内的并购对企业研发的影响机制,从并购可能性和议价能力平均水平两个维度,揭示了并购通过改变企业对市场竞争条件变化的预期来影响其研发的机制。本文使用了行业内并购交易额与行业总资产之比的三年移动平均数、累积超额收益率滞后三年的均值,分别衡量并购可能性、议价能力的行业平均水平,并提出了含有交叉项的计量经济模型,检验影响方向和大小,以及这种影响在不同企业规模和所有制上的差异。研究表明,并购可能性越大,企业预期市场竞争压力越大,研发水平越高;但对不同规模的企业,并购可能性对研发努力的正向作用并未表现出显著的差异;而且,若议价能力的行业平均水平较高,企业研发也较强;从所有制来看,由于所面对的竞争压力较大,在非国有企业中,行业内可能发生的并购对研发的正向作用要大于国有企业。在政策上,政府应破除妨碍并购的制度因素,发挥并购在促进研发上的市场作用。

关键词：并购可能性议价能力的行业平均水平企业规模研发

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SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui xu Fuqiang Hu Jiao Dai Baigen Cai Wei wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

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一种基于网络计算机的虚拟设备音频传输模型和实现

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计算机工程与应用 2004年第21期40卷 131-134页

作者：许猛王柏生中国科学院软件研究所互联网软件技术实验室北京100080

网络计算机是新一代的计算模式,该文提出并实现了一种基于共享虚拟设备的网络音频传输模型,为网络计算机提供多媒体扩展。通过RAB协议传输音频流,端到端链路带宽测量、自适应编码和分布式实时传输控制为网络音频流提供QoS支持。

关键词：网络计算机网络音频虚拟设备数字信号处理 Linux 带宽测量 RAB

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Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen wang Yuchen wang mengjie Zhu Zhile Liang Kanghong Zhang Yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan wang Lina Huang Zifeng xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

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