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Advances in endocrine and targeted therapy for hormone-receptorpositive,human epidermal growth factor receptor 2-negative advanced breast cancer

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Chinese Medical Journal 2020年第9期133卷 1099-1108页

作者： Le-Sang Shen Xiao-Yan Jin xu-meng wang Lai-Zhen Tou Jian Huang Department of Breast Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province HangzhouZhejiang 310009China Department of Surgical Oncology Zhejiang Taizhou Municipal HospitalTaizhouZhejiang 318000China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Nearly 70%of breast cancer(BC)is hormone-receptor(HR)-positive,human epidermal growth factor receptor 2(HER2)-negative,and endocrine therapy is the mainstay of treatment for this ***,intrinsic or acquired endocrine resistance can occur during the endocrine *** on insights of endocrine resistance mechanisms,a number of targeted therapies have been and continue to be *** regard to HR-positive,HER2-negative advanced BC,aromatase inhibitor(AI)is superior to tamoxifen,and fulvestrant is a better option for patients previously exposed to endocrine *** drugs,such as cyclindependent kinases(CDK)4/6 inhibitors,mammalian target of rapamycin(mTOR)inhibitors,phosphoinositide-3-kinase(PI3K)inhibitors,and histone deacetylase(HDAC)inhibitors,play a significant role in the present and show a promising *** the application of CDK4/6 inhibitors becoming common,mechanisms of acquired resistance to them should also be taken into consideration.

关键词： Endocrine therapy Advanced breast cancer Endocrine resistance Targeted therapy

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基于最大熵原理的对数正态树期权定价方法

系统工程 2016年第8期34卷 45-49页

作者：徐睿孟生旺中国人民大学统计学院北京100872 中国人民大学应用统计科学研究中心北京100872

期权作为非常重要的金融衍生品,关于其定价方法的研究长期以来一直受到关注。根据最大熵原理可以得到未知分布的最小误差估计的特点,将其应用于对数正态树期权定价方法中,得到一种新的对数正态树期权定价方法,并应用韩国交易所(KRX)的KO... 详细信息

期权作为非常重要的金融衍生品,关于其定价方法的研究长期以来一直受到关注。根据最大熵原理可以得到未知分布的最小误差估计的特点,将其应用于对数正态树期权定价方法中,得到一种新的对数正态树期权定价方法,并应用韩国交易所(KRX)的KOSPI200股指期权进行实证研究,对经典方法、Black-Scholes公式和提出的改进方法进行比较研究,表明本文提出的方法在期权定价中具有一定的实际应用价值。

关键词：对数正态树最大熵原理期权定价股指期货

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微信舆情主动防御系统及监测算法

情报科学 2017年第8期35卷 40-46页

作者：徐萌王晓河北科技大学图书馆河北石家庄050000

【目的/意义】随着以微信为代表的社交软件的普及和社交网络的搭建,大众的舆论影响力不断提升,一旦舆论导向被动机不良的犯罪分子掌握,将会产生巨大的破坏力。【方法/过程】在此背景下,本文以蜜罐网络主动防御模型为基础,借助适应性聚... 详细信息

【目的/意义】随着以微信为代表的社交软件的普及和社交网络的搭建,大众的舆论影响力不断提升,一旦舆论导向被动机不良的犯罪分子掌握,将会产生巨大的破坏力。【方法/过程】在此背景下,本文以蜜罐网络主动防御模型为基础,借助适应性聚类分析技术,对微信中的舆论信息进行实例结果分析。【结果/结论】验证了适应性聚类分析算法的效力和准确度,证明了投放诱饵数量与舆论调和间的正比关系,印证了本文所构建的蜜罐主动防御系统对社交媒体的舆情监控具有积极的作用。

关键词：微信舆情蜜罐主动防御诱饵

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie wang Wei wang xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng xu Sheng Pang Liangwei Cong Guoyu Qian Dong wang Laishi Li Yusheng Wu Zhi wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo wang Ruifeng xu xu Zhang Peiyu wang Bao Yang Bingjun Yang Juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

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计算机联锁软件制式的安全性评价

铁道学报 2004年第1期26卷 59-63页

作者：郦萌徐翥王铁江同济大学计算机科学与技术系上海200331

计算机联锁软件是铁路信号计算机控制系统中复杂性最大、安全性要求最高的软件。根据制式测试结果颁发计算机联锁的生产许可证 ,是铁道部有关部门加强计算机联锁质量管理的重要措施。以制式测试为依据对联锁软件的安全性进行的评价 ,能... 详细信息

计算机联锁软件是铁路信号计算机控制系统中复杂性最大、安全性要求最高的软件。根据制式测试结果颁发计算机联锁的生产许可证 ,是铁道部有关部门加强计算机联锁质量管理的重要措施。以制式测试为依据对联锁软件的安全性进行的评价 ,能够比较准确地获得软件开发方对于联锁安全性问题的理解和处理能力的完整信息 ,以补充“合格”或“不合格”两个评价结论过于粗略的不足。本文首先根据严重性和诱发可能性为每个安全性问题 (即软件缺陷 )定义了一个安全性指数 ,然后提出针对制式测试的安全性评价指标———联锁软件安全性问题处理完善性 ,用以反映联锁软件的开发水平。这部分包括评价模型和方法 ,特别是对安全性经验关系系统到数值关系系统的映射 ,进行了一致性的证明。文章最后介绍了对某些已经完成制式测试的软件进行安全性问题处理完善性的评价实例。

关键词：计算机联锁软件安全性苛求评价

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi xu Tianyi Huang Ying wang Siyuan xu Yiting wang Wencong wang Zhiping wang Hongkui wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan wang Daidi Li Kaifei xu Guoqing wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease