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游离静脉动脉化皮瓣在修复合并双侧指动脉损伤及皮肤缺损的手指外伤中的临床疗效

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现代预防医学 2012年第19期39卷 5192-5193+5195页

作者：徐丽辉邢台市人民医院创伤骨科手外科

目的探讨分析运用游离静脉动脉化皮瓣修复合并双侧指动脉损伤及皮肤缺损的手指外伤中的临床效果。方法将某院42例双侧指动脉损伤及皮肤缺损采用游离静脉动脉化皮瓣修复方法治疗的病例作为观察组,另外随机选取30例合并双侧指动脉损伤及... 详细信息

目的探讨分析运用游离静脉动脉化皮瓣修复合并双侧指动脉损伤及皮肤缺损的手指外伤中的临床效果。方法将某院42例双侧指动脉损伤及皮肤缺损采用游离静脉动脉化皮瓣修复方法治疗的病例作为观察组,另外随机选取30例合并双侧指动脉损伤及皮肤缺损的病例采用结扎、单侧吻合的作为对照组。治疗后按照中华医学会手功能评定标准进行评定。结果从效果看,72例均进行0.3～1.5年的随访显示,对照组优良率36.7%;观察组优良率85.7%。从术后恢复看,对照组治疗1周后6例皮肤坏死,其中2例出现真菌感染,经过抗真菌感染后末端仍坏死,予以截指。有28例出现外形凹陷,色泽较深,8例出现感觉和屈伸功能障碍。观察组治疗1周后未出现皮肤坏死,有1例出现真菌感染,经过抗感染治疗后愈合,有30例色泽稍暗,外形均满意,1例出现感觉障碍。两组以上情况差异均有统计学意义(P﹤0.05)。结论运用游离静脉动脉化皮瓣修复合并双侧指动脉损伤及皮肤缺损的手指外伤能明显提高临床效果,可降低并发症和功能障碍情况,值得临床借鉴推广。

关键词：游离静脉动脉化皮瓣双侧指动脉损伤及皮肤缺损临床效果

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： li xu huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

International Transferring Trend in Manufacturing Industry

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厦门大学学报（自然科学版） 2002年第S1期41卷 222-223页

作者： ZHAO Xin-jun 1, xu li-hui 2 (1. School of Mechanical Engineering and Automation, Northeastern Unive rsity, Shenyang 110004, China 2. School of Business Administration, Northea stern University, Shenyang 110004, China)

This paper addressed the international transferring t endency of manufacturing industry one by one as follows: (1) The developed count ries realize manufacturing industry structure upgrade reling on worldwide tr ansference not only domestic transference. On one hand, the TNCs make cross-inv estments, transnational merger & acquisition so as to achieve the optimum colloc ation of R&D resources, and obtain innovation in knowledge and technology. On th e other hand, the developed countries transfer labor and resource intensive indu stry as well as the labor-intensive link of the production chain in highly tech nology industry to the developing countries, to make their industrial structure escalation. (2) The adjustment and upgrade of manufacturing industry presents "m ulti-step type". First, the object of international transference substitutes th e capital-intensive industry and maturing industry with complicate technique fo r the industry with labor-intensive, simple technique or higher pollution, or s ubstitutes non-core complex technological procedure and parts and components fo r assembly in manufacturing process. Secondly, technology transference forms "br ain-hand and foot" pattern, i.e. the developed countries are increasingly p aying more and more attention to the research and control of core technology, th us transferring simple technique and labor-intensive procedure in higher scienc e and technology. Thirdly, the developed countries begins to transfer both capit al and technology intensive production, as well as transfer certain procedures i n higher technology production process to a few developing countries, even t o transfer parts of R & D to developing countries. (3) TNCs promote the global m anufacturing network (GMN) by recombination and transfer. TNCs organize producti on, trade, technological research and transference through foreign direct invest ment (FDI) all over the world, as a result, GMN makes the national competence no longer depend on absolu

关键词： manufacturing industry international transferrin g tendency

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang xuan Cheng hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao xu xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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湖南省设区城市房地产投资环境评价

特区经济 2009年第5期244卷 194-195页

作者：徐小慧瞿理铜湖南工程职业技术学院管理工程系湖南长沙410114 湖南师范大学资源与环境科学学院湖南长沙410081

房地产投资环境的好坏直接关系到房地产的投资效益,是决定投资成败的关键因素,是房地产投资的决策者进行投资决策的重要依据。本文对湖南省13个设区城市房地产投资环境进行了评价,评价结果显示长沙、株洲、湘潭、娄底的房地产投资环境较... 详细信息

房地产投资环境的好坏直接关系到房地产的投资效益,是决定投资成败的关键因素,是房地产投资的决策者进行投资决策的重要依据。本文对湖南省13个设区城市房地产投资环境进行了评价,评价结果显示长沙、株洲、湘潭、娄底的房地产投资环境较好,张家界、岳阳、怀化、衡阳、永州、常德、郴州、邵阳、益阳等城市房地产投资环境较差。并对出现这种结果的原因进行了分析。

关键词：投资环境评价房地产城市湖南

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： hui Zhu li Mu Xi xu Tianyi Huang Ying Wang Siyuan xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin li Wen-Tao Kuai lin Chen Ming-hui Zeng xue-Mei Tao Jia-Xin Han Yue-Kui Wang lian-Xin xu li-Ying Ge Yong-Gang liu Shuang li liang xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles