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geometry of holomorphic invariant strongly pseudoconvex complex Finsler metrics on the classical domains

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Science China Mathematics 2024年第8期67卷 1827-1864页

作者： Xiaoshu ge Chunping Zhong School of Mathematical Sciences Xiamen UniversityXiamen 361005China

In this paper,a class of holomorphic invariant metrics is introduced on the irreducible classical domains of typesⅠ-Ⅳ,which are strongly pseudoconvex complex Finsler metrics in the strict sense of Abate and Patrizio(1994).These metrics are of particular interest in several complex variables since they are holomorphic invariant complex Finsler metrics found in the literature which enjoy good regularity as well as strong pseudoconvexity and can be explicitly expressed to admit differential geometry *** are,however,not necessarily Hermitian quadratic as the Bergman *** metrics are explicitly constructed via deformation of the corresponding Bergman metric on the irreducible classical domains of typesⅠ-Ⅳ,respectively,and they are all proved to be complete K?hler-Berwald *** enjoy very similar curvature properties as those of the Bergman metric on the irreducible classical domains,i.e.,their holomorphic sectional curvatures are bounded between two negative constants and their holomorphic bisectional curvatures are always nonpositive and bounded below by negative constants,*** the viewpoint of complex analysis,these metrics are analogs of Bergman metrics in complex Finsler geometry which do not necessarily have Hermitian quadratic restrictions in the sense of Chern(1996).

关键词： holomorphic invariant metric Kahler-Berwald metric irreducible classical domains

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Analysis of blocking slurry diffusion parameters for a new self-starting drainage anchor cable

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Journal of Earth Science 2024年

作者： WANG xu ge Qi Lü Chengcheng SHU Junwei SUN Hongyue Sino-Italy Ningbo Ecological Park Holding Group Co. Ltd Ocean College Zhejiang University College of Civil Engineering and Architecture Zhejiang University School of Civil Engineering Nanjing Forestry University

A new self-starting drainage anchor that combines prestressed anchor cables with self-starting drainage is proposed. The novelty of the self-starting drainage method is the realization of the drainage and anchoring in the one inclined borehole. Reduction in the number of boreholes can greatly decrease the construction cost and duration of the project. The adverse effect of drilling construction disturbance on the slope is reduced. To tackle the possible blockage of the drainage cavity due to slurry leakage during the solidification process after finishing grouting in the blocking section. To this end， a theoretical equation for the slurry diffusion radius under slurry self-weight pressure boundary conditions is deduced. The result is verified for precision through comparison with numerical simulation. The findings reveal that the permeability coefficient of rock and soil mass makes the most significant impact on the slurry diffusion radius， succeeded by the length of the grouting blocking section， slurry initial setting time， and drilling inclination in descending order of influence. With the 5% mass ratio of a "711" type slurry quick-setting agent， the maximum slurry diffusion radius can be reduced from 0.925m to 0.449m， a reduction of 0.476m， which is comparatively more recommended.

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Carbonic anhydrase-like enzymes in the formation of Lycopodium alkaloid

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Chinese Journal of Natural Medicines 2024年第3期22卷 193-194页

作者： DONG Huiwen ge Huiming State key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China

Plant alkaloids,renowned for their structural diversity and bioactivity,are prominent in both modern and traditional medicine[1].Unraveling the intricacies of plant alkaloid biosynthesis could pave the way for the discovery of new natural products and *** may also shed light on the roles of existing pathways in host biology and provide valuable tools for metabolic engineering in plants and microbes[2].Unlike other major classes of plant natural products,such as terpenoids and polyketides,the formation of alkaloid scaffolds does not conform to a uniform chemical theme or depend on a singular enzyme class[3].A case in point is the Lycopodium alkaloids in the Lycopodiaceae family,where the enzymes responsible for their core scaffold construction remain unidentified[4].

关键词： Lycopodium alkaloid Carbonic anhydrase-like enzymes Biosynthesis

The character of Thurston's circle packings

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Science China Mathematics 2024年第7期67卷 1623-1640页

作者： Huabin ge Aijin Lin School of Mathematics Renmin University of ChinaBeijing100872China Department of Mathematics National University of Defense TechnologyChangsha410073China

We introduce the character of Thurston's circle packings in the hyperbolic background ***, some quite simple criteria are obtained for the existence of hyperbolic circle packings. For example,if a closed surface X admits a circle packing with all the vertex degrees d_(i)≥7, then it admits a unique complete hyperbolic metric so that the triangulation graph of the circle packing is isotopic to a geometric decomposition of X. This criterion is sharp due to the fact that any closed hyperbolic surface admits no triangulations with all d_(i)≤6. As a corollary, we obtain a new proof of the uniformization theorem for closed surfaces with genus g≥2;moreover, any hyperbolic closed surface has a geometric decomposition. To obtain our results, we use Chow-Luo's combinatorial Ricci flow as a fundamental tool.

关键词： character circle packings combinatorial Ricci flow

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gene cloning,protein expression,and enzymatic characterization of a double-stranded RNA degrading enzyme in Apolygus lucorum

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Insect Science 2024年第1期31卷 119-133页

作者： Jie-Yu Zhang Jing Zhao Keyan Zhu-Salzman Qin-Qin Ji Yi-Ping Jiang Liu-Bin Xiao De-Jin xu Guang-Chun xu Lin-Quan ge Yong-An Tan College of Plant Protection Yangzhou UniversityYangzhouJiangsu ProvinceChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingJiangsu ProvinceChina Department of Entomology Texas A&M UniversityCollege StationTXUSA Taizhou Customs of the People's Republic of China TaizhouJiangsu ProvinceChina

RNA interference(RNAi)is a powerful tool that post-transcriptionally silences target genes in eukaryotic ***,silencing efficacy varies greatly among different insect ***,we met with little success when attempting to knock down genes in the mirid bug Apolygus lucorum via dsRNA *** disappearance of double-stranded RNA(dsRNA)could be a potential factor that restricts RNAi ***,we found that dsRNA can be degraded in midgut fluids,and a dsRNase of ***(AldsRNase)was identified and *** alignment indicated that its 6 key amino acid residues and the Mg2+-binding site were similar to those of other insects’*** signal peptide and endonuclease non-specific domain shared high sequence identity with the brown-winged green stinkbug Plautia stali *** showed high salivary gland and midgut expression and was continuously expressed through the whole life cycle,with peaks at the 4th instar ecdysis in the whole *** purified AldsRNase protein obtained by heterologously expressed can rapidly degrade *** comparing the substrate specificity of AldsRNase,3 specific substrates(dsRNA,small interfering RNA,and dsDNA)were all degraded,and the most efficient degradation is ***,immunofluorescence revealed that AldsRNase was expressed in the cytoplasm of midgut *** cloning and functional study of AldsRNase,the enzyme activity and substrate specificity of the recombinant protein,as well as the subcellular localization of nuclease,the reason for the disappearance of dsRNA was explained,which was useful in improving RNAi efficiency in *** and related species.

关键词： Apolygus lucorum cloning dsRNase enzymatic activity protein expression

Correction:Anti-lymphangiogenesis for boosting drug accumulation in tumors

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3141-3142页

作者： Chunling Wang Junchao xu Xiaoyu Cheng ge Sun Fenfen Li Guangjun Nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China Sino-Danish College University of Chinese Academy of Sciences Beijing 100190 China Sino-Danish Center for Education and Research Beijing 100190 China Department of Bioengineering University of Pennsylvania Philadelphia PA 19104 USA School of Nanoscience and Engineering University of Chinese Academy of Sciences Beijing 100049 China

Correction to:Signal Transduction and Targeted Therapy https://***/10.1038/s41392-024-01794-4,published online 15 April 2024 After the article was published online,1 the authors noticed one inadvertent mistake in Supplementary *** image of lung H&E in the Lip-Dox group was repeatedly inserted as the image of Dox group by mistake during the preparation of the *** correct figure was provided as *** correction did not affect any of our results or discussion presented in the original *** apologize for this inadvertent *** original article has been corrected.

关键词： lung boosting repeatedly

Can perfluorooctanoic acid be effectively degraded usingβ-PbO_(2)reactive electrochemical membrane?

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Chinese Chemical Letters 2024年第7期35卷 196-199页

作者： xubin Qian Lei xu xu ge Zhun Liu Cheng Fang Jianbing Wang Junfeng Niu College of Environmental Science and Engineering North China Electric Power UniversityBeijing 102206China College of Water Resources and Hydropower Engineering North China Electric Power UniversityBeijing 102206China Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan 523808China Global Centre for Environmental Remediation(GCER) University of NewcastleCallaghanNSW 2308Australia School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China

Aqueous perfluorooctanoic acid(PFOA)elimination has raised significant concerns due to its persistence and ***β-PbO_(2)plate anodes have shown efficient mineralization of PFOA,it remains unclear whether PFOA can be effectively degraded usingβ-PbO_(2)reactive electrochemical membrane(REM).Herein,we assessed the performance of Ti/SnO_(2)-Sb/La-PbO_(2)REM for PFOA removal and proposed a possible degradation *** a current density of 10 mA/cm2and a membrane flux of 8500(liters per square meter per hour,LMH),the degradation efficiency of 10 mg/L PFOA was merely8.8%,whereas the degradation efficiency of 0.1 mg/L PFOA increased to 96.6%.Although the porous structure of theβ-PbO_(2)REM provided numerous electroactive sites for PFOA,the generated oxygen bubbles in the pores could block the pore channels and adsorb PFOA *** hindered the protonation process and significantly impeded the degradation of high-concentration *** experiments indicated that·OH played dominant role in PFOA *** electrical energy per order to remove 0.1 mg/L PFOA was merely 0.74 Wh/L,which was almost an order of magnitude lower than that of other anode *** study presents fresh opportunities for the electrochemical degradation of low-concentration PFOA usingβ-PbO_(2)REM.

关键词： Perfluorooctanoic acid β-PbO_(2) Reactive electrochemical membrane Electrochemical oxidation

Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(Science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu xu Wenyi Wang Liang Qiao Yunzhe Fu Xichuan ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

Characteristics of Paleontological Communities in Surface Sediments of the Southern South China Sea and Their Paleoclimatic and Paleoenvironmental Significance

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Journal of Earth Science 2024年第1期35卷 144-154页

作者： Jing Zhao Li Zhang Xiaoyan Wang Jinglian ge Min xu Wei Chen Mao Luo Qianyong Liang Qiuhua Yu Shuaibing Luo Wenkun Qie Key Laboratory of Marine Mineral Resoures Ministry of Natural ResourcesGuangzhou Marine Geological SurveyChina Geological SurveyGuangzhou 511458China National Engineering Research Center for Gas Hydrate Exploration and Development Guangzhou 511458China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China

Understanding the spatial and temporal distribution of different paleontological communities in the southern South China Sea(SCS)is fundamental to explore its paleoclimatic and paleoenvironmental *** this study,foraminifera,pollen and diatoms from 100 surface sediment samples covering 40000 km^(2) of sea floor in the southern SCS were comprehensively investigated in terms of their assemblage and *** results showed the existence of abundant foraminifera and pollen in most of the samples,although diatom communities were relatively *** were dominated by ***,***,***,while diatoms were characterized by ***,*** and ***,indicating a typical tropical marine *** pollen assemblages showed a better reflection of montane rainforest,tropical rainforest and *** spatial differences among foraminifera assemblages may indicate the effect of water depth and a warmer environment in the southeast part of the study area,while the spatial patterns of diatom and pollen assemblages imply the influence of coastal *** study also noted that the compositions of paleontological communities in the SCS can vary significantly in a short distance,and synthesized studies on multiple biological groups are needed to reconstruct the Quaternary climate and the oceanographic environment.

关键词： southern South China Sea sediments foraminifera diatom pollen