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Effects of N_2/O_2 flow rate on the surface properties and biocompatibility of nano-structured TiO_xN_y thin films prepared by high vacuum magnetron sputtering

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Chinese Physics B 2015年第7期24卷 321-326页

作者： Sehrish Saleem R.Ahmad Uzma Ikhlaq R.Ayub Jin Wei Hong xu rui zhen Li Peng Hui Khizra Abbas Paul K.Chu Department of Physics Government College University Department of Physics and Materials Science City University of Hong Kong Centre for Advanced Studies in Physics (CASP) Government College University

NiTi shape memory alloys（SMA） have many biomedical applications due to their excellent mechanical and biocompatible properties. However, nickel in the alloy may cause allergic and toxic reactions, which limit some applications. In this work, titanium oxynitride films were deposited on NiTi samples by high vacuum magnetron sputtering for various nitrogen and oxygen gas flow rates. The x-ray diffraction（XRD） and x-ray photoelectron spectroscopy（XPS） results reveal the presence of different phases in the titanium oxynitride thin films. Energy dispersive spectroscopy（EDS） elemental mapping of samples after immersion in simulated body fluids（SBF） shows that Ni is depleted from the surface and cell cultures corroborate the enhanced biocompatibility in vitro.

关键词： titanium oxynitride films magnetron sputtering biocompatibility

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均匀带电圆环在空间任意点电势分布的计算

福建师范大学学报（自然科学版） 2007年第4期23卷 70-73页

作者：许瑞珍蔡声镇福建师范大学物理与光电信息科技学院福建福州350007

利用MATLAB数值计算和图形处理功能,研究均匀带电圆环在空间任意点的电势分布,计算出轴线上的电势与电磁学中的结论进行比较.结果表明:利用MATLAB获得的结果是可靠的.该结论对研究电磁场的分布提供了一种可行的方法,对研究与静电放电有... 详细信息

利用MATLAB数值计算和图形处理功能,研究均匀带电圆环在空间任意点的电势分布,计算出轴线上的电势与电磁学中的结论进行比较.结果表明:利用MATLAB获得的结果是可靠的.该结论对研究电磁场的分布提供了一种可行的方法,对研究与静电放电有关的电磁场的特性有积极的指导意义.

关键词：带电圆环电势 MATLAB

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稀土镁球墨铸铁的断裂韧性和疲劳断裂特性

金属学报 1978年第1期14卷 40-50页

作者：徐驰余瑞珍中国科学院上海冶金研究所

本文指出,用断裂力学参数代替冲击韧性更能正确反映球铁承受静、动载荷抗断能力。介绍了稀土镁球铁KIc,da/dN,△Kth等参数的测定方法和特点,研究了金相组织如球化率、石墨形态、球径、基体组织等对球铁断裂韧性的影响,对强韧球铁应具有... 详细信息

本文指出,用断裂力学参数代替冲击韧性更能正确反映球铁承受静、动载荷抗断能力。介绍了稀土镁球铁KIc,da/dN,△Kth等参数的测定方法和特点,研究了金相组织如球化率、石墨形态、球径、基体组织等对球铁断裂韧性的影响,对强韧球铁应具有的冶金结构进行了探讨。同时,对疲劳断裂过程各个阶段的裂纹扩展特性进行了观察。作者认为,改善球铁的金相组织有可能在强度和韧性方面出现较大突破。

关键词：球铁稀土镁球墨铸铁金相组织砂型铸造石墨球径疲劳断裂特性断裂韧性破断韧性力学强度

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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闽南民间古眠床工艺考

泉州师范学院学报 2008年第5期26卷 46-49页

作者：许瑞珍泉州师范学院艺术学院福建泉州362000

闽南民间古眠床不仅是一件实用家具,也是一件精美雅致的工艺制品。随着时代的变迁,绝大多数古眠床已经毁坏并逐渐消失。因此,抢救、保护这些民间文化遗产,记载和传承其工艺中的优秀内涵,便成为我们今天的重要任务。文章着重探讨闽南民... 详细信息

闽南民间古眠床不仅是一件实用家具,也是一件精美雅致的工艺制品。随着时代的变迁,绝大多数古眠床已经毁坏并逐渐消失。因此,抢救、保护这些民间文化遗产,记载和传承其工艺中的优秀内涵,便成为我们今天的重要任务。文章着重探讨闽南民间古眠床制作的基本工艺流程及其特色。

关键词：古眠床工艺闽南

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RLC介观电路的量子化和量子涨落

福建师范大学学报（自然科学版） 2001年第2期17卷 40-42页

作者：许瑞珍福建师范大学物理系福建福州350007

分析 RLC电路的两种量子化方案。

关键词： RLC电路量子化量子涨落量子效应电荷电流介观电路

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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四螺旋桨家族蛋白质序列——结构关系研究

科技信息 2008年第12期 13-13,6页

作者：许瑞珍杨雄波三峡大学理学院湖北宜昌443002

蛋白质的三级结构唯一地由其氨基酸序列决定,这是广为人所接受的。然而,很多具有规则三级结构的蛋白质其氨基酸序列接近随机,这使得人们感到很困惑。本文将以四螺旋桨家族蛋白质为例,通过简化氨基酸残基,根据相似性方法把序列中的隐含... 详细信息

蛋白质的三级结构唯一地由其氨基酸序列决定,这是广为人所接受的。然而,很多具有规则三级结构的蛋白质其氨基酸序列接近随机,这使得人们感到很困惑。本文将以四螺旋桨家族蛋白质为例,通过简化氨基酸残基,根据相似性方法把序列中的隐含对称性显示出来。结果表明氨基酸序列中的隐含对称性与三级结构的四重准对称性一致。

关键词：蛋白质对称性四螺旋桨家族氨基酸序列