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Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats

World Journal of Gastroenterology 2018年第6期24卷 706-715页

作者： Chun-lan xu Yu Guo lei Qiao li Ma yi-yi Cheng The Key Laboratory for Space Bioscience and Biotechnology School of Life Sciences Northwestern Polytechnical University

AIM To investigate the modulatory effect of recombinantexpressed vasoactive intestinal peptide(VIP) analogue(rVIPa) on trinitrobenzene sulfonic acid(TNBS)-induced colitis in rats. METHODS Forty-eight rats were randomized into six groups: normal control group(Control), model control group(TNBS), ethanol treatment group(ETOH), and VIP treatment groups with different dosage(rVIPa_(1nmol), rVIPa_(2nmol), rVIPa_(4nmol)). Diarrhea and bloody stool were observed. Colonic damage was evaluated histologically. The levels of tumor necrosis factor-α( TNF-α), interleukin-10(Il-10), myeloperoxidase(MPO) and endotoxin in colonic tissue and serum were determined by enzyme-linked immunosorbent assay(ElISA). The expression of occludin, ZO-1, Toll-like receptor 4(TlR4),and nuclear factor-kappa B p65(NF-κBp65), IκBα, and p-IκBα were detected by Western blot. RESULTS Administration with 2 nmol rVIPa prevented TNBSinduced necrosis, hyperemia, swelling, inflammation, etc., pathologic changes observed in the inner surface of colon in experimental rats. Moreover, rVIPa significantly decreased colonic TNF-α level(P < 0.001), MPO activity(P < 0.001) and serum endotoxin level(P < 0.01), and remarkably increased colonic Il-10 content(P < 0.001) in rats with TNBS-induced colitis. Furthermore, compared to the TNBS-induced colitis group, 2 nmol rVIPa treatment up-regulated the levels of occludin(P < 0.05) and ZO-1(P < 0.05), NF-κB p65(P < 0.01) and IκBα(P < 0.001), and down-regulated the levels of TlR4. CONCLUSION rVIPa ameliorates TNBS-induced colonic injury and inflammation and effectively protected the intestinal mucosal barrier function in rats. The mechanism may be related to TlR4/NF-κB-mediated signaling pathway. rVIPa could be used as a new alternative therapy for intestinal inflammatory disorders.

关键词： Vasoactive intestinal peptide Intestinal mucosal barrier Tight junction Toll-like receptors Recombinant expression

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南县油菜新品种引进及适应性试验初报

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湖南农业科学 2012年第9期 16-18页

作者：聂丽群徐一兰高建彬杨佑兵南县农业局湖南南县413200 湖南生物机电职业技术学院湖南长沙410127

以705A×10R、9EA×1655、763A×10R、H8贵州神农大丰、S203A×10R、706A×10R和湘杂9006等7个油菜新品种(组合)为材料,对不同油菜新品种植株的生长发育、抗性、产量构成因素和产量等进行了研究。结果表明:各品种(组合)全生育期间均无... 详细信息

以705A×10R、9EA×1655、763A×10R、H8贵州神农大丰、S203A×10R、706A×10R和湘杂9006等7个油菜新品种(组合)为材料,对不同油菜新品种植株的生长发育、抗性、产量构成因素和产量等进行了研究。结果表明:各品种(组合)全生育期间均无明显差异,为207～210 d。705A×10R和S203A×10R的抗倒、耐旱渍、抗寒、抗菌核病和病毒病综合表现均为最好。各品种(组合)油菜产量大小顺序为:H8贵州神农大丰>763A×10R>9EA×1655>S203A×10R>705A×10R>706A×10R>湘杂9006。引进的7个新品种(组合)的长势、抗逆性较强,熟期适中,适宜在洞庭湖区作水稻后茬作物种植。

关键词：油菜新品种品比产量

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Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

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Organic geochemistry characteristics of Jurassic black shales from the Amdo area, northern Tibet, China

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Acta Geochimica 2022年第3期41卷 393-405页

作者： Guiwen xu lan Chen Weiguang Zhu xuejuan Da Zhangxiong Zhu Haisheng yi State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of Sciences99 West Lincheng RoadGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Department of Earth Sciences Chongqing University of Science and TechnologyChongqing 401331China Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059China

The Jurassic black shales of the Qiangtang Basin,northern Tibet are known to be amongst the most important source *** date,there is no detailed study on the organic geochemistry of the Bathonian/Callovian coccolith-bearing sediments and their source-rock ***,we focus on the black limestones,marls,and shales at the Amdo 114 station section using Rock–Eval pyrolysis and biomarkers for sources,types,and thermal maturity of organic matter and the reconstructed depositional *** samples are characterized by(1)relatively high TOC values(0.20–2.56 wt%)and relatively low Tmax values between 428 and 452℃;(2)shortchain n-alkanes with a maximum at C_(14) to C_(18) and Pr/Ph>1;(3)31–35 homohopanes and gammacerane with lower abundance;and (4)C_(27)–C_(28)–C_(29) regular steranes with C_(29) being slightly *** organic matter is TypeⅡand thus dominantly derived from phytoplankton,especially *** maturity indicators include the Ts/(Ts+Tm),C_(31)22S/(22S+2R),C_(29)aaa20S/(20S+0R),C_(29)ββ/(ββ+aa)and C_(27)Dia/(Dia+Reg),which are regarded as immature to very early ***,the high Pr/Ph,Pr/nC_(17),and Ph/nC_(18) ratios,Pr/Ph vs Gammacerane index suggest that these black shales were deposited in unstratified marine waters of normal salinity under dysoxic to weakly reduced conditions.

关键词： Rock–Eval pyrolysis Biomarkers Source rocks Jurassic Northern Tibet

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不同土壤耕作模式对双季稻植株生物学特性的影响

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广东农业科学 2018年第1期45卷 1-8页

作者：徐一兰刘唐兴付爱斌李益锋皮俊黄新杰湖南生物机电职业技术学院湖南长沙410127

土壤耕作方式是影响稻田土壤物理性状和水稻产量的关键因素,以双季稻种植模式为研究对象,分析了双季水稻免耕(NT)、双季水稻翻耕(MP)、双季水稻旋耕(RT)、早稻旋耕-晚稻免耕(RT–NT)和早稻旋耕-晚稻翻耕(RT–MP)5种不同土壤耕作措施对... 详细信息

土壤耕作方式是影响稻田土壤物理性状和水稻产量的关键因素,以双季稻种植模式为研究对象,分析了双季水稻免耕(NT)、双季水稻翻耕(MP)、双季水稻旋耕(RT)、早稻旋耕-晚稻免耕(RT–NT)和早稻旋耕-晚稻翻耕(RT–MP)5种不同土壤耕作措施对双季稻植株生物学特性及产量的影响。结果表明:早稻和晚稻各个主要生育时期,各处理植株叶面积指数表现依次为早稻MP>RT>RTNT>RT-MP>NT,晚稻MP>RT-MP>RT>RT-NT>NT。其中,早稻各生育时期,MP处理植株的根系、茎、叶和穗干重均高于其他处理,均表现为MP>RT>RT-NT>RT-MP>NT;晚稻各生育时期,MP、RT-MP处理植株根系、茎和穗干重均显著高于NT,均表现为MP>RT-MP>RT-NT>RT>NT;MP、RT、RT-NT、RT-MP处理早稻产量比NT分别增加681.3、395.9、248.1、210.0kg/hm^2,晚稻产量比NT分别增加880.3、495.5、99.1、710.1kg/hm^2。说明不同土壤耕作模式下水稻植株干物质积累和产量有各自特征,以土壤翻耕和旋耕方式下水稻植株干物质总量大而且分配合理,有利于改善产量构成因素,增加水稻产量。

关键词：水稻土壤耕作叶面积指数干物质产量

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Seawater barium and sulfide removal improved marine habitability for the Cambrian Explosion of early animals

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National Science Review 2024年第8期11卷 136-145页

作者： Wei Wei Lin-Hui Dong Shuhai Xiao yi-Bo Lin Lingang xu Guang-yi Wei Wenzhong Wang lan-lan Tian Hai-Zhen Wei Fang Huang State Key Laboratory of Lithospheric and Environmental Coevolution School of Earth and Space Sciences University of Science and Technology of China CAS Center for Excellence in Comparative Planetology University of Science and Technology of China Department of Geosciences Virginia Tech State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University School of Earth Sciences and Resources China University of Geoscience Deep Space Exploration Lab School of Earth and Space SciencesUniversity of Science and Technology of China

An increase in atmospheric pO2has been proposed as a trigger for the Cambrian Explosion at ～539-514 Ma but the mechanistic linkage remains *** gain insights into marine habitability for the Cambrian Explosion,we analysed excess Ba contents(Baexcess) and isotope compositions(δ138Baexcess) of～521-Myr-old metalliferous black shales in South *** δ138Baexcessvalues vary within a large range and show a negative logarithmic correlation with Baexcess,suggesting a major（>99%） drawdown of oceanic Ba inventory via barite *** variations in Baexcessand δ138Baexcessindicate that Ba removal was driven by sulfate availability that was ultimately derived from the upwelling of deep *** oceanic oxygenation across the Ediacaran-Cambrian transition may have increased the sulfate reservoir via oxidation of sulfide and concurrently decreased the Ba reservoir by barite *** removal of both H2S and Ba that are deleterious to animals could have improved marine habitability for early animals.

关键词： early Cambrian animals radiation sulfate availability barite precipitation toxic material removal

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Preliminary results of a Compton camera based on a single 3D position-sensitive CZT detector

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Nuclear Science and Techniques 2018年第10期29卷 210-220页

作者： yi-Lin Liu Jian-Qiang Fu Yu-lan Li Yuan-Jing Li xu-Ming Ma lan Zhang Department of Engineering Physics Tsinghua UniversityBeijing 100084China Nuctech Co Ltd Haidian DistrictBeijing 10084China

A Compton camera prototype has been developed using a pixelated CZT detector with 4-by-4 *** of the detector are read out by a VASTAT ASIC that is controlled by a self-developed DAQ board. The DAQ software is developed using LabVIEW, and the offline Compton imaging codes are written in C++. The prototype has been successfully calibrated, and its capabilities for source detection, spectroscopy, and Compton imaging have been demonstrated using a Cs-137 *** angular resolution of the 662 keV line is 36° FWHM for the simple back-projection method and 9.6° FWHM for the MLEM reconstruction method. The system is ready to be extended to 11-by-11 pixels in the future, and a better imaging quality can be expected due to the better relative position resolution.

关键词： Compton imaging 3D position-sensitive technique CZT detector

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利伐沙班在犬和猫临床应用的研究进展

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动物医学进展 2025年第1期46卷 97-102页

作者：王炜江蓝路心怡付诗懿刘亦婷韦力煣俞峰刘波中国农业大学动物医学院北京100193 中国农业大学教学动物医院北京100193

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够... 详细信息

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够特异性抑制活性凝血因子X从而抑制血栓形成。近年来人医领域对利伐沙班的相关临床研究逐渐丰富,涉及单用利伐沙班或使用双通路抑制疗法防治不同类型的动、静脉血栓栓塞,可为其应用于兽医临床提供据。犬、猫临床使用利伐沙班的研究正相继开展,论文就犬、猫血栓栓塞疾病发病情况、防治现状,利伐沙班的药理学特性及其在人医、兽医领域的临床试验研究进展进行综述,以期为兽医临床上利伐沙班的进一步研究提供参考。

关键词：新型口服抗凝药利伐沙班血栓栓塞犬猫

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The Minimum Stretch Spanning Tree Problem for Typical Graphs

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 510-522页

作者： lan LIN yi-xun LIN School of Electronics and Information Engineering Tongji UniversityShanghai 200092China School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

With applications in communication networks,the minimum stretch spanning tree problem is to find a spanning tree T of a graph G such that the maximum distance in T between two adjacent vertices is *** problem has been proved NP-hard and fixed-parameter polynomial algorithms have been obtained for some special families of *** this paper,we concentrate on the optimality characterizations for typical classes of *** determine the exact formulae for the complete k-partite graphs,split graphs,generalized convex graphs,and several planar grids,including rectangular grids,triangular grids,and triangulated-rectangular grids.

关键词： communication network spanning tree optimization tree spanner max-stretch congestion

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Lipase and photodecarboxylase coexpression: A potential strategy for alkane-based biodiesel production from natural triglycerides

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Chinese Journal of Chemical Engineering 2024年第3期67卷 238-246页

作者： Yong-yi Zeng Xin-yi xu Jin-xuan Xie Wen-Li Chen lan Liu Xin-Jian yin Bi-Shuang Chen School of Marine Sciences Sun Yat-Sen UniversityZhuhai 519080China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Alkane-based biodiesel is considered the next generation of biodiesel owing to its potential environmental benefits and the fact that it exhibits much higher specific caloric values than traditional ***,the formidable obstacle impeding the commercialization of this cutting-edge fuel alternative lies in the cost associated with its *** this study,an engineered strain Escherichia coli(***)showcasing harmonized coexpression of a lipase(from Thermomyces lanuginosus lipase,TLL)and a fatty acid photodecarboxylase(from Chlorella variabilis,CvFAP)was first constructed to transform triglycerides into *** potential of *** BL21(DE3)/pRSFDuet-1-TLL-CvFAP for alkane synthesis was evaluated with tripalmitin as a model substrate under various process *** a comprehensive examination of the reaction parameters,the scope of the biotransformation was expanded to‘real’substrates(vegetable oils).The results showed that bioderived oils can be transformed into alkanes with high yields(0.80-10.20 mmol·L^(-1))under mild conditions(35℃,pH 8.0,and 36 h)and blue light *** selected processes were performed on an increased lab scale(up to 100 ml)with up to 24.77 mmol·L^(-1) tripalmitin,leading to a yield of 18.89 mmol·L^(-1) *** the employment of a method for efficiently producing alkanes under mild conditions and a simple procedure to isolate alkanes from the reaction system,the utilization of sustainable biomass as a fundamental feedstock emerges as the primary solution to lower the cost of alkane-based ***,this study proposes a readily implementable and highly effective approach for alkane-based biodiesel production.

关键词： Alkane-based biodiesel Renewable biomass Co-overexpression Lipase Photodecarboxylase

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