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Total glucosides of paeony improve complete freund’s adjuvant-induced rheumatoid arthritis in rats by inhibiting toll-like receptor 2-mediated tumor necrosis factor receptor-associated factor 6/nuclear factor-kappa B pathway activation

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Journal of Traditional Chinese Medicine 2019年第4期39卷 566-574页

作者： Chen huan Wen Yueqiang Pan Ting xu Shijun Institute of Meterial Medica Integration and Transformation for Brain Disorders CDUTCMChengdu 610075China Chengdu University of Traditional Chinese Medicine Chengdu 610075China

OBJECTIVE: To investigate the mechanism underlying anti-inflammatory and immunoregulatory effect of total glucosides of paeony(TGP) based on toll-like receptor 2(TLR2) mediated tumor necrosis factor(TNF) receptor-associated factor 6(TRAF6)/nuclear factor-kappa B(NF-κB) pathway activation in rats with rheumatoid ***: Adjuvant arthritis(AA) model was developed by complete freund’s adjuvant(CFA) immunization. TGP(100, 50, 25 mg/kg) and celecoxib(2.8 mg/kg) were administered by intragastric administration for 21 d. Right hind paw swelling was assessed every 2 d. After 21 d, synovial changes of the ankle were detected by histopathology. CD4+and CD8+ T cell amounts in peripheral blood were measured by flow-cytometrically. Gene and protein levels of toll-like receptor(TLR)2, TRAF6, tumor necrosis factor ligand superfamily member 6(FASLG)in the spleen were assessed by RT-qPCR and Western Bolt, respectively. Nuclear expression of NF-κB p65 was detected by NF-κB p65 Assay ***: Paw swelling and synovium lesions were obviously aggravated in AA rats. These symptoms were significantly relieved by *** ratio of CD4+/CD8+ T cell was increased in AA rats, while TGP reduced this increased *** and protein levels of splenic TLR2, TFAR6 and FASLG, and nuclear NF-κB p65 in AA rats were significantly increased, but overtly inhibited by ***: These findings suggest that TGP’s anti-inflammatory effect onRA in rats with CFA may be related to the downregulation of TLR2/TRAF6/NF-κB pathway and the regulation of T cell subsets.

关键词： Arthritis,rheumatoid Arthritis,experimental Toll-like receptor 2 TNF receptor-associated factor 6 Transcription factor RelA Fas ligand protein CD4-CD8 ratio Total glucosides of paeony

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Broadband illusion optical devices based on conformal mappings

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Frontiers of physics 2017年第5期12卷 129-133页

作者： Zhan Xiong Lin xu Ya-Dong xu huan-Yang Chen College of Physics Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology Sooehow University Suzhou 215006 China

In this paper, we propose a simple method of illusion optics based on conformal mappings. By carefully developing designs with specific conformal mappings, one can make an object look like another with a significantly... 详细信息

关键词： optical devices llusion optics onformal transformation

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Generation and characterization of transgenic mice expressing tamoxifen-inducible cre-fusion protein specifically in mouse liver

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World Journal of Gastroenterology 2003年第8期9卷 1844-1847页

作者： huan-ZhangZhu Jian-QuanChen guo-XiangCheng Jing-Lunxue IstimteofPathology SouthwestHospitalThirdMilitaryMedicalUniversityChongqing400038China ShanghaiTransgenicResearchCenter Shanghai201203China StateKeyLaboratoryofGeneticEngineering.InstituteofGenetics SchoolofLifeSciencesFudanUniversityShanghai200433Chian

AIM: To establish transgenic mice expressing tamoxifeninducible Cre-ERt recombinase specifically in the liver and to provide an efficient animal model for studying gene function in the liver and creating various mouse models mimicking human ***: Alb-Cre-ERt transgenic mice were produced by microinjecting the construct with Cre-ERt fusion gene of DNA fragments into fertilized eggs derived from inbred C57BL/6strain. Transgenic mice were identified by using PCR and Southern blotting. Expression of Cre-ERt fusion gene was analyzed in the liver, kidney, brain and lung from F1generation transgenic mice at 8 weeks of age by reverse transcription (RT)-***: Four hundred and fourteen fertilized eggs of C57 BL/6 mice were microinjected with recombinant AlbCre-ERt DNA fragments, and 312 survival eggs injected were transferred to the oviducts of 12 pseudopregnant recipient mice, 6 of 12 recipient mice became pregnant and gave birth to 44 offsprings. Of the 44 offsprings, two males and one female carried the hybrid Cre-ERt fusion gene. Three mice were determined as founders, and were back crossed to set up F1 generations with other inbred C57BL/6 *** of Cre-ERt fusion gene in F1 offspring followed Mendelian rules. The expression of Cre-ERt mRNA was detected only in the liver of F1 offspring from two of three founder ***: Transgenic mice expressing tamoxifeninducible Cre-ERt recombinase under control of the liverspecific promoter are preliminary established.

关键词：它莫西芬 Cre-ERt 肝动物模型

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FedAdaSS: Federated Learning with Adaptive Parameter Server Selection Based on Elastic Cloud Resources

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 609-629页

作者： Yuwei xu Baokang Zhao huan Zhou Jinshu Su School of Computer National University of Defense TechnologyChangsha410000China

The rapid expansion of artificial intelligence(AI)applications has raised significant concerns about user privacy,prompting the development of privacy-preserving machine learning(ML)paradigms such as federated learning(FL).FL enables the distributed training of ML models,keeping data on local devices and thus addressing the privacy concerns of ***,challenges arise from the heterogeneous nature of mobile client devices,partial engagement of training,and non-independent identically distributed(non-IID)data distribution,leading to performance degradation and optimization objective bias in FL *** the development of 5G/6G networks and the integration of cloud computing edge computing resources,globally distributed cloud computing resources can be effectively utilized to optimize the FL *** the specific parameters of the server through the selection mechanism,it does not increase the monetary cost and reduces the network latency overhead,but also balances the objectives of communication optimization and low engagement mitigation that cannot be achieved simultaneously in a single-server framework of existing *** this paper,we propose the FedAdaSS algorithm,an adaptive parameter server selection mechanism designed to optimize the training efficiency in each round of FL training by selecting the most appropriate server as the parameter *** approach leverages the flexibility of cloud resource computing power,and allows organizers to strategically select servers for data broadcasting and aggregation,thus improving training performance while maintaining cost *** FedAdaSS algorithm estimates the utility of client systems and servers and incorporates an adaptive random reshuffling strategy that selects the optimal server in each round of the training *** analysis confirms the convergence of FedAdaSS under strong convexity and L-smooth assumptions,and comparative experiments within the FLSim framework demonstra

关键词： Machine learning systems federated learning server selection artificial intelligence of things non-IID data

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Effects of Coal Rank and High Organic Sulfur on the Structure and Optical Properties of Coal-based Graphene Quantum Dots

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Acta Geologica Sinica(English Edition) 2018年第3期92卷 1218-1230页

作者： TANG Yuegang huan xuan LAN Chunyuan xu Miaoxin College of geoscience and Surveying Engineering China University of Mining & Technology (Beijing) Beijing 100083 China

Coal-based graphene quantum dots(GQDs) were successfully produced via a one-step chemical synthesis from six different coal ranks, from which two superhigh organic sulfur(SHOS) coals were selected as natural S-doped carbon sources for the preparation of S-doped GQDs. The effects of coal properties on coal-based GQDs were analyzed by means of high-resolution transmission electron microscopy(HRTEM), X-ray diffraction(XRD), Fourier transform infrared(FTIR) spectroscopy, X-ray photoelectron spectroscopy(XPS), ultraviolet-visible(UV-Vis) absorption spectroscopy, and fluorescence emission spectra. It was shown that all coal samples can be used to prepare GQDs, which emit bluegreen and blue fluorescence under ultraviolet light. Anthracite-based GQDs have a hexagonal crystal structure without defects, the largest size, and densely arranged carbon rings in their lamellae; the highrank bituminous coal-based GQDs are relatively reduced in size, with their hexagonal crystal structure being only faintly visible; the low-rank bituminous coal-based GQDs are the smallest, with sparse lattice fringes and visible internal defects. As the metamorphism of raw coals increases, the yield decreases and the fluorescence quantum yield(QY) initially increases and then decreases. Additionally, the surface of GQDs that were prepared using high-rank SHOS coal(high-rank bituminous coal) preserves rich sulfur content even after strong oxidation, which effectively adjusts the bandgap and improves the fluorescence QY. Thus, high-rank bituminous coal with SHOS content can be used as a natural S-doped carbon source to prepare S-doped GQDs, extending the clean utilization of low-grade coal.

关键词： coal graphene quantum dots coal rank organic sulfur China

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Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1954-1965页

作者： Qinglan guoy huan Xiay Yuzhuo Wu Shuai Shao Chengbo xu Tiantai Zhang Jiangong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Three new C20-diterpenoid alkaloids with a sulfonic acid unit,named aconicarmisulfonines B and C(1 and 2)and chuanfusulfonine A(3),respectively,were isolated from the Aconitum carmichaelii lateral roots("fu zi"in Chinese).Structures of 1-3 were determined by spectroscopic data *** chemical properties and reactions were observed for the C20-diterpenoid alkaloids:(a)specific selective nucleophilic addition of the carbonyl(C-12)in 1 with CD3 OD;(b)interconversion between 1 and 2 in D2 O;(c)stereo-and/or regioselective deuterations of H-11αin 1-3 and both H-11αand H-11βin aconicarmisulfonine A(4);(d)TMSP-2,2,3,3-d4 promoted cleavage of the C-12-C-13 bond of 4 in D2 O;(e)dehydrogenation of 4 in pyridine-d5,and(f)Na2 SO3-assisted dehydrogenation and N-deethylation of songorine(5,a putative precursor of 1-4).Biogenetically,1 and 2 are correlated with 4,for which the same novel carbon skeleton is proposed to be derived from semipinacol rearrangements via migrations of C-13-C-16 and C-15-C-16 bonds of the napelline-type skeleton,***,3 is a highly possible precursor or a concurrent product in the biosynthetic pathways of 1,2,and *** the acetic acid-induced mice writhing assay,at 1.0 mg/kg(i.p.),compounds 1,2,5,5 a,and 5 b exhibited analgesic effects against mice writhing.

关键词： Ranunculaceae Aconitum carmichaelii Sulfonated C20-diterpenoid alkaloid Aconicarmisulfonines Chuanfusulfonine A Analgesic effect

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基于光谱技术的典型互花米草入侵湿地土壤属性预测研究

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光谱学与光谱分析 2025年第1期45卷 197-203页

作者：陈旭曹思珩杨仁敏陈秋宇李建国徐璐 4 江苏师范大学地理测绘与城乡规划学院地理信息科学系江苏徐州221116

为了高效监测互花米草入侵海岸带湿地生态系统的土壤属性变化,选取江苏省盐城湿地珍禽国家级自然保护区的一处典型互花米草入侵湿地作为研究区,利用随机分层采样方法选取15个样点,在3个深度(0~30、30~60、60~100 cm)共采集45个土壤样品... 详细信息

为了高效监测互花米草入侵海岸带湿地生态系统的土壤属性变化,选取江苏省盐城湿地珍禽国家级自然保护区的一处典型互花米草入侵湿地作为研究区,利用随机分层采样方法选取15个样点,在3个深度(0~30、30~60、60~100 cm)共采集45个土壤样品,测定了土壤可见光-近红外反射光谱和10种土壤理化属性,研究了偏最小二乘和随机森林两种方法的预测能力,分析了不同光谱变换形式对预测精度的影响,探讨了入侵年限和土壤深度作为辅助预测变量的潜力。结果表明:(1)可见光-近红外光谱技术可以较好地预测有机碳、无机碳、全氮、含水量、pH、容重、盐分和黏粒等属性;(2)偏最小二乘回归法比随机森林法更适合监测互花米草入侵湿地的关键土壤理化属性,利用偏最小二乘法对土壤属性建立的预测模型精度(R^(2))在0.341~0.979之间,随机森林方法对土壤属性建立的预测模型精度(R^(2))最高为0.722;(3)基于原始光谱可以获得土壤全氮的最优预测模型(R^(2)为0.769,RMSE为0.091 g·kg^(-1)),而其他土壤属性的最优模型多是基于微分变换或倒数变换建立的模型,微分变换和倒数变换可以有效地提高模型预测精度;(4)模型预测精度在加入入侵年限和土壤深度两个变量后总体上有所提高,其中有机碳、全氮、盐分、pH和容重等属性的预测精度对这两个变量更为敏感,土壤有机碳最优模型的精度(R^(2))从0.794提高到0.806,pH最优模型的精度(R^(2))从0.838提升至0.884,盐分最优模型的精度(R^(2))从0.978提升至0.997。综上所述,可见光-近红外光谱技术在互花米草入侵湿地关键土壤理化属性预测方面具有明显的优越性,通过适当的光谱变换、变量筛选、模型选择等方面可以实现互花米草入侵湿地土壤变化的快速监测。

关键词：互花米草入侵可见光-近红外光谱土壤监测偏最小二乘法随机森林光谱变换

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Analysis of torque transmitting behavior and wheel slip prevention control during regenerative braking for high speed EMU trains

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Acta Mechanica Sinica 2016年第2期32卷 244-251页

作者： Kun xu guo-Qing xu Chun-Hua Zheng Shenzhen Institutes of Advanced Technology Chinese Academy of Sciencesand The Chinese University of Hong Kong Shenzhen College of Advanced Technology University of Chinese Academy of Sciences School of Electronics and Information Tongji University

The wheel-rail adhesion control for regenerative braking systems of high speed electric multiple unit trains is crucial to maintaining the stability,improving the adhesion utilization,and achieving deep energy *** remain technical challenges mainly because of the nonlinear,uncertain,and varying features of wheel-rail contact *** research analyzes the torque transmitting behavior during regenerative braking,and proposes a novel methodology to detect the wheel-rail adhesion ***,applications to the wheel slip prevention during braking are investigated,and the optimal slip ratio control scheme is proposed,which is based on a novel optimal reference generation of the slip ratio and a robust sliding mode *** proposed methodology achieves the optimal braking *** simulation results for uncertain slippery rails verify the effectiveness of the proposed methodology.

关键词： High speed electric multiple unit(EMU) train Regenerative braking Wheel-rail adhesion Optimal slip ratio

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Seismic resilient shear wall structures:A state-of-the-art review

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Science China(Technological Sciences) 2023年第6期66卷 1640-1661页

作者： xu Gang guo Tong LI AiQun Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Southeast UniversityNanjing 211189China Multi-Functional Shaking Tables Laboratory Beijing University of Civil Engineering and ArchitectureBeijing 100044China

The ductile design principle has been widely adopted in seismic design of structures,so the main structural components are designed to have the dual functions of bearing and energy dissipation under the *** recent years,the intensity of major earthquakes occurred in China,Chile,New Zealand,and Japan had reached or exceeded the design level of the maximum credible *** most cases,the designed structures did not collapse and the casualties were ***,many structures were seriously damaged and must be overhauled or rebuilt,resulting in huge economic ***,researchers have paid more attention to the seismic resilient *** shear wall can provide an efficient lateral force resisting capacity and has a wide range of applications in building *** review firstly summarized the research advances of seismic resilient shear wall structures,mainly from three aspects:high-performance materials,replaceable components,and hybrid structural systems;then,the development of seismic performance analysis,design methods,and engineering applications of seismic resilient shear wall structures were presented;finally,the key issues that need to be explored in the future research were discussed,which was helpful for the wide application of seismic resilient shear wall structures.

关键词： seismic resilience shear wall self-centering structure seismic design engineering application

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Regression Function Comparison for Paired Data

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Journal of Systems Science & Complexity 2020年第5期33卷 1558-1570页

作者： guo xu ZHANG Jun FANG Yun School of Statistics Beijing Normal UniversityBeijing 100875China College of Mathematics and Statistics Shenzhen UniversityShenzhen 518060China Department of Mathematics Shanghai Normal UniversityShanghai 200234China

In this paper,the regression function comparison for paired data is *** proposed test statistic is based on the weighted integral of characteristic function marked by the difference of *** are several merits of the proposed *** instance,it takes a simple V-statistic *** bandwidth is *** moment conditions are required for *** can be applied to covariates of any fixed *** asymptotic results are also *** is proven that n times the proposed test statistic converges to a finite limit under the null hypothesis and the test is consistent against any fixed *** alternative hypotheses which converge to the null hypothesis at the rate of n-1/2 are also detected.A suitable Bootstrap algorithm is also proposed for the implementation of the proposed test *** studies are carried out to illustrate the merits of the proposed method.A real data example is also used to illustrate the proposed testing procedures.

关键词： Bootstrap characteristic function paired data regression function comparison V-statistic

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