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Safety and clinical efficacy of linezolid in children:a systematic review and meta-analysis

World Journal of Pediatrics 2023年第2期19卷 129-138页

作者： Yi Shi Hai-Lan Wu yu-Hang Wu Shuang Li Li-Ya Zhang Shan-Shan xu He-yu Huang Chun-Hong Zhang xu-ben yu Kang Cai Jing Zhang Li-Su Huang Department of Infectious Disease Xinhua Children’s HospitalXinhua HospitalShanghai Jiao Tong University School of MedicineShanghai200092China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou310052China Institute of Antibiotics Huashan HospitalFudan UniversityShanghai200040China Department of Pharmacy the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China

Background We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial *** A systematic literature search was conducted up to April 23,2021,using linezolid and its synonyms as search *** reviewers independently identified and extracted relevant randomized controlled trials and prospective cohort *** extracted studies were included in a single-rate meta-analysis of adverse events and clinical outcomes using random-effects *** A total of 1082 articles were identified,and nine studies involving 758 children were included in the *** overall proportion of adverse events was 8.91%[95%confidence interval(CI)=1.64%–36.52%],with diarrhea(2.24%),vomiting(2.05%),and rash(1.72%)being the most *** incidences of thrombocytopenia and anemia were 0.68%and 0.16%,*** specific adverse events,including rash and gastrointestinal events,were more frequent in the oral administration *** terms of efficacy,the overall proportion of clinical improvement was 88.80%(95%CI=81.31%–93.52%).Children with a history of specific bacteriological diagnosis or concomitant antibiotic therapy had a 1.13-fold higher clinical improvement than children without such *** proportion of microbial eradication was 92.68%(95%CI=84.66%–96.68%).The proportion of all-cause mortality was 0.16%(95%CI=0.00%–7.75%).Conclusions Linezolid was well-tolerated in pediatric patients and was associated with a low frequency of adverse events,such as anemia,thrombocytopenia,and ***,linezolid was effective in children with diagnosed and suspected Gram-positive infections.

关键词： Children Efficacy Linezolid Meta-analysis Safety

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显像管磁偏转散焦的分析

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电视技术 2001年第4期25卷 94-97页

作者：徐本裕华中科技大学电子与信息工程系湖北武汉430074

通过对显像管中受偏转后电子束光点尺寸的测量及数据处理，可得到屏上光点尺寸与偏转线圈绕组分布之间的对应关系，根据该关系提出了减小光点尺寸的偏转绕组分布的设计方法。

关键词：偏转散焦偏转线圈显像管电视

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Multicomponent polymerization of elemental sulfur,difluoromethylene phosphobetaine and aryl silyl ethers toward aromatic poly(O,O′-monothiocarbonate)s

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Science China Chemistry 2025年

作者： Yongjiang yu Rongrong Hu ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of Technology School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong AIE Institute

Polythiocarbonates with similar structures to polycarbonates, have emerged as a group of promising sulfur-containing polymers with a range of practical applications, taking advantages of their excellent optical properties, good thermal stability and filmforming ability, and so on. However, the synthesis of polythiocarbonates generally suffered from mixed isomeric structures of repeating units, and hazardous sulfur-containing reagents. In this work, an efficient multicomponent reaction of elemental sulfur,difluoromethylene phosphobetaine（PDFA）, and aryl silyl ethers was designed with the assistance of organic base 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene（MTBD） to produce 12 kinds of O,O′-monothiocarbonate compounds in up to 93% yields,taking advantages of the unique chemical property of difluorocarbene, and the deprotection of silyl group by F-generated from PDFA. Most importantly, the MTBD-assisted multicomponent polymerization of bis（aryl silyl ether）s, elemental sulfur, and PDFA was developed, affording 12 kinds of poly（O,O′-monothiocarbonate）s with well-defined structures, high Mws of up to16900 g/mol and high yields（up to 99%）. These poly（O,O′-monothiocarbonate）s possessed good film-forming properties and thermal stability, high light refractive indices and transmittance. The facile synthesis of these polymonothiocarbonates might pave the way for the development of promising sulfur-containing polymer materials.

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Mechanism Study on the Effect of Retarder on Polyurethane Setting Time Based on Molecular Simulation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 224-231页

作者： WU yuxuan xu Wenyuan yu Tianlai JI Yongcheng School of Civil Engineering Northeast Forestry UniversityHarbin 150040China

This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal *** mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics *** transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane *** results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of *** phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component *** reduction in interaction slows the setting ***,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.

关键词： polyurethane retarder setting time molecular dynamics diffusion coefficient

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Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： xu Rongqi MI Jianxin WANG Shulin xu Man ZHU Li BAI Lei TANG Dandan LEI yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

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Recent progress in exploring heterogeneous catalyst surface chemistry with near ambient pressure XPS

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Science China Chemistry 2025年

作者： yuanjie xu Zemin An yu Tang Institute of Molecular Engineering Plus Institute of Molecule Catalysis and In Situ/Operando Studies College of Chemistry Fuzhou University

X-ray photoelectron spectroscopy(XPS) is a crucial surface analysis technique that has become a key tool in the study of heterogeneous catalysis. Detecting surface chemistry under conditions that closely mimic actual industrial catalytic processes is essential for understanding the mechanisms involved. In the past decade, near ambient pressure X-ray photoelectron spectroscopy(NAP-XPS) has been increasingly utilized to study the surface chemistry of catalysts during heterogeneous catalytic processes, offering insights into structure-performance correlations. This review begins with a brief overview of NAP-XPS instrumentation. Next, we discuss the application of NAP-XPS in the study of thermal catalysis reactions, followed by a summary of the research on catalyst restructuring under reaction conditions. Additionally, we address the challenges and future perspectives for the development and application of NAP-XPS. Catalysis is inherently dynamic, requiring an understanding of the real-time behavior of catalysts under varying conditions. Therefore, future improvements in the ability to probe reaction intermediates with higher spatial and temporal resolution under conditions that closely mimic industrial environments are needed.

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Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian Liang Li xu Changsheng Ding yu Liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

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Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun xu Desmond Loke Bin yu Yishu Zhang Rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua xu Miao yu yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： CHEN Wuxing CHEN Shuang yu Yan ZHANG Jiangyi xu Haiyang GUO Wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

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