检索结果-南通市图书馆

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

引用

Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na li Zhengxiang Zhou Ru Ye liyan Zhong Yashuang xu Junhui Ren Yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

引用

Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian xu Fei Niu Xinlong Dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical simulation of formaldehyde distribution characteristics in the high-speed train cabin

引用

Building Simulation 2024年第2期17卷 285-300页

作者： Fan Wu hang Dong Chao Yu Hengkui li Qingmin Cui Renze xu Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangshaHunan410075China Joint International Research Laboratory of Key Technologies for Rail Traffic Safety ChangshaHunan410075China National&Local Joint Engineering Research Center of Safety Technology for Rail Vehicle ChangshaHunan410075China School of Software Henan University of EngineeringZhengzhouHenan451191China

The global concern over indoor air pollution in public vehicles has grown *** a focus on enhancing passengers’comfort and health,this study endeavors to investigate the distribution characteristics of formaldehyde within a high-speed train cabin by employing a computational fluid dynamics(CFD)model which is experimentally validated in a real cabin *** research focuses on analyzing the impact of air supply modes,temperature,relative humidity,and fresh air change rate on the distribution and concentration of *** results demonstrate that the difference in average formaldehyde concentration between the two air supply modes is below 1.3%,but the top air supply mode leads to a higher accumulation of formaldehyde near the sidewalls,while the bottom air supply mode promotes a more uniform distribution of ***,the temperature,relative humidity,and fresh air change rate are the primary factors affecting formaldehyde concentration levels,but they have modest effects on formaldehyde’s distribution pattern within the *** the temperature and relative humidity increase,the changes in formaldehyde concentrations in response to variations in these factors become more ***,the formaldehyde concentration may surpass the standard limit of 0.10 mg/m^(3)if the fresh air change rate falls below 212 m^(3)/*** research provides a systematic approach and referenceable results for exploring formaldehyde pollution in high-speed train cabins.

关键词： indoor air pollution formaldehyde CFD simulation high-speed train ventilation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distributed Observer for Full-Measured Nonlinear Systems Based on Knowledge of FMCF

引用

IEEE/CAA Journal of Automatica Sinica 2025年第1期 69-85页

作者： Haotian xu Shuai liu Yueyang li Ke li the School of Control Science and Engineering Shandong University and also with Key Laboratory of Machine Intelligence and System Control Ministry of Education IEEE the School of Electrical Engineering University of Jinan

Driven by practical applications, the achievement of distributed observers for nonlinear systems has emerged as a crucial advancement in recent years. However, existing theoretical advancements face certain limitations: They either fail to address more complex nonlinear phenomena, rely on hard-to-verify assumptions, or encounter difficulties in solving system ***, this paper aims to address these challenges by investigating distributed observers for nonlinear systems through the full-measured canonical form(FMCF), which is inspired by full-measured system(FMS) theory. To begin with, this study addresses the fact that the FMCF can only be obtained through the observable canonical form(OCF) in existing FMS *** paper demonstrates that a class of nonlinear systems can directly obtain FMCF through state space equations, independent of OCF. Also, a general method for solving FMCF in such systems is provided. Furthermore, based on the FMCF, A distributed observer is developed for nonlinear systems under two scenarios: lipschitz conditions and open-loop bounded *** paper establishes their asymptotic omniscience and demonstrates that the designed distributed observer in this study has fewer design parameters and is more convenient to construct than existing approaches. Finally, the effectiveness of the proposed methods is validated through simulation results on Van der Pol oscillators and microgrid systems.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

TiO2/g-C3N4 heterojunctions： In situ fabrication mechanism and enhanced photocatalytic activity

引用

Frontiers of Materials Science 2016年第3期10卷 310-319页

作者： li-Cheng WU hang ZHAO li-Guo JIN Huan-Yan xu School of Materials Science and Engineering Harbin University of Science and Technology Harbin 150040 China

In situ fabrication of TiO21g-C3N4 （TCN） heterojunctions was achieved by a modified sol-gel method. TG analysis was employed to determine the content of Ti02 in TCN composites. XRD, FTIR, TEM and HRTEM were used to analyze the phase composition, functional groups, morphology and microstructure of as-obtained pro- ducts, respectively. Based on the measurement of surface Zeta potential of g-C3N4, a possible mechanism on in situ fabrication of TCN heterojunctions was concluded. The control experiments indicated that TCN heterojunctlons exhibited better photocatalytic performance than either Ti02 or g-C3N4, suggesting that the enchanced photocatalytic activity could be realized by TCN heterojunctionso Then, the evaluation of parameters affecting the photocatalytic performance of TCN heterojunctions was investigated. Even after five cycles, TCN heterojunctions still maintained high photocatalytic activity, exhibiting the good photocatalytic stability. UV-vis absorption spectra showed that almost all MB molecules were decomposed in the photocatalytic process. Finally, the possible mechanism on enhanced photocatalytic performance of TCN heterojunctions was discussed.

关键词： TiO2 g-C3N4 heterojuncUons photocatalytic mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Water diversion and agricultural production:Evidence from China

引用

Journal of Integrative Agriculture 2023年第4期22卷 1244-1257页

作者： YANG Rui xu hang College of Humanities and Development Studies China Agricultural UniversityBeijing 100193P.R.China College of Economics and Management Northwest A&F UniversityYangling 712100P.R.China

Water diversion can alleviate water shortages caused by the uneven distribution of water ***’s Southto-North Water Diversion Project(SNWD)is the largest water diversion project *** on the prefecturelevel data of China’s Huang-Huai-Hai Plain from 2000 to 2020,this study employs an empirical strategy of Differencesin-Differences(DID)to analyze the impact of SNWD on agricultural *** results show that SNWD has significantly increased agricultural production,measured by the agricultural value *** estimated results of the benchmark model remain robust when the contemporaneous policy is addressed,an alternative outcome is used,subsamples are estimated,and alternative estimation techniques are *** study argues that the potential impact mechanism may be that SNWD significantly increases the acreage for cash crops but reduces that for grain *** analysis shows that in prefectures with high temperature or land potential,SNWD’s impact on agricultural value added is relatively *** contrast,in areas with prolonged sunshine or high slopes,SNWD’s impact on agricultural value added is relatively *** the low added value of grain crops,the government should consider strengthening food security by subsidizing water supply to sustain grain production.

关键词： South-to-North Water Diversion Project agricultural production Differences-in-Differences China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cobalt-catalyzed divergent functionalization of N-sulfonyl amines via β-carbon elimination

引用

Science China Chemistry 2022年第11期65卷 2214-2218页

作者： Lun xu hang Shi Department of Chemistry Zhejiang UniversityHangzhou310027China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province School of ScienceWestlake UniversityHangzhou310024China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

This article demonstrates a catalytic method for C(aryl)-C(alkyl) bond functionalization of N-sulfonyl amines. A cobalt(III)catalyst was used to cleave the C-C bond via β-carbon elimination, providing a metallacycle intermediate. Subsequent allylation,amidation, or alkenylation of the intermediate led to divergent conversions in the presence of diverse coupling partners. when the coupling partner was a diene, an insertion-type functionalization was realized with an exclusive 1,3-regioselectivity, in which both of the fragments derived from N-sulfonyl amines were utilized.

关键词： cobalt amine β-carbon elimination C-C bond activation divergent functionalization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pufferfish gasdermin Ea is a significant player in the defense against bacterial pathogens

引用

Marine life Science & Technology 2024年第3期6卷 462-474页

作者： hang xu Kunpeng Qin Kangwei Hao Zihao Yuan li Sun CAS and Shandong Province Key Laboratory of Experimental Marine Biology Institute of OceanologyCAS Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China Laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China School of Marine Science University of Chinese Academy of SciencesQingdao 266400China

Gasdermins(GSDMs)are proteins cleaved by caspase(CASP)to trigger *** teleosts,pyroptosis is mediated by gasdermin E(GSDME).The Pufferfish,Takifugu rubripes,possesses two GSDME orthologs:named TrGSDMEa and *** is cleaved by CASP3/7 to liberate the N-terminal(NT)domain that can trigger pyroptosis in mammalian ***,the biological function of TrGSDMEa in pufferfish is unknown,and TrGSDMEb is poorly *** found that TrGSDMEb was cleaved by CASP1/3/6/7/8,but the resulting NT domain,despite its similarity to TrGSDMEa-NT domain in sequence and structure,failed to induce *** and TrGSDMEb exhibited similar expression patterns in pufferfish under normal physiological conditions but were up-and downregulated,respectively,in expression during Vibrio harveyi and Edwardsiella tarda *** infection induced the activation of TrGSDMEa and CASP3/7 in pufferfish cells,resulting in pyroptosis accompanied with IL-1βproduction and *** of TrGSDMEa-mediated pyroptosis via TrCASP3/7 reduced the death of pufferfish cells and augmented bacterial dissemination in fish ***-oriented mutagenesis identified 16 conserved residues in teleost GSDMEa that were required for the pore formation or auto-inhibition of *** study illustrates the role of GSDMEa-mediated pyroptosis in teleost defense against bacterial pathogens and provides new insights into the structure-based function of vertebrate GSDME.

关键词： GSDME Caspase Takifugu rubripes Bacterial infection Immune defense

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polar Coded Iterative Multiuser Detection for Sparse Code Multiple Access System

引用

China Communications 2018年第11期15卷 51-61页

作者： hang MU Youhua Tang li li Zheng Ma Pingzhi Fan Weiqiang xu School of Information Science and Technology Southwest Jiaotong University Chengdu 610031 China National Engineering Laboratory for integrated traffic data application technology Chengdu 610031 China School of Information Science and Technology Zhejiang Sci-Tech University Hangzhou 310018 China

Polar coded sparse code multiple access(SCMA) system is conceived in this paper. A simple but new iterative multiuser detection framework is proposed, which consists of a message passing algorithm(MPA) based multiuser detector and a soft-input soft-output(SISO) successive cancellation(SC) polar decoder. In particular, the SISO polar decoding process is realized by a specifically designed soft re-encoder, which is concatenated to the original SC decoder. This soft re-encoder is capable of reconstructing the soft information of the entire polar codeword based on previously detected log-likelihood ratios(LLRs) of information bits. Benefiting from the soft re-encoding algorithm, the resultant iterative detection strategy is able to obtain a salient coding gain. Our simulation results demonstrate that significant improvement in error performance is achieved by the proposed polar-coded SCMA in additive white Gaussian noise(AWGN) channels, where the performance of the conventional SISO belief propagation(BP) polar decoder aided SCMA, the turbo coded SCMA and the low-density parity-check(LDPC) coded SCMA are employed as benchmarks.

关键词： iterative multiuser receiver polarcode sparse code multiple access (SCMA)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Approximate Controllability for Degenerate Heat Equation with Bilinear Control

引用

Journal of Systems Science & Complexity 2021年第2期34卷 537-551页

作者： li lingfei GAO hang School of Science Northeast Electric Power UniversityJilin 132012China School of Mathematics and Statistics Northeast Normal UniversityChangchun 130024China

This paper investigates the nonnegative approximate controllability for the one-dimensional degenerate heat equation governed by bilinear *** non-controllability and approximate controllability are studied for the *** the control is restricted to act on a fixed domain,it is not *** the control is allowed to mobile,it is approximately controllable.

关键词： Approximate controllability bilinear control degenerate heat equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：